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Degradable and Tunable Keratin-fibrinogen Hydrogel as Controlled Release System for Skin Tissue Regeneration

Journal of Bionic Engineering 2023年第3期20卷 1049-1059页

作者： Sung Jun Min Jae Seo Lee Haram Nah Ho-Jin Moon Sang Jin Lee Hyeon Jeong Kang Yu-Shik Hwang Il Keun Kwon Dong Nyoung Heo Department of Dentistry Graduate SchoolKyung Hee University26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Biofriends Inc 26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Department of Dental Materials School of DentistryKyung Hee University26 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology School of DentistryKyung Hee UniversitySeoul02447Korea Kyung Hee University Medical Science Research Institute Kyung Hee University23 Kyungheedae-RoDongdaemun-GuSeoul02447Republic of Korea

Biodegradable hydrogels are promising biomaterials for use in controlled-release systems for skin tissue regeneration. Controlled delivery systems constitute an important aspect of tissue engineering because they can modulate various physiological responses, including early immune response, tissue remodeling, and cell proliferation and maturation in the wound-healing process. Hydrogels composed of various biomaterials have been developed to overcome the limitations of conventional drug- or protein-delivery systems, such as limited targeting ability, low stability, and the induction of drug resistance. Hydrogels based on keratin, a natural polymer extracted from human hair, can provide adequate cell support and control homeostasis. Consequently, they can be applied for skin tissue engineering. In this study, we prepared degradable, tunable, and biocompatible hydrogels for controllable protein delivery. We synthesized keratin-fibrinogen (KER-FBG) by the chemical coupling reaction and prepared hydrogels through polymerization with thrombin. The structures and morphologies of the KER-FBG hydrogels were confirmed. Furthermore, the mechanical properties, swelling ratio, degradation, release behavior, and biocompatibility were investigated. The KER-FBG hydrogels presented promising biological performance, indicating that the material is suitable as a controlled protein delivery carrier.

关键词： Keratin Fibrinogen Hydrogel Drug delivery Degradable

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Are human dental papilla-derived stem cell and human brain-derived neural stem cell transplantations suitable for treatment of Parkinson’s disease?

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Neural Regeneration Research 2013年第13期8卷 1190-1200页

作者： Hyung Ho Yoon Joongkee Min Nari Shin Yong Hwan Kim Jin-Mo Kim Yu-Shik Hwang Jun-Kyo Francis Suh Onyou hwang Sang Ryong Jeon Department of Neurological Surgery Asan Medical Center University of Ulsan College of Medicine Department of Biochemistry and Molecular Biology University of Ulsan College of Medicine Department of Computer Science and Engineering University of Notre Dame Notre Dame Center for Bionics of Korea Institute of Science and Technology Department of Maxillofacial Biomedical Engineering Institute of Oral Biology School of Dentistry Kyung Hee University

Transplantation of neural stem cells has been reported as a possible approach for replacing impaired dopaminergic neurons. In this study, we tested the efficacy of early-stage human dental papilla-derived stem cells and human brain-derived neural stem cells in rat models of 6-hydroxydopamine-induced Parkinson＇s disease. Rats received a unilateral injection of 6-hydroxydopamine into right medial forebrain bundle, followed 3 weeks later by injections of PBS, early-stage human dental papilla-derived stem cells, or human brain-derived neural stem cells into the ipsilateral striatum. All of the rats in the human dental papilla-derived stem cell group died from tumor formation at around 2 weeks following cell transplantation. Postmortem examinations revealed homogeneous malignant tumors in the striatum of the human dental papilla-derived stem cell group. Stepping tests revealed that human brain-derived neural stem cell transplantation did not improve motor dysfunction. In apomorphine-induced rotation tests, neither the human brain-derived neural stem cell group nor the control groups （PBS injection） demonstrated significant changes. Glucose metabolism in the lesioned side of striatum was reduced by human brain-derived neural stem cell transplantation. [18F]-FP-CIT PET scans in the striatum did not demonstrate a significant increase in the human brain-derived neural stem cell group. Tyrosine hydroxylase （dopaminergic neuronal marker） staining and G protein-activated inward rectifier potassium channel 2 （A9 dopaminergic neuronal marker） were positive in the lesioned side of striatum in the human brain-derived neural stem cell group. The use of early-stage human dental papilla-derived stern cells confirmed its tendency to form tumors. Human brain-derived neural stem cells could be partially differentiated into dopaminergic neurons, but they did not secrete dopamine.

关键词： neural regeneration stern cells cell transplantation glucose metabolism human brain-derivedneural stem cells human dental papilla-derived stem cells Parkinson＇s disease positron emissiontomography grants-supported paper neuroregeneration

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Nutraceutical support for respiratory diseases

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Food Science and Human Wellness 2018年第3期7卷 205-208页

作者： yu-Ya hwang yuan-Soon Ho Graduate Institute of Medical Sciences College of MedicineTaipei Medical UniversityTaipei 10031TaiwanChina

Respiratory diseases have been a major health concern for human beings since several decades.Soothing the irritated nasal passages and airways had been a mutual necessity in multiple ancient cultures.In ancient China,herbs were largely used to help deal with cough and reduce mucus,thereby maintaining respiratory health.In India,knowledge of herb-related remedies passed down through generations.In the human society,freshly prepared herb ointments,including air-dried herbs,and boiled herbal soups have had a long history of combining botanical nutrients with local cuisine.Although the use of herbs and natural products from plants(NPFPs)has been primarily cited in reviews based on modern respiratory diseases,the concept of soothing and alleviating disease progression or reducing mucus production has been highly valued.Nevertheless,only a few herbs could directly disrupt the irreversible fibrotic progression.On the other hand,natural products from animals(NPFAs)have more potential in disrupting procollagen or extracellular matrix deposition.Due to these reasons,NPFAs could be considered as important functional foods for patients with respiratory diseases.In this article,we provide a review of both NPFAs and NPFPs that are adjuvant to respiratory health.

关键词： Respiratory disease NPFP NPFA Nutrition Antioxidants

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Early prediction of myocardial viability after acute myocardial infarction by two-dimensional speckle tracking imaging

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Journal of Geriatric Cardiology 2015年第5期12卷 474-481页

作者： Jong Shin Woo Tae-Kyung yu Woo-shik Kim Kwon Sam Kim Weon Kim Division of Cardiology Department of lnternal Medicine Kyung Hee University Hospital Kyung Hee University Seoul South Korea

BackgroundIdentifying 心肌的坏死和在尖锐心肌的梗塞(AMI ) 的心肌的生存能力的度的 transmural 程度临床上是重要的。这研究的目的是用二维的点缀追踪估计心肌的生存能力在有 AMI.Methods2D-STI 的病人的成像( 2D-STI )与 AMI 在 30... 详细信息

BackgroundIdentifying 心肌的坏死和在尖锐心肌的梗塞(AMI ) 的心肌的生存能力的度的 transmural 程度临床上是重要的。这研究的目的是用二维的点缀追踪估计心肌的生存能力在有 AMI.Methods2D-STI 的病人的成像( 2D-STI )与 AMI 在 30 个病人在主要经皮的冠的干预(一种总线标准)以后在起始的表示，三天，和六个月被执行，谁有左前面的下降冠的动脉(男孩)犯人损害。另外，有最小的 stenotic 损害的 20 个病人(<；30% 狭窄) 也在控制组在冠的 angiography 上被包括。在六月 dobutamine， echocardiography 在 LAD 领土的七个片断为生存能力评价被执行。根据墙运动反常的恢复，片断作为可行被分类或 131 个片断全部的 non-viable.ResultsA 是可行的，并且 44 是不能生存的。Multivariate 分析在山峰揭示了可行、不能生存的片断之间的重要差别收缩紧张，山峰在起始的表示的收缩紧张率，和山峰在主要一种总线标准以后的收缩紧张率三天。在这些之中，起始的山峰收缩紧张率为心肌的生存能力有最高预兆的价值(危险比率：31.22， P <；0.01 ).Conclusions2D-STI 为估计收缩紧张率可能是的心肌的生存能力，和山峰是可行的在有 AMI 的病人的心肌的生存能力的最可靠的预言者。

关键词：急性心肌梗死早期预测成像技术追踪斑点二维冠状动脉造影峰值应变

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Development of high performance and high strength heavy concrete for radiation shielding structures

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International Journal of Minerals,Metallurgy and Materials 2011年第1期18卷 89-93页

作者： yu-Chu Peng Chao-Lung hwang Graduate Institute of Construction Engineering Taiwan University of Science and Technology Taipei 11243 China Taipei Department of Resort and Leisure Management Taiwan Hospitality ＆ Tourism College Taipei 11243 China Taipei

Heavy concrete currently used for construction contains special materials that are expensive and difficult to work with.This study replaced natural aggregate（stones） in concrete with round steel balls,which are inexpensive and easily obtainable.The diameters of the steel balls were 0.5 and 1 cm,and their density was 7.8 kg/m3.Dense packing mixture methods were used to produce heavy concrete with densities of 3500 and 5000 kg/m3.The various properties of this concrete were tested according to the standards of the American Society for Testing and Materials（ASTM）.The results indicated that the construction slump of the concrete could reach 260-280 mm and its slump flow could reach 610-710 mm.More important,its compressive strength could reach 8848 MPa.These results will significantly alter traditional construction methods that use heavy concrete and enhance innovative ideas for structural design.

关键词： radiation shielding composite structures concretes concrete construction materials properties

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Vitreous haemorrhage:a population-based study of the incidence and risk factors in Taiwan

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 461-466页

作者： Ching-yu Wang Wai-Man Cheang De-Kuang hwang Ching-Heng Lin Department of Ophthalmology Taichung Veterans General Hospital Taichung City 40705 Taiwan China Department of Ophthalmology Taichung Tzu Chi HospitalBuddhist Tzu Chi Medical Foundation Taichung City 42743Taiwan China Department of Ophthalmology Taipei Veterans General Hospital Taipei City 11217 Taiwan China Department of Medical Research Taichung Veterans General Hospital Taichung City 40705 Taiwan China

AIM：To report the epidemiology and incidence of vitreous hemorrhage and to evaluate risk factors for patients with vitreous hemorrhage（VH）in Taiwan.METHODS：A retrospective population-based study.Analyzing a sample of one million subjects from all enrollees of the Taiwan Health Insurance programme. All data were obtained from the Taiwan Health Insurance Research Database,which contained patient sex,date of birth,all records of clinical visits and hospitalizations,and diagnosis codes as included in the International Classification of Diseases,Ninth Revision,Clinical Modification（ICD-9-CM）. The main outcome measures were the incidence and risk factors of VH.RESULTS：From 2001 to 2010,the database claim 4379 newly diagnosed cases were identified with VH. The average incidence of VH in Taiwan was 4.8 cases per ten-thousand person-years generally and increased with time especially in subjects who aged between 40 and 59 y and when the VH was associated with proliferative diabetic retinopathies or retinal vein occlusions. A de-finitely upward trends in the incidence of VH from 2001 to 2010 were noted（P-value for increasing trend 〈0.001）. Univariate Cox＇s regression analysis pointed out that older age（for 40-59,P〈0.001,HR=9.39; for ≥60,P〈0.001,HR=11.39）,male gender（P=0.03,HR=1.07）and subjects who had been prescribed anti-coagulation drug included aspirin,warfarinand clopidogrel（P〈0.001,HR=2.20）were significant risk factors for suffering from VH.CONCLUSION：The incidence of VH is estimated being 4.8 cases per 10 000 person-years in Taiwan. Age,male gender and having been prescribed anti-coagulation drugs are associated with the incidence of VH.

关键词： vitreous hemorrhage incidence risk factor

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Development of Comment Correlation Matrix for Mobile Application Recommendation

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Journal of Electronic Science and Technology 2016年第3期14卷 268-274页

作者： Yi-Lun Chi yu-Fan Ho Iuon-Chang Lin Min-Shiang hwang Department of Marketing and Supply Chain Management Overseas Chinese UniversityTaichung Department of Management Information Systems National Chung Hsing UniversityTaiehung the Department of Photonics and Communication Engineering Asia UniversityTaiehung Department of Computer Science and Information Engineering Asia UniversityTaichung

As the evolution of mobile technology, mobile devices have become an essential tool in people＇s daily life. Moreover, with the rapid growth of Internet and mobile networks, people can easily access various services provided by mobile platforms. Many services can be executed on the mobile devices with various mobile applications launched to mobile platforms. People can choose what they like to install in their mobile devices and hence make their life more convenient, entertaining, and productive. However, there are too many mobile applications for users to choose. The goal of this research is to propose a methodology which can recommend top-N lists for mobile applications. A comment correlation matrix is proposed. Furthermore, a recommendation algorithm for mobile applications based on user comments and key attributes is built. With the proposed method, it outperforms Google play and is closer to user real feelings.

关键词： Comment correlation matrix mobile applications recommendation system user comment.

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背根神经节Toll样受体4信号通路参与奥沙利铂诱导的周围神经病变

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中国疼痛医学杂志 2021年第11期27卷 824-824页

作者： Illias AM yu KJ hwang SH 陈博(译) 张瑛(校) 不详北京大学神经科学研究所

化疗诱发的周围神经病变(chemotherapy-induced peripheral neuropathy, CIPN)是化疗药物临床应用中的棘手问题,病人表现出持续刺痛、针刺感、深部痛和烧灼痛等各种症状。随着肿瘤治疗技术的进步和肿瘤病人生存期的延长,CIPN对肿瘤病人... 详细信息

化疗诱发的周围神经病变(chemotherapy-induced peripheral neuropathy, CIPN)是化疗药物临床应用中的棘手问题,病人表现出持续刺痛、针刺感、深部痛和烧灼痛等各种症状。随着肿瘤治疗技术的进步和肿瘤病人生存期的延长,CIPN对肿瘤病人生活质量的影响日益突出。由于化疗药物不能通过血脑屏障,因此外周感觉神经元—背根神经节(dorsal root ganglion, DRG)被认为是化疗药物诱发CIPN的主要部位。既往研究表明,DRG组织Toll样受体4 (toll-like receptor 4, TLR4)激活参与紫杉醇诱导CIPN。但作为结直肠癌治疗的一线药物—奥沙利铂是否也通过类似的机制诱导CIPN? 2021年9月,美国德克萨斯大学MD Anderson癌症中心的Patrick M. Dougherty教授团队发表在Pain杂志的研究表明,DRG中TLR4激活同样参与奥沙利铂诱导CIPN的产生,并且可作为CIPN治疗的药物靶点。

关键词：周围神经病变癌症中心药物诱发 Toll样受体4 烧灼痛针刺感德克萨斯大学背根神经节

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Quantum logic operations on two distant atoms trapped in two optical-fibre-connected cavities

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Chinese Physics B 2011年第12期20卷 88-94页

作者：张英俏张寿 Yeon Kyu-hwang yu Seong-Cho Department of Physics College of ScienceYanbian University BK21 Physics Program and Department of Physics College of Natural SciencesChungbuk National UniversityCheongjuChungbuk361-763Republic of Korea

Based on the coupling of two distant three-level atoms in two separate optical cavities connected with two optical fibres, schemes on the generation of several two-qubit logic gates are discussed under the conditions of △ = δ- 2v cos πk/2 〉〉 g/2 and v-g. Discussion and analysis of the fidelity, gate time and experimental setups show that our schemes are feasible with current optical cavity, atomic trap and optical fibre techniques. Moreover, the atom-cavityfibre coupling can be used to generate an N-qubit nonlocal entanglement and transfer quantum information among N distant atoms by arranging N atom cavity assemblages in a line and connecting each two adjacent cavities with two optical fibres.

关键词： quantum logic gate cavity QED optical fibre

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Improving hydroxyapatite coating ability on biodegradable metal through laser-induced hydrothermal coating in liquid precursor:Application in orthopedic implants

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Bioactive Materials 2023年第7期25卷 796-806页

作者： Jaeho Park Seung-Hoon Um Youngmin Seo Jaehong Lee yu-Chan Kim Myoung-Ryul Ok Suk-Won hwang Jeong-yun Sun Hyung-Seop Han Hojeong Jeon Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul02792South Korea Department of Materials Science and Engineering Seoul National University(SNU)Seoul08826South Korea Division of Biomedical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul02792South Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841South Korea

During the past decade,there has been extensive research toward the possibility of exploring magnesium and its alloys as biocompatible and biodegradable materials for implantable applications.Its practical medical application,however,has been limited to specific areas owing to rapid corrosion in the initial stage and the consequent complications.Surface coatings can significantly reduce the initial corrosion of Mg alloys,and several studies have been carried out to improve the adhesion strength of the coating to the surfaces of the alloys.The composition of hydroxyapatite(HAp)is very similar to that of bone tissue;it is one of the most commonly used coating materials for bone-related implants owing to favorable osseointegration post-implantation.In this study,HAp was coated on Mg using nanosecond laser coating,combining the advantages of chemical and physical treatments.Photothermal heat generated in the liquid precursor by the laser improved the adhesion of the coating through the precipitation and growth of HAp at the localized nanosecond laser focal area and increased the corrosion resistance and cell adhesion of Mg.The physical,crystallographic,and chemical bondings were analyzed to explore the mechanism through which the surface adhesion between Mg and the HAp coating layer increased.The applicability of the coating to Mg screws used for clinical devices and improvement in its corrosion property were confirmed.The liquid environment-based laser surface coating technique offers a simple and quick process that does not require any chemical ligands,and therefore,overcomes a potential obstacle in its clinical use.

关键词： Biodegradable metal HAp coating Nanosecond laser Photothermal synthesis Soret effect(thermophoresis)

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