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Prenatal amoxicillin exposure induces developmental toxicity in fetal mice and its characteristics

Journal of Environmental Sciences 2024年第3期137卷 287-301页

作者： Yongguo Dai yu Peng Wen Hu Yi Liu Hui wang Department of Pharmacology Wuhan University School of Basic Medical SciencesWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Provincial Key Laboratory of Developmentally Originated Disease Wuhan 430071China

Amoxicillin,a widely used antibiotic in human and veterinary pharmaceuticals,is now considered as an“emerging contaminant”because it exists widespreadly in the environment and brings a series of adverse ***,systematic studies about the developmental toxicity of amoxicillin are still *** explored the potential effects of amoxicillin exposure on pregnancy outcomes,maternal/fetal serum phenotypes,and fetal multiple organ development in mice,at different doses(75,150,300 mg/(kg·day))during late-pregnancy,or at a dose of 300 mg/(kg·day)during different stages(mid-/latepregnancy)and courses(single-/multi-course).Results showed that prenatal amoxicillin exposure(PAmE)had no significant infuence on the body weights of dams,but it could inhibit the physical development and reduce the survival rate of fetuses,especially during the ***,PAmE altered multiple maternal/fetal serum phenotypes,especially in *** multi-organ function results showed that PAmE inhibited testicular/adrenal steroid synthesis,long bone/cartilage and hippocampal development,and enhanced ovarian steroid synthesis and hepatic glycogenesis/lipogenesis,and the order of severity might be gonad(testis,ovary)>liver>*** analysis found that PAmE-induced multiorgan developmental and functional alterations had differences in stages,courses and fetal gender,and the most obvious changes might be in high-dose,late-pregnancy and multicourse,but there was no typical rule of a dose-response *** conclusion,this study confirmed that PAmE could cause abnormal development and multi-organ function alterations,which deepens our understanding of the risk of PAmE and provides an experimental basis for further exploration of the long-term harm.

关键词： Amoxicillin Prenatal exposure Fetal development Organ function Developmental toxicity

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Performance Analysis of Cooling Wall of Supercritical CO_(2) Coal-Fired Plants

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Journal of Thermal Science 2022年第6期31卷 1881-1890页

作者： wang Yanjuan yu Binhui GAO Shuo LIU Qibin XU Jinliang The Beijing Key Laboratory of Multiphase Flow and Heat Transfer North China Electric Power UniversityBeijing 102206China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Using supercritical CO_(2)(S-CO_(2)) instead of water steam as heat transfer fluid for coal-fired power plants is another way to further improve the power generation efficiency. In this paper, a multi-field coupling model that integrates fluid flow, heat transfer and thermal stress is proposed to solve the complex problem. The effects of the key operating parameters on the performances of the cooling wall are numerically investigated. More details of the characteristics of fluid dynamics, thermal stress, pressure drop, coupled heat transfer and the whole flow and temperature fields in the S-CO_(2) cooling wall are revealed and discussed. A comparison study is made between the cooling wall tube and waterwall tube. Both temperature and thermal deformations of cooling wall tube are much higher than that of water. Numerical simulation results indicate that inclination angle has little effects on the temperature distribution, while increase of pressure drop is obvious as the inclination angle increases. Increasing tube diameter can effectively reduce both the pressure drop and the temperature of the cooling wall tube. As a result, a new insight is introduced for the design of S-CO_(2) power cycle.

关键词： supercritical CO_(2) cooling wall coal-fired power plant heat transfer

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Metastatic patterns and surgical methods for lymph nodes No.5 and No.6 in proximal gastric cancer

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Chinese Journal of Cancer Research 2019年第1期31卷 171-177页

作者： Jinou wang Pei Wu Zhenning wang Kai Li Baojun Huang Pengliang wang Huimian Xu zhi Zhu Department of Pathology Shengjing Hospital of China Medical UniversityShenyang 110001China Department of Surgical Oncology the First Hospital of China Medical UniversityShenyang 110001China

Objective: The current surgical treatment guidelines for early proximal gastric cancer(PGC) still lack agreement. Lymphadenectomy of lymph nodes No. 5 and No. 6 is the major difference between total and proximal gastrectomy. We elucidated the appropriate surgical procedure for PGC by investigating the pathological characteristics and prognostic significance of lymph nodes No. 5 and No. ***: In total, 333 PGC patients who underwent total gastrectomy were enrolled in this study. We investigated their clinicopathological characteristics and the metastatic patterns of the lymph nodes. Patients with metastasis in lymph nodes No. 5 and No. 6 were combined into one group and we compared the difference in survival between those with and without metastasis in lymph nodes No. 5, 6(lymph nodes No. 5 and No. 6 in any group of metastasis) for different ***: The metastatic rates for lymph nodes No. 5 and No. 6 in PGC were 9.91% and 16.11%, *** metastatic rate for both lymph nodes No. 5, 6 was 20.42%. Multivariate analysis showed that positive metastasis in lymph node No. 4, depth of invasion, and tumor size were independently correlated with the presence of metastasis in lymph nodes No. 5, ***: When lymph node No. 4 is positive(intraoperative pathology) or tumor size ≥5 cm or T4 stage,lymphadenectomy should be performed for lymph nodes No. 5 and No. 6, and total gastrectomy is recommended.

关键词： Gastrectomy lymph nodes No.5 and No.6 metastasis prognosis proximal gastric cancer

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Associations of Sedentary Time and Physical Activity with Metabolic Syndrome among Chinese Adults:Results from the China Health and Nutrition Survey

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Biomedical and Environmental Sciences 2021年第12期34卷 963-975页

作者： BAI Jing wang yun ZHANG Xian Fan OUYANG Yi Fei ZHANG Bing wang zhi Hong DU Shu Fa wang Hui Jun National Institute for Nutrition and Health Chinese Center for Disease Control and PreventionBeijing 100050China Department of Nutrition and Carolina Population Center University of North Carolina at Chapel Hill 123 W.Franklin St.Chapel Hill NC 27599USA

Objective This study aimed to determine the independent and joint associations of sedentary time(ST)and physical activity(PA) with metabolic syndrome(MetS) and its components among Chinese *** The study analyzed data from 4,865 adults aged ≥ 18 years who participated in the 2009 and2015 China Health and Nutrition Surveys(CHNS). Four types of leisure ST and three types of PA selfreported at baseline were collected. Multivariable logistic regressions were used to determine the independent and joint associations of ST and PA with the odds of MetS or its *** For independent effects, higher levels of television time and total leisure ST was associated with higher MetS risk [odds ratio(OR) 1.3, 95% confidence interval(CI) 1.1–1.6, P 7 hours/week(h/w) group was higher than that in the < 7 h/w group in(OR 1.5, 95% CI 1.2–1.9). Higher levels of moderate-to-vigorousintensity physical activity(MVPA) and total PA were associated with a lower MetS risk(OR 0.7, 95% CI0.6–0.9, P < 0.001;OR 0.8, 95% CI 0.7–0.9, P < 0.001, respectively). For the joint effects, compared with those reporting the lowest level of total leisure ST(< 14 h/w) and the most active tertile of MVPA(≥ 61.0 MET-h/w), participants reporting the most total leisure ST(≥ 35 h/w) and the lowest level of MVPA(0 MET-h/w) had the highest odds of MetS(OR 2.0;95% CI 1.4–2.7). Except for people reporting ST(14–21 h/w) within the most active tertile of MVPA, the associations in all other groups were *** the increase of TV time and decreased MVPA, the odds of MetS almost showed a curve *** MVPA and total PA have independent preventive effects, and sedentary behavior(mainly watching TV) has an unsafe effect on MetS and its components. Strengthening the participation of MVPA and combining the LPA to replace the TV-based ST to increase the total PA may be necessary to reduce t

关键词： Sedentary time Physical activity Metabolic syndrome Adults

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Uncertainties in Quantitatively Estimating the Atmospheric Heat Source over the Tibetan Plateau

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Atmospheric and Oceanic Science Letters 2014年第1期7卷 28-33页

作者： DUAN An-Min wang Mei-Rong XIAO zhi-Xiang State Key Laboratory of Numerical Modeling for Atmospheric Science and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of Sciences Nanjing University of Information Science&Technology University of Chinese Academy of Sciences

As a huge,intense,and elevated atmospheric heat source(AHS) approaching the mid-troposphere in spring and summer,the Tibetan Plateau(TP) thermal forcing is perceived as an important factor contributing to the formation and variation of the Asian summer *** numerous studies devoted to determine the strength and change of the thermal forcing of the TP on the basis of various data sources and methods,uncertainties remain in quantitative estimation of the AHS and will persist for the following reasons:(1) Routine meteorological stations cover only limited regions and show remarkable spatial inhomogeneity with most distributed in the central and eastern ***,all of these stations are situated at an altitude below 5000 ***,the large area above that elevation is not included in the data.(2) Direct observations on heat fluxes do not exist at most stations,and the sensible heat flux(SHF) is calculated by the bulk formula,in which the drag coefficient for heat is often treated as an empirical constant without considering atmospheric stability and thermal roughness length.(3) Radiation flux derived by satellite remote sensing shows a large discrepancy in the algorithm in data inversion and complex terrain.(4) In reanalysis data,besides the rare observational records employed for data assimilation,model bias in physical processes induces visible errors in producing the diabatic heating fields.

关键词： Tibetan Plateau atmospheric heat source data bias uncertainties

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Influence of Operating Parameters on NO_(x)and SO_(2)Emissions in Circulating Fluidized Bed with Post-Combustion

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Journal of Thermal Science 2023年第5期32卷 1858-1867页

作者： wang Chao SONG Guoliang CHEN Rui JIANG yu Lyu Qinggang School of Engineering Science University of Science&Technology of ChinaHefei 230026China Institute of Engineering Thermophysics Chinese Academy of ScienceBeijing 100190China University of Chinese Academy of Science Beijing 100049China Dalian National Laboratory for Clean Energy Dalian 116023China

Post-combustion technology of circulating fluidized bed can largely reduce the emission of nitrogen oxides(NOx)in the process of combustion and succeed in meeting the ultra-low NO_(x)standard for some fuels like Shenmu *** the potential of synergistic control of the emissions of NO_(x)and sulphur dioxide(SO_(2))under post-combustion technology has become a direction that needs further *** experiments were conducted on a 0.1 MW(thermal)circulating fluidized bed(CFB)test platform,composed of a CFB main combustor and post-combustion chamber(PCC).The paper focuses on the effects of air distribution ratio and temperature in CFB and limestone addition on NO_(x)and SO_(2)*** experimental results showed that compared with traditional CFB combustion,post-combustion technology can reduce NO_(x)emission largely,but lead to a slight increase in SO_(2)*** higher SO_(2)emissions at post-combustion can lead to less NO_(x)*** the decrease inλ_(CFB),NO_(x)emission first decreased and then increased;by contrast,SO_(2)emission withλ_(CFB)first increased and then *** post-combustion,whenλ_(CFB)was 0.9,NO_(x)emission was the minimum,while the SO_(2)emission was the *** temperature and limestone addition has less adverse effects on NO_(x)emission under post-combustion,compared with traditional CFB *** injection into the furnace is applicable under post-combustion,and the sulfur removal efficiency under post-combustion is very high,almost equivalent to that under traditional combustion.

关键词： circulating fluidized bed post-combustion NO_(x) SO_(2) synergistic control

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Robust Polystyrene/Fluorinated Silica Superhydrophobic Composite Coatings with Rapid Curing at Room Temperature Prepared by One-Step Spraying

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Journal of Bionic Engineering 2023年第6期20卷 2742-2754页

作者： Yong wang Lihua yu Junhua Xu Kai Jing Ningxin Mao School of Materials Science and Engineering Jiangsu University of Science and Technology2 Mengxi RoadZhenjiang CityJiangsu ProvinceChina

Superhydrophobic materials are severely limited in their applications due to their weak mechanical properties and complex preparation *** this paper,polystyrene/fluorinated silica(PS/SiO_(2))superhydrophobic composite coatings were prepared on the surface of 304 stainless steel using a simple one-step spraying *** effects of different PS contents on the wettability as well as the wear properties of the samples were ***_(2) was encapsulated in polystyrene to form a structure similar to cement encapsulated *** the addition of PS,a mound-like structure was formed on the sample surface,and a more optimized micro–nano structure was obtained when the content of PS was 0.6 *** this time,the sample exhibited excellent wettability with a contact angle of 157.86°and a sliding angle of 0.84°.In addition,the contact angle of 151.09°was achieved after 180 cm of friction under a 100 g load and the composite coating prepared by this method also has excellent chemical stability,water impact resistance,corrosion resistance,and self-cleaning *** opens up new possibilities for the development of simple and robust superhydrophobic materials.

关键词： Superhydrophobic Room temperature curing Mechanical durability Corrosion resistance Self-cleaning

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Thermal Properties of Poly（vinyl chloride-co-vinyl acetate-co-2-hydroxypropyl acrylate）（PVVH） Polymer and Its Application in ZnO Based Nanogenerators ：

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Chinese Physics Letters 2011年第1期28卷 164-166页

作者： ZHANG Lei YANG Jun-He wang Xian-Ying HE Xing ZHAO Bin TANG zhi-Hong YANG Guang-zhi QIU Uan-Xun School of Materials Science and Engineering University of Shanghai for Science and Technology Shanghai 200093

A novel piezoelectricity based nano energy conversion device using vertically aligned ZnO nanowires/PVVH matrix as the working unit is proposed. Thermal energy is converted to electricity via the interaction of the PVVH polymer and ZnO nanowires. The thermal properties of PVVH ave studied using Raman spectroscopy under different temperatures. The results show that the structure of PVVH is sensitive to fluctuations of the environmental temperatures. With the increasing temperature, PVVH tends to be crystallized and stress can be developed inside the polymer. The stress is responsible for the deformation and voltage generation of the ZnO nanowires.

关键词： Soft matter liquids and polymers Condensed matter: electrical magnetic and optical Condensed matter: structural mechanical & thermal Nanoscale science and low-D systems

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Numerical simulation of flow hydrodynamics of struvite pellets in a liquid–solid fluidized bed

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Journal of Environmental Sciences 2017年第7期29卷 391-401页

作者： Xin Ye Dongyuan Chu Yaoyin Lou zhi-Long Ye Ming Kuang wang Shaohua Chen Key Laboratory of Urban Pollutant Conversion Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China College of the Environment and Ecology Xiamen UniversityXiamen 361102China Fujian Academic of Agricultural Sciences Fuzhou 350003China

Phosphorus recovery in the form of struvite has been aroused in recent decades for its dual advantages in eutrophication control and resource *** usage of the struvite products is normally determined by the size which is largely depended on the *** this study,flow behavior of struvite pellets was simulated by means of Eulerian–Eulerian two-fluid model combining with kinetic theory of granular flow in a liquid–solid fluidized bed reactor（FBR）.A parametric study including the mesh size,time step,discretization strategy,turbulent model and drag model was first developed,followed by the evaluations of crucial operational conditions,particle characteristics and reactor *** results showed that a cold model with the mesh resolution of 16 × 240,default time step of 0.001 sec and first order discretization scheme was accurate enough to describe the *** struvite holdup profile using Syamlal–O＇Brien drag model was best fitted to the experimental data as compared with other drag models and the empirical Richardson–Zaki *** the model evaluation,it showed that liquid velocity and particle size played important roles on both solid holdups and *** reactor diameter only influenced the solid velocity while the static bed height almost took no *** results are direct and can be applied to guide the operation and process control of the struvite ***,the model parameters can also be used as the basic settings in further crystallization simulations.

关键词： Numerical simulation Flow hydrodynamics Struvite Liquid–solid fluidized bed

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Simultaneous approach for simulation of a high-temperature gas-cooled reactor

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第7期12卷 567-574页

作者： Yang CHEN Jiang-hong YOU zhi-jiang SHAO Ke-xin wang Ji-xin QIAN State Key Laboratory of Industrial Control Technology Zhejiang University Hangzhou 310027 China

The simulation of a high-temperature gas-cooled reactor pebble-bed module(HTR-PM) plant is *** lumped parameter model has the form of a set differential algebraic equations(DAEs) that include stiff equations to model point neutron *** nested approach is the most common method to solve DAE,but this approach is very expensive and time-consuming due to inner *** paper deals with an alternative approach in which a simultaneous solution method is *** DAEs are discretized over a time horizon using collocation on finite elements,and Radau collocation points are *** resulting nonlinear algebraic equations can be solved by existing *** discrete algorithm is discussed in detail;both accuracy and stability issues are ***,the simulation results are presented to validate the efficiency and accuracy of the simultaneous approach that takes much less time than the nested one.

关键词： Differential algebraic equations(DAEs) High-temperature gas-cooled reactor(HTR) Simulation Simultaneous approach

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