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High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia

Science China(Life Sciences) 2024年第8期67卷 1635-1647页

作者： Feng-Qi Liu Qing-yuan Qu Ying Lei Qi chen yu-xiu chen Meng-Lin Li Xue-Yan Sun Ye-Jun Wu Qiu-Sha Huang Hai-Xia Fu yuan Kong yue-Ying Li Qian-Fei Wang Xiao-Jun Huang Xiao-Hui Zhang Peking University People’s Hospital Peking University Institute of HematologyBeijing 100044China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China National Clinical Research Center for Hematologic Disease Beijing 100044China Collaborative Innovation Centre of Hematology Peking UniversityBeijing 100044China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100074China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the *** soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP *** the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T *** contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell *** a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune ***-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of *** conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of *** may offer novel targets to develop personalized immunotherapies.

关键词： immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow

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对化学精品课程研究和建设的统计分析

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化学教育 2016年第22期37卷 11-14页

作者：俞晨秀安徽中医药高等专科学校

以爱课程（中国大学精品开放课程）网、全民终身学习课程平台（原国家精品课程网）、中国知网上的信息为依据，对我国大学本科和高职高专院校的化学和基础类化学精品课程的研究状况和建设情况进行了比较分析。结果表明，精品课程建设受... 详细信息

以爱课程（中国大学精品开放课程）网、全民终身学习课程平台（原国家精品课程网）、中国知网上的信息为依据，对我国大学本科和高职高专院校的化学和基础类化学精品课程的研究状况和建设情况进行了比较分析。结果表明，精品课程建设受政策推动影响较大，课程建设水平与精品课程级别有一定的对应关系，精品课程的创建受课程属性的影响。

关键词：基础化学化学精品课程大学本科高职高专

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基于LASSO算法的恒星α元素丰度估计方法研究

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光谱学与光谱分析 2017年第1期37卷 278-282页

作者：卜育德潘景昌王春雨陈修梅山东大学(威海)数学与统计学院山东威海264209 山东大学(威海)信息工程学院山东威海264209 中国人民大学统计学院北京100872 山东青年政治学院信息工程学院山东济南250103

主要研究了一种新的基于LASSO算法的恒星α元素丰度估计方法。海量恒星的α元素(O,Mg,Si,Ca和Ti)丰度信息将有助于我们了解银河系的演化进程。但目前从中低分辨率光谱中确定α元素丰度的方法主要是模板匹配法,但该方法算法复杂,优化参... 详细信息

主要研究了一种新的基于LASSO算法的恒星α元素丰度估计方法。海量恒星的α元素(O,Mg,Si,Ca和Ti)丰度信息将有助于我们了解银河系的演化进程。但目前从中低分辨率光谱中确定α元素丰度的方法主要是模板匹配法,但该方法算法复杂,优化参数较为困难且对噪声敏感,因此有必要研究新的方法。实验结果显示,LASSO算法对ELODIE光谱的α丰度的估计精度为0.003(0.078)dex。为验证光谱分辨率变化对LASSO算法结果的影响,我们首先用ELODIE光谱通过高斯卷积得到了分辨率为42 000,21 000,10 500,4 200和2 100的光谱,然后使用LASSO算法估计α元素丰度,精度分别为0.003 3(0.078)dex,-0.05(0.059)dex,-0.007(0.060)dex,0.008 0(0.069)dex和-0.004 5(0.067)dex。上述结果证明LASSO算法对分辨率变化不敏感。为验证LASSO算法对信噪比变化的鲁棒性,使用ELODIE光谱分别构造了信噪比为30,25,20,15和5的光谱。LASSO算法在上述数据集上的精度分别为-0.002(0.076)dex,-0.09(0.073)dex,0.003 6(0.075)dex,0.007 6(0.078)dex和-0.009(0.08)dex,因而LASSO算法对信噪比变化不敏感。因此,LASSO算法适用于低分辨率低信噪比的LAMOST和SDSS光谱。LASSO算法在SDSS光谱上的估计精度为0.003 7(0.097)dex,而在球状星团和疏散星团成员星上的结果显示LASSO算法给出的丰度与文献给出α丰度值误差在1σ以内。因此,LASSO算法能够用于估计恒星的α元素丰度。

关键词： LASSO α元素丰度线性回归特征提取

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Progress in recent study of drought,flood and waterlogging damages in China

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Journal of Geographical Sciences 1998年第1期8卷 52-64页

作者： Liao RonghuaShaoyang Teacher’s College, Hunan 422000, CHINAyu Guangming xiu Dongwen chen Ping Wang ChaonanDepartment of Geography, Central China Normal University, Wuhan 430070, CHINA

The Drought, Flood and Waterlogging Damage (DFWD) study is related to many subjects such as meteorology and climatology, hydrology, geography, and agricultural science In the aforementioned subjects, substantial work has been done on DFWD study by a lot of researchers from the views of their specialities This paper tries to introduce the recent progress on the field Four main problems are referred to the DFWD study, they are as following: (1) The change sequence in historical period The historical data must be quantatitively processed For this purpose, many schemes were suggested in the past years Studies of the historical DFWD have been emphasized in the last fivehundred years as well as the other time scales (2) The mechanism and trigger event Natural disasters are related to factors disastrous to human activities in the evolution of physical environment, and they can reflect natural features of constitution of the physical environment The factors include the monsoon circulation, the sea tempereature effects, the ENSO, and the others (3) The loss estimation The DFWD is not a pure meteorological damage, and it is also a complex ecological damage The ecological effects, crop influences and other socialenvironment features will be considered on the estimation of DFWD loss (4) The measures of prevention and control Many forecast models are developed, and the measures of prevention and control are suggested, ie, the adoption of measures combining engineering techniques with biological measurres In the past years, advances have been made in those four aspects

关键词： drought flood and waterlogging damage basic study recent progress

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中草药高效广谱复合防晒组分的筛选和性能测试

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日用化学工业 2011年第6期41卷 434-437页

作者：俞晨秀潘武安徽省中医药高等专科学校安徽芜湖241000 安徽药用植物研究所安徽南陵241314 广州浩雨化妆品有限公司广东广州510440

通过对201种中草药在防晒光区(290～400 nm)紫外吸收能力的研究,选取紫外吸收强、吸收波段互补、调配着色浅的苦丁茶和槐米两种生药萃取液复配制得复合防晒剂。结果表明:复合防晒剂在水剂中的用量≤0.3 g/L,乳剂中的用量≤0.7 g/L时的... 详细信息

通过对201种中草药在防晒光区(290～400 nm)紫外吸收能力的研究,选取紫外吸收强、吸收波段互补、调配着色浅的苦丁茶和槐米两种生药萃取液复配制得复合防晒剂。结果表明:复合防晒剂在水剂中的用量≤0.3 g/L,乳剂中的用量≤0.7 g/L时的使用色度合适,累积日照20 h下稳定,50℃下热稳定,pH=4～7之间稳定,室内存放1 a稳定,具有广谱、高效的防晒效果。

关键词：复合防晒剂中草药广谱稳定

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing chen Chao Wu Xiaoling Liu Biao Meng Tao chen yu Han Jun Wang Shibo Xi yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

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Co/Co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang chen Yongyue Zhuang Yanxin Qiao yu Zhang Aihua yuan Hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by controlling the alloying *** optimal CoFe_(0.08)@NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan chen xiu-Qing Qiao Guo Hui Bojing Sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

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学习古代文献,拓展治疗糖尿病足的思路

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北京中医药大学学报（中医临床版） 2013年第3期20卷 5-9页

作者：于秀辰北京中医药大学东直门医院北京100700

从箍围的定义及作用、根据局部具体表现辨证选药、箍围法与多种外用方法并用、箍围法与内治法联合应用等几方面,对古代文献中关于痈疽疖肿的外治法进行学习,并将之应用于糖尿病足的治疗中,拓展中医治疗糖尿病足的思路。糖尿病足局部常... 详细信息

从箍围的定义及作用、根据局部具体表现辨证选药、箍围法与多种外用方法并用、箍围法与内治法联合应用等几方面,对古代文献中关于痈疽疖肿的外治法进行学习,并将之应用于糖尿病足的治疗中,拓展中医治疗糖尿病足的思路。糖尿病足局部常见湿热内蕴、热毒炽盛、寒湿流注、阳虚血瘀等证型。箍围法与其他的外治法联合应用对局部进行序贯性治疗,发挥不同外治法的优势;外治法与内治法联合应用使局部辨证与整体辨证有机结合,充分发挥中医辨证治疗的特色,外治法可以使药物直达病所,内治法则能改善患者的整体体质;内治、外治联合应用,可促进溃疡向愈。

关键词：糖尿病足箍围外治法内治法

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超声浸渍法萃取苦丁茶防晒成分工艺的可视化分析

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日用化学工业 2013年第5期43卷 367-371页

作者：俞晨秀孙益民吴晟安徽省中医药高等专科学校安徽芜湖241000 安徽省药用植物研究所安徽南陵241314 安徽省功能性分子固体重点实验室安徽芜湖241000 安徽师范大学化学与材料科学学院安徽芜湖241000

对超声浸渍法萃取苦丁茶防晒成分的工艺条件进行了系统研究。选择超声时间、超声温度、萃取剂乙醇溶液中乙醇体积分数和样品目数4个主要影响因素，运用多因素多水平可视化设计法安排超声萃取实验。以防晒光区紫外吸收面积值作为防晒成... 详细信息

对超声浸渍法萃取苦丁茶防晒成分的工艺条件进行了系统研究。选择超声时间、超声温度、萃取剂乙醇溶液中乙醇体积分数和样品目数4个主要影响因素，运用多因素多水平可视化设计法安排超声萃取实验。以防晒光区紫外吸收面积值作为防晒成分萃取浓度的实验评定指标，用自主提出的多因素多水平实验结果可视化分析方法对多维空间实验数据进行分析。结果表明，当苦丁茶萃取母液质量浓度为25．0g·L-1时，超声浸渍陈化1d后，优化工艺条件为：超声时间30～40min，超声温度25～35℃，p（乙醇）=45％～70％，原料目数120～160目。

关键词：防晒成分苦丁茶超声萃取多因素多水平可视化设计可视化分析

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