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Minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis

World Journal of Gastroenterology 2024年第17期30卷 2354-2368页

作者： Kai Zhou Cai-Ling Li Hua zhang Bao-Jun Suo yu-xin zhang xin-Lu Ren yu-xin Wang Chang-Min Mi Ling-Ling Ma Li-Ya Zhou Xue-Li Tian Zhi-Qiang Song Department of Gastroenterology Peking University Third HospitalBeijing 100191China

BACKGROUND Difficulty in obtaining tetracycline,increased adverse reactions,and relatively complicated medication methods have limited the clinical application of the classic bismuth quadruple therapy.Therefore,the search for new alternative drugs has become one of the research hotspots.In recent years,minocycline,as a semisynthetic tetracycline,has demonstrated good potential for eradicating Helicobacter pylori(H.pylori)infection,but the systematic evaluation of its role remains lacking.AIM To explore the efficacy,safety,and compliance of minocycline in eradicating H.pylori infection.METHODS We comprehensively retrieved the electronic databases of PubMed,Embase,Web of Science,China National Knowledge Infrastructure,SinoMed,and Wanfang database as of October 30,2023,and finally included 22 research reports on H.pylori eradication with minocycline-containing regimens as per the inclusion and exclusion criteria.The eradication rates of H.pylori were calculated using a fixed or a random effect model,and the heterogeneity and publication bias of the studies were measured.RESULTS The single-arm meta-analysis revealed that the minocycline-containing regimens achieved good overall H.pylori eradication rates,reaching 82.3%[95%confidence interval(CI):79.7%-85.1%]in the intention-to-treat analysis and 90.0%(95%CI:87.7%-92.4%)in the per-protocol analysis.The overall safety and compliance of the minocycline-containing regimens were good,demonstrating an overall incidence of adverse reactions of 36.5%(95%CI:31.5%-42.2%).Further by traditional meta-analysis,the results showed that the minocycline-containing regimens were not statistically different from other commonly used eradication regimens in eradication rate and incidence of adverse effects.Most of the adverse reactions were mild to moderate and well-tolerated,and dizziness was relatively prominent in the minocycline-containing regimens(16%).CONCLUSION The minocycline-containing regimens demonstrated good efficacy,safety,and compliance in H.pylori eradication.Minocycline

关键词： Helicobacter pylori Minocycline Eradication Safety Resistance

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Compound extreme inundation risk of coastal wetlands caused by climate change and anthropogenic activities in the Yellow River Delta,China

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Advances in Climate Change Research 2024年第1期15卷 134-147页

作者： Xiao-Li WANG Ai-Qing FENG Xi-Yong HOU Qing-Chen CHAO Bai-yuan SONG yu-Bin LIU Qi-Guang WANG He XU yu-xin zhang Dong Li Li-Jie DONG yu GUO CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Tongji Urban Planning Design Research Institute Shanghai 200092China School of Geography and Tourism Qilu Normal UniversityJinan 250200China China Meteorological Administration Training Centre China Meteorological AdministrationBeijing 10008China University of Chinese Academy of Sciences Beijing 100049China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316022China

The coastal wetlands of the Yellow River Delta(YRD)in China are crucial for their valuable resources,environmental significance,and economic contributions.However,these wetlands are also vulnerable to the dual threats of climate change and human disturbances.Despite substantial attention to the historical shifts in YRD's coastal wetlands,uncertainties remain regarding their future trajectory in the face of compound risks from climate change and anthropogenic activities.Based on a range of remote sensing data sources,this study undertakes a comprehensive investigation into the evolution of YRD's coastal wetlands between 2000 and 2020.Subsequently,the potential fate of coastal wetlands is thoroughly analyzed through the Land Use/Cover Change(LUCC)simulation using System Dynamic-Future Land Use Simulation(SD-FLUS)model and the extreme water levels projection integrated future sea-level rise,storm surge,and astronomical high tide in 2030,2050,and 2100 under scenarios of SSP1-2.6,SSP2-4.5,and SSP5-8.5.Results revealed that YRD's coastal wetlands underwent a marked reduction,shrinking by 1688.72 km²from 2000 to 2020.This decline was mostly attributed to the substantial expansion in the areas of artificial wetlands(increasing by 823.78 km2),construction land(increasing by 767.71 km²),and shallow water(increasing by 274.58 km²).Looking ahead to 2030-2100,the fate of coastal wetlands appears to diverge based on different scenarios.Under the SSP1-2.6 scenario,the area of coastal wetland is projected to experience considerable growth.In contrast,the SSP5-8.5 scenario anticipates a notable decrease in coastal wetlands.Relative to the inundated area suffered from the current extreme water levels,the study projects a decrease of 6.8%-10.6%in submerged coastal wetlands by 2030 and 9.4%-18.2%by 2050 across all scenarios.In 2100,these percentages are projected to decrease by 0.4%(SSP2-4.5)and 27.1%(SSP5-8.5),but increase by 35.7%(SSP1-2.6).Results suggest that coastal wetlands in the YRD will face a serious compound risk from cli

关键词： Climate change Anthropogenic activities Compound extreme risk Coastal wetlands Yellow River Delta

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Bimagnetic metal constructed core-shell structure of Fe@Co nanowires for multi-band microwave absorption

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Progress in Natural Science:Materials International 2024年第2期34卷 354-361页

作者： Ping-an Yang Rui Cai Haibo Ruan Nanqing zhang xin Huang Rui Li yuxin zhang Yi Lu Zhihao Zhou School of Automation Chongqing University of Posts and Telecommunications Chongqing Key Laboratory of Materials Surface & Interface Science Chongqing University of Arts and Sciences College of Engineering and Technology Zunyi Normal College College of Material Science and Engineering Chongqing University

Controlled fabrication of materials by surface modification techniques has been a hot research topic. In this paper,one-dimensional(1D) core-shell structure Fe@Co nanowires(NWs) were successfully prepared by anchoring 0-dimensional(0D) Co nanoparticles on 1D Fe NWs based on the in situ reduction method. The electromagnetic parameters of the specimens at a filler mass fraction of 25 wt% were tested and the microwave loss mechanism was deeply analyzed. Binary magnetic metals in a core-shell structure have excellent multi-band microwave absorption capability(S-band, X-band and Ku-band). This is due to the heterogeneous interface and magnetic coupling effects tuning the dielectric and magnetic loss. This study offers a workable plan for creating effective multi-band magnetic metal-based microwave absorbers.

关键词： Core-shell structure Interface Magnetic coupling Microwave absorption One-dimensional nanowires

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Let-7i-5p maintains the stemness via R-spondin2/Wnt pathway in hepatocellular carcinoma

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Genes & Diseases 2024年第4期11卷 20-23页

作者： Qinghua Wei Xueshan Dai Jiahui Wei Wenwei Sun Xiaoqian Yang yuxin zhang xin Guo Yi Chen College of Pharmaceutical Sciences&Chinese Medicine Southwest UniversityChongqing 400716China Center for Basic Medical Research TEDA International Cardiovascular HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300457China Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine Chongqing 400716China pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine Chongqing 400716China Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China National Demonstration Center for Experimental Pharmacy Education(Southwest University) Chongqing 400716China Engineering Research Center of Coptis Development and Utilization(Ministry of Education) College of Pharmaceutical Sciences and Chinese MedicineSouthwest UniversityChongqing 400716China

Cancer stem cells(CSCs)are related to tumorigenesis,recurrence,metastasis,and drug resistance in hepatocellular carcinoma(HCC).1 Let-7i is a noncoding small RNA,belonging to the famous miRNA let-7 family.Recently,let-... 详细信息

关键词： hepatocellular Cancer metastasis

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Double enzyme mimetic activities of multifunctional Ag nanoparticle-decorated Co_(3)V_(2)O_(8)hollow hexagonal prismatic pencils for application in colorimetric sensors and disinfection

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Nano Materials Science 2024年第2期6卷 244-255页

作者： Ying Gao Peng Ju yu zhang yuxin zhang Xiaofan Zhai Jizhou Duan Baorong Hou Key Laboratory of Marine Environmental Corrosion and Bio-fouling Institute of OceanologyChinese Academy of SciencesQingdao266071PR China Key Laboratory of Marine Eco-Environmental Science and Technology Marine Bioresource and Environment Research CenterFirst Institute of OceanographyMinistry of Natural ResourcesQingdao266061PR China University of Chinese Academy of Sciences Beijing100049PR China Open Studio for Marine Corrosion and Protection Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao266071PR China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao266071PR China College of Materials Science and Engineering Chongqing UniversityChongqing400044China

Since the catalytic activity of most nanozymes is still far lower than the corresponding natural enzymes,there is urgent need to discover novel highly efficient enzyme-like materials.In this work,Co_(3)V_(2)O_(8)with hollow hexagonal prismatic pencil structures were prepared as novel artificial enzyme mimics.They were then decorated by photo-depositing Ag nanoparticles(Ag NPs)on the surface to further improve its catalytic activities.The Ag NPs decorated Co_(3)V_(2)O_(8)(ACVPs)showed both excellent oxidase-and peroxidase-like catalytic activities.They can oxidize the colorless 3,3’,5,5’-tetramethylbenzidine rapidly to induce a blue change.The enhanced enzyme mimetic activities can be attributed to the surface plasma resonance(SPR)effect of Ag NPs as well as the synergistic catalytic effect between Ag NPs and Co_(3)V_(2)O_(8),accelerating electron transfer and promoting the catalytic process.ACVPs were applied in constructing a colorimetric sensor,validating the occurrence of the Fenton reaction,and disinfection,presenting favorable catalytic performance.The enzyme-like catalytic mechanism was studied,indicating the chief role of⋅O_(2)-radicals in the catalytic process.This work not only discovers a novel functional material with double enzyme mimetic activity but also provides a new insight into exploiting artificial enzyme mimics with highly efficient catalytic ability.

关键词： Co_(3)V_(2)O_(8) Ag NPs Enzyme mimetic Colorimetric sensor Disinfection

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Diverse atomic structure configurations of metal-doped transition metal dichalcogenides for enhancing hydrogen evolution

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Nano Research 2024年第5期17卷 3586-3602页

作者： Longlu Wang yuxin zhang Chen Gu Haoxuan yu Yanling Zhuang Zechao Zhuang College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Jiangsu Province Engineering Research Center for Fabrication and Application of Special Optical Fiber Materials and DevicesNanjing University of Posts and TelecommunicationsNanjing 210023China Department of Chemical Engineering Columbia UniversityNew YorkNY 10027USA

Doping foreign metal atoms into the substrate of transition metal dichalcogenides(TMDs)enables the formation of diverse atomic structure configurations,including isolated atoms,chains,and clusters.Therefore,it is very important to reasonably control the atomic structure and determine the structure-activity relationship between the atomic configurations and the hydrogen evolution reaction(HER)performance.Although numerous studies have indicated that doping can yield diverse atomic structure configurations,there remains an incomplete understanding of the relationship between atomic configurations within the lattice of TMDs and their performance.Here,diverse atomic structure configurations of adsorptive doping,substitutional doping,and TMDs alloys are summarized.The structure-activity relationship between different atomic configurations and HER performance can be determined by micro-nanostructure devices and density functional theory(DFT)calculations.These diverse atomic structure configurations are of great significance for activating the inert basal plane of TMDs and improving the catalytic activity of HER.Finally,we have summarized the current challenges and future opportunities,offering new perspectives for the design of highly active and stable metal-doped TMDs catalysts.

关键词： transition metal dichalcogenides(TMDs) dopant effect diverse atomic structure configurations hydrogen evolution reaction(HER)

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Designing multi-heterogeneous interfaces of Ni-MoS_(2)@NiS_(2)@Ni_(3)S_(2)hybrid for hydrogen evolution

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Nano Research 2024年第6期17卷 4782-4789页

作者： Haoxuan yu Junan Pan yuxin zhang Longlu Wang Huachao Ji Keyu Xu Ting Zhi Zechao Zhuang College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts&Telecommunications(NJUPT)Nanjing 210023China Department of Chemical Engineering Columbia UniversityNew YorkNY 10027USA

The transition metal chalcogenides represented by MoS_(2)are the ideal choice for non-precious metal-based hydrogen evolution catalysts.However,whether in acidic or alkaline environments,the catalytic activity of pure MoS_(2)is still difficult to compete with Pt.Recent studies have shown that the electronic structure of materials can be adjusted by constructing lattice-matched heterojunctions,thus optimizing the adsorption free energy of intermediates in the catalytic hydrogen production process of materials,so as to effectively improve the electrocatalytic hydrogen production activity of catalysts.However,it is still a great challenge to prepare heterojunctions with lattice-matched structures as efficient electrocatalytic hydrogen production catalysts.Herein,we developed a one-step hydrothermal method to construct Ni-MoS_(2)@NiS_(2)@Ni_(3)S_(2)(Ni-MoS_(2)on behalf of Ni doping MoS_(2))electrocatalyst with multiple heterogeneous interfaces which possesses rich catalytic reaction sites.The Ni-MoS_(2)@NiS_(2)@Ni_(3)S_(2)electrocatalyst produced an extremely low overpotential of 69.4 mV with 10 mA·cm^(−2)current density for hydrogen evolution reaction(HER)in 1.0 M KOH.This work provides valuable enlightenment for exploring the mechanism of HER enhancement to optimize the surface electronic structure of MoS_(2),and provides an effective idea for constructing rare metal catalysts in HER and other fields.

关键词： MoS_(2) heterojunctions multiple heterogeneous interfaces hydrogen evolution

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Self-assembly multifunctional DNA tetrahedron for efficient elimination of antibiotic-resistant bacteria

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Aggregate 2024年第1期5卷 204-215页

作者： Tiantian Wu yu Fu Shuang Guo Yanqiang Shi yuxin zhang Zhijin Fan Bin Yang Baoquan Ding yuhui Liao Molecular Diagnosis and Treatment Center for Infectious Diseases Dermatology HospitalSouthern Medical UniversityGuangzhouChina CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina Longgang District Central Hospital of Shenzhen ShenzhenChina

Antibiotic resistance is a major challenge in the clinical treatment of bacterial infectious diseases.Herein,we constructed a multifunctional DNA nanoplatform as a versatile carrier for bacteria-specific delivery of clinical antibiotic ciprofloxacin(CIP)and classic nanoantibiotic silver nanoparticles(AgNP).In our rational design,CIP was efficiently loaded in the self-assembly double-bundle DNA tetrahedron through intercalation with DNA duplex,and single-strand DNA-modified AgNP was embedded in the cavity of the DNA tetrahedron through hybridization.With the site-specific assembly of targeting aptamer in the well-defined DNA tetrahedron,the bacteria-specific dual-antibiotic delivery system exhibited excellent combined bactericidal properties.With enhanced antibiotic accumulation through breaking the out membrane of bacteria,the antibiotic delivery system effectively inhibited biofilm formation and promoted the healing of infected wounds in vivo.This DNAbased antibiotic delivery system provides a promising strategy for the treatment of antibiotic-resistant infections.

关键词： antibiotic resistance anti-infection therapy biofilm DNA nanotechnology targeted delivery

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Dissipation-Driven Superradiant Phase Transition of a Two-Dimensional Bose-Einstein Condensate in a Double Cavity

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Chinese Physics Letters 2024年第6期41卷 44-48页

作者： Bo-Hao Wu xin-xin Yang yu Chen Wei zhang Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Renmin University of ChinaBeijing 100872China Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China Graduate School of China Academy of Engineering Physics Beijing 100193China Beijing Academy of Quantum Information Sciences Beijing 100193China

We study superradiant phase transitions in a hybrid system of a two-dimensional Bose–Einstein condensate of atoms and two cavities arranged with a tilt angle.By adjusting the loss rate of cavities,we map out the phase diagram of steady states within a mean field framework.It is found that when the loss rates of the two cavities are different,superradiant transitions may not occur at the same time in the two cavities.A first-order phase transition is observed between the states with only one cavity in superradiance and both in superradiance.In the case that both cavities are superradiant,a net photon current is observed flowing from the cavity with small decay rate to the one with large decay rate.The photon current shows a non-monotonic dependence on the loss rate difference,owing to the competition of photon number difference and cavity field phase difference.Our findings can be realized and detected in experiments.

关键词： Einstein transitions decay

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Atomically Dispersed Ruthenium Catalysts with Open Hollow Structure for Lithium-Oxygen Batteries

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Nano-Micro Letters 2024年第2期16卷 154-164页

作者： xin Chen yu zhang Chang Chen Huinan Li yuran Lin Ke yu Caiyun Nan Chen Chen Beijing Advanced Innovation Center for Materials Genome Engineering Institute of Solid State ChemistryUniversity of Science and Technology BeijingBeijing 100083People’s Republic of China Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084People’s Republic of China Beijing Key Laboratory of Energy Conversion and Storage Materials Institution College of ChemistryBeijing Normal UniversityBeijing 100875People’s Republic of China

Lithium–oxygen battery with ultrahigh theoretical energy density is considered a highly competitive next-generation energy storage device,but its practical application is severely hindered by issues such as difficult decomposition of discharge products at present.Here,we have developed N-doped carbon anchored atomically dispersed Ru sites cathode catalyst with open hollow structure(h-RuNC)for Lithium–oxygen battery.On one hand,the abundance of atomically dispersed Ru sites can effectively catalyze the formation and decomposition of discharge products,thereby greatly enhancing the redox kinetics.On the other hand,the open hollow structure not only enhances the mass activity of atomically dispersed Ru sites but also improves the diffusion efficiency of catalytic molecules.Therefore,the excellent activity from atomically dispersed Ru sites and the enhanced diffusion from open hollow structure respectively improve the redox kinetics and cycling stability,ultimately achieving a high-performance lithium–oxygen battery.

关键词： Atomically dispersed Open hollow structure Discharge product Lithium Oxygen battery

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