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Estimation of enhanced low dose rate sensitivity mechanisms using temperature switching irradiation on gate-controlled lateral PNP transistor

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Chinese Physics B 2018年第3期27卷 342-350页

作者： Xiao-Long Li Wu Lu xin Wang xin yu Qi Guo Jing Sun Mo-Han Liu Shuai Yao xin-yu wei Cheng-Fa He Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Technical Institute of Physics and ChemistryChinese Academy of SciencesUrumqi 830011China xinjiang Key Laboratory of Electronic Information Material and Device Urumqi 830011China University of Chinese Academy of Sciences Beijing 100049China

The mechanisms occurring when the switched temperature technique is applied,as an accelerated enhanced low dose rate sensitivity(ELDRS)test technique,are investigated in terms of a specially designed gate-controlled lateral PNP transistor(GLPNP)that used to extract the interface traps(Nit)and oxide trapped charges(Not).Electrical characteristics in GLPNP transistors induced by ^(60)Co gamma irradiation are measured in situ as a function of total dose,showing that generation of Nit in the oxide is the primary cause of base current variations for the *** on the analysis of the variations of Nit and Not,with switching the temperature,the properties of accelerated protons release and suppressed protons loss play critical roles in determining the increased Nit formation leading to the base current degradation with dose *** the hydrogen cracking mechanisms responsible for additional protons release are related to the neutralization of Not extending enhanced Nit *** this study the switched temperature irradiation has been employed to conservatively estimate the ELDRS of GLPNP,which provides us with a new insight into the test technique for ELDRS.

关键词： ionizing radiation damage enhanced low dose rate sensitivity(ELDRS) switched temperature irradiation gate-controlled lateral PNP transistor(GLPNP)

Dysregulated microRNAs as a biomarker for diagnosis and prognosis of hepatitis B virus-associated hepatocellular carcinoma

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World Journal of Gastroenterology 2023年第31期29卷 4706-4735页

作者： Ming-He Zhang yu-Feng yuan Li-Juan Liu yu-xin wei Wan-yue Yin Lan-Zhuo-Yin Zheng Ying-Ying Tang Zhao Lv Fan Zhu Department of Hepatobiliary&Pancreatic Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina State Key Laboratory of Virology Department of Medical MicrobiologySchool of Basic Medical SciencesWuhan UniversityWuhan 430071Hubei ProvinceChina Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Cardiology Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina Hubei Province Key Labora

Hepatocellular carcinoma(HCC)is a malignancy with a high incidence and fatality rate *** B virus(HBV)infection is one of the most important risk factors for its occurrence and *** detection of HBV-associated HCC(HBV-HCC)can improve clinical decision-making and patient *** are extremely helpful,not only for early diagnosis,but also for the development of ***(miRNAs),a subset of non-coding RNAs approximately 22 nucleotides in length,have increasingly attracted scientists’attention due to their potential utility as biomarkers for cancer detection and *** profoundly impacts the expression of miRNAs potentially involved in the development of *** this review,we summarize the current progress on the role of miRNAs in the diagnosis and treatment of *** a molecular standpoint,we discuss the mechanism by which HBV regulates miRNAs and investigate the exact effect of miRNAs on the promotion of *** the near future,miRNA-based diagnostic,prognostic,and therapeutic applications will make their way into the clinical routine.

关键词： Hepatitis B virus Hepatocellular carcinoma MicroRNA Diagnosis Prognosis Biomarker

Spermatozoal protein profiles in male infertility with asthenozoospermia

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Chinese Medical Journal 2010年第20期123卷 2879-2882页

作者： LI Hong-ju yu Ning ZHANG xin-yu JIN wei LI Han-zhong Department of Urology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China

Background Infertility is a major medical and social problem, and elementary research on the spermatozoal proteins and their functions are relatively scarce and there are very few confirmed and effective options for the treatment of male infertility. Thus, it is essential to find candidate proteins that affect male infertility. This study was designed to detect the proteins with differential expression in sperm from infertile patients and normal *** Semen samples from patients with idiopathic asthenozoospermia （n=114） and from fertile men with normal spermiograms （n=37） were collected. Semen sample analysis, sperm protein extraction, SDS-PAGE electrophoresis and Western blotting analysis were performed. Results were analyzed by SPSS 16.0 statistical *** Western blotting analysis of spermatic proteins displayed a major differentially expressed protein in spermatozoa from fertile and idiopathic asthenozoospermia patients. Densities and volumes of the identified protein in the patients were significantly decreased compared to normal donors （P=0.034 and P=0.036, respectively）. The protein was identified as DEAD-box protein 4 （DDX4, VASA）. The expression and correction value （CV） of DDX4/VASA in the patients was reduced significantly compared to normal donors （P=0.037 and P=0.031, respectively）.Conclusions The expression of spermatic protein DDX4/VASA associates with spermatic motility, implying that DDX4NASA may be a candidate marker for evaluation of spermatic motility.

关键词： male infertility asthenozoospermia proteomics

一种基于UKF的井下机器人超声网络定位方法

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煤炭学报 2016年第9期41卷 2396-2404页

作者：谭玉新杨维北京交通大学电子信息工程学院北京100044

机器人将在未来煤矿少人或无人化开采中发挥重要作用。根据井下工作光线较暗,空间封闭的特点,提出了一种基于无损卡尔曼滤波(unscented Kalman filter,UKF)的井下机器人超声网络定位方法。方法的核心是通过对光电码盘和电子罗盘定位以... 详细信息

机器人将在未来煤矿少人或无人化开采中发挥重要作用。根据井下工作光线较暗,空间封闭的特点,提出了一种基于无损卡尔曼滤波(unscented Kalman filter,UKF)的井下机器人超声网络定位方法。方法的核心是通过对光电码盘和电子罗盘定位以及超声网络定位输出的井下机器人位置坐标和航向角度进行UKF滤波,来对井下机器人进行位置更新和预测。由于对机器人进行位置更新和预测是复杂的非线性函数,采用UKF能有效提高滤波精度,降低定位误差。由于越接近当前时刻的转弯半径误差对转弯半径影响越大,故采用Sigmoid函数作为转弯半径误差系数来计算M个转弯半径误差和。以误差和为权重调节机器人左右驱动轮的转弯半径,可以减小转弯半径误差。仿真结果表明,采用所提出的基于UKF的井下机器人超声网络定位方法实现了井下机器人更稳定和更精确的定位。

关键词：机器人定位煤矿井下超声网络无损卡尔曼滤波

Predictors of atrial fibrillation after coronary artery bypass graft： a meta-analysis

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Journal of Geriatric Cardiology 2009年第3期6卷 162-167页

作者： Liang Yin Zhi-Nong Wang Yi-Feng Wang Wen-Tao Wang Guang-yu Ji xin-wei Yang Zhi-yun Xu Department of Cardiothoracic Surgery Changhai Hospital Second Military Medical University of PLA Shanghai 200433 China

Objectives Postoperative atrial fibrillation （AF） has been associated with less favorable outcomes in patients undergoing coronary artery bypass graft surgery （CABG） and may result in increased post-operative morbidity and mortality. A systematic review and meta-analysis of published studies was conducted to examine the risk factors of occurrence AF after CABG. Methods Using the Medline database, the Cochrane clinical trials database and online clinical trial databases, we reviewed all randomized controlled trials （RCTs） and observational studies examining the risk factors of occurrence of AF after CABG. We searched for literature published April 2009 or earlier. Results Our review identified 8 studies （observational studies）, involving 14548 patients, that examined the risk factors of occurrence of AF after CABG. Although studies provide conflicting results, the overall outcomes suggests that advanced age, previous hypertension, numbers of bridge vessels may increase the occurrence of AF after CABG, while no significant difference of diabetes, preoperative myocardial infarction, and preoperative medication of 13 -Blocker have been observed between the AF patients and no-AF patiens. Conclusions Patients with advanced age, previous hypertension and more numbers of bridge vessels had higher risk for the occurrence of AF after CABG, and perioperative medication and care must be intensified to decrease the postoperative occurrence ofAF（J Geriatr Cardio12009; 6：162-167）.

关键词： atrial fibrillation coronary artery bypass graft postoperative meta-analysis predictors

The Benefit Risk Assessment of Consumption of Marine Species Based on Benefit-Risk Analysis for Foods(BRAFO)-tiered Approach

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Biomedical and Environmental Sciences 2015年第4期28卷 243-252页

作者： GAO Yi Xiong ZHANG Hong Xia LI Jing Guang ZHANG Lei yu xin wei HE Jia Lu SHANG Xiao Hong ZHAO yun Feng WU Yong Ning China National Center for Food Safety Risk Assessment Key Lab of Food Safety Risk Assessment Ministry of Health National Institute for Nutrition and Health Chinese Center for Disease Control and Prevention Maternal and Child Care Service Centre of Shiquan County Zhejiang Provincial Key Laboratory of Health Risk Factors for Seafood Zhoushan Municipal Center of Disease Control and Prevention

Objective To assess the net health effect caused by the consumption of specific marine species based on Benefit-Risk Analysis for Foods （BRAFO）-tiered approach. Methods Twenty species were collected from the Zhoushan Archipelago, China. Concentrations of n-3 long-chain polyunsaturated fatty acids, methyl mercury （MeHg）, and dioxin-like compounds （DLCs） in the samples were analyzed for benefit risk assessment based on BRAFO-tiered approach. Results Based on the BRAFO-tiered approach, reference scenario （no intake） and alternative scenario （intake of specific species of 200 g/week） were determined. The exposure to MeHg/DLCs via alternative scenario of all studied species did not exceed provisional tolerable weekly/monthly intake. However, the adult population with high DLCs exposure in China would significantly exceed the upper limit of DLCs via an additional alternative scenario of some species such as Auxis thazard. The results of deterministic computation showed that alternative scenario of all studied species generated clear net beneficial effects on death prevention and child IQ gain. Conclusion The alternative scenario of all studied species could be recommended to population with average DLCs exposure, and the reference scenario of species with relatively high DLCs concentration could be recommended to population exposed to high DLCs.

关键词： N-3 long-chain polyunsaturated fatty acid Methyl mercury Dioxin-like compound Benefit-Risk Analysis for Foods (BRAFO) Benefit risk assessment

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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《诸病源候论》对宣导术的发挥

中华医史杂志 2006年第3期36卷 142-144页

作者：俞欣玮浙江中医药大学基础医学院杭州310053

《诸病源候论》是一部中医临床病理学和证候学方面的不朽专著,在记述诸证之后多附养生法和宣导术以防治疾病。书中所载不仅保存早已失传的很多内容,并对宣导术有诸多发挥,如解释行功的具体做法,对宣导术理论阐发,对宣导基本术语进行通... 详细信息

《诸病源候论》是一部中医临床病理学和证候学方面的不朽专著,在记述诸证之后多附养生法和宣导术以防治疾病。书中所载不仅保存早已失传的很多内容,并对宣导术有诸多发挥,如解释行功的具体做法,对宣导术理论阐发,对宣导基本术语进行通俗易懂的解释,宣导后附有医嘱,强调调气伴咽津,宣导结合存思,导引饮食忌宜,最早明确“六字决”与脏腑配对及“辨证施功”。

关键词：《诸病源候论》宣导术

Visible-light-responsive homologous heterostructure of oxynitrides constructed to boost charge separation and water splitting

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Science China Chemistry 2025年第1期68卷 186-191页

作者： Hai Zou yunfeng Bao Xueshang xin yu Qi Tengfeng Xie Fuxiang Zhang State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences School of Chemistry and Chemical Engineering Liaoning Normal University College of Chemistry Jilin University

Constructing type II heterostructures represents a widely recognized strategy for enhancing charge separation and photocatalytic efficiency,but it remains challenging to fabricate homologous heterostructures based on visible-light-responsive semiconductors,especially for popularly investigated （oxy）nitrides with low thermal ***,we synthesized a homologous heterostructure （denoted as YTON＿H） based on the oxynitrides of YTaO4-xNyand YTa *** heterostructure exhibits type II band structure alignment and intimate interface achieved through a magnesium （Mg） powder-assisted nitridation *** with widely reported heterologous heterostructures,the as-obtained YTON＿H homologous heterostructure could similarly exhibit enhanced charge separation as well as photocatalytic water splitting performance with respect to its counterparts(YTaO4-xNyand YTaON2).Meanwhile,detailed structural characterizations and spectroscopy analysis have been made to confirm the formation of heterostructure and promotion of spatial charge separation.

关键词： charge separation heterostructure oxynitride photocatalysis visible light