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Surgical management of pituitary adenoma during pregnancy

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World Journal of Clinical Cases 2023年第12期11卷 2694-2707页

作者： xin-yu jia Xiao-Peng Guo Yong Yao Kan Deng Wei Lian Bing xing Department of Plastic Surgery Plastic Surgery HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100144China Department of Neurosurgery Key Laboratory of Endocrinology of Ministry of HealthChina Pituitary Adenoma Specialist CouncilPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Plastic Surgery Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Neurosurgery Medical Research CenterState Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China

BACKGROUND Although conservative treatment is typically recommended for pregnant patients with pituitary adenoma(PA),surgical treatment is occasionally necessary for those with acute ***,surgical interventions utilized among these patients is poorly *** To evaluate the surgical indications,timing,perioperative precautions and postoperative complications of PAs during pregnancy and to provide comprehensive *** Six patients with PAs who underwent surgical treatment during pregnancy at Peking Union Medical College Hospital between January 1990 and June 2021 were recruited for this *** 35 pregnant patients who were profiled in the literature were included in our *** The 41 enrolled patients had acute symptoms including visual field defects,severe headaches or vision loss that required emergency pituitary *** apoplexies were found in 23 *** majority of patients(55.9%)underwent surgery in the second trimester of pregnancy.A multidisciplinary team was involved in patient care from the preoperative period through the postpartum *** the exception of 1 patient who underwent an induced abortion and 1 fetus that died due to a nuchal cord,39 patients delivered *** them,37 fetuses were healthy until the most recent *** PA surgery during pregnancy is effective and safe during the second and third *** patients requiring emergency PA surgery require multidisciplinary evaluation and healthcare management.

关键词： Pituitary adenoma Pregnancy Surgery Surgical indication Surgical timing

Synthesis of flower-like WS_(2) by chemical vapor deposition

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Chinese Physics B 2021年第12期30卷 523-528页

作者： Jin-Zi Ding Wei Ren Ai-Ling Feng Yao Wang Hao-Sen Qiao yu-xin jia Shuang-Xiong Ma Bo-yu Zhang Institute of Physics&Optoelectronics Technology Baoji University of Arts and SciencesBaoji 721016China School of Science Xi’an University of Posts&TelecommunicationsXi’an 710121China

Flower-like tungsten disulfide(WS_(2))with a diameter of 5-10μm is prepared by chemical vapor deposition(CVD).Scanning electron microscopy(SEM),energy dispersive spectrometer(EDS),Raman spectroscopy,and ultraviolet-visible(UV-vis)spectroscopy are used to characterize its morphological and optical properties,and its growth mechanism is *** key factors for the formation of flower-like WS_(2)are ***,the cooling process causes the generation of nucleation dislocations,and then the"leaf"growth of flower-like WS_(2)is achieved by increasing the temperature.

关键词： flower-like WS_(2) chemical vapor deposition(CVD) optical property growth mechanism

Alkaloid Constituents of Ficus hispida and Their Antiinfammatory Activity

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Natural Products and Bioprospecting 2020年第1期10卷 45-49页

作者： xin-yu jia Yong-Mei Wu Jing-Ya Li Chun Lei Ai-Jun Hou School of Pharmacy State Key Laboratory of Medical NeurobiologyFudan UniversityShanghai 201203China National Center for Drug Screening Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Four new alkaloids,fcuhismines A-D(1-4),together with three known ones,were isolated from Ficus *** structures were elucidated by spectroscopic analysis and chemical *** new compounds represent the frst amine alkaloids with a rhamnosyl moiety(1-2)or with a N-oxide motif(2-4)from the genus *** 2 showed potent inhibitory efect in nuclear factor-κB(NF-κB)pathway luciferase assay with IC_(50) value of 0.52±0.11μM.

关键词： Ficus hispida Moraceae Alkaloids Antiinfammation Nuclear factor-κB

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天基双基地预警雷达地杂波频率特性研究

系统仿真学报 2008年第24期20卷 6866-6870页

作者：王瑜贾鑫装备指挥技术学院北京101416

为了进行空时自适应地杂波抑制,分析研究了天基双基地预警雷达系统中的空间几何向量关系,建立了由相对运动产生的地杂波单程多普勒频率计算模型,通过具体配置分别调用得到了基于B-SBR和HB-SBR配置的地杂波多普勒频率特性。然后以星载平... 详细信息

为了进行空时自适应地杂波抑制,分析研究了天基双基地预警雷达系统中的空间几何向量关系,建立了由相对运动产生的地杂波单程多普勒频率计算模型,通过具体配置分别调用得到了基于B-SBR和HB-SBR配置的地杂波多普勒频率特性。然后以星载平台为例,计算分析了地球自转运动对地杂波多普勒频率的影响,提出了以升交点升角分析偏航角、偏航量和偏航差的方法,并对频率特性进行了仿真,仿真结果表明,这一方法使地杂波多普勒频率受地球自转运动的影响得到全部趋势而非局部的反映。

关键词：天基雷达双基地雷达杂波建模多普勒频率

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一种改进的原子力显微镜摩擦力标定方法

摩擦学学报 2007年第5期27卷 472-476页

作者：余家欣钱林茂西南交通大学牵引动力国家重点实验室摩擦学研究所四川成都610031

在传统标定AFM测力系统的楔形法基础上,通过线形加载的扫描方式,得到不同载荷下AFM针尖在平面和斜面上的切向力-位移循环曲线,并进一步计算出不同载荷下的摩擦力标定系数,进而根据该系数随载荷的变化趋势,选取高载下相对稳定的数据作为... 详细信息

在传统标定AFM测力系统的楔形法基础上,通过线形加载的扫描方式,得到不同载荷下AFM针尖在平面和斜面上的切向力-位移循环曲线,并进一步计算出不同载荷下的摩擦力标定系数,进而根据该系数随载荷的变化趋势,选取高载下相对稳定的数据作为最终的标定结果.结果表明,由于改进的楔形法全面考察了摩擦力标定系数随载荷的变化趋势,避免了低载标定所引入的误差,标定结果更合理.

关键词：原子力显微镜摩擦力标定纳米摩擦学

基于光谱特征的高寒山区森林生态系统水源涵养分布反演研究

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光谱学与光谱分析 2022年第2期42卷 530-536页

作者：牛腾卢杰于佳鑫武英达龙芊芊于强西藏农牧学院高原生态研究所西藏林芝860000 西藏高原森林生态教育部重点实验室西藏林芝860000 北京林业大学精准林业北京重点实验室北京100083 石家庄市林业局滹沱河国有林场河北石家庄050000 中国消防救援学院森林草原防灭火研究中心北京102202

森林生态系统水源涵养具有调节气候,维持生态水平衡等生态功能。青藏高原作为高寒地区,由于其高海拔,环境恶劣的特征,无法实地人工观测水源涵养量。为更好地获取高寒地区的水源涵养量,通过遥感反演的方式得到特定地区的水源涵养价值量... 详细信息

森林生态系统水源涵养具有调节气候,维持生态水平衡等生态功能。青藏高原作为高寒地区,由于其高海拔,环境恶劣的特征,无法实地人工观测水源涵养量。为更好地获取高寒地区的水源涵养量,通过遥感反演的方式得到特定地区的水源涵养价值量。以林芝巴宜区为研究区,研究区内林芝云杉、高山栎、高山松和雪层杜鹃四种植被为主要树种,遥感影像无法直接获得水源涵养信息,但可以通过构建植被叶片光谱信息与水源涵养量之间的定量关系来反演水源涵养价值量。研究不同植被与水源涵养量的定量关系,每种植被采集10个样点共1000个叶片样本和水源涵养数据,利用ASD光谱仪获取高光谱数据,通过相关性选取拟合参数,构建水源涵养回归模型。利用Sentinel-2遥感影像反演研究区内植被的水源涵养分布,并对反演结果进行验证。结果表明,四类植被叶片的反射光谱,均呈现出相似的规律性,在可见光波段差异不明显,近红外到中红外波段呈现出明显四个水吸收带,在红光到近红外波段(700~1400 nm)反射率最高。光谱反射率大小表现为高山栎>高山松>林芝云杉≈雪层杜鹃。通过实验获取植被冠层截流量、枯落物持水量和土壤含水量,三者之和代表植被的水源涵养量,分析植被的光谱特征与水源涵养量的关系,并通过Pearson系数评价波段参数与水源涵养的定量化关系,确定R_(540),R_(1950),NDWI和NDVI四个参数与水源涵养量显著相关。根据上述参数与四类植被的水源涵养量构建水源涵养回归模型,并通过模型反演研究区内植被水源涵养量,检验模拟精度,整体反演精度R^(2)大于0.7,RMSE基本小于10,说明预测模型反演效果较好,模型可有效估算森林生态系统的水源涵养量。

关键词：高寒山地区水源涵养高光谱预测模型遥感反演

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抗菌药物管理评价指标和评估方法研究进展

中国药学杂志 2023年第15期58卷 1349-1354页

作者：吴嘉昱杨阳左玮于佳鑫乔露瑶张波中国医学科学院北京协和医学院北京协和医院药剂科疑难重症及罕见病国家重点实验室北京100730 中国医学科学院北京协和医学院药物研究所北京100050

抗菌药物管理项目(antimicrobial stewardship program,ASP)是一项由多学科医疗团队干预抗菌药物使用以促进抗菌药物合理使用、保障医疗质量和医疗安全的干预项目。随着抗菌药物管理的开展,确定合适的评价方法和评价指标作为证明ASP干... 详细信息

抗菌药物管理项目(antimicrobial stewardship program,ASP)是一项由多学科医疗团队干预抗菌药物使用以促进抗菌药物合理使用、保障医疗质量和医疗安全的干预项目。随着抗菌药物管理的开展,确定合适的评价方法和评价指标作为证明ASP干预措施有效性至关重要。笔者通过查阅梳理国内外抗菌药物管理政策效果评价领域的相关文献,对不同评价指标与评价方法等方面进行了综述。总结了ASP主要的4个指标:临床结局指标、微生物指标、过程指标、经济学效益,以及包括随机对照试验、随机整群对照试验、中断时间序列分析、Meta分析等ASP的评价方法,为进一步完善抗菌药物管理政策提供参考,也为后续相关研究提供方向和依据。

关键词：抗菌药物管理项目干预效果评价指标评估方法

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N31型磷酸盐激光玻璃的摩擦磨损性能研究

摩擦学学报 2014年第6期34卷 641-649页

作者：简清云余家欣宋丹路张瑞西南科技大学制造过程测试技术教育部重点实验室四川绵阳621010 中核核电运行管理有限公司浙江海盐314300

在Rtec-MFT3000多功能摩擦磨损试验机上采用硅酸盐玻璃球作为对摩副,研究了0.2~2 N的载荷条件下N31型磷酸盐激光玻璃的摩擦磨损性能,着重讨论了载荷对该玻璃摩擦磨损性能的影响.结果显示:稳定磨损阶段的摩擦系数随载荷的增加而减小,且... 详细信息

在Rtec-MFT3000多功能摩擦磨损试验机上采用硅酸盐玻璃球作为对摩副,研究了0.2~2 N的载荷条件下N31型磷酸盐激光玻璃的摩擦磨损性能,着重讨论了载荷对该玻璃摩擦磨损性能的影响.结果显示:稳定磨损阶段的摩擦系数随载荷的增加而减小,且载荷越大摩擦系数达到稳定所需的时间越短.随着载荷的增加,N31型磷酸盐激光玻璃的磨损体积先急剧增加后缓慢增加,同时磨损机理经历从磨粒磨损为主到磨粒磨损和裂纹滋生并存最后到脆性剥落为主的转变过程.而硅酸盐玻璃球的磨损体积在给定载荷范围内随载荷的增加保持线性增加,且在所有试验载荷下的磨损机理均以磨粒磨损为主.在目前试验条件下N31型磷酸盐玻璃表面磨损区域未发生可被EDS检测到的明显的摩擦化学反应,磨屑成分为对摩副两种材料的混合体.

关键词：磷酸盐激光玻璃硅酸盐玻璃摩擦磨损裂纹

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB