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Genetic polymorphisms in pri-let-7a-2 are associated with ischemic stroke risk in a Chinese Han population from Liaoning, China: a case-control study

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Neural Regeneration Research 2021年第7期16卷 1302-1307页

作者： yu-ye wang He-yu Zhang Wen-Juan Jiang Fang Liu Lei Li Shu-Min Deng Zhi-Yi He Yan-Zhe wang Department of Neurology Key Laboratory for Neurological Big Data of Liaoning ProvinceThe First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Neurology The First Affiliated HospitalSun Yat-sen University/Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological DiseasesNational Key Clinical Department and Key Discipline of NeurologyGuangzhouGuangdong ProvinceChina Department of Pharmacology School of PharmacyChina Medical UniversityShenyangLiaoning ProvinceChina

Ischemic stroke is a complicated disease, and its pathogenesis has been attributed to the occurrence of genetic polymorphisms.Evidence has suggested that the microRNA let-7a is involved in the pathogenesis of ischemic stroke.Pri-miRNA is the primary transcript, which undergoes several processing steps to generate pre-miRNA and, later, mature miRNAs.In this case-control study, we analyzed the distribution of prilet-7a-2 variants in patients at a high risk for ischemic stroke and the interactions of pri-let-7a-2 variants and environmental factors.Blood samples and clinical information were collected from 1086 patients with ischemic stroke and 836 healthy controls between December 2013 and December 2015 at the First Affiliated Hospital of China Medical University.We found that the rs1143770 CC genotype and the C allele were associated with a decreased risk of ischemic stroke, whereas the rs629367 CC genotype was associated with an increased risk for ischemic stroke.Moreover, these two single-nucleotide polymorphisms were in linkage disequilibrium in this study sample.We analyzed gene-environment interactions and found that rs1143770 exerted a combined effect on the pathogenesis of ischemic stroke, together with alcohol use, smoking, and a history of hypertension.Therefore, the detection of pri-let-7a-2 polymorphisms may increase the awareness of ischemic stroke risk.This study was approved by the Institutional Ethics Committee of the First Affiliated Hospital of China Medical University, China(approval No.2012-38-1) on February 20, 2012, and was registered with the Chinese Clinical Trial Registry(registration number: ChiCTR-COC-17013559) on December 27, 2017.

关键词： case-control study Chinese Han population ischemic stroke pri-micro RNA pri-let-7a-2 risk factors rs1143770 rs629367 single-nucleotide polymorphism single-nucleotide polymorphism-environment interaction

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Feasibility of terahertz imaging for discrimination of human hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2019年第2期11卷 153-160页

作者： Feng Duan yu-ye wang De-Gang Xu Jia Shi Lin-yu Chen Li Cui Yan-Hua Bai Yong Xu Jing yuan Chao Chang Department of Interventional Radiology the General Hospital of Chinese People’s Liberation Army Institute of Laser and Optoelectronics School of Precision Instruments and Optoelectronic Engineering Key Laboratory of Optoelectronic Information Science and Technology (Ministry of Education) Tianjin University Department of Hepatobiliary and Pancreatic Surgical Oncology the General Hospital of Chinese People’s Liberation Army Department of Pathology the General Hospital of Chinese People’s Liberation Army Advanced Interdisciplinary Technology Research Center National Innovation Institute of Defense Technology

BACKGROUND Hepatocellular carcinoma(HCC) is one of the most common malignant tumors worldwide, and novel methods for early/rapid diagnosis of HCC are needed.Terahertz(THz) spectroscopy is considered to have the potential to distinguish between normal liver tissue and HCC tissue; however, there are few reports on it.We conduct this observational study to explore the feasibility of THz imaging for the diagnosis of HCC.AIM To evaluate the feasibility of THz for discriminating between HCC and normal liver tissues using fresh tissue specimens obtained from HCC patients who had undergone surgery.METHODS Normal liver tissue and HCC tissue were cryosectioned into 50 μm-thick slicesand placed on cover glass. Two adjacent tissue sections were separated subjected to histopathological examination by hematoxylin and eosin staining or THz transmission examination, and THz images were compared with pathologically mapped images. We determined the typical tumor and normal liver tissue regions by pathological examination; the corresponding areas of adjacent sections were examined by THz transmission.RESULTS The transmission rate of HCC tissue was 0.15-0.25, and the transmission rate of typical HCC tissue was about 0.2. THz transmittance in normal liver tissue is slightly higher than 0.4, but there were many influencing factors, including the degree of liver cirrhosis, fat components, ice crystals in frozen sections, and apoptosis.CONCLUSION In conclusion, this study shows that THz imaging can detect HCC tissue. Further research will yield more detailed data of the THz transmission rates of HCC tissue with different degrees of differentiation.

关键词： Terahertz imaging Hepatocellular carcinoma Hematoxylin and eosin staining Terahertz transmittance Liver pathology

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Review of a New IR Nonlinear Optical BaGa_4Se_7 Crystal

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Journal of Electronic Science and Technology 2016年第1期14卷 6-11页

作者： Wen-Tao Xu De-Gang Xu yu-ye wang Peng-Xiang Liu Wei Shi Jian-Quan Yao the Institute of Laser & Opto-Electronic College of Precision Instruments and Opto-Electronic EngineeringTianjin University

A newly grown Ba Ga4Se7 crystal has been synthesized via the Bridgman-Stockbarger technique.This new crystal has advantages of high nonlinear optics（NLO） coefficients,high laser damage thresholds,and wide transparent regions.The Ba Ga4Se7 crystal has bright application prospects as a nonlinear gain medium in mid-infrared and terahertz regions.In this paper,the crystalline structure and synthetic method of the Ba Ga4Se7 crystal are introduced.The refractive indices and absorption coefficients along three dielectric axes between 0.1 THz and 1.0 THz are also obtained.The terahertz difference frequency generation（THz-DFG） characteristics based on the BaG a4Se7 crystal in the frequency range of 0.1 THz to 1.0 THz are analyzed theoretically and the phase-matching conditions are calculated.The application of Ba Ga4Se7 crystals in terahertz wave generation is also discussed.

关键词： BaGa4Se7 Bridgman-Stockbarger mid-infrared nonlinear gain medium THz-DFG

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Hypoglycemic effect and the mechanism of action of a polysaccharide from sweet corncob in a high-fat diet and streptozotocin-induced diabetic mice

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Food Science and Human Wellness 2024年第3期13卷 1543-1555页

作者： Xin wang Weiye Xiu ye Han Zhili wang yu Luo Yongqiang Ma Heilongjiang Provincial Key Laboratory of Cereals and Comprehensive Processing of Cereal Resources College of Food EngineeringHarbin University of CommerceHarbin 150028China

Type 2 diabetes mellitus(T2DM)is a metabolic disease caused by a glycolipid metabolism disorder and isletβ-cell dysfunction.SCP-80-I is a biologically active water-soluble polysaccharide isolated from sweet corncob,an agricultural byproduct.The hypoglycemic effects of SCP-80-I on T2DM mice and its mechanisms were investigated in this study.SCP-80-I was found to significantly reduce blood glucose and lipid deposition levels in T2DM mice,as well as decrease serum leptin and increase adiponectin secretion.Interestingly,real time-polymerase chain reaction(RT-PCR)and Western blotting results revealed that SCP-80-I could regulate the expression of several glycolipid metabolisms and insulin secretion genes and proteins,including 5'-AMP-activated protein kinase(AMPK),carnitine palmitoyltransferase I(CPTI),and acetyl coenzyme A carboxylase(ACC)in the liver and AMPK,sirtuin1(Sirtl),peroxisome proliferator-activated receptorycoactivator-1(PGC-1α),and uncoupling protein 2(UCP2)in the pancreas.To have a hypoglycemic effect,SCP-80-1 regulated glycolipid metabolism and islet cell function in the liver by regulating the AMPK/AC C/CPT1 signaling pathway and the AMPK/Sirt1/PGC-1αand AMPK/Sirtl/UCP2 signaling pathways.These findings improve our understanding of polysaccharides derived from sweet corncob and the use of SCP-80-I in the production of hypoglycemic foods.

关键词： Sweet corn cob polysaccharide Type 2 diabetes Signal pathway 5’-AMP-activated protein kinase(AMPK)

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What factors control plant height?

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Journal of Integrative Agriculture 2024年第6期23卷 1803-1824页

作者： Li Miao Xiangyu wang Chao yu Chengyang ye Yanyan Yan Huasen wang College of Horticulture Qingdao Agricultural UniversityQingdao 266109China Key Laboratory for Quality and Safety Control of Subtropical Fruits and Vegetables College of Horticulture ScienceZhejiang Agriculture and Forestry UniversityHangzhou 311300China

Plant height(PH)is one of the most important components of the plant ideotype,and it affects plant biomass,yield,lodging resistance,and the ability to use mechanized harvesting.Since many complex pathways controlling plant growth and development remain poorly understood,we are still unable to obtain the most ideal plants solely through breeding efforts.PH can be influenced by genotype,plant hormonal regulation,environmental conditions,and interactions with other plants.Here,we comprehensively review the factors influencing PH,including the regulation of PH-related developmental processes,the genetics and QTLs contributing to PH,and the hormone-regulated molecular mechanisms for PH.Additionally,the symbiotic influence of grafting on PH is discussed,focusing on the molecular regulation of gene expression and genetics.Finally,we propose strategies for applying recent findings to breeding for better PH,highlight some knowledge gaps,and suggest potential directions for future studies.

关键词： dwarfism plant hormones interaction grafting QTLs phenotyping

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Mesenchymal stromal cells modulate unfolded protein response and preserve β-cell mass in type 1 diabetes

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BIOCELL 2024年第7期48卷 1115-1126页

作者： SIyuAN LIU yuAN ZHAO yu yu DOU ye QIAN wang ZHAOYAN wang ZUO LUAN Department of Pediatrics The Sixth Medical CenterChinese PLA General HospitalBeijing100037China

Introduction:Transplantation of mesenchymal stromal cells(MSCs)is a promising therapy for type 1 diabetes(T1D).However,whether the infused MSCs affect the endoplasmic reticulum stress or subsequent unfolded protein response inβcells remains unclear.Methods:To investigate this,we induced early-onset T1D in non-obese diabetic mice using streptozotocin.Subsequently,T1D mice were randomly assigned to receive either MSCs or phosphate-buffered saline.We observed the in vivo homing of MSCs and assessed their effectiveness by analyzing blood glucose levels,body weight,histopathology,pancreatic protein expression,and serum levels of cytokines,proinsulin,and C-peptide.Results:Infused MSCs were found in the lungs,liver,spleen,and pancreas of T1D mice.They exhibited various effects,including reducing blood glucose levels,regulating immunity,inhibiting inﬂammation,increasingβ-cell areas,and reducing the expression of key proteins in the unfolded protein response pathway.Fasting serum proinsulin and C-peptide levels were signiﬁcantly higher in the MSCs treatment group than in the T1D model group.However,there was no signiﬁcant difference in the biomarker ofβ-cell endoplasmic reticulum stress,the ratio of fasting serum proinsulin to C-peptide,between the two groups.Conclusion:Ourﬁndings reveal that MSCs infusion does not alleviate endoplasmic reticulum stress inβcells directly but modulates the unfolded protein response pathway to preserveβ-cell mass and function in T1D mice.

关键词： Type 1 diabetes Mesenchymal stromal cells Endoplasmic reticulum stress Unfolded protein response Non-obese diabetic mice

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Commentary:Gut microbiota reduce the risk of hyperuricemia and gout in the human body

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Acta Pharmaceutica Sinica B 2024年第1期14卷 433-435页

作者： Lin wang Jianping ye Metabolic Disease Research Center Zhengzhou University Affiliated Zhengzhou Central HospitalZhengzhou 450007China Research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Gout,a prevalent and painful metabolic disease often associated with obesity and aging,is caused by the deposition of urate crystals in joints,bones,or soft tissues1.Urate is an intermediate metabolite within the purine degradation pathway,predominantly derived from uric acid under physiological pH levels.Hyperuricemia occurs due to excessive uric acid production or insufficient excretion2,which is associated with various chronic diseases,including type 2 diabetes.

关键词： Uric acid Gout Microbiota Gut Uricase

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Monochromatic and Tunable Terahertz Source Based on Nonlinear Optics

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Journal of Electronic Science and Technology 2013年第4期11卷 339-348页

作者： De-Gang Xu Peng-Xiang Liu yu-ye wang Kai Zhong Wei Shi Jian-Quan Yao the Institute of Laser & Opto-Electronic the College of Precision Instruments and Opto-Electronic Engineering Tianjin University the Institute of Laser & Opto-Electronic the College of Precision Instruments and Opto-Electronic Engineering Tianjin University Tianjin 300072 China

Recent progresses made by authors on monochromatic and tunable terahertz （THz） generation based on nonlinear optics are reviewed, including THz parametric oscillation （TPO） and difference frequency generation （DFG）. From the technical point of view, we develop extra- and intra-cavity surface-emitted TPO, as well as DFG with QPM-GaAs crystal. From the point of view of mechanism, Cherenkov phase-matching is comprehensively investigated in both bulk crystal and planar waveguide. A novel scheme for cascading enhanced Cherenkov DFG in waveguide is proposed. From the point of view of material, organic crystal 4-N,N-dimethylamino-4＇-N＇-methyl-stibazolium tosylate （DAST） is utilized as the nonlinear medium.

关键词： Differencenonlinear optics, parametricsource.frequency generation oscillation, terahertz

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A new liquid membrane diffusion model for characterizing the adsorption kinetics of europium by using a continuous measurement of adsorption platform

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Nuclear Science and Techniques 2024年第1期35卷 59-72页

作者： Hao-Qi yu Tao yu Jian-Hua ye State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China CGN Cangnan Nuclear Power Co. Ltd.Cangnan 325800China Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices East China University of TechnologyNanchang 330013China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

To explore the kinetic adsorption under continuous and nonequilibrium states, an integration of continuous measurement and adsorption platform kinetics method was proposed, which was initially called the ICM-AP kinetics method, and a corresponding kinetic adsorption experimental method was developed. Adsorption experiments of europium(Eu) on Ca-bentonite,Na-bentonite, and the D231 cation exchange resin were performed using the ICM-AP kinetics method and continuous measurements. Because the kinetic experimental results observed in this study were different from those of traditional batch adsorption data, pseudo-first-order or pseudo-second-order kinetic models were unsuitable for fitting the experimental data.Hence, a liquid membrane diffusion(LMD) model was developed based on the assumption of simultaneous adsorption/desorption to discuss the mechanism of kinetic adsorption. The kinetic adsorption mechanism was also studied by using XPS.The results indicated that the proposed adsorption model can fit the experimental data more suitably, and the adsorption/desorption behaviors of Eu on bentonite and the D231 resin were simultaneously observed, suggesting that the adsorption kinetics of Eu(Ⅲ) was mainly dominated by hydrated Eu(Ⅲ) ions on the liquid membrane.

关键词： ICM-AP method LMD model Adsorption mechanism Eu(Ⅲ)

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Tunable Terahertz Source Based on Optics Pumped Nonlinear Crystals

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Journal of Electronic Science and Technology 2014年第4期12卷 377-382页

作者： De-Gang Xu Peng-Xiang Liu yu-ye wang Kai Zhong Wei Shi Jian-Quan Yao the College of Precision Instruments and Opto-Electronic Engineering Tianjin University the Institute of Laser & Opto-Electronic the College of Precision Instruments and Opto-Electronic Engineering Tianjin University

Recent progresses about optical pumped tunable terahertz （THz） sources are interviewed, including THz parametric oscillation （TPO） and difference frequency generation （DFG）. We develop high efficiency and high power surface-emitted TPO, as well as DFG with nonlinear crystals. A novel scheme for the high efficiency DFG source based on the Cherenkov phase-matching technology is comprehensively investigated in both bulk crystals. The widely tunable optical THz radiation is also researched based on the organic nonlinear 4-N,N-dimethylamino-4＇-N＇- methylstilbazolium 2,4,6-trimethylbenzenesulfonate （DSTMS） crystal.

关键词： Cherenkov phase-matching differencefrequency generation nonlinear optics parametricoscillation.

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