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巴西金刚石的宝石矿物学特征

岩石矿物学杂志 2024年第3期43卷 685-696页

作者：李雨璇黄颖刘迎新中国地质大学(北京)珠宝学院北京100083 大连银行股份有限公司北京分行北京100026

采用常规宝石学测试结合红外光谱、拉曼光谱以及Diamond View^(TM)测试,对巴西金刚石开展了常规宝石学、光谱学和荧光特征分析。结果显示,巴西金刚石表面微形貌特征丰富,可见多种形态的生长丘,三角、六边或不规则形态的溶蚀坑以及塑性... 详细信息

采用常规宝石学测试结合红外光谱、拉曼光谱以及Diamond View^(TM)测试,对巴西金刚石开展了常规宝石学、光谱学和荧光特征分析。结果显示,巴西金刚石表面微形貌特征丰富,可见多种形态的生长丘,三角、六边或不规则形态的溶蚀坑以及塑性变形滑移线等特征。巴西金刚石以ⅠaAB型为主(90%以上),N含量在400×10^(-6)~1 700×10^(-6)范围内,B心转化率介于15%~66%之间,具有高N含量和低-中等N聚集程度的特点。拉曼光谱分析进一步揭示了样品内部均残余压应力或者结晶度较差。Diamond View^(TM)发光图像显示ⅠaAB型金刚石样品具有蓝色和黄绿色调荧光;ⅠaB型金刚石样品为带有绿色调的蓝色和不均匀的蓝色荧光;Ⅱa型金刚石样品表现为暗橙色和蓝色荧光。

关键词：金刚石宝石学特征谱学特征荧光

Inflammatory response in gastrointestinal cancers:Overview of six transmembrane epithelial antigens of the prostate in pathophysiology and clinical implications

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World Journal of Clinical Oncology 2024年第1期15卷 9-22页

作者： Ze-xuan Fang Wen-Jia Chen Zheng Wu Yan-yu Hou Yang-Zheng Lan Hua-Tao Wu Jing Liu The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

Chronic inflammation is known to increase the risk of gastrointestinal cancers(GICs),the common solid tumors *** lesions,such as chronic atrophic inflammation and ulcers,are related to inflammatory responses in vivo and likely to occur in hyperplasia and ***,due to the lack of effective therapeutic targets,the prognosis of patients with GICs is still ***,it is found that six transmembrane epithelial antigens of the prostate(STEAPs),a group of metal reductases,are significantly associated with the progression of malignancies,playing a crucial role in systemic metabolic homeostasis and inflammatory *** structure and functions of STEAPs suggest that they are closely related to intracellular oxidative stress,responding to inflammatory *** the imbalance status of abnormal oxidative stress,STEAP members are involved in cell transformation and the development of GICs by inhibiting or activating inflammatory *** review focuses on STEAPs in GICs along with exploring their potential molecular regulatory mechanisms,with an aim to provide a theoretical basis for diagnosis and treatment strategies for patients suffering from these types of cancers.

关键词： Six transmembrane epithelial antigens of the prostate Gastrointestinal cancer Inflammation

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星载二维转台U型架结构轻量化与优化设计

中国光学（中英文） 2024年第4期17卷 896-908页

作者：魏钰轩王振宇李治国黄乐弘杨凯马玉宝中国科学院西安光学精密机械研究所陕西西安710119 中国科学院大学北京100049 中国科学院空间精密测量技术重点实验室陕西西安710119

星载二维转台是空间相机等光电设备的主要承载机构,U型架是转台的关键支撑部件。为了对星载二维转台U型架进行结构优化与轻量化设计,研制高承载比和轻量化的星载二维转台,本文设计了一种用于星载二维转台的碳纤维复合材料U型架。首先,... 详细信息

星载二维转台是空间相机等光电设备的主要承载机构,U型架是转台的关键支撑部件。为了对星载二维转台U型架进行结构优化与轻量化设计,研制高承载比和轻量化的星载二维转台,本文设计了一种用于星载二维转台的碳纤维复合材料U型架。首先,利用碳纤维复合材料代替钛合金材料,结合考虑工艺性,设计了一种变截面管状结构U型架。接着,按照基于铺层工艺的有限元建模方法对碳纤维U型架进行有限元建模与仿真分析。然后,试制U型架样机并通过模态试验验证有限元模型的准确性。最后,提出一种理论分析法、遗传算法、有限元法相结合的三级优化方法对碳纤维U型架铺层角度、铺层厚度与铺层顺序进行优化设计。结果表明:模态试验与仿真得到的U型架振型完全一致,频率相差在5%以内。初始设计的碳纤维U型架比钛合金U型架质量减少了45.7%,通过对复合材料铺层的优化设计,使U型架质量进一步减少了13.8%,固有频率提升了10.14%。本文所采用的复合材料建模与优化方法正确,设计的碳纤维U型架满足星载二维转台轻量化设计需求。

关键词：结构优化设计轻量化设计碳纤维复合材料有限元分析星载二维转台遗传算法

基于正弦函数拟合的高动态捷联惯导姿态更新算法

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中国惯性技术学报 2024年第1期32卷 1-7页

作者：路永乐杨杰孙旗罗毅肖轩刘宇重庆邮电大学智能传感技术与微系统重庆市高校工程研究中心重庆400065

为提高捷联惯导在高动态条件下的姿态解算精度,基于等效旋转矢量泰勒级数展开法,提出一种基于正弦函数拟合的高动态捷联惯导姿态更新算法。以正弦函数拟合载体运动角速度,考虑Bortz方程高阶项的影响,对陀螺角增量表示的旋转矢量进行泰... 详细信息

为提高捷联惯导在高动态条件下的姿态解算精度,基于等效旋转矢量泰勒级数展开法,提出一种基于正弦函数拟合的高动态捷联惯导姿态更新算法。以正弦函数拟合载体运动角速度,考虑Bortz方程高阶项的影响,对陀螺角增量表示的旋转矢量进行泰勒六阶展开,对比旋转矢量不同形式表达式求得误差补偿系数。在MATLAB平台上,以圆锥运动与大角速率转动并存环境作为仿真条件,对所提算法与传统算法进行对比仿真分析。仿真结果表明,在小半锥角低频圆锥运动伴随高速角速率转动情况下,所提算法性能较好,当半锥角为0.5°、角频率为2.26πrad/s、常值角速率为5.30 rad/s、姿态解算周期为0.02 s时,所提正弦函数拟合三子样旋转矢量算法与传统扩展形式频率级数/显示频率三子样圆锥算法相比误差降低了2个数量级。

关键词：捷联姿态算法高动态正弦函数拟合等效旋转矢量

碳达峰碳中和视域下我国生态安全的现状、难点及进路

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新疆师范大学学报（哲学社会科学版） 2024年第4期45卷 70-79页

作者：于文轩冯瀚元中国政法大学民商经济法学院北京100088

实现碳达峰碳中和、保障生态安全是生态文明建设的重要内容。目前,我国适应碳达峰碳中和的生态安全保障体系已基本形成,但在理念融合、治理体系、发展模式、法治保障等方面仍存在难点。为此,应以整体主义为基本立场,以协同治理为进路,... 详细信息

实现碳达峰碳中和、保障生态安全是生态文明建设的重要内容。目前,我国适应碳达峰碳中和的生态安全保障体系已基本形成,但在理念融合、治理体系、发展模式、法治保障等方面仍存在难点。为此,应以整体主义为基本立场,以协同治理为进路,完善生态安全保障体系。在理念层面,生态安全观与低碳发展理念的融合基础在于主体的生态理性实践。在治理层面,政府、企业和公众在现代环境治理体系中承担不同的角色和功能,应结合碳达峰碳中和的特点,注重实现主体之间的协同。在发展方式层面,应将生态安全作为发展与转型的底线,实现减污降碳协同增效。在法治层面,应从立法、执法、司法三个方面完善以碳达峰碳中和为导向的生态安全法治保障体系,实现碳达峰碳中和与生态安全的协同共进。

关键词：碳达峰碳中和生态安全整体主义协同治理

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县域内儿童入园时机与早期发展

华中农业大学学报（社会科学版） 2024年第4期 178-190页

作者：白钰宣智翀程怡中央民族大学经济学院北京100081 中央民族大学中国兴边富民战略研究院北京100081

基于西部N县2018年全体6~36月龄儿童及其家庭三轮跟踪调查所形成的面板数据,分析入园时机对儿童早期发展的影响。结果表明:(1)有近三分之一的样本儿童未按时入园,提前入园的比例高于推迟入园。(2)提前入园使得儿童社交情绪滞后比例提高... 详细信息

基于西部N县2018年全体6~36月龄儿童及其家庭三轮跟踪调查所形成的面板数据,分析入园时机对儿童早期发展的影响。结果表明:(1)有近三分之一的样本儿童未按时入园,提前入园的比例高于推迟入园。(2)提前入园使得儿童社交情绪滞后比例提高,入园月龄与儿童的社交情绪滞后比例之间存在“U形”曲线关系,而推迟入园会降低儿童认知能力。(3)机制分析表明,养育环境是提前入园和推迟入园不利于儿童早期发展的决定因素,家校共育过程家庭养育和学校教育投资决策存在互补关系。据此建议灵活入园政策、改善农村儿童在园养育环境、加强对家庭儿童养育的支持和指导。

关键词：入园时机儿童早期发展认知能力社交情绪

儿童跟骨骨折超声引导闭合复位经皮克氏针固定

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中国矫形外科杂志 2024年第14期32卷 1273-1278页

作者：于佳袁馨赵璐李绚璇杨浩青岛大学附属青岛市中医医院功能检查科山东青岛266033 青岛大学附属青岛市中医医院骨科山东青岛266033

[目的]探究超声引导闭合复位经皮克氏针固定儿童跟骨骨折的临床疗效。[方法]回顾性分析本院2020年1月—2022年8月收治的100例跟骨骨折患儿的临床资料,均接受闭合撬拨复位克氏针内固定治疗,根据医患沟通结果,超声引导下操作55例(超声组)... 详细信息

[目的]探究超声引导闭合复位经皮克氏针固定儿童跟骨骨折的临床疗效。[方法]回顾性分析本院2020年1月—2022年8月收治的100例跟骨骨折患儿的临床资料,均接受闭合撬拨复位克氏针内固定治疗,根据医患沟通结果,超声引导下操作55例(超声组),透视下操作45例(透视组)。对比两组患儿围手术期、随访及影像资料。[结果]超声组手术时间[(35.0±6.8)min vs(58.2±10.4)min,P0.05)。影像方面,随时间推移,两组Bohler角、Gissane角、关节软骨塌陷高度均显著改善(P0.05)。[结论]超声引导闭合复位内固定治疗儿童跟骨骨折疗效较好,相比透视下操作具有手术时间短、辐射损伤小、术中出血量少的优点。

关键词：儿童跟骨骨折超声闭合复位经皮克氏针固定

Gene replacement therapy in Bietti crystalline corneoretinal dystrophy:an open-label,single-arm,exploratory trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2275-2284页

作者： Jinyuan Wang Jinlu Zhang Shicheng yu Hongyan Li Shaohong Chen Jingting Luo Haibo Wang yuxia Guan Haihan Zhang Shiyi Yin Huili Wang Heping Li Junle Liu Jingyuan Zhu Qiong Yang Ying Sha Chuan Zhang yuhang Yang xuan Yang Xifang Zhang Xiuli Zhao Likun Wang Liping Yang Wenbin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical University100730 BeijingChina School of Clinical Medicine Tsinghua University100084 BeijingChina Chigenovo Co. Ltd.102206 BeijingChina Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third Hospital100191 BeijingChina Department of Ophthalmology The Third People’s Hospital of Dalian116091 DalianChina Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina Institute of Systems Biomedicine Department of PathologySchool of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina

Bietti crystalline corneoretinal dystrophy is an inherited retinal disease caused by mutations in CYP4V2,which results in blindness in the working-age population,and there is currently no available ***,we report the results of the first-in-human clinical trial(NCT04722107)of gene therapy for Bietti crystalline corneoretinal dystrophy,including 12 participants who were followed up for 180-365 *** open-label,single-arm exploratory trial aimed to assess the safety and efficacy of a recombinant adeno-associated-virus-serotype-2/8 vector encoding the human CYP4V2 protein(rAAV2/8-hCYP4V2).Participants received a single unilateral subretinal injection of 7.5×10^(10)vector genomes of rAAV2/***,73 treatment-emergent adverse events were reported,with the majority(98.6%)being of mild or moderate intensity and considered to be procedure-or corticosteroid-related;no treatment-related serious adverse events or local/systemic immune toxicities were *** with that measured at baseline,77.8%of the treated eyes showed improvement in best-corrected visual acuity(BCVA)on day 180,with a mean±standard deviation increase of 9.0±10.8 letters in the 9 eyes analyzed(p=0.021).By day 365,80%of the treated eyes showed an increase in BCVA,with a mean increase of 11.0±10.6 letters in the 5 eyes assessed(p=0.125).Importantly,the patients’improvement observed using multifocal electroretinogram,microperimetry,and Visual Function Questionnaire-25 further supported the beneficial effects of the *** conclude that the favorable safety profile and visual improvements identified in this trial encourage the continued development of rAAV2/8-hCYP4V2(named ZVS101e).

关键词： cor dystrophy crystalline

Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

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Zoological Research 2024年第3期45卷 617-632页

作者： Jing-Hang Jiang Yi-Fu Wang Jie Zheng Yi-Ming Lei Zhong-yuan Chen Yi Guo Ya-Jie Guo Bing-Qian Guo yu-Fang Lv Hong-Hong Wang Juan-Juan Xie Yi-xuan Liu Ting-Wei Jin Bi-Qi Li Xiao-Shu Zhu Yong-Hua Jiang Zeng-Nan Mo Center for Genomic and Personalized Medicine Guangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China Department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Reproductive Medicine Center Jingmen People’s HospitalJingChu University of Technology Affiliated Central HospitalJingmenHubei 448000China School of Computer Science and Engineering Yulin Normal UniversityYulinGuangxi 537000China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Department of Pathology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China Department of Obstetrics and Gynecology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China

The Chinese tree shrew(Tupaia belangeri chinensis)has emerged as a promising model for investigating adrenal steroid synthesis,but it is unclear whether the same cells produce steroid hormones and whether their production is regulated in the same way as in ***,we comprehensively mapped the cell types and pathways of steroid metabolism in the adrenal gland of Chinese tree shrews using single-cell RNA sequencing,spatial transcriptome analysis,mass spectrometry,and *** compared the transcriptomes of various adrenal cell types across tree shrews,humans,macaques,and *** showed that tree shrew adrenal glands expressed many of the same key enzymes for steroid synthesis as humans,including CYP11B2,CYP11B1,CYB5A,and *** analysis confirmed the production of aldosterone,cortisol,and dehydroepiandrosterone but not dehydroepiandrosterone sulfate in the tree shrew adrenal ***,genes in adrenal cell types in tree shrews were correlated with genetic risk factors for polycystic ovary syndrome,primary aldosteronism,hypertension,and related disorders in humans based on genome-wide association ***,this study suggests that the adrenal glands of Chinese tree shrews may consist of closely related cell populations with functional similarity to those of the human adrenal *** comprehensive results(publicly available at http://***:16245/scAGMap/)should facilitate the advancement of this animal model for the investigation of adrenal gland disorders.

关键词： Tree shrew Adrenal gland Dehydroepiandrosterone Genome-wide association studies Disease model