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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie li Wenbo yu Zhenyu Sun Weichen Zheng liangwei Zhang Yanling Xue Wenning liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin li Xiaolei Chu Qi li Ruihua li Qingwen li Kai-yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

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基于神经网络的空调负荷实时预测模型

石油化工高等学校学报 2007年第Z1期20卷 12-15页

作者：魏东李锐于力轩北京建筑工程学院电气与信息工程学院北京100044 北京建筑工程学院环境与能源学院北京100044 北京建筑工程学院电气与信息工程学院北京100044

针对暖通空调系统优化和预测控制,研究了利用神经网络进行空调负荷预测的方法.首先对影响空调负荷的因素进行了分析,并讨论了对空调负荷起主要影响作用的气象参数的预测,在此基础上建立了神经网络负荷预测模型.根据神经网络的泛化性能要... 详细信息

针对暖通空调系统优化和预测控制,研究了利用神经网络进行空调负荷预测的方法.首先对影响空调负荷的因素进行了分析,并讨论了对空调负荷起主要影响作用的气象参数的预测,在此基础上建立了神经网络负荷预测模型.根据神经网络的泛化性能要求,采用最优停止法训练神经网络.将所研究的负荷预测模型用来实时预测北京市某建筑物的空调负荷,仿真结果表明,该模型能对任意气候条件下的空调负荷进行准确预测,可用于暖通空调系统的实时控制.

关键词：神经网络变风量空调优化反馈控制预测控制热负荷预测

Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 204-251页

作者： Jiawen Hu Xinwei li Qianqian liang li Xu Changsheng Ding yu liu Yanfeng Gao School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.

关键词： Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies

High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun Zhang Xiaoyun Wang Shuai Wang Yan li libo Chen Handong Jiao Zhijing yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (liMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** liMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of liMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of liMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable liMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： lithium manganese iron phosphate High energy density lithium-ion batteries Reaction mechanism Tap density

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan li Xi liu Wenping liang yu li liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

外源亚精胺对淹涝胁迫下黄瓜根HSP70表达的影响

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广西植物 2013年第5期33卷 669-673页

作者：张健刘美艳申杰刘丹俞立璇李雪华江苏师范大学生命科学学院江苏徐州221116

采用逆转录聚合酶链式反应(RT-PCR)及蛋白免疫印迹杂交(Western Blot)技术,研究0.5mmol/L亚精胺浸种的黄瓜幼苗在淹水胁迫下,根热激蛋白70基因(HSP70)mRNA和蛋白质的表达量的变化。结果表明:淹水胁迫使黄瓜根HSP70的mRNA和蛋白的表达呈... 详细信息

采用逆转录聚合酶链式反应(RT-PCR)及蛋白免疫印迹杂交(Western Blot)技术,研究0.5mmol/L亚精胺浸种的黄瓜幼苗在淹水胁迫下,根热激蛋白70基因(HSP70)mRNA和蛋白质的表达量的变化。结果表明:淹水胁迫使黄瓜根HSP70的mRNA和蛋白的表达呈现先上升后下降的趋势,在淹水4h时,HSP70的mRNA和蛋白表达量均极显著高于未淹水处理;亚精胺浸种的黄瓜根HSP70的mRNA和蛋白的表达量在24h内呈一直上升的趋势,在淹水24h时,HSP70的mRNA和蛋白表达量均极显著高于未淹水处理。淹涝胁迫下,亚精胺浸种的黄瓜根HSP70的mRNA和蛋白表达量在淹水12h和24h时极显著高于蒸馏水浸种。外源亚精胺能诱导淹涝胁迫下黄瓜幼苗根HSP70mRNA和蛋白质的表达量的增加,缓解淹涝胁迫对黄瓜造成的伤害。

关键词：黄瓜亚精胺淹涝 HSP70

Genetic dissection of developmental behavior of crop growth rate and its relationships with yield and yield related traits in rice

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Genetic dissection of developmental behavior of crop growth ...

湖北省遗传学会、江西省遗传学会2006年学术年会暨学术讨论会

作者： Shao-Bo li, Zhi-Hong Zhang, Ying Hu, Chen-yu li, xuan Jiang, Ting Mao, Yang-Sheng li, Ying-Guo Zhu Key Laboratory of the Education Ministry of China for Plant Developmental Biology, College of life Sciences, Wuhan University, Wuhan 430072, China

Crop growth rate is a dynamic character that determines the final yield in cereal crops. The objective of the current study is to reveal its genetic basis and to genetically understand its relationships with grain yield and yield related traits like heading date, grain-filling duration, 1000-grain weight and plant height in rice (Oryza saliva L.). With 258 recombinant inbred lines (RILs) derived from a cross between cv. Lemont and cv. Teqing, time-related QTL mapping was conducted. Eight QTL for crop growth rate were identified at four consecutive growth periods. These QTL individually explained 5-29% of the trait variation. The Teqing alleles increased the trait values at all the four QTL detected before heading, while Lemont contributed alleles to increase the trait values at three of the other four QTL mapped after heading, which was in agreement with the observation that Teqing was the high-value parent before heading, while Lemont became the high-value parent after heading. No common QTL was observed at different growth periods. These results implied that crop growth rate of rice might be controlled by different genes (QTL) during different time intervals. A total of 22 QTL were identified for the other five traits, and the amount of variation explained by individual QTL ranged from 3% to 26%. The interval RM25-CSU754 on chromosome 8 was identified to produce a major effect on multiple traits such as crop growth rate Ⅳ, grain yield, heading date, grain-filling duration, plant heights Ⅱ and Ⅳ, which provided a genetic explanation for the close correlations among the traits. The implications of the results for further improvement in rice yield potential were discussed.

关键词： Crop growth rate Heading date Grain-filling duration Time-related QTL mapping

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外源亚精胺对芽涝玉米根系保护作用的研究

玉米科学 2013年第3期21卷 61-65页

作者：刘丹刘美艳俞立璇李雪华张健江苏师范大学生命科学学院江苏徐州221116

以农大108为材料,研究外源亚精胺对淹涝胁迫下玉米幼苗根系细胞膜透性、乳酸脱氢酶(LDH)和乙醇脱氢酶(ADH)活性以及根尖细胞核DNA损伤情况的影响。结果表明,亚精胺能维持淹涝胁迫下玉米根细胞膜透性的稳定,延缓乳酸脱氢酶和乙醇脱氢酶... 详细信息

以农大108为材料,研究外源亚精胺对淹涝胁迫下玉米幼苗根系细胞膜透性、乳酸脱氢酶(LDH)和乙醇脱氢酶(ADH)活性以及根尖细胞核DNA损伤情况的影响。结果表明,亚精胺能维持淹涝胁迫下玉米根细胞膜透性的稳定,延缓乳酸脱氢酶和乙醇脱氢酶活性的上升,降低根尖细胞核DNA的损伤百分比和级别。外源亚精胺浸种能提高玉米对芽涝的抵抗能力。

关键词：玉米亚精胺细胞膜透性乳酸脱氢酶乙醇脱氢酶

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang li Pengjun Wang Xiaoxu Zhang Song Mao Yini li Dongzhen yu Xiaoyan li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron