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World Journal of Stem Cells 2022年第1期14卷 41-53页

作者： Chuan-Jing Dai yu-ting cao Fang Huang Yi-Gang Wang College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018Zhejiang ProvinceChina Department of Pathology Zhejiang Provincial People’s Hospital of Hangzhou Medical UniversityHangzhou 310014Zhejiang ProvinceChina

The transforming growth factor(TGF)-βsignaling pathway controls many cellular processes,including proliferation,differentiation,and *** in the TGF-βsignaling pathway and its components are closely related to the occurrence of many human diseases,including *** against decapentaplegic homolog 4(Smad4),also known as deleted in pancreatic cancer locus 4,is a typical tumor suppressor candidate gene locating at q21.1 of human chromosome 18 and the common mediator of the TGF-β/Smad and bone morphogenetic protein/Smad signaling *** is believed that Smad4 inactivation correlates with the development of tumors and stem cell fate ***4 also interacts with cytokines,miRNAs,and other signaling pathways,jointly regulating cell ***,the regulatory function of Smad4 in tumorigenesis,stem cells,and drug resistance is currently *** addition,Smad4 represents an attractive therapeutic target for *** the specific role of Smad4 is important for understanding the mechanism of tumorigenesis and cancer ***,we review the identification and characterization of Smad4,the canonical TGF-β/Smad pathway,as well as the multiple roles of Smad4 in tumorigenesis,stem cells,and drug ***,we provide novel insights into the prospects of Smad4-targeted cancer therapy and the challenges that it will face in the future.

关键词： Cancer therapy Drug resistance Mothers against decapentaplegic homolog 4 Stemness Transforming growth factor-β Tumorigenesis

MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self-Powered Motion Sensing

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： Wang, yu-Ze Wang, yu-Chang Liu, ting-ting Zhao, Quan-Liang Li, Chen-Sha cao, Mao-Sheng Beijing Inst Technol Sch Mat Sci & Engn Beijing 100081 Peoples R China Peking Univ Sch Mat Sci & Engn Beijing 100871 Peoples R China North China Univ Technol Sch Mech & Mat Engn Beijing 100144 Peoples R China Heilongjiang Univ Minist Educ Peoples Republ China Key Lab Funct Inorgan Mat Chem Harbin 150080 Peoples R China

Polymeric microwave actuators combining tissue-like softness with programmable microwave-responsive deformation hold great promise for mobile intelligent devices and bionic soft robots. However, their application is challenged by restricted electromagnetic sensitivity and intricate sensing coupling. In this study, a sensitized polymeric microwave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx (MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique space-charge polarization and interfacial polarization, resulting in significant improvements of 230% in the dielectric loss factor and 830% in the apparent efficiency of electromagnetic energy harvest. The sensitized microwave actuation demonstrates as the shortened response time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (up to 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combines driving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of similar to 3 mV) during actuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approach for developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

Geochemical and geochronologic constraints for Paleozoic magmatism related to the orogenic collapse in the Qimantagh–South Altyn region,northwestern China

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Geochemical and geochronologic constraints for Paleozoic mag...

2014年中国地球科学联合学术年会——专题41：花岗岩大地构造

作者： Chao Wang Liang Liu Pei-Xi Xiao yu-ting cao Hui-Yang yu Joseph G.Meert Wen-Tian Liang MLR Key Laboratory of Genesis and Exploration of Magmatic Ore deposits Orogen Research Centre of China Geological SurveyXi'an Center of Geological Survey State Key Laboratory of Continental Dynamics Department of GeologyNorthwest University College of Geological Science & Engineering Shandong University of Science and Technology Department of Geological Sciences University of Florida 241 Williamson Hall Gainesville FL 32611 U.S.A.

Voluminous and discrete early Paleozoic bimodal magmatic suites are thought to be the result of post-collisional extension following the amalgamation of East Kunlun and Altyn *** this paper,four representative magmatic units were studied for their geochemical fingerprint in conjunction with geochronological *** 467–445 Ma Mangya mafic suite shows E-MORB type rare earth element

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特色旅游小镇生态景观艺术设计研究

艺术百家 2017年第4期33卷 233-234页

作者：吴曼朱宇婷曹磊南京林业大学艺术设计学院江苏南京210037

文章从生态优先、尊重保护自然现状、修复断裂的乡土景观肌理、传承乡镇地域文化、生产活动与生态体验功能互补这五大方面,探讨特色旅游小镇生态景观艺术设计的策略与方法,将景观艺术设计回归自然,以安徽省当涂县的生态景观艺术设计为例... 详细信息

文章从生态优先、尊重保护自然现状、修复断裂的乡土景观肌理、传承乡镇地域文化、生产活动与生态体验功能互补这五大方面,探讨特色旅游小镇生态景观艺术设计的策略与方法,将景观艺术设计回归自然,以安徽省当涂县的生态景观艺术设计为例,为特色旅游小镇生态景观艺术设计提供了新思路。

关键词：环境景观设计特色旅游小镇生态景观地域文化艺术设计

Recognition and tectonic implications of an extensive Neoproterozoic volcano-sedimentary rift basin along the southwestern margin of the Tarim Craton, northwestern China

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Recognition and tectonic implications of an extensive Neopro...

Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

2014年中国地球科学联合学术年会——专题48：前寒武纪地质与超大陆演化

作者： Chao Wang Liang Liu Yong-He Wang Shi-Ping He Rong-She Li Meng Li Wen-Qiang Yang Alan S.Collins yu-ting cao Chao Shi Hui-Yang yu MLR Key Laboratory of Genesis and Exploration of Magmatic Ore deposits Orogen Research Centre of China Geological SurveyXi’an Center of China Geological Survey State Key Laboratory of Continental Dynamics Department of Geology Northwest University Centre for Tectonics Resources and Exploration (TRaX) Department of Earth Sciences University of Adelaide College of Geological Science & Engineering Shandong University of Science and Technology

The Tiekelik Belt includes a large outcrop area of Precambrian continental crust,which is exposed along the southwestern margin of the Tarim Craton,NW *** is characterized by the occurrence of high-grade metamorphic rocks and volcano-sedimentary *** this contribution,we present zircon U-Pb results from ten samples of rocks from these volcano-sedimentary successions for provenance and age determinations,and geochemical analyses on basalts of the bimodal volcanic rocks from the Sailajiazitage *** schist and paragneiss samples from the Ailiankate Group contain numerous zircons with ages of 650–850 Ma,suggesting that this group was deposited after the late Neoproterozoic and is not part of the Paleoproterozoic

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei Zheng tingwei cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

Green building materials lit up by electromagnetic absorption function:A review

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Journal of Materials Science & Technology 2022年第17期112卷 329-344页

作者： ting-ting Liu Mao-Qing cao Yong-Sheng Fang yu-Hang Zhu Mao-Sheng cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Heilongjiang Institute of Construction Technology Harbin 150025China

Healthy and livable living environments,as well as anti-electromagnetic(EM)radiation buildings,are the long-term goals of human *** introduction of advanced EM wave absorbing materials into buildings is one of the most feasible ways to address the increasing EM pollution in building ***-efficiency,broadband,low-cost and good building performance EM wave absorbing materials,as an important support in the field of sustainable building,has gradually become the hotspot ***,we review the research progress of building materials with EM wave absorption functions,and comb their classification,including cement,concrete,ceramics,and prefabs,especially highlighting the advanced coating *** objectively outline and evaluate the latest technology of building materials with EM wave absorption performance,and discuss the main problems and bottlenecks,highlighting potential research opportunities.

关键词： Anti-electromagnetic radiation building Electromagnetic wave absorption Building materials Green building

Unraveling post-growth mechanisms of monolayer CsPbBr3 nanocubes:Laser-enhanced transformations and cathodoluminescence-electron microscopy correlations

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Journal of Energy Chemistry 2025年第1期100卷 146-156页

作者： Mingxing Li Xiaoge Wang Xiaofan cao Zhiqun He Chunjun Liang Mingxing Chen Jing Ju Fangtian You Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University

Lead-halide perovskite nanoparticles（LHP NPs） are highly promising materials for next-generation displays and solid-state lighting due to their exceptional optical properties. However, their inherent instability presents a significant challenge. Recent advances have demonstrated that optoelectronic devices based on monolayer nanoparticle films exhibit both high luminescence efficiency and long-term *** research demonstrates that mobility limitations and anisotropic alignments in CsPbBr3nanocube monolayer films are key to their stabilization, hindering spontaneous growth through face-to-face fusion and resulting in the formation of connecting necks in a diagonal direction. Introducing laser irradiation confirmed this by significantly accelerating nanocubes growth, increasing mobility, and enhancing local structural ordering, leading to larger and more regularly shaped nanosheets. Fourier transform infrared spectroscopy and energy dispersive spectroscopy line-scan analyses indicated that laser irradiation did not disrupt the ligand structure. Transmission electron microscopy and correlative cathodoluminescence electron microscopy revealed the effects of post-growth and heterogeneous structures, including enhanced luminescence and inhomogeneous intensity in the nanosheets. These findings deepen the understanding of the post-growth mechanism of monolayer nanoparticles and the structure-emission correlation and highlight the unique role of laser irradiation in directing the formation of well-defined and regular nanostructures.

关键词： Post-growth mechanism Heterogeneous structure Single-particle spectroscopy Laser irradiation

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao Xiang cao yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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信息茧房对大学生信息素养的影响机制研究

高校教育管理 2025年第1期19卷 113-124页

作者：于文卿宋宪萍曹宇驰北京理工大学教育学院北京理工大学马克思主义学院北京102488

探究算法时代如何打破信息茧房,进而提高大学生的信息素养已成为高等教育领域亟待解决的关键课题。本研究通过扎根理论对不同教育背景的30位大学生进行半结构化访谈,系统探究信息茧房对大学生信息素养的影响机制。结果发现,当大学生困... 详细信息

探究算法时代如何打破信息茧房,进而提高大学生的信息素养已成为高等教育领域亟待解决的关键课题。本研究通过扎根理论对不同教育背景的30位大学生进行半结构化访谈,系统探究信息茧房对大学生信息素养的影响机制。结果发现,当大学生困于信息茧房之中时,其信息素养的各个维度都会受到不同程度的影响;信息茧房通过信息技术这一载体,对大学生信息素养产生直接影响;被信息技术“装备”的信息茧房经由信息驱动力这一中介,对大学生信息素养产生间接影响,在此过程中,主体内驱力和信息情境分别通过改变个体动机强度和环境感知强度,进一步调节信息茧房对大学生信息素养的影响。政府、社会、高校等主体应通过多种举措帮助大学生在信息知识层面下拓展信息视野、在信息意识层面下锐化信息敏感度、在信息能力层面下优化数字技能、在信息道德层面下规范信息行为,从而全面提升大学生的信息素养。

关键词：信息茧房大学生信息素养影响机制扎根理论质性研究