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Liver metastasis as the initial clinical manifestation of sublingual gland adenoid cystic carcinoma: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5238-5244页

作者： Xiao-Hong Li yu-tao zhang Hao Feng Department of Pathology The First People’s Hospital of ZigongZigong 643099Sichuan ProvinceChina Department of Radiology The First People’s Hospital of ZigongZigong 643099Sichuan ProvinceChina

BACKGROUND Adenoid cystic carcinoma(ACC)is a common malignant tumor of salivary *** lung and liver are frequent sites of distant *** metastasis as the initial clinical manifestation of sublingual gland ACC is very *** SUMMARY A 51-year-old Chinese woman presented with a painless mass in the right lobe of *** tumor was composed of ductal cells and myoepithelial cells with a morphology including tubiform and cribriform *** results showed ductal cells positive for CK7,CK14,CK19,CD117,and 34βE12,and negative for MYB,vimentin,ER,PR,and *** myoepithelial cells were positive for p63,calponin and CK5/*** salivary ACC was considered,and a sublingual gland mass was revealed by computed *** evaluation confirmed primary sublingual gland *** in situ hybridization(FISH)did not find an MYB-NFIB fusion gene in specimens from either the primary or metastatic ACC *** sublingual gland ACC relapsed in 20 *** recurrent lesion disappeared following local radiation therapy and computed tomography-guided radioactive seed *** patient remains in good condition until *** Metastatic sublingual gland ACC with initial clinical manifestation as a liver mass is very rare,and was pathologically confirmed in this patient by its histological *** hepatic tumors and metastatic carcinomas should be included in the differential *** detection of MYB protein and MYB-NFIB fusion gene detection by FISH can be helpful,but occasional negative results confuse the diagnosis.

关键词： Liver metastasis Adenoid cystic carcinoma Sublingual gland Differential diagnosis Immunohistochemistry Fluorescence in situ hybridization Case report

Evaluating the immune responses of mice to subcutaneous immunization with Helicobacter pylori urease B subunit

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Journal of Animal Science and Biotechnology 2014年第2期5卷 181-187页

作者： Peng Sun Jia-Qi Wang yu-tao zhang Sheng-Guo Zhao State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesNo.2 Yuanmingyuan West RoadBeijing 100193P.R.China

Background： Helicobacter pylori, a gram-negative bacterial pathogen that expresses a strong urease activity, is associated with the development of gastroduodenal disease. Urease B subunit, one of the two structural subunits of urease, was expressed in E. coil BL21 （DE3） strain. The objective of this study was to evaluate the effects of He/icobacter py/ori urease B subunit on the immune responses in mice by subcutaneous immunization. Methods： The mice were immunized and boosted with Helicobacter pylori urease B subunit antigen subcutaneously three times with 2-wk intervals between the immunizations and boosters. The mice in the control group were immunized with PBS. The adjuvant group received PBS containing complete/incomplete freund＇s adjuvant identical to antigen group without Helicobocter pylori urease B subunit antigen. Four weeks after the final booster, all the mice were sacrificed. Blood was collected on d 0, 14, 28 and 56 before immunization, booster and sacrifice, respectively. Immediately after sacrifice, gastric liquid and spleen were collected for antibody and cytokine analyses. Results： Urease B subunit increased the concentrations of serum and gastric anti-urease B antigen specific IgG, and the levels of interteukin-4 and interferon-y in splenocytes of the mice （P 〈 0.05）. Conclusions： This study demonstrated that recombinant responses in mice by subcutaneous immunization, which against Helicobocter pylori. urease B subunit can induce systemic and local immune might be used as the effective component of vaccine

关键词： Antibody Cytokines Helicobacter pylori urease B subunit Mice

Evaluation of the propensity for coal spontaneous combustion based on catastrophe theory

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Journal of Coal Science & Engineering(China) 2011年第3期17卷 265-269页

作者： zhang yu-tao zhang Xi-chen TIEN Jerry C LI Ya-qing Missouri University of Science ＆ Technology Rolla MO USA

Generally, different prevention measures should be taken according to spontaneous combustion propensities. The current methods to evaluate the propensity of coal spontaneous combustion, such as chromatographic method of oxygen adsorption, oxidation kinetics method and activation energy method, are mostly affected by human factors. Their boundaries among different classes of propensities were all established by subjective judgments. A new evaluation method using catastrophe theory is introduced. This method can accurately depict the process of coal spontaneous combustion and the evaluation index, ＂catastrophe temperature＂, be obtained based on the model. In terms of catastrophe temperature, the spontaneous combustion propensity of different coals can be sequenced. Experimental data indicate that this method is appropriate to describe the spontaneous combustion process and to evaluate the propensity of coal svontaneous combustion.

关键词： spontaneous combustion catastrophe theory catastrophe temperature

Assessment of pancreatic carcinoma cell chemosensitivity using a three-dimensional culture system

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Chinese Medical Journal 2010年第14期123卷 1871-1877页

作者： LIAO Quan HU Ya ZHAO yu-pei ZHOU tao zhang Qiang Department of General Surgery Peking Union Medical College Hospital National Laboratory of Medical Molecular Biology Chinese Academy of Medical Sciences Beijing 100730 China

Background Monolayer cell culture models are the traditional culture models used for in vitro research of pancreatic carcinoma chemosensitivity. However, these models neglect the interactions between tumor cells and the impact of the tumor microenvironment. Such tumor cell monolayers poorly mimic the solid tumor microenvironment. The present study aimed to investigate the chemosensitivity characteristics of pancreatic cancer cells in a three-dimensional culture system by analyzing the differences in drug sensitivity between a scattered cell culture model and a multicellular spheroid culture model. Methods Three pancreatic cancer cell lines （SW1990, ASPC-1 and PCT-3） were cultured in three-dimensional collagen gels as well as in traditional two-dimensional monolayers. The chemosensitivities of the pancreatic carcinoma cells to 5-fluorouracil （5-FU）, gemcitabine, and oxaliplatin in vitro were detected by both the Cell Counting Kit-8 test and the collagen gel droplet-embedded culture drug-sensitivity test. Results In the two-dimensional culture model, differences in the chemosensitivities of the cloned pancreatic carcinoma cells and scattered cells existed for some concentrations of 5-FU, gemcitabine and oxaliplatin. In the three-dimensional culture model, there were significant differences in the chemosensitivities of the pancreatic cancer cells between the scattered cells and multicellular spheroids （P 〈0.05）. Conclusion Pancreatic carcinoma cells exhibit multicellular resistance in three-dimensional cultures.

关键词： pancreatic carcinoma cell chemosensitivity three-dimensional culture

A 23 GHz high-temperature superconducting microstrip filter for radio astronomy

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Chinese Science Bulletin 2009年第19期54卷 3485-3488页

作者： GAO Lu GUO Jin WANG yueHui yu tao zhang Qiang LI ChunGuang zhang XueQiang LI Hong LI JunJie LI WuXia GU ChangZhi MENG JiBao FENG Ji HE yuSheng Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China

This paper reports a 6-pole high-temperature superconducting (HTS) microstrip bandpass filter for radio astronomy applications. The filter has a center frequency of 23 GHz and a bandwidth the 2 GHz. We have made many efforts, such as adopting 0.25-mm-thick substrate, carefully designing the housing box and filter layout, to solve the problems in realizing a K-band planar filter. A special straight-line half-wavelength resonator (center-widen resonator) was also designed to reduce the insertion loss of the filter. The measured results showed a midband insertion loss of 0.11 dB with a ripple of 0.4 dB, and a return loss better than 11.5 dB. Good agreement was obtained between simulated and measured results.

关键词：微波传输带无线电通信电波天文学超导

科技金融对生产性服务业与制造业协同集聚的影响研究

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中国软科学 2018年第3期 47-55页

作者：张玉华张涛上海师范大学商学院上海200234

本文从产业地理集中与产业集聚角度测度了生产性服务业与制造业协同集聚水平,并利用2005-2015年我国省际间数据构建了动态空间杜宾模型,实证分析了生产性服务业与制造业协同集聚的空间相关性和空间溢出效应。研究结果表明:我国生产性服... 详细信息

本文从产业地理集中与产业集聚角度测度了生产性服务业与制造业协同集聚水平,并利用2005-2015年我国省际间数据构建了动态空间杜宾模型,实证分析了生产性服务业与制造业协同集聚的空间相关性和空间溢出效应。研究结果表明:我国生产性服务业与制造业协同集聚水平呈现空间集聚性,且协同集聚水平很大程度上受自身前期惯性的影响;科技金融主要通过研发经费投入和政府科技投入促进生产性服务业与制造业协同集聚发展。本文的研究为我国深化供给侧结构性改革提供了政策性启示。

关键词：科技金融协同集聚溢出效应

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui yu Yan Xie Jian yu Kun-Ning zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi zhang yu-Ying Tan Li zhang Wen-tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

DOM不同相对分子质量组分在无机矿物上的吸附及其对卡马西平吸附的影响实验

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环境科学 2018年第5期39卷 2219-2229页

作者：梁雨何江涛张思中国地质大学(北京)水资源与环境学院水资源与环境工程北京市重点实验室北京100083

为探究溶解性有机质(DOM)不同相对分子质量组分在矿物质上的吸附特征及其与药物和个人护理品(PPCPs)类污染物的结合作用对两者吸附过程的影响,以卡马西平作为目标污染物,用商用腐殖酸制备DOM,以石英砂代表无机矿物,开展吸附实验,并采用... 详细信息

为探究溶解性有机质(DOM)不同相对分子质量组分在矿物质上的吸附特征及其与药物和个人护理品(PPCPs)类污染物的结合作用对两者吸附过程的影响,以卡马西平作为目标污染物,用商用腐殖酸制备DOM,以石英砂代表无机矿物,开展吸附实验,并采用透析实验和红外光谱表征等手段,探讨了不同相对分子质量腐殖酸(HA)的结构特征及其与卡马西平(CBZ)的结合作用对HA或CBZ在固相介质上吸附作用的差异及产生机制.结果表明,大分子量HA有更多的羟基、芳香烃和脂肪烃,以疏水物质为主;而小分子量HA有更多的醇和羧基,以亲水物质为主.HA与CBZ的结合主要通过CBZ的氨基与小分子量HA中极性官能团的结合,以及CBZ疏水基团与大分子量HA中脂肪族与芳香族的疏水作用.CBZ与HA之间的相互作用对腐殖酸或卡马西平的吸附产生明显差异.当CBZ不存在时,石英砂主要通过疏水作用结合HA中疏水性大分子或与HA的羟基、羧基等发生交换配位反应,且石英砂更倾向于吸附HA中的脂肪性及疏水性大分子组分.当CBZ存在时,石英砂转而吸附HA中的小分子量部分,且HA在石英砂上的最大吸附量减小.当HA不存在时,CBZ可通过疏水作用,范德华力和极性相互作用使其在石英砂上有一定量的吸附.加入HA后,石英砂吸附增加的CBZ归因于部分HA分子与CBZ结合后共吸附或累积吸附于石英砂上.

关键词：腐殖酸卡马西平石英砂吸附相对分子质量

From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua Lu Jun Shen Xin zhang Lingcong Chao Liang Chen Ding zhang tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added