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An Evaluation Framework for Virtual Articulatory Movements Based on Medical Video

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Chinese Journal of Electronics 2019年第3期28卷 585-592页

作者： LI Rui yu Jun LI xian FANG Peng WANG Zengfu Department of Automation University of Science and Technology of China Institute of Intelligent Machines Chinese Academy of Sciences

An important aspect of a Speech tutoring aimed talking-head system(STTS) is the accuracy of produced articulatory movements. Little work has been done for the Articulatory movements’ accuracy(AMA)evaluation in STTSs. Although subjective evaluation is reliable, it is time consuming and inconvenient. The traditional objective evaluation is comparing the motion of several points on the surface of the synthetic articulator to the Electromagnetic articulography(EMA) data which describes the motion of corresponding points on the articulatory surface of a speaker. The EMA information is too limited to describe the whole shape changing of deformable articulators for a speech process. To solve this problem, we propose a substantially different objective evaluation method based on a separately recorded medical video. The synthetic articulatory shapes in a speech process are compared to the corresponding shapes tracked from the medical video. This method is translation,rotation, and scaling invariant which allows the comparison of the shapes from the synthetic tongue and the medical images. The time difference problem of synthesis results and medical video is solved by introducing Dynamic time warping(DTW) to the proposed method. Experimental results demonstrate that our method has the ability to evaluate the deformation shape accuracy from an entire articulation process. The comparison results suggest that our method is more accurate than the traditional method especially for deformable articulators.

关键词： Accuracy evaluation Medical video Articulatory animation Speech tutoring aimed talkinghead system

Twelve-year outcomes after revascularization for ostial/shaft lesions in unprotected left main coronary artery

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Journal of Geriatric Cardiology 2020年第6期17卷 338-343页

作者： xian-Peng yu yu LI Ji-Qiang HE Ze-Ning JIN Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Cardiology and Macrovascular Disease Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Objective To evaluate a very long-term clinical outcomes of patients treated with coronary artery bypass grafting(CABG) and percutaneous coronary intervention(PCI) with drug-eluting stents(DES) for ostial/shaft lesions in unprotected left main coronary artery(ULMCA). Methods & Results A total of 472 patients with isolated ostial/shaft lesions in ULMCA were enrolled, who received DES implantation or underwent CABG between January 2003 and July 2009 in Beijing Anzhen Hospital. The major endpoints of this study were death, repeat revascularization, non-procedural myocardial infarction(MI) and stroke. The median follow-up was twelve years(interquartile range: 9.4–14.0 years) in the overall patients. There were no significant differences of incidence of death(23.3% vs. 25.6%, P = 0.227), repeat revascularization(27.3% vs. 28.4%, P = 0.423), non-procedural MI(20.0% vs. 14.5%, P = 0.561), and stroke(6.1% vs. 9.3%, P = 0.255) between PCI and CABG groups before multivariate adjusting. After adjusting covariates with multivariate Cox hazard regression model, there were still no significant differences between PCI and CABG groups. Conclusions During the median follow-up of twelve years, we found that PCI with DES was as effective and safe as CABG in patients with left main ostial/shaft lesion in this observational study.

关键词： Coronary artery bypass grafting Left main ostial/shaft lesions Percutaneous coronary intervention Prognosis

New-onset diabetes secondary to acute pancreatitis:An update

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World Journal of Clinical Cases 2022年第30期10卷 10862-10866页

作者： xian-Qiang yu Qian Zhu Department of General Surgery Women's and Children’s Hospital Affiliated to Qingdao UniversityQingdao 266034Shandong ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina

Diabetes is a condition of persistent hyperglycemia caused by the endocrine disorder of the ***,all pancreatic diseases have the risk of *** particular,increasing attention has been paid recently to new-onset diabetes secondary to acute pancreatitis(AP).The complications of secondary diabetes have caused a lot of trouble for patients and have garnered increasing *** present,the pathophysiological mechanism of new-onset diabetes caused by AP is not *** review summarizes the current understanding of new-onset diabetes secondary to AP.

关键词： Acute pancreatitis New-onset diabetes β-cell Hyperglycemia

Time to think: Selecting patients who may benefit from synchronous resection of primary pancreatic cancer and liver metastases

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World Journal of Gastroenterology 2018年第33期24卷 3677-3680页

作者： Si Shi xian-Jun yu Department of Pancreatic Surgery Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical College Fudan University Pancreatic Cancer Institute Fudan University

Pancreatic cancer remains a lethal disease and is associated with poor prognosis, particularly for patients with distant metastasis at diagnosis. Recently, Oweira reported a retrospective study that included 13233 metastatic pancreatic cancer patients from the Surveillance, Epidemiology and End Results database. They demonstrated that pancreatic cancer patients with isolated liver metastases had worse outcomes than patients with isolated lung metastases or distant nodal metastases. At present, the standard treatment for metastatic pancreatic cancer is chemotherapy. However, improvement in the safety of pancreatic surgery has led to the consideration of more aggressive surgical approaches. Schneitler reported two cases of hepatic metastatic pancreatic cancer in which negative margin(R0) resection and long survival were achieved after effective preoperative chemotherapy. In general, these two studies indicate that although pancreatic cancer patients with liver metastasis have a poor prognosis, surgical approaches may prolong survival for a few of these patients. A strategy to select hepatic metastatic pancreatic cancer patients who may benefit from surgical intervention is urgently needed.

关键词： Liver metastasis Chemotherapy Pancreatic cancer Surgery

Plant polyploidy and evolution

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Journal of Integrative Plant Biology 2019年第1期61卷 4-6页

作者： Gai Huang yu-xian Zhu Institute for Advanced Studies Wuhan University

Polyploidy refers to two or more complete sets of chromosomes that are combined within a nucleus,and includes both autopolyploidy and allopolyploidy(Otto 2007).Polyploidy is a recurring theme in the evolutionary history of plants and it has been considered an important mechanism for speciation and also for adaptability to changing environments(Shimizu-Inatsugi et al.2017).In nature,about one-third of flowering plants are polyploids,and a great majority of them are *** are many cultivated allopolyploid species,such as cotton,Brassica and potato,the possible evolutionary history of which can be inferred with high certainty.

关键词： Polyploidy history

Risk factors for relapse and nomogram for relapse probability prediction in patients with minor ischemic stroke

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World Journal of Clinical Cases 2021年第31期9卷 9440-9451页

作者： xian-Feng yu Wen-Wen Yin Chao-Juan Huang Xin yuan yu Xia Wei Zhang Xia Zhou Zhong-Wu sun Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina

BACKGROUND The identification of risk factors for recurrence in patients with minor ischemic stroke(MIS)is a critical medical *** To develop a nomogram for individualized prediction of in-hospital recurrence in MIS *** Based on retrospective collection,a single-center study was conducted at the First Affiliated Hospital of Anhui Medical University from January 2014 to December *** and multivariate logistic regression analyses were used to determine the risk factors associated with MIS *** least absolute shrinkage and selection operator regression was performed for preliminary identification of potential risk *** acid,systolic blood pressure,serum total bilirubin(STBL),and ferritin were integrated for nomogram *** predictive accuracy and calibration of the nomogram model were assessed by the area under the receiver operating characteristic curve(AUC-ROC)and Hosmer-Lemeshow test,*** A total of 2216 MIS patients were *** them,155 were excluded for intravascular therapy,146 for unknown National Institutes of Health Stroke Scale score,195 for intracranial hemorrhage,and 247 for progressive ***,1244 patients were subjected to further analysis and divided into a training set(n=796)and a validation set(n=448).Multivariate logistic regression analysis revealed that uric acid[odds ratio(OR):0.997,95%confidence interval(CI):0.993-0.999],ferritin(OR:1.004,95%CI:1.002-1.006),and STBL(OR:0.973,95%CI:0.956-0.990)were independently associated with in-hospital recurrence in MIS *** model showed good discrimination;the AUC-ROC value was 0.725(95%CI:0.646-0.804)in the training set and 0.717(95%CI:0.580-0.785)in the validation ***,the calibration between nomogram prediction and the actual observation showed good ***-Lemeshow test results confirmed that the nomogram was well-calibrated(P=0.850).CONCLUSION Our present findings suggest that the nomogram ma

关键词： Minor ischemic stroke Recurrence Risk factor Nomogram Prediction Chinese ethnic

Fracture Toughness Properties of Three Different Biomaterials Measured by Nanoindentation

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Journal of Bionic Engineering 2007年第1期4卷 11-17页

作者： Ji-yu sun Jin Tong Key Laboratory of Terrain-Machine Bionics Engineering （Ministry of Education China） Jilin University （Nanling Campus） Changchun 130022 P. R. China

The fracture toughness of hard biomaterials, such as nacre, bovine hoof wall and beetle cuticle, is associated with fibrous or lamellar structures that deflect or stop growing cracks. Their hardness and reduced modulus were measured by using a nanoindenter in this paper. Micro/nanoscale cracks were generated by nanoindentation using a Berkovich tip. Nanoindentation of nacre and bovine hoof wall resulted in pile-up around the indent. It was found that the fracture toughness （Kc） of bovine hoof wall is the maximum, the second is nacre, and the elytra cuticle of dung beetle is the least one.

关键词： biomimetics bionics biomaterials nanoindentation laminated structure fracture toughness

Global exponential p-norm stability of BAM neural networks with unbounded time-varying delays:A method based on the representation of solutions

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International Journal of Biomathematics 2023年第5期16卷 71-86页

作者： Xi Chen Tingting yu xian Zhang School of Mathematical Science Heilongjiang University No.74 Xuefu Road Harbin 150080P.R.China Heilongjiang Provincial Key Laboratory of the Theory and Computation of Compler Systems Heilongjiang University No.74 Xuefu Road Harbin 150080P.R.China

This paper studies the global exponential p-norm stability of bidirectional associative memory(BAM)neural networks with unbounded time-varying delays.A novel method based on the representation of solutions is put forward to deduce a global exponential p-norm stability *** method does not need to set up any Lyapunov-Krasovskii functionals(LKF),which can greatly reduce a large amount of computations and is simpler than the existing *** the end,representative numerical examples are given to llustrate the availability of the method.

关键词： BAM neural networks global exponential p-norm stability unbounded timevarying delays representation of solutions

Therapeutic targets and biomarkers of tumor immunotherapy:response versus non-response

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3784-3810页

作者： Dong-Rui Wang xian-Lin Wu Ying-Li sun Bone Marrow Transplantation Center The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Liangzhu Laboratory Zhejiang University Medical CenterHangzhouChina Institute of Hematology Zhejiang UniversityHangzhouChina Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy HangzhouChina Central Laboratory National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academic of Medical Sciences and Peking Union Medical CollegeShenzhenChina CAS Key Laboratory of Genomic Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijingChina

Cancers are highly complex diseases that are characterized by not only the overgrowth of malignant cells but also an altered immune *** inhibition and reprogramming of the immune system play critical roles in tumor initiation and *** aims to reactivate antitumor immune cells and overcome the immune escape mechanisms of *** by immune checkpoint blockade and adoptive cell transfer,tumor immunotherapy has seen tremendous success in the clinic,with the capability to induce long-term regression of some tumors that are refractory to all other *** them,immune checkpoint blocking therapy,represented by PD-1/PD-L1 inhibitors(nivolumab)and CTLA-4 inhibitors(ipilimumab),has shown encouraging therapeutic effects in the treatment of various malignant tumors,such as non-small cell lung cancer(NSCLC)and *** addition,with the advent of CAR-T,CAR-M and other novel immunotherapy methods,immunotherapy has entered a new *** present,evidence indicates that the combination of multiple immunotherapy methods may be one way to improve the therapeutic ***,the overall clinical response rate of tumor immunotherapy still needs improvement,which warrants the development of novel therapeutic designs as well as the discovery of biomarkers that can guide the prescription of these *** from the past success and failure of both clinical and basic research is critical for the rational design of studies in the *** this article,we describe the efforts to manipulate the immune system against cancer and discuss different targets and cell types that can be exploited to promote the antitumor immune response.

关键词： immunotherapy prescription overcome