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Application of superb microvascular imaging in focal liver lesions

World Journal of Gastroenterology 2017年第43期23卷 7765-7775页

作者： Meng-Na He Ke Lv yu-xin jiang Tian-An jiang Department of Ultrasound Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical Sciences Department of Ultrasound The First Affiliated HospitalCollege of MedicineZhejiang University

AIM To explore the ability of superb microvascular imaging(SMI) in differential diagnosis of focal liver lesions(FLLs) and to compare SMI morphology findings to those of color Doppler ultrasound and enhanced *** Twenty-four patients with 31 FLLs were included in our study,with diagnoses of hemangioma(HE)(n = 17),hepatocellular carcinoma(HCC)(n = 5),metastatic lesions(n = 5),primary hepatic lymphoma(n = 1),focal nodular hyperplasia(FNH)(n = 2),and adenoma(n = 1). Nine lesions were pathologically diagnosed,and 22 lesions were radiologically confirmed,all of which were evaluated by at least two types of enhanced imaging techniques. All patients had undergone SMI. Patients were divided into subgroups based on pathological and radiological diagnoses to analyze SMI manifestations. We also compared the SMI manifestations of the most common malignant FLLs(HCCs and metastatic lesions) with those of the most common benign FLLs(HEs).RESULTS HEs were classified into three SMI subgroups: diffuse dot-like type(n = 6),strip rim type(n = 8),and nodular rim type(n = 3). The sizes of the three types of HEs were significantly different(P = 0.00,< 0.05). HCCs were classified into two subgroups: diffuse honeycomb type(n = 2) and non-specific type(n = 3). Four of the metastatic lesions were the strip rim type,and the other metastatic lesion was the thick rim type,which is the same as that of lymphoma. FNH was described as a spoke-wheel type,and adenoma as a diffuse honeycomb type. The SMI types of HCCs and metastatic lesions were significantly different from those of HEs(P = 0.048,< 0.05).CONCLUSION SMI technology enables microvascular evaluation of FLLs without using any contrast agent. For HEs,lesion size may affect SMI performance. SMI is able to provide useful information for differential diagnosis of HCCs and metastatic lesions from HEs.

关键词： Primary hepatic lymphoma Hemangioma Color doppler ultrasound Focal liver lesions Superbmicrovascular imaging

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Application of ultrasound in aggressive angiomyxoma: Eight case reports and review of literature

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World Journal of Clinical Cases 2018年第14期6卷 811-819页

作者： Chen-Yang Zhao Na Su yu-xin jiang Meng Yang Department of Ultrasound Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Hospital

Aggressive angiomyxoma （AAM） is a rare tumour that often occurs in soft tissues of the female genital tract. Eight cases of AAM are reported in this article, and the clinical features and ultrasound and magnetic resonance imaging （MRI） results of the eight cases are reviewed and summarized. The main complaints of all the patients were palpable and painless masses in the vulva or scrotum. The lesions were mainly located in the vulva, pelvis, and perineal region, with a large scope of involvement. The sonographic features of AAM were characteristic. On sonography, all of the masses were of irregular shape and showed hypoechogenicity, with a heterogeneous inner echotexture. Intratumoural and peritumoural blood fows were detected by colour Doppler imaging. On real-time ultrasonic imaging, prominent deformation of the lesions was observed bycompressing the masses with the probe. Some special imaging features were also revealed, including a la-minated or swirled appearance of inner echogenicity, and a fnger-like or tongue-like growth pattern. On MRI imaging, the lesions showed intermediate-intensity signals and intermediate to high-intensity signals on TI-weighted and T2-weighted sequences. A rapid and uneven enhancement pattern was demonstrated. After the comparison of sonographic features with MRIand pathological findings, we found the relevance of the ultrasonographic characteristics with MRI and his-tological features of AAM. Ultrasound can be a valuable imaging method for the preoperative diagnosis, eva-luation of scope, and follow-up of AAM.

关键词： Aggressive angiomyxoma Ultrasound Soft tissue neoplasm Case report Gynaecological neoplasm

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In vivo longitudinal and multimodal imaging of hypoxia-inducible factor 1a and angiogenesis in breast cancer

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Chinese Medical Journal 2020年第2期133卷 205-211页

作者： He-Wen Tang Hai-Liang Feng Ming Wang Qing-Li Zhu yu-Qin Liu yu-xin jiang Department of Ultrasound Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Cell Resource Center Institute of Basic Medical ScienceChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Background:Angiogenesis and hypoxia-inducible factor 1a(HIF-1a)play major roles in solid *** study aimed to establish a longitudinal and multimodal imaging model for in vivo evaluation of HIF1a and angiogenesis in breast ***:By transfection of a 5 hypoxia-responsive element(HRE)/green fluorescent protein(GFP)plasmid,the cell line Ca761-hregfp was established,which emitted green fluorescence triggered by HIF-1a under *** cells were subjected to CoCl2-simulated hypoxia to confirm the imaging *** grew Ca761-hre-gfp cells in the left rear flanks of twelve 615 *** were conducted on days 4,9,15,and *** in vivo analysis,Ca761-hre-gfp subcutaneous allografted tumors were imaged in vivo using contrast-enhanced ultrasound(CEUS)and fluorescence imaging(FLI)during tumor *** tumor size,CEUS peak intensity,and FLI photons were measured to evaluate tumor growth,angiogenesis,and HIF-1a activity,*** each experiment,three mice were randomly sacrificed and tumor specimens were collected to examine HIF-1a activity and the microvessel density(MVD).Results:In vitro,both green fluorescence and HIF-1a expression were detected in Ca761-hre-gfp cells treated with CoCl2,indicating the suitability of the cells to detect HIF-1a *** vivo,HIF-1a activity first increased and then decreased,which was significantly correlated with angiogenic changes(r=0.803,P=0.005).These changes were confirmed by immunohistochemical staining of HIF-1a and ***:The findings validated the Ca761-hre-gfp murine allograft model for reliable evaluation of HIF-1a activity and angiogenesis longitudinally using both molecular and pre-clinical non-invasive imaging *** cell line may be useful for studies of anti-HIF pathway therapies.

关键词： Breast cancer Hypoxia-inducible factor 1 Pathological neovascularization Ultrasonography Fluorescence imaging

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A Gas-Kinetic Unified Algorithm for Non-Equilibrium Polyatomic Gas Flows Covering Various Flow Regimes

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Communications in Computational Physics 2021年第6期30卷 144-189页

作者： Wen-Qiang Hu Zhi-Hui Li Ao-Ping Peng xin-yu jiang National Laboratory for Computational Fluid Dynamics Beijing University of Aeronautics and AstronauticsBeijing 100191China Hypervelocity Aerodynamics Institute China Aerodynamics Research and Development CenterMianyang 621000China

In this paper,a gas-kinetic unified algorithm(GKUA)is developed to investigate the non-equilibrium polyatomic gas flows covering various *** on the ellipsoidal statistical model with rotational energy excitation,the computable modelling equation is presented by unifying expressions on the molecular collision relaxing parameter and the local equilibrium distribution *** constructing the corresponding conservative discrete velocity ordinate method for this model,the conservative properties during the collision procedure are preserved at the discrete level by the numerical method,decreasing the computational storage and *** and implicit lower-upper symmetric Gauss-Seidel schemes are constructed to solve the discrete hyperbolic conservation equations *** the new GKUA,some numerical examples are simulated,including the Sod Riemann problem,homogeneous flow rotational relaxation,normal shock structure,Fourier and Couette flows,supersonic flows past a circular cylinder,and hypersonic flow around a plate placed *** results obtained by the analytic,experimental,direct simulation Monte Carlo method,and other measurements in references are compared with the GKUA results,which are in good agreement,demonstrating the high accuracy of the present ***,some polyatomic gas non-equilibrium phenomena are observed and analysed by solving the Boltzmann-type velocity distribution function equation covering various flow regimes.

关键词： Gas-kinetic unified algorithm polyatomic gas ellipsoidal statistical model conservative discrete velocity ordinate method implicit scheme

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Contrast-enhanced Ultrasound in Detecting Endoleaks with Failed Computed Tomography Angiography Diagnosis after Endovascular Abdominal Aortic Aneurysm Repair

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Chinese Medical Journal 2015年第18期128卷 2491-2497页

作者： Xiao Yang yue-xin Chen Bo Zhang yu-xin jiang Chang-Wei Liu Rui-Na Zhao Qiong Wu Da-Ming Zhang Department of Ultrasound Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Radiology Peking Union Medical College Hospital ChineseAcademy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： Endovascular aneurysnl repair （EVAR） is one of the first-line therapies of abdominal aortic aneurysms. Postoperative endoleak is the most common complication of EVAR. Computed tomography angiography （CTA）, which is routine for follow-up, has side effects （e.g., radiation） and also has a certain percentage of missed diagnosis. Preliminary studies on contrast-enhanced ultrasound （CEUS） have shown that the sensitivity of CEUS for detecting endoleak is no lower than that of CTA. To investigate the advantages of CEUS, we conducted CEUS examinations of post-EVAR cases in which CTA failed to detect endoleak or could not verify the type of endoleak. Methods： Post-EVAR patients, who were clinically considered to have endoleak and met the inclusion criteria were enrolled between March 2013 and November 2014. All of the patients underwent color Doppler flow imaging （CDFI） and a CEUS examination. Size, location, microbubble dispersion, and hemodynamic characteristics of leaks were recorded. Comparison between the diagnosis of CEUS and CDF1 was conducted using Fisher＇s exact test and clinical outcomes of all patients were followed up. Results： Sixteen patients were enrolled, and 12 （75%） had endoleaks with verified types by CEUS. Among 12 cases of endoleaks were positive by CEUS, 10 were CDFl-positive, and the four CEUS-negative cases were all negative by CDFI. The diagnostic values of CEUS and CDFI were statistically difl＇erent （P = 0,008）. Six patients with high-pressure endoleaks received endovascular re-intervention guided by CEUS results. One patient with type Ⅲ endoleak had open surgery when endovascular repair failed. Conclusions： C EUS is a new, safe, and effective means for detection ofendoleaks post-EVAR. This technique can be used as a supplement for routine CTA follow-up to provide more detailed information on endoleak and its category.

关键词： Abdominal Aortic Aneurysnl: Color Doppler Flow Imaging Contrast-enhanced Ultrasound: Endoleak EndovascularAneurysm Repair

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＂Onion Skin-liked Sign＂ in Thyroid Ultrasonography： A Characteristic Feature of Benign Thyroid Nodules

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Chinese Medical Journal 2016年第13期129卷 1533-1537页

作者： Shen-Ling Zhu yu-xin jiang Xiao Yang Qiong Wu Rui-Na Zhao Jian-Chu Li Ru-yu Liu Bo Zhang Department of Ultrasound Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Translational Medicine Center of Peking Union Medical College Hospital Beijing 100730 China

Background： Some ultrasonographic （US） signs overlap between benign and malignant nodules. The purpose of this study was to raise a special US sign of benign thyroid nodules, termed the ＂onion skin-liked sign.＂ Methods： Twenty-seven patients with 27 nodules who shrank naturally and the ＂onion skin-liked sign＂ appeared on the final US images were enrolled in the study. The ultrasound characters and risk stratifications at the start and end of observation were compared. Then, thirty goiters with fibrosis and thirty papillary thyroid carcinomas （PTC） were randomly selected from the database of our hospital, matched the sizes of 27 nodules at the end point of observation. The differences of ＂onion skin-liked sign＂ between the two groups were analyzed. Results： The average duration of follow-up of 27 nodules was 24.0 ± 12.2 months （range, 12-65 months）. At the end of the follow-up, the size of the nodules decreased on average by 1.26 ± 0.82 cm （range, 0.3-3.4 cm） and calcification was found in 21 nodules, compared with only 2 nodules with calcification at the start of the follow-up. In addition, only negligible or no blood flow signal could be detected at the periphery of all the nodules and 100% （27/27） were high suspicion at the end of observation. In matched groups, all PTC showed high suspicion of malignancy, 18/30 （60%） goiters with fibrosis were high suspicion and 11/30 （37%） were intermediate suspicion. Twenty-two patients in the group of nodular fibrosis presented ＂onion skin-liked sign,＂ which was not shown in any patient of PTC group. The sensitivity, specificity, positive predictive value, and negative predictive value of ＂onion skin-liked sign＂ in predicting nodular goiter with fibrosis were 73.3%, 100%, 100%, and 78.9%, respectively. Conclusions： The ＂onion skin-liked sign＂ was a characteristic US feature of benign thyroid nodules detected in the follow-up of thyroid nodules. It is useful to differentiate PTCs and nodular goiters with fibrosis.

关键词： Diagnosis Nodular Goiters Papillary Carcinoma Thyroid Ultrasound

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Investigation on the vortical structures by the Liutex method in turbulent channels at Re_(τ)=180 with scalloped and triangular riblet control

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Journal of Hydrodynamics 2024年第1期36卷 35-52页

作者： Zhang-dan yu Shang jiang Hai-dong yu Bi-yu Pang xin Dong Yi-qian Wang School of Mathematical Sciences Soochow UniversitySuzhou215006China Beijing Institute of Astronautical System Engineering Beijing100076China

Riblets are a series of small protrusions formed along the flow direction,which have been extensively studied as a passive turbulent drag reduction *** and numerical simulations have shown that well-designed riblets can significantly reduce drag in turbulent flows,making them highly promising and valuable for various *** this study,we focus on a scalloped riblet,which is designed by smoothly connecting two third-order polynomials,and thus the sharpness of the tip and the curvature of the valley can be well *** conduct direct numerical simulations of turbulent channel with smooth plate,scalloped riblet-mounted and triangular riblet-mounted *** in wall units of W^(+)=20 and height-width ratio ofγ=0.5 are selected for both riblet *** with the smooth plate case,the scalloped riblet case achieves an 8.68%drag reduction,while the triangular riblet case achieves a 4.79%drag *** obtained drag reduction rate of the triangular riblet is consistent with previous experiments and simulations,and the results indicate that the scalloped riblet is more effective in reducing drag and deserves further *** compare turbulent statistics of the scalloped riblet case with those of the triangular riblet *** mean velocity profiles of riblets are similar,but both the Reynolds shear stress and second-order statistics of velocity fluctuations and Liutex are significantly reduced in the scalloped riblets controlled turbulent channel,indicating that the scalloped riblet can more effectively suppress the spanwise and wall-normal turbulent intensity near the *** also compare the pre-multiplied spectra of streamwise velocity and streamwise Liutex component for the three cases to investigate the energy distribution and characteristics of Liutex *** Liutex vortex identification method is also utilized to analyze the instantaneous flow field,which provides insights into the flow field and could be bene

关键词： Liutex vector riblet drag reduction tip sharpness turbulent channel scalloped

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Toward High-Performance Delta-Based Iterative Processing with a Group-Based Approach

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Journal of Computer Science & Technology 2022年第4期37卷 797-813页

作者： Hui yu xin-yu jiang Jin Zhao Hao Qi yu Zhang Xiao-Fei Liao Hai-Kun Liu Fu-Bing Mao Hai Jin National Engineering Research Center for Big Data Technology and System Huazhong University of Science and TechnologyWuhan 430074China Service Computing Technology and System Laboratory Huazhong University of Science and TechnologyWuhan 430074China Cluster and Grid Computing Laboratory Huazhong University of Science and TechnologyWuhan 430074China School of Computer Science and Technology Huazhong University of Science and TechnologyWuhan 430074China

Many systems have been built to employ the delta-based iterative execution model to support iterative algorithms on distributed platforms by exploiting the sparse computational dependencies between data items of these iterative algorithms in a synchronous or asynchronous approach. However, for large-scale iterative algorithms, existing synchronous solutions suffer from slow convergence speed and load imbalance, because of the strict barrier between iterations;while existing asynchronous approaches induce excessive redundant communication and computation cost as a result of being barrier-free. In view of the performance trade-off between these two approaches, this paper designs an efficient execution manager, called Aiter-R, which can be integrated into existing delta-based iterative processing systems to efficiently support the execution of delta-based iterative algorithms, by using our proposed group-based iterative execution approach. It can efficiently and correctly explore the middle ground of the two extremes. A heuristic scheduling algorithm is further proposed to allow an iterative algorithm to adaptively choose its trade-off point so as to achieve the maximum efficiency. Experimental results show that Aiter-R strikes a good balance between the synchronous and asynchronous policies and outperforms state-of-the-art solutions. It reduces the execution time by up to 54.1% and 84.6% in comparison with existing asynchronous and the synchronous models, respectively.

关键词： iterative algorithm delta-based execution model efficiency

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Unexpected Carrier Mobility Anisotropy in the Two-dimensional Ca2Si Monolayer from First-principles Calculations

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Chinese Journal of Structural Chemistry 2020年第7期39卷 1243-1251页

作者： LI Rui-Feng yu xin-jiang WEN Cui-Lian ZHANG Ying-Gan LIN Hui-Ling SA Bai-Sheng Multiscale Computational Materials Facility and Key Laboratory of Eco-materials Advanced TechnologyCollege of Materials Science and EngineeringFuzhou UniversityFuzhou 350100China College of Materials Xiamen UniversityXiamen 361005China College of Mathematics and Informatics Fujian Normal UniversityFuzhou 350100China

Development of the nano-electronics requires materials with both high carrier mobility and a sufficiently large electronic band *** this work,by means of ab initio calculations,we have predicted a new 2D Ca2Si monolayer with a quasi-planar hexa-coordinate *** geometrical structure,stability and electronic properties of Ca2Si monolayer have been systemically *** Ca2Si monolayer is an indirect semiconductor with band gap of about 0.77 eV,which exhibits stable chemical bonding interactions as well as thermal and dynamic ***,the carrier mobility in Ca2Si monolayer is electron dominated with a high electron mobility about 4590.47 cm2×V-1×*** is excited that the 2D Ca2Si monolayer exhibits strong directionally anisotropic carrier mobility,which could effectively facilitate the migration and separation of the generated electron-hole *** calculations demonstrate that the 2D Ca2Si monolayer is potential for high efficiency solar cells and other nano-electronic applications.

关键词： two-dimensional materials Ca2Si monolayer first-principles calculations carrier mobility

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Role of Contrast-enhanced Ultrasound in the Evaluation of Inflammatory Arthritis

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Chinese Medical Journal 2017年第14期130卷 1722-1730页

作者： Chen-Yang Zhao yu-xin jiang Jian-Chu Li Zhong-Hui Xu Qing Zhang Na So Meng Yang Department of Ultrasound Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730 China

Objective：Contrast-enhanced ultrasound （CEUS） is a well-established imaging modality which has been put into clinical use in recent years with the development of second-generation contrast agent and imaging devices,and its applications in the assessment of inflammatory arthritis,such as rheumatoid arthritis,psoriatic arthritis,and ankylosing spondylitis,have provoked abundant discussion and researches among radiologists and *** summarize the achievements of clinical studies on CEUS in the application of arthritis,and to keep up with the latest progresses of the imaging technique,we reviewed the literature in recent years,hoping to establish the role of CEUS in joint *** Sources：PubMed and *** Selection：We searched the database with the conditions ＂contrast-enhanced ultrasound AND arthritis＂ with the time limitation of recent 10 *** studies applying CEUS in inflammatory arthritis and review articles about development of CEUS in joint diseases in English were ***：As it is proved by most studies in recent years,by delineating microvasculature within the inflamed joints,CEUS can indicate early arthritis with high sensitivity and ***,the imaging of CEUS has been proved to be consistent with histopathological changes of inflammatory *** analysis of CEUS permits further evaluation of disease *** also plays a significant role in the therapeutic monitoring of the disease,which has been backed up by a number of ***：CEUS may be a new choice for the rheumatologists to evaluate inflammatory arthritis,because of its low price,ability to provide dynamic pictures,and high sensitivity to *** can also be applied in disease classification and therapeutic *** studies about CEUS need to be done to set up the diagnostic standards.

关键词： Conlrast-enhanced Ultrasound hlflammatory Arthritis Rheumatoid Arthritis Ultrasound

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