检索结果-南通市图书馆

Mechanism study of the molluscicide candidate PBQ on Pomacea canaliculata using a viscosity-sensitive fluorescent probe

引用

Chinese Chemical Letters 2025年第1期36卷 447-452页

作者： Lanyun Zhang Weisi Wang yu-Qiang Zhao Rui huang yuxun Lu Ying Chen Liping Duan Ying Zhou yunnan Characteristic Plant Extraction Laboratory College of Chemical Science and TechnologyYunnan UniversityKunming 650091China National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Centre for Tropical DiseasesNational Key Laboratory of Inteligent Tracking and Forecasting for Infectious DiseasesKey Laboratory on Parasite and Vector Biology MinistryofHealthShanghai200025China

PBQ[1-(4-chlorophenyl)-3-(pyridin-3-yl)urea],an enormous potent molluscicide,showed excellent Pomacea canaliculata(***)control activity and low toxicity for other aquatic organisms,but its snail-killing mechanisms are still not fully *** employed an optical method to elucidate PBQ action via a novel fluorescent viscosity probe,*** the viscosity in the test solutions increased,compared with that in pure ethanol,a 54-fold fluorescence intensity enhancement of NCV was observed in 310 cP of 90%***,NCV successfully exhibited a selective fluorescence response towards monensin-induced cellular viscosity changes in HepG2 *** liver,stomach,and foot plantar of the tested snails were frozen and sectioned for fluorescent imaging experiments after the treatment with different PBQ concentrations over various times.A significant fluorescent increase in the snail's liver was observed upon exposure to 0.75 mg/L PBQ for 72 h,which highlighted an increase in *** and eosin(HE)staining further supported PBQ-induced liver damage with a viscosity increase in *** study provides a new rapid optical visualization method to study the killing mechanisms of PBQ and may help discover new chemicals that control snail populations.

关键词： Fluorescence sensor Viscosity Pomacea canaliculata Molluscicide mechanisms Bio-imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Kinesin family member 14 expression and its clinical implications in colorectal cancer

引用

World Journal of Gastrointestinal Oncology 2025年第3期17卷 299-321页

作者： Kai Qin Jia-yuan Luo Da-Tong Zeng Wan-Ying huang Bin Li Qi Li Yan-ting Zhan Rong-Quan He Wei-Jian huang Gang Chen Zu-yuan Chen Bang-Teng Chi yu-Xing Tang Rui-Xue Tang Hui Li Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Redcross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChina Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalJinan 250000Shandong ProvinceChina Department of Colorectal and Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Colorectal cancer(CRC)is the third most common cancer globally,causing over 900000 deaths *** factors include aging,diet,obesity,sedentary lifestyle,tobacco use,genetic predisposition,and inflammatory bowel *** current treatments,survival rates for advanced CRC remain low,highlighting the need for better therapeutic *** To evaluate both the clinical significance and the pathological implications of the Kinesin family member 14(KIF14)expression within CRC ***,this study aims to investigate the interaction between nitidine chloride(NC)and KIF14,considering their potential as therapeutic *** The expression of the KIF14 protein in CRC was analyzed using immunohistochemical *** integration of multicenter high-throughput data facilitated the calculation of the standardized mean difference(SMD)for KIF14 mRNA *** assessment of clinical and pathological impact was enhanced by analyzing combined receiver operating characteristic curves,along with measures of sensitivity,specificity,and likelihood ***,clustered regularly interspaced short palindromic repeats knockout screening for cell growth and single-cell sequencing were employed to validate the significance of KIF14 expression in *** analysis established the prognostic value of KIF14 in *** molecular mechanism of NC against CRC was elucidated through whole-genome sequencing and enrichment analysis,and molecular docking was utilized to explore the targeting affinity between NC and *** KIF14 was highly expressed in 208 CRC *** from 17 platforms involving 2436 CRC samples and 1320 noncancerous colorectal tissue controls indicated that KIF14 expression was significantly higher in CRC samples,with an SMD of 1.92(95%CI:1.49-2.35).The area under the curve was 0.94(95%CI:0.92-0.96),with a sensitivity of 0.85(95%CI:0.78-0.90)and a specificity of 0.90(95%CI:0.85-0.93).The positive and negative l

关键词： Colorectal cancer Kinesin family member 14 Nitidine chloride Molecular docking Standardized mean difference

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

杀菌方式对湘西酸鱼挥发性风味物质及质构的影响

引用

食品工业科技 2018年第19期39卷 237-242页

作者：孔钰婷何丹黄群安凤平福建农林大学食品科学学院福建福州350002

采用固相微萃取(SPME)结合气相色谱-质谱联用(GC-MS)技术,研究两种杀菌方式对湘西酸鱼挥发性风味成分的影响,并通过质地剖面测定其对质构特性的影响。结果表明:从湘西酸鱼中共检出87种化合物,主要是酸类(6种)、酯类(33种)、羰基类(22种... 详细信息

采用固相微萃取(SPME)结合气相色谱-质谱联用(GC-MS)技术,研究两种杀菌方式对湘西酸鱼挥发性风味成分的影响,并通过质地剖面测定其对质构特性的影响。结果表明:从湘西酸鱼中共检出87种化合物,主要是酸类(6种)、酯类(33种)、羰基类(22种)、醇类(6种)和碳氢化合物(16种)等。低温杀菌方式形成的风味种类最多,有58种;高温杀菌方式次之,有52种;未处理最差,仅48种。低温杀菌处理有助于挥发性风味物质的形成,而高温杀菌可以最大限度地保持酸鱼固有的感官,其弹性、粘性、咀嚼度优于低温杀菌。

关键词：湘西酸鱼固相微萃取气相色谱-质谱联用挥发性成分质构特性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-throughput screening and evaluation of double-linker metal–organic frameworks for CO_(2)/H_(2)adsorption and separation

引用

Chinese Physics B 2025年第2期34卷 408-417页

作者： Ji-Long huang Xiu-Ying Liu Hao Chen Xiao-Dong Li Jing-Xin yu School of Physics Henan University of TechnologyZhengzhou 450001China R&D Center for Advanced Energy Materials Henan University of TechnologyZhengzhou 450001China

The capture of CO_(2)from CO_(2)/H_(2)gas mixtures in syngas is a crucial issue for hydrogen production from steam methane reforming in industry,as the presence of CO_(2)directly affects the purity of H_(2).A combination of a high-throughput screening method and grand canonical Monte Carlo simulation was utilized to evaluate and screen 1725 metal–organic frameworks(MOFs)in detail as a means of determining their adsorption performance for CO_(2)/H_(2)gas *** adsorption and separation performance of double-linker MOFs was comprehensively evaluated using eight evaluation indicators,namely,the largest cavity diameter,accessible surface area,pore occupied accessible volume,porosity,adsorption selectivity,working capacity,adsorbent performance score and percent *** optimal performance frameworks were screened to further study their single-component adsorption and binary competitive adsorption of CO_(2)/H_(2)*** CO_(2)adsorption selectivity at different CO_(2)/H_(2)feed ratios was also evaluated,which indicated their excellent adsorption and separation *** microscopic adsorption mechanisms for CO_(2)and H_(2)at the molecular level were investigated by analyzing the radial distribution function and density *** study may provide directional guidance and reference for subsequent experiments on the adsorption and separation of CO_(2)/H_(2).

关键词： metal–organic framework adsorption separation high-throughput screening grand canonical Monte Carlo simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacological Mechanism of Chinese Medicine in Systemic Lupus Erythematosus:A Narrative Review

引用

Chinese Journal of Integrative Medicine 2025年第2期31卷 157-169页

作者： ZHU Bo-yu LIU Zhi-chao ZHAO Zhen-xi huang Hui-ping ZHANG Na XIA Jia CHEN Wei-wei Department of Rheumatology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghai University of Traditional Chinese MedicineShanghai(200071)China

Systemic lupus erythematosus(SLE)is a chronic autoimmune disorder affecting multiple systems,characterized by the development of harmful autoantibodies and immune complexes that lead to damage in organs and *** medicine(CM)plays a role in mitigating complications,enhancing treatment effectiveness,and reducing toxicity of concurrent medications,and ensuring a safe ***,CM mainly solves the disease comprehensively through multi-target and multi-channel regulation process,therefore,its treatment mechanism is often complicated,involving many molecular *** review introduces the research progress of pathogenesis of SLE from the aspects of genetics,epigenetics,innate immunity and acquired immunity,and then discusses the molecular mechanism and target of single Chinese herbal medicine and prescription that are commonly used and effective in clinic to treat SLE.

关键词： systemic lupus erythematosus Chinese medicine natural extracts treatment review

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dual roles ofα1,4-galactosyltransferase 1 in spermatogenesis of Drosophila melanogaster

引用

Insect Science 2025年第1期32卷 127-139页

作者： Yanhong Xiao Bo huang Sibo Chen Zhikai Lin Zhiying Zhu yuzhen Lu Xiao-Qiang yu Liang Wen Qihao Hu Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina School of Life Sciences Hubei Key Laboratory of Genetic Regulation and Integrative BiologyCentral China Normal UniversityWuhanChina

Spermatogenesis is critical for insect reproduction and the process is regulated by multiple *** have been shown to participate in the development of Drosophila melanogaster;however,their role in spermatogenesis is still *** this study,we found thatα1,4-galactosyltransferase 1(α4GT1)was expressed at a significantly higher level in the testis than in the ovary of ***,the hatching rate was significantly decreased whenα4GT1 RNA interference(RNAi)males were crossed with w1118 females,with only a few mature sperm being present in the seminal vesicle ofα4GT1 RNAi *** staining further revealed that the individualization complex(IC)in the testes fromα4GT1 RNAi flies was scattered and did not move synchronically,compared with the clustered IC observed in the control *** deoxyribonucleotide transferase(TdT)-mediated dUTP nick end labeling(TUNEL)assay showed that apoptosis signals in the sperm bundles ofα4GT1 RNAi flies were significantly ***,the expression of several individualization-related genes,such as Shrub,Obp44a and Hanabi,was significantly decreased,whereas the expression of several apoptosis-related genes,including Dronc and Drice,was significantly increased in the testes ofα4GT1 RNAi ***,these results suggest thatα4GT1 may play dual roles in Drosophila spermatogenesis by regulating the sperm individualization process and maintaining the survival of sperm bundles.

关键词： apoptosis α4GT1 galactosyltransferase individualization spermatogenesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metabolic landscape of human alveolar type II epithelial cells undergoing epithelial-mesenchymal transition induced directly by silica exposure

引用

Journal of Environmental Sciences 2025年第3期149卷 676-687页

作者： Jin Sun Na Zhao Ruijia Zhang Yizheng Li Tiantian yu Qiying Nong Li Lin Xubin Yang Tiangang Luan Baowei Chen Yongshun huang Southern Marine Science and Engineering Guangdong Laboratory School of Marine SciencesSun Yat-Sen UniversityZhuhai 519082China Guangdong Province Hospital for Occupational Disease Prevention and Treatment Guangzhou 510300China Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Jieyang 515200China State Key Lab of Bioresource and Biocontrol School of Life ScienceSun Yat-sen UniversityGuangzhou 510275China Metabolic Innovation Center Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 540080China Department of Endocrinology and Metabolism Guangdong Provincial Key Laboratory of DiabetologyThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China

Epithelial-mesenchymal transition(EMT)plays an irreplaceable role in the development of ***,molecular mechanisms of EMT induced by silica exposure still remain to be ***,metabolic profiles of human alveolar type II epithelial cells(A549 cells)exposed directly to silica were characterized using non-targeted metabolomic approaches.A total of 84 differential metabolites(DMs)were identified in silica-treated A549 cells undergoing EMT,which were mainly enriched in metabolisms of amino acids(e.g.,glutamate,alanine,aspartate),purine metabolism,glycolysis,*** number of DMs identified in the A549 cells obviously increased with the elevated exposure concentration of ***,glutamine catabolism was significantly promoted in the silica-treated A549 cells,and the levels of related metabolites(e.g.,succinate)and enzymes(e.g.,α-ketoglutarate(α-KG)dehydrogenase)were substantially up-regulated,with a preference toα-KG *** of glutamine into the cell culture could substantially enhance the expression levels of both EMT-related markers and Snail(zinc finger transcription factor).Our results suggest that the EMT of human alveolar epithelial cells directly induced by silica can be essential to the development of silicosis.

关键词： Silica exposure Human alveolar type II epithelial cells(ATII cells) Epithelial-mesenchymal transition (EMT) Metabolomics Glutamine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Laser assisted phase transformation of carbon-based transition metal oxide electrode for high-performance supercapacitor application

引用

Science China Chemistry 2025年

作者： Mingzhen Xiu Jianghong Zhang yu Lu Xun Cao Kang huang Siyu Zhu Bowei Zhang yu Liang Chunwang Zhao Junsheng Wu Yizhong huang School of Materials Science and Engineering Nanyang Technological University Energy Research Institute Interdisciplinary Graduate Programme Nanyang Technological University Institute of Sustainability for Chemicals Energy and Environment Agency for Science Technology and ResearchSingapore Institute of Advanced Materials and Technology University of Science and Technology Beijing School of Materials Science and Technology Shenyang University of Chemical Technology School of Materials Science and Hydrogen Energy Foshan University

Transitional metal oxides have a wide range of applications due to their superior *** enhanced performance of metal oxide relies on their desirable oxidation states,which is challenging to achieve and requires complex *** study demonstrates a facile strategy enabling rapid phase transformation of transition metal *** approach involves synthesis of a tetragonal Mn3O4/carbon cloth composite using the liquid plasma discharge deposition （LPDD） technique,followed by laser irradiation with the presence of ethylene glycol under an N2gas *** resulting face-centered cubic MnO/carbon cloth electrode exhibits an excellent capacitance of 1,125 F g-1at 2 A g-1,with remarkable capacitance retention of 95%after10,000 *** approach can be extended to other transition metals including Co,Cu,Cr,Fe,Ni,and *** simulations reveal the significance of ethylene glycol and the underlying mechanism associated with the phase transformation of transition metal *** present study offers a powerful technique for the phase transformation of transition metal oxide which can guide the development of new electrode materials with enhanced electrochemical properties for high-performance energy storage applications.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Dark energy effects on surface gravitational redshift and Keplerian frequency of neutron stars

引用

Communications in Theoretical Physics 2025年第1期77卷 122-129页

作者： Jia-Jing He Yan Xu Yi-Bo Wang Xiu-Lin huang Xing-Xing Hu yu-Fu Shen Changchun Observatory National Astronomical ObservatoriesChinese Academy of SciencesChangchun 130117China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China

Research on the properties of neutron stars with dark energy is a particularly interesting yet unresolved problem in *** analyze the influence of dark energy on the equation of state,the maximum mass,the surface gravitational redshift and the Keplerian frequency for the traditional neutron star and the hyperon star matter within the relativistic mean field theory,using the GM1 and TM1 parameter sets by considering the two flavor symmetries of SU(6)and SU(3)combined with the observations of PSR J1614-2230,PSR J0348+0432,PSR J0030+0451,RX J0720.4-3125,and 1E *** is found that the existence of dark energy leads to the softened equations of the state of the traditional neutron star and the hyperon *** radius of a fixed-mass traditional neutron star(or hyperon star)with dark energy becomes smaller,which leads to increased *** existence of dark energy can also enhance the surface gravitational redshift and the Keplerian frequency of traditional neutron stars and hyperon *** growth of the Keplerian frequency may cause the spin rate to speed up,which may provide a possible way to understand and explain the pulsar glitch ***,we infer that the mass and the surface gravitational redshift of PSR J1748-2446ad without dark energy for the GM1(TM1)parameter set are 1.141 M_(☉)(1.309 M_(☉))and 0.095(0.105),*** corresponding values for the GM1(TM1)parameter set are 0.901 M_(☉)(1.072M_(☉))and 0.079(0.091)if PSR J1748-2446ad contains dark energy withα=*** J1748-2446ad may be a low-mass pulsar with a lower surface gravitational redshift under our selected models.

关键词： dark energy neutron stars gravitational redshift Keplerian frequency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：