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Neuroendocrine carcinoma of the gastric stump:A case report and literature review

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World Journal of Gastroenterology 2018年第4期24卷 543-548页

作者： Fu-Hai Ma Li-Yan Xue Ying-Tai Chen Yi-Bin Xie yu-xin zhong Quan Xu Yan-Tao Tian Department of Pancreatic and Gastric Surgery National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

We herein report a case of neuroendocrine carcinoma of the gastric stump found 47 years after Billroth II gastric resection for a benign gastric ulcer. A 74-yearold man was referred to another hospital with melena. Endoscopic examination revealed a localized ulcerative lesion at the gastrojejunal anastomosis. The diagnosis by endoscopic biopsy was neuroendocrine carcinoma. A total gastrectomy of the remnant stomach with D2 lymphadenectomy was performed at our hospital. The lesion invaded the subserosa, and metastasis was found in two of nine the lymph nodes retrieved. The lesion was positive for synaptophysin and chromogranin A, and the Ki-67 labeling index was 60%. The diagnosis of neuroendocrine carcinoma of the gastric stump was confirmed using World Health Organization 2010 criteria. Subsequently, the patient underwent one course of adjuvant chemotherapy with the etoposide plus cisplatin(EP) regimen; however, treatment was discontinued due to grade 3 myelosuppression. The patient showed lymph node metastasis in the region around the gastrojejunal anastomosis in the abdominal cavity 7 mo post-surgery. He then underwent radiotherapy and platinum-based combination chemotherapy; however, the disease progressed and liver recurrence was observed on follow-up computedtomography at 16 mo post-surgery. The patient then received chemotherapy with regimens used for the treatment of small cell lung cancer in first-and secondline settings. The patient died of disease progression 31 months after surgery.

关键词： Gastric stump Gastric stump cancer Neuroendocrine carcinoma

Study on Heat Treatment Process of AB/EQ56 Steel Plate

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Journal of Iron and Steel Research International 2011年第S1期18卷 978-982页

作者： ZHANG Zhi-jun,yu zhong-xin,YANGyue-hui (Wuyang Iron and Steel Co.,Ltd.,Wuyang 462500,Henan,China) Wuyang Iron & Steel Co Ltd Wuyang 462500 Henan Peoples R China

The article mainly describes the development process of AB/EQ56 steel plate for ocean engineering with thickness ≤50mm in Wuyang Iron and Steel Co.,Ltd.(Wugang),and studies the chemical analysis,metallographic structure,tensile strength and serial temperatures impact toughness of the steel *** results show that a good match of strength and toughness of AB/EQ56 steel plate with thickness ranging from 12mm to 95mm produced by ultra low alloying component control,controlled rolling and controlled cooling,proper quenching and tempering process,of which the properties are all conforming to the requirements of ABS *** steel plate has passed the certification of ABS and is qualified for *** than 7000 tons of such steel plate have been ordered,which mainly apply for the cantilever beam of offshore oil platform.

关键词： low alloy composition design controlled rolling quenching process microstructure property

Treatment of afferent loop syndrome using fluoroscopic-guided nasointestinal tube placement: Two case reports

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World Journal of Clinical Cases 2020年第21期8卷 5353-5360页

作者： Hai-Tao Hu Fu-Hai Ma Zhen-Min Wu Xiu-Heng Qi yu-xin zhong Yi-Bin Xie Yan-Tao Tian Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Oncology Hebei Petro China Central HospitalLangfang 065000Hebei ProvinceChina

BACKGROUND Afferent loop syndrome(ALS)is a rare mechanical complication that occurs after reconstruction of the stomach or esophagus to the jejunum,such as Billroth II gastrojejunostomy,Roux-en-Y gastrojejunostomy,or Roux-en-Y ***,an operation is the first choice for benign ***,for patients in poor physical condition who experience ALS soon after R0 resection,the type of treatment remains ***,we present an efficient conservative method to treat *** SUMMARY Case 1 was a 69-year-old male patient who underwent total gastrectomy with Roux-en-Y *** postoperative day(POD)10 he developed symptoms of ALS that persisted and increased over 1 *** 2 was a 59-yearold male patient who underwent distal gastrectomy with Billroth II *** postoperative day POD 9 he developed symptoms of ALS that persisted for 2 *** patients underwent fluoroscopic-guided nasointestinal tube placement with maintenance of continuous negative pressure *** 20 d after the procedure,both patients had recovered well and were discharged from hospital after removal of the *** 3-mo follow-up,there were no signs of ALS in these two *** This is the first report of treating postoperative ALS by fluoroscopic-guided nasointestinal tube *** cases demonstrate that this procedure is an effective and safe method to treat ALS that relieves patients’symptoms and avoids complications caused by other invasive procedures.

关键词： Afferent loop syndrome Fluoroscopy Nasointestinal tube Case report Rouxen-Y

Treatment strategies for gastric cancer during the COVID-19 pandemic

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World Journal of Clinical Cases 2020年第21期8卷 5099-5103页

作者： Wen-Zhe Kang yu-xin zhong Fu-Hai Ma Hao Liu Shuai Ma Yang Li Hai-Tao Hu Wei-Kun Li Yan-Tao Tian Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

The coronavirus disease 2019 pandemic has become a major global public health *** are taking the necessary steps to reduce the movement of people to contain the spread of the ***,these measures have caused considerable distress to patients with gastric cancer who are newly diagnosed or are undergoing *** addition to the cancer,they must deal with longer waiting times for surgery and poor communication with ***,gastric cancer patients generally have low immunity and a poor nutritional status,so they are a high-risk group for infection with the novel ***,it is necessary to formulate reasonable outpatient management strategies to reduce the adverse effects of the pandemic on their *** summarize the management strategies for patients with gastric cancer during the pandemic.

关键词： COVID-19 pandemic Gastric cancer Treatment Strategies Management Outside the hospital

Survival outcomes and prognostic indicators for gastric cancer patients with positive peritoneal wash cytology but no peritoneal metastasis after radical gastrectomy

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World Journal of Gastrointestinal Oncology 2021年第1期13卷 24-36页

作者： Wen-Zhe Kang yu-xin zhong Fu-Hai Ma Li-Yan Xue Jian-Ping Xiong Shuai Ma Yang Li Yi-Bin Xie Xu Quan Yan-Tao Tian Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100021China

BACKGROUND Positive peritoneal wash cytology with no peritoneal metastasis(CY1P0)is a special type of distant gastric cancer metastasis,which describes a patient with positive peritoneal lavage cytology,but no definitive peritoneal metastasis,and there are no widely accepted treatment *** enrolled 48 primary CY1P0 gastric cancer patients treated by radical gastrectomy in this *** study illustrated the efficacy of radical gastrectomy for CY1P0 gastric cancer patients,and suggested that the pathological N factor and vascular invasion were significant independent risk factors for overall survival(OS).AIM To assess the survival of CY1P0 gastric cancer patient post-radical gastrectomy,and to identify factors associated with long-term *** Our study included 48 patients with primary CY1P0 gastric cancer who had radical gastrectomies at the Cancer Hospital,Chinese Academy of Medical Sciences,Beijing,China between 2013 and 2018.R0 resection was achieved in all 48 *** patients received neoadjuvant *** patients received adjuvant chemotherapy and four received adjuvant *** statistics were available for 48 ***-up continued through March *** and multivariate analyses were performed using a Cox proportional hazards model to identify prognostic *** Median OS was 22.0 mo(95%confidence interval:13.366-30.634 mo)*** analyses demonstrated that tumor site(P=0.021),pathological N factor(P=0.001),pathological T factor(P=0.028),vascular invasion(P=0.046),and the level of CA199 prior to initiating therapy(P=0.002)were significant risk factors for *** analyses demonstrated that pathological N factor(P=0.001)and vascular invasion(P=0.031)were significant independent risk factors for *** This study suggested that radical gastrectomy may be efficient for CY1P0 gastric cancer patient post-radical gastrectomy and the pathological N factor and vas

关键词： Gastric cancer Overall survival R0 resection Prognostic factors Lymph node metastasis

Additional laparoscopic gastrectomy after noncurative endoscopic submucosal dissection for early gastric cancer: A single-center experience

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World Journal of Gastroenterology 2019年第29期25卷 3996-4006页

作者： Yan-Tao Tian Fu-Hai Ma Gui-Qi Wang yue-Ming Zhang Li-Zhou Dou Yi-Bin Xie yu-xin zhong Ying-Tai Chen Quan Xu Dong-Bing Zhao Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China Department of Endoscopy National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

BACKGROUND The necessity of additional gastrectomy for early gastric cancer (EGC) patients who do not meet curative criteria after endoscopic submucosal dissection (ESD) is controversial. AIM To examine the clinicopathologic characteristics of patients who underwent additional laparoscopic gastrectomy after ESD and to determine the appropriate strategy for treating those after noncurative ESD. METHODS We retrospectively studied 45 patients with EGC who underwent additional laparoscopic gastrectomy after noncurative ESD from January 2013 to January 2019 at the Cancer Hospital of the Chinese Academy of Medical Sciences. We analyzed the patients’ clinicopathological data and identified the predictors of residual cancer (RC) and lymph node metastasis (LNM). RESULTS Surgical specimens showed RC in ten (22.2%) patients and LNM in five (11.1%).Multivariate analysis revealed that positive horizontal margin [odds ratio (OR)=13.393, 95% confidence interval (CI): 1.435-125, P=0.023] and neural invasion (OR=14.714, 95%CI: 1.087-199, P=0.043) were independent risk factors for RC. Undifferentiated type was an independent risk factor for LNM (OR=12.000, 95%CI: 1.197-120, P=0.035). Tumors in all patients with LNM showed submucosal invasion more than 500 μm. Postoperative complications after additional laparoscopic gastrectomy occurred in five (11.1%) patients, and no deaths occurred among patients with complications. CONCLUSION Gastrectomy is necessary not only for patients who have a positive margin after ESD, but also for cases with neural invasion, undifferentiated type, and submucosal invasion more than 500 μm. Laparoscopic gastrectomy is a safe, minimally invasive, and feasible procedure for additional surgery after noncurative ESD. However, further studies are needed to apply these results to clinical practice.

关键词： Early gastric cancer Endoscopic submucosal dissection Laparoscopic gastrectomy Residual cancer Lymph node metastasis

Surgical resection of gastric stump cancer following proximal gastrectomy for adenocarcinoma of the esophagogastric junction

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World Journal of Gastrointestinal Oncology 2019年第5期11卷 416-423页

作者： Fu-Hai Ma Li-Yan Xue Ying-Tai Chen Wei-Kun Li Yang Li Wen-Zhe Kang Yi-Bin Xie yu-xin zhong Quan Xu Yan-Tao Tian Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

BACKGROUND Proximal gastrectomy(PG) is performed widely as a function-preserving operation for early gastric cancer located in the upper third of the stomach and is an important function-preserving approach for esophagogastric junction(EGJ)adenocarcinoma. The incidence of gastric stump cancer(GSC) after PG is increasing. However, little is known about the GSC following PG because very few studies have been conducted on the *** To clarify clinicopathologic features, perioperative complications, and long-term survival rates after the resection of GSC following *** Data for patients with GSC following PG for adenocarcinoma of the EGJ diagnosed between January 1998 and December 2016 were retrospectively reviewed. Multivariate analysis was performed to identify factors associated with overall survival(OS). GSC was defined in accordance with the Japanese Gastric Cancer *** A total of 35 patients were identified. The median interval between the initial PGand resection of GSC was 4.9(range 0.7-12) years. In 21 of the 35 patients, the tumor was located in a nonanastomotic site of the gastric stump. Total gastrectomy was performed in 27 patients; the other 8 underwent partial gastrectomy. Postoperative complications occurred in 6 patients(17.1%). The tumor stage according to the depth of tumor invasion was T1 in 6 patients, T2 in3 patients, T3 in 9 patients, and T4 in 17 patients. Lymph node metastasis was observed in 18 patients. Calculated 1-, 3-, and 5-year OS rates were 86.5%, 62.3%,and 54.2%, respectively. Multivariate analysis showed advanced T stage to be associated with *** This study reveals the characteristics of GSC following PG for adenocarcinoma of the EGJ and suggests that a surgical approach can lead to a satisfactory outcome.

关键词： Gastric stump cancer Proximal gastrectomy Esophagogastric junction Distal gastrectomy

融通内外:跨学科视野下的中医知识史研究刍议

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齐鲁学刊 2018年第5期 28-35页

作者：余新忠南开大学中国社会史研究中心天津300350

随着医学人类学和医疗社会文化史等研究的兴起和发展,医学的社会文化属性日渐受到关注,然而,对于医史的研究来说,如何回到医学本身,依然是个不容回避的问题的。回到医学本身,显然并不是要回归传统的技术史研究,而需要将医学外部的社会... 详细信息

随着医学人类学和医疗社会文化史等研究的兴起和发展,医学的社会文化属性日渐受到关注,然而,对于医史的研究来说,如何回到医学本身,依然是个不容回避的问题的。回到医学本身,显然并不是要回归传统的技术史研究,而需要将医学外部的社会文化因素与内在的知识理论很好地结合起来。要做到这点,知识史可谓是非常恰当的研究路径,知识史研究并不仅仅将医学视为纯粹的科学技术,不但会充分关注医学知识建构机制中的社会文化因素,也会思考知识建构所反映的社会文化变迁和建构的知识对社会文化的型塑作用。另一方面,对医学知识的探讨,必然会指向对现实中医学问题及其发展的思考和理解。在跨学科的视野下探究中医知识史,不仅可以实现中国医史研究中内外史之间的融通,而且也可以藉此打破国内普遍存在的对中医的本质化和自足性认知,理清现代中医传统与现代的关系。

关键词：跨学科中医知识史内外史

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超声清洗用水基清洗剂

材料保护 2000年第9期33卷 48-49页

作者：朱焱俞忠新武汉汽车工业大学化工系 430070

阐述了与超声波清洗机配套的水基清洗剂研制应考虑的因素 ,列出了使用超声波清洗机时应选择的功率密度、频率和清洗温度等工艺参数。通过试验筛选了BJ2 0 1B型水基清洗剂的优选配方。应用试验证明 ,该产品可以代替三氯乙烯等溶剂 ,可与... 详细信息

阐述了与超声波清洗机配套的水基清洗剂研制应考虑的因素 ,列出了使用超声波清洗机时应选择的功率密度、频率和清洗温度等工艺参数。通过试验筛选了BJ2 0 1B型水基清洗剂的优选配方。应用试验证明 ,该产品可以代替三氯乙烯等溶剂 ,可与超声波清洗机配套使用 ,且效果良好。

关键词：超声波清洗机水基清洗剂金属清洗配方