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Innovations in education:A prospective study of storytelling narratives to enhance hepatitis C virus knowledge among substance users

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World Journal of Hepatology 2022年第5期14卷 972-983页

作者： Andrew H Talal yu-xin ding Marianthi Markatou Department of Medicine University at BuffaloState University of New YorkBuffaloNY 14203United States Department of Biostatistics University at BuffaloState University of New YorkBuffaloNY 14214United States

BACKGROUND Even though substance users have the highest hepatitis C virus(HCV)burden,many lack knowledge about the *** of knowledge is an important obstacle to pursuing HCV *** printed materials are conventionally utilized to disseminate HCV-related knowledge,narrative story-telling videos may be an *** are extremely limited,however,in the ability of storytelling videos to increase HCV knowledge among substance *** this study,we hypothesized that a story-telling narrative video would increase substance user’s immediate and 1-month HCV-related knowledge compared to a printed *** To assess immediate and 1-month HCV-related knowledge retention among substance users comparing education delivered via a storytelling narrative video compared to a printed *** We conducted a prospective matched,case-control study among substance users actively prescribed buprenorphine enrolled from two *** intervention site received the video and the control site,the ***(n=176)were matched on age,gender,and *** obtained extensive patient and stakeholder input on the video’s design,validated the video’s content,and developed a recruitment plan to guide participant *** was assessed by administration of a 25-item instrument immediately before,immediately after,or one month after the *** were analyzed using nonparametric and generalized linear mixed-effects *** We recruited a total of 176 substance users,90 and 86 individuals,from each site,***-month follow up occurred in 92%and 94%of enrollees in the control and intervention groups,*** comparison with the pre-intervention scores,immediate knowledge recall increased significantly for both the intervention(P<0.0001)and control(P<0.0001)*** modeling revealed a significant improvement in HCV-related knowledge and retention(P=0.033)among participants who viewed the storytelling video.

关键词： Hepatitis C virus education Hepatitis C Virus Hepatitis C virus knowledge Persons with opioid use disorder Decision-making in healthcare

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Parainfluenza Virus Types 1, 2, and 3 in Pediatric Patients with Acute Respiratory Infections in Beijing During 2004 to 2012

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Chinese Medical Journal 2015年第20期128卷 2726-2730页

作者： Fang Wang Lin-Qing Zhao Ru-Nan Zhu Jie Deng yu Sun Ya-xin ding Run Tian yuan Qian Laboratory of Virology Beijing Key Laboratory of Etiology of Viral Diseases Capital Institute of Pediatrics Beijing 100020 China

Background： Although human parainfluenza virus （HPIV） has been determined as an important viral cause of acute respiratory infections （ARIs） in infants and young children, data on long-term investigation are still lacking to disclose the infection pattern of HPIV in China. Methods： Nasopharyngeal aspirates were collected from 25,773 hospitalized pediatric patients with ARIs from January 2004 through December 2012 for respiratory virus screen by direct immuno-fluorescence assay. Results： Out of these specimens, 1675 （6.50%, 1675/25,773） showed HPIV positive, including 261 （1.01%, 261/25,773） for HPIVI, 28 （0.11%, 28/25,773） for HPIV2, and 1388 （5.39%, 1388/25373） for HPIV3, 2 of the samples were positive for both HPIV1 and HPIV3, and 36 were co-detected with other viruses. The positive rates of HPIVs were higher in those younger than 3 years old. HPIV3 was detected from all age groups, predominantly from patients under 3 years of age, and the highest frequency was found in those 6 months to 1-year old （352/4077, 8.63%）. HPlV3 was the dominant type in each of the years detected between May and July. HPIV1 showed a peak in every odd year, mainly in August or September. HPIV was detected most frequently from patients with upper respiratory infection （12.49%, 157/1257）, followed by bronchitis （ 11.13%, 176/2479）, asthma （9.31%, 43/462）, bronchiolitis （5.91%, 150/2536）, pneumonia （6.06%, 1034/17,068）, and those with underlying diseases （1.0%, 15/1506）. HPIV3 is the dominant type in these six disease groups referred above, especially in the asthma group. Conclusions： HPIV is one of the important viral causes of ARIs in infants and young children in Beijing based on the data from the hospitalized children covering a 9-year term. HPIV3 is the predominant type in all these years and in most of the disease groups. HPIVs with different types show different seasonality.

关键词： Acute Respiratory Infection China Human Parainfluenza Virus Infants and Young Children

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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： xin Yang yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

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The Investigations of Nanosecond Pulse Argon Plasma Discharge of Low Pressure

The Investigations of Nanosecond Pulse Argon Plasma Discharg...

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第十五届全国等离子体科学技术会议

作者： Xueqing Wen,Cnunlei Feng,yu xin,Hongbin ding~ School of Physics and Optical Electronic Technology,Dalian University of Technology,Dalian 116024,PR China

The behavior of argon plasma in a low pressure driven by nano-second pulsed plasma reactor is investigated using a global model and experimental *** time evolution of plasma density and the electron energy distribution function is calculated by solving energy balance equations and Boltzmann *** electron energy distribution function during and shortly after the pulse can be represented by a bi-temperature Maxwellian distribution indicating two energy groups of electrons. According to the calculation of effective electron temperature,we find that the high energy electrons which play an important role in excitation,ionization process in reactive plasma are much more dominant compared to low energy ***,the effective temperature is measured by use of optical emission spectroscopy with the same physical parameters as in our *** with the experimental studies, the simulation result agrees well with the experimental *** investigate the concentration variation verse time of the excited state 4p(1.5)2 of Argon atom. Excellent agreement is obtained between the simulation and ***, we report the variation of the effective electron temperature and concentration of the the excited state 4p(1.5)2 with gas pressure,pulse width and pulse rising edge.

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磁头臂钢珠铆合工序动力学仿真与分析

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科技信息 2012年第7期 247-248页

作者：喻定新东莞新科技术研究开发有限公司广东东莞523087

为研究磁头臂的动态特性和形变特性,在ANSYS中建立了磁头臂钢珠铆合工序有限元模型,实现了磁头臂钢珠铆合工序的动力学仿真,得到了磁头臂在不同位置的变形量和钢珠冲压过程中的压力,将仿真结果与理论计算值比较,数据基本吻合,说明仿真... 详细信息

为研究磁头臂的动态特性和形变特性,在ANSYS中建立了磁头臂钢珠铆合工序有限元模型,实现了磁头臂钢珠铆合工序的动力学仿真,得到了磁头臂在不同位置的变形量和钢珠冲压过程中的压力,将仿真结果与理论计算值比较,数据基本吻合,说明仿真模型构建合理,仿真具有可信度。为改善磁头臂的质量及预防失效提供了理论参考依据,具有现实的意义。

关键词：磁头臂钢珠仿真

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磁头臂自动锡球焊接技术研究

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机电产品开发与创新 2012年第2期25卷 66-67页

作者：喻定新东莞新科技术研究开发有限公司广东东莞523087

为解决低效率的人工焊接技术对现代硬盘生产效率的制约,论文着重研究了磁头臂自动锡球焊接技术,基于提出全自动钎焊机的研制要求,设计了一种低成本、高效率的磁头臂全自动钎焊机。实例证明了磁头臂自动锡球焊接的可行性和高效性,具有现... 详细信息

为解决低效率的人工焊接技术对现代硬盘生产效率的制约,论文着重研究了磁头臂自动锡球焊接技术,基于提出全自动钎焊机的研制要求,设计了一种低成本、高效率的磁头臂全自动钎焊机。实例证明了磁头臂自动锡球焊接的可行性和高效性,具有现实的意义。

关键词：磁头臂焊接高效率

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基于Labview的虚拟仪器开发

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机械工程师 2000年第4期 50-51页

作者：魏海燕杨建新郁鼎新张玉峰清华大学北京100084

阐述了虚拟仪器出现的背景，概念和特点，并简要介绍了开放式虚拟仪器开发平台Ｌａｂｖｉｅｗ。

关键词：虚拟仪器 Labview CAE CAT

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Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 204-251页

作者： Jiawen Hu xinwei Li Qianqian Liang Li Xu Changsheng ding yu Liu Yanfeng Gao School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.

关键词： Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies

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Molecular mechanism of pancreatic ductal adenocarcinoma:The heterogeneity of cancer-associated fibroblasts and key signaling pathways

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World Journal of Clinical Oncology 2025年第2期16卷 18-28页

作者： Zhong-yuan Hu ding ding yu Song Ya-Feng Deng Cheng-Ming Zhang Tao yu First School of Clinical Medicine Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina College of Acupuncture and Massage Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Graduate School Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Digestive Department I Shaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 710000Shaanxi ProvinceChina

Pancreatic ductal adenocarcinoma stands out as an exceptionally fatal cancer owing to the complexities associated with its treatment and diagnosis,leading to a notably low five-year survival *** study offers a detailed exploration of epidemiological trends in pancreatic cancer and key molecular drivers,such as mutations in CDKN2A,KRAS,SMAD4,and TP53,along with the influence of cancer-associated fibroblasts(CAFs)on disease *** particular,we focused on the pivotal roles of signaling pathways such as the transforming growth factor-βand Wnt/β-catenin pathways in the development of pancreatic cancer and investigated their application in emerging therapeutic *** study provides new scientific perspectives on pancreatic cancer treatment,especially in the development of precision medicine and targeted therapeutic strategies,and demonstrates the importance of signaling pathway research in the development of effective therapeutic *** studies should explore the subtypes of CAFs and their specific roles in the tumor microenvironment to devise more effective therapeutic methods.

关键词： Pancreatic cancer Fibroblasts Signaling pathways Tumor microenvironment

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超临界流体干燥法制备纳米级TiO_2的研究

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无机材料学报 1999年第1期14卷 29-35页

作者：张敬畅曹维良于定新石锦华窦正仓北京化工大学应用化学系北京100029

本文以廉价无机盐为原料，采用溶胶-凝胶法（Sol－Gel）结合超临界流体干燥（SupercriticalFluidDrying简称SCFD）制备了纳米级TiO2，并采用XRD、DTA－TG、TEM技术研究了Sol－Gel过程中溶液的pH值、浓度、陈化时间及SCFD技术等条件对TiO... 详细信息

本文以廉价无机盐为原料，采用溶胶-凝胶法（Sol－Gel）结合超临界流体干燥（SupercriticalFluidDrying简称SCFD）制备了纳米级TiO2，并采用XRD、DTA－TG、TEM技术研究了Sol－Gel过程中溶液的pH值、浓度、陈化时间及SCFD技术等条件对TiO2粒径大小的影响，实现了干燥晶化一步完成．用该方法制得的TiO2超细粉体，粒径大都在3～6um之间，呈球形微粒，粉体晶型为锐钛矿型，并具有纯度高、热稳定性好、失重小和粒度分布均匀等特性．

关键词：超临界流体干燥二氧化钛气凝胶纳米材料

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