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Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis

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World Journal of Psychiatry 2025年第1期15卷 128-136页

作者： Zhi-Wei Fu yue-Jing Li Ran yu Rui-Qing Guo Li-Xia Gao Sheng-Xia zhao Department of Children's Health Shijiazhuang Maternity and Child Healthcare HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age *** To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional *** We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September *** children and their parents were evaluated using a questionnaire ***'s correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating *** The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of *** paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.

关键词： Preschool children Parenting stress Children's behavioral and emotional problems Family rearing Mediating effect

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong wu Dan-Dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi wu Qian-Qian Jiang Shao-yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Fixed-Time Output Consensus Tracking for High-Order Multi-Agent Systems With Directed Network Topology and Packet Dropout

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IEEE/CAA Journal of Automatica Sinica 2021年第4期8卷 817-836页

作者： Junkang Ni Peng Shi yu zhao Zhonghua wu School of Automation Northwestern Polytechnical UniversityXi’an 710072China School of Electrical and Electronic Engineering University of AdelaideSA 5005Australia College of Electrical Engineering and Automation Henan Polytechnic UniversityJiaozuo 454000China

This paper studies the problem of fixed-time output consensus tracking for high-order multi-agent systems(MASs)with directed network topology with consideration of data packet ***,a predictive compensation based distributed observer is presented to compensate for packet dropout and estimate the leader’s ***,stability analysis is conducted to prove fixed time convergence of the developed distributed ***,adaptive fixed-time dynamic surface control is designed to counteract mismatched disturbances introduced by observation error,and stabilize the tracking error system within a fixed time,which overcomes explosion of complexity problem and singularity ***,simulation results are provided to verify the effectiveness and superiority of the consensus tracking strategy *** contribution of this paper is to provide a fixed-time distributed observer design method for high-order MAS under directed graph subject to packet dropout,and a novel fixed-time control strategy which can handle mismatched disturbances and overcome explosion of complexity and singularity problem.

关键词： Directed graph fixed-time control multi-agent system output consensus tracking packet dropout

Application of focused laser differential interferometer to hypersonic boundary-layer instability study

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Chinese Journal of Aeronautics 2021年第5期34卷 17-26页

作者： Tao yu Youde XIONG Jiaquan zhao Jie wu School of Aerospace Engineering Huazhong University of Science and TechnologyWuhan 430074China Hubei Key Laboratory of Engineering Structural Analysis and Safety Assessment Wuhan 430074China

Accurate prediction of hypersonic boundary-layer transition plays an important role in thermal protection system design of hypersonic *** by the capability of spatial diagnostics for hypersonic boundary-layer study,quite a lot of problems of hypersonic boundary-layer transition,such as nonlinearity and receptivity,remain *** work reports the application of focused laser differential interferometer to instability wave development across hypersonic boundary-layer on a flared cone *** begin with,the focused laser differential interferometer is designed and set up in a Mach number 6 hypersonic quiet wind tunnel with the focal point in the laminar boundary-layer of a 5 degree half-angle flared cone ***,instability experiments are carried out by traversing the focal point throughout the hypersonic boundary-layer and the density fluctuation along the boundary-layer profile is measured and *** results show that three types of instability waves ranging from 10 k Hz to over 1 MHz are co-existing in the hypersonic boundary-layer,indicating the powerful capability of focused laser differential interferometer in dynamic response resolution for instability wave study in hypersonic flow regime;furthermore,quantitative analyses including spectra and bicoherence analysis of instability waves throughout the hypersonic boundary-layer for both cold and heated cone models are performed.

关键词： Bicoherence analysis Focused laser differential interferometer Hypersonic boundary-layer instability Non-intrusive measurement Wind tunnel experiment

Interannual Variability of Late-spring Circulation and Diabatic Heating over the Tibetan Plateau Associated with Indian Ocean Forcing

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Advances in Atmospheric Sciences 2018年第8期35卷 31-45页

作者： yu zhao Anmin DUAN Guoxiong wu State Key Laboratory of Numerical Modelling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China University of Chinese Academy of Sciences Beijing 100049 China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and Technology Nanjing 210044 China

The thermal forcing of the Tibetan Plateau （TP） during boreal spring, which involves surface sensible heating, latent heating released by convection and radiation flux heat, is critical for the seasonal and subseasonal variation of the East Asian summer monsoon. Distinct from the situation in March and April when the TP thermal forcing is modulated by the sea surface temperature anomaly （SSTA） in the North Atlantic, the present study shows that it is altered mainly by the SSTA in the Indian Ocean Basin Mode （IOBM） in May, according to in-situ observations over the TP and MERRA reanalysis data. In the positive phase of the IOBM, a local Hadley circulation is enhanced, with its ascending branch over the southwestern Indian Ocean and a descending one over the southeastern TP, leading to suppressed precipitation and weaker latent heat over the eastern TP. Meanwhile, stronger westerly flow and surface sensible heating emerges over much of the TP, along with slight variations in local net radiation flux due to cancellation between its components. The opposite trends occur in the negative phase of the IOBM. Moreover, the main associated physical processes can be validated by a series of sensitivity experiments based on an atmospheric general circulation model, FAMIL. Therefore, rather than influenced by the remote SSTAs of the northern Atlantic in the early spring, the thermal forcing of the TP is altered by the Indian Ocean SSTA in the late spring on an interannual timescale.

关键词： Indian Ocean Tibetan Plateau circulation diabatic heating

Spatio-temporal keyword query in semantic trajectories

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Frontiers of Computer Science 2022年第2期16卷 182-184页

作者： Xia wu Jiankun yu Xiaoming zhao Big Data Research Institute of yunnan Economy and Society Yunnan University of Finance and EconomicsKunming 650221China

1 Introduction With the development of the GPS positioning technology and the popularization of smart mobile devices,more and more trajectory data are collected *** trajectories can be obtained by adding semantic information such as landmarks and activities to raw *** query in semantic trajectory database that returns the relevant places/routes has attracted increasing attention from researchers in recent years.[1]studies spatial keyword query which consists of a set of query locations and a set of query keywords representing user’s preference.[2]is the first work to study the activity query on semantic *** query is in the form of a sequence of query locations,each associated with a set of desired activities.[3]is an extended work of[2]to support approximate keyword ***,these works only consider spatial and textual feature of keywords,which cannot answer the query with temporal ***,they match keywords only by string similarity without considering their semantic meanings.

关键词： string keyword representing

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山西沁水盆地天然气封存箱成藏机理与模式

地球科学与环境学报 2017年第1期39卷 95-102页

作者：林玉祥吴玉琛赵承锦朱传真李佳山东科技大学地球科学与工程学院山东青岛266590

依据沁水盆地现有勘探资料及研究成果,从构造特征、地下水及天然气分布等方面出发,综合分析盆地内天然气封存箱成藏模式。盆地内水动力条件复杂,地层水可依次划分为补水带、强径流带、弱径流带、交替阻滞带及泄水带5个区带。根据地下水... 详细信息

依据沁水盆地现有勘探资料及研究成果,从构造特征、地下水及天然气分布等方面出发,综合分析盆地内天然气封存箱成藏模式。盆地内水动力条件复杂,地层水可依次划分为补水带、强径流带、弱径流带、交替阻滞带及泄水带5个区带。根据地下水动力条件与地层水矿化度的关系,并结合地层水矿化度的变化趋势与盆地内地层含气量的展布特征,提出了由煤岩、泥岩等致密岩层组成的顶、底板,形成了在盆地内广泛展布的近同心圆状的"饼状"箱体模式。同时,还进一步分析了盆地内致密砂岩气的成藏机理及封闭机理,发现区内"饼状"箱体可分为上、下两层,上层为3#煤层上部山西组致密砂岩段箱体,下层为3#煤层与15#煤层之间的致密砂岩段箱体。上、下封存箱封存机理虽然不同,但自盆地边缘到盆地内部,再到盆地边缘,"饼状"箱体稳定展布。

关键词：矿化度封存箱成藏机理地层水水动力条件 “饼状”箱体致密砂岩气沁水盆地

Sulforaphane protects primary cultures of cortical neurons against injury induced by oxygen-glucose deprivation/reoxygenation via anti-apoptosis

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Neuroscience Bulletin 2012年第5期28卷 509-516页

作者： Xuemei wu Jing zhao Shanshan yu Yanlin Chen , Jingxian wu Yong zhao Department of Pathology Department of Pathophysiology Chongqing Medical University Chongqing 400016 China

Objective To determine whether sulforaphane （SFN） protects neurons against injury caused by oxygen-glucose deprivation/reoxygenation （OGD/R） and, if so, to investigate the possible mechanisms. Methods Primary cultures of neurons were prepared from the cerebral cortex of 1-day-old Sprague-Dawley rats. On days 5-6 in vitro, the neurons were exposed to OGD for 1 h, followed by reoxygenation for 24 h. Cells were treated with 0, 0.1, 0.2, 0.5, 1, 2.5, or 5 μmol/L SFN, with or without 10 μmol/L LY294002, a PI3K-specific inhibitor, during OGD/R （a total of 25 h）. After 24-h reoxygenation, MTT was used to assess viability and injury was assessed by Hoechst 33258/propidium iodide （PI） staining; immunofluorescence staining and Western blot were performed to detect molecular events associated with apoptosis. Results The MTT assay showed that 1 μmol/L SFN significantly increased viability, and Hoechst 33258/PI staining showed that the numbers of injured neurons were reduced significantly in the SFN group. Furthermore, immunofluorescence staining and Western blot showed that SFN increased Bcl-2 and decreased cleaved caspase-3 levels. Moreover, LY294002 inhibited the phosphorylated-Akt expression evoked by SFN, decreased Bcl-2 expression and increased cleaved caspase-3 expression. Conclusion SFN protects neurons against injury from OGD/R and this effect may be partly associated with an anti-apoptosis pathway.

关键词： sulforaphane oxygen-glucose deprivation apoptosis neuroprotection

Dynamics,stability,and control of a four-cable mount system for wind tunnel test

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Chinese Journal of Aeronautics 2023年第2期36卷 58-75页

作者： Zhenjun zhao Zhanwei zhao yu YAN Kaichun ZENG Xiaojun SHI Han wu School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144China High Speed Aerodynamics Institute China Aerodynamics Research and Development CenterMianyang 621000China

A four-cable mount system is proposed for full-model wind tunnel flutter tests,which may adjust the pitch and roll attitude of the aircraft scaled model and ensure that the model is not subjected to cable *** system provides sufficient support to simulate the free flight of the aircraft by applying appropriate spring stiffness and cable *** proposed fourcable mount system is modeled based on Lagrange mechanics,and its dynamics equations consider aerodynamic *** singularity of the system and its bifurcation characteristics under flow conditions are analysed to determine the supercritical bifurcation phenomenon for different tension levels and distances from the front suspension point to the mass centre of the *** mathematical expressions of the longitudinal flight stability of the cable mount system are derived by linearising the system dynamics equations using small *** influence of the cable tension,spring stiffness,suspension point position,and other factors on the flight stability of the aircraft are analysed.A feedforward control algorithm is proposed to minimize the total elastic potential energy of the *** results show that the model is in the level flight state when the elastic potential energy of the four-cable mount system is minimized.A feedback control design method is proposed based on the Lyapunov stability theory to derive the closed-loop stability *** system dynamics model that includes the aircraft rigid body model,flexible cables,pulleys,springs,aerodynamic model,and servo motor control is established using the flexible multibody dynamics method.A multibody dynamics solver and Simulink are used to simulate the attitude adjustment of the model in the wind tunnel and verify the supercritical bifurcation characteristics of the system and the effectiveness of the feedback and feedforward control.

关键词： Bifurcation Cable Flight dynamics Flutter Nonlinear control systems Wind tunnels