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A new horizon for neuroscience:terahertz biotechnology in brain research

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Neural Regeneration Research 2025年第2期20卷 309-325页

作者： Zhengping Pu yu Wu Zhongjie Zhu Hongwei zhao Donghong Cui Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Kangci Hospital of JiaxingTongxiangZhejiang ProvinceChina Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of ScienceShanghaiChina National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina

Terahertz biotechnology has been increasingly applied in various biomedical fields and has especially shown great potential for application in brain *** this article,we review the development of terahertz biotechnology and its applications in the field of *** evidence indicates promising prospects for the use of terahertz spectroscopy and terahertz imaging techniques in the diagnosis of amyloid disease,cerebrovascular disease,glioma,psychiatric disease,traumatic brain injury,and myelin *** vitro and animal experiments have also demonstrated the potential therapeutic value of terahertz technology in some neuropsychiatric *** the precise underlying mechanism of the interactions between terahertz electromagnetic waves and the biosystem is not yet fully understood,the research progress in this field shows great potential for biomedical noninvasive diagnostic and therapeutic ***,the biosafety of terahertz radiation requires further exploration regarding its two-sided efficacy in practical *** review demonstrates that terahertz biotechnology has the potential to be a promising method in the field of neuropsychiatry based on its unique advantages.

关键词： biological effect brain neuron neuropsychiatry neuroscience non-thermal effect terahertz imaging terahertz radiation terahertz spectroscopy terahertz technology

Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai Shan Guoliang Li Xuechun Chen wen zhao Bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

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插销缺口附近局部应力的有限元分析

天津大学学报 1983年第3期 73-83页

作者：杜则裕张文钺赵忠许玉环陈邦固

本文采用轴对称弹塑性非均质材料的有限元程序,分析了插销缺口局部区域的应力状态和塑性变形行为。计算结果表明,缺口处的应力集中系数在弹性范围保持不变;在塑性范围,应力集中系数随外加载荷的增加而下降。当焊缝强度较低时,塑性变形... 详细信息

本文采用轴对称弹塑性非均质材料的有限元程序,分析了插销缺口局部区域的应力状态和塑性变形行为。计算结果表明,缺口处的应力集中系数在弹性范围保持不变;在塑性范围,应力集中系数随外加载荷的增加而下降。当焊缝强度较低时,塑性变形区主要在焊缝中扩大;当焊缝强度增加时,焊缝中的应力增加,塑性变形区减小。插销缺口横截面上轴向应力σx与外加载荷σN在弹性范围有如下关系: σx=1.8σN/（2πr）1/2 最后,在插销试验结果应用于工程实际方面,本文应用线弹性断裂力学进行了新的尝试。

关键词：插销法应力集中系数应力状态受力状态粗晶区焊缝强度插销试验缺口数值分析有限元分析局部应力

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu yue Li Hua Zhang Lian-Lian Wang wen-wen Liu Xin Yang Ming-zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

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德清县水环境压力与胁迫类型区划分

长江流域资源与环境 2016年第6期25卷 981-988页

作者：文玉钊陆玉麒靳诚陈博文杨忠臣南京师范大学地理科学学院江苏南京210023 江苏省地理信息资源开发与利用协同创新中心江苏南京210023 虚拟地理环境教育部重点实验室江苏南京210023

在第一次地理国情普查统计数据与调研数据的支持下,采取小流域划分与圩区划分相结合的方法,对德清县进行水环境空间评价单元划分。选用畜禽养殖污水排放量、重点企业污水排放量、农药化肥入河量、城镇与乡村生活污水排放量等5个指标,运... 详细信息

在第一次地理国情普查统计数据与调研数据的支持下,采取小流域划分与圩区划分相结合的方法,对德清县进行水环境空间评价单元划分。选用畜禽养殖污水排放量、重点企业污水排放量、农药化肥入河量、城镇与乡村生活污水排放量等5个指标,运用GIS空间分析与统计分析方法进行水污染负荷综合分析,并进行压力类型划分。尝试利用水环境功能区划及生态环境功能区划的既有成果对各空间评价单元进行水环境目标类型区划分,并将水环境目标类型与其水环境压力类型进行空间匹配分析,共划分为7种水环境胁迫类型区。此外,对各胁迫类型区的主要村域分布进行了识别。

关键词：水环境压力胁迫类型区空间分析德清县

A novel and efficient formal synthesis of jaspine B

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A novel and efficient formal synthesis of jaspine B

单硫代和双硫代甘油醚在直链淀粉三(3,5-二甲基苯基氨基甲酸酯)固定相上的手性拆分

2011年全国药物化学学术会议——药物的源头创新

作者： Jie Gao,Ming-Li zhao,zhao Zhang,yu-Tao zhao,wen Qu,Peng-yun Li,Hong-Min Liu School of Pharmaceutical Science,New Drug Research & Development Center, Zhengzhou Univercity,Zhengzhou,450001

Jaspine B 1,also known as pachastrissamine,is a naturally occurring novel anhydrosphingosine derivative,was found to posses cytotoxicity at a level of IC 0.01μg/mL against P388,A549,HT29 and Mell 28 cell *** to the i...

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色谱 2000年第1期18卷 39-41页

作者：于兆文刘霞蒋生祥陈立仁中国科学院兰州化学物理研究所甘肃兰州730000

合成了直链淀粉三(3,5二甲基苯基氨基甲酸酯)手性固定相。用该固定相对6种单硫代甘油醚和4种双硫代甘油醚进行了手性拆分。单硫代甘油醚对映异构体得到了较好的分离,而双硫代甘油醚完全不能拆分。提出了样品与固定相的作用模式。

关键词：高效液相色谱法硫代甘油醚手性拆分

3-羧基水杨醛缩2-氨甲基吡啶合铜配合物的合成、表征和晶体结构

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河南大学学报（自然科学版） 2010年第2期40卷 147-150,155页

作者：何民会张武于兆文河南大学化学化工学院分子与晶体工程研究所河南开封475004

合成了3-羧基水杨醛缩2-氨甲基吡啶(H2SP)及其Cu(Ⅱ)配合物[Cu(HSP)(H2O)2]ClO4,通过红外光谱、紫外光谱、X射线单晶衍射分析等手段对配合物的结构进行了表征.该配合物属于单斜晶系,P-1空间群,晶胞参数为:a=0.871 53(12)nm,b=1.017 05(1... 详细信息

合成了3-羧基水杨醛缩2-氨甲基吡啶(H2SP)及其Cu(Ⅱ)配合物[Cu(HSP)(H2O)2]ClO4,通过红外光谱、紫外光谱、X射线单晶衍射分析等手段对配合物的结构进行了表征.该配合物属于单斜晶系,P-1空间群,晶胞参数为:a=0.871 53(12)nm,b=1.017 05(15)nm,c=1.939 3(3)nm,β=93.3°,V=1.716 13 nm3,Z=4,Dc=1.758 12 g/cm3,Mr=454.27,F(000)=924.00,R1=0.072 5,wR2=0.092 2.配合物中铜离子为五配位,处于变形的四方锥形配位环境中.分子间通过π-π堆积和氢键作用形成双分子链,然后通过π-π堆积形成二维层状结构,最后通过C-H…O弱氢键形成三维结构.

关键词： 3-羧基水杨醛 2-氨甲基吡啶铜配合物晶体结构

PIR传感器网络中行为轨迹重构的几何代数方法

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电子学报 2017年第5期45卷 1096-1102页

作者：王健健冯琳耀朱帅罗文俞肇元袁林旺南京师范大学虚拟地理环境教育部重点实验室江苏南京210023 重庆知行地理信息咨询服务有限公司重庆404100 江苏省地理环境演化国家重点实验室培育建设点江苏南京210023 江苏省地理信息资源开发与利用协同创新中心江苏南京210023

基于高密度、低成本的PIR(Passive Infrared Detector)被动式红外探测器传感器进行人群行为轨迹的定位与重建是人群行为分析的重要方向.PIR传感器通过0-1响应确定附近是否有行人通过,并通过不同传感器响应序列的时空序列关系实现对人群... 详细信息

基于高密度、低成本的PIR(Passive Infrared Detector)被动式红外探测器传感器进行人群行为轨迹的定位与重建是人群行为分析的重要方向.PIR传感器通过0-1响应确定附近是否有行人通过,并通过不同传感器响应序列的时空序列关系实现对人群行为轨迹的识别与跟踪.已有PIR传感器网络分析方法多从群体行为视角揭示人群运动的统计特征,在行为估算精度、不确定性等方面仍存在诸多问题.本文针对PIR传感器网络中个人行为轨迹的重构问题,引入几何代数工具,实现PIR传感器网络拓扑、时空响应数据序列和行为轨迹的代数化统一表达,进而以传感器响应的时空关系为基础进行网络连通性的判定.基于几何代数算子构建轨迹路径的延拓与扩展规则,并集成传感器对轨迹的时空响应关系构建基于PIR传感器网络响应序列数据的行为轨迹重构算法.最后以MERL实验室连续观测数据为案例,论证了方法的合理性与有效性.

关键词：行为轨迹传感器网络几何代数网络分析