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Journal of Pharmaceutical Analysis 2024年第1期14卷 140-148页

作者： Jingxian Zhang Qinsheng Chen Lianglong Zhang Biru shi Men yu Qingxia Huang Huiru tang State Key Laboratory of Genetic Engineering School of Life SciencesHuman Phenome InstituteZhangjiang Fudan International Innovation CenterMetabonomics and Systems Biology Laboratory at Shanghai International Centre for Molecular PhenomicsZhongshan HospitalFudan UniversityShanghai200032China Wuhan Laboratory for Shanghai Metabolome Institute(SMI)Ltd. Wuhan430000China

Acylcarnitines are metabolic intermediates of fatty acids and branched-chain amino acids having vital biofunctions and pathophysiological significances. Here, we developed a high-throughput method for quantifying hundreds of acylcarnitines in one run using ultrahigh performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS). This enabled simultaneous quantification of 1136 acylcarnitines (C0–C26) within 10-min with good sensitivity (limit of detection 0.992), accuracy (relative error ship (goodness of fit > 0.998) for predicting retention time (tR) of acylcarnitines with no standards and built a database of their multiple reaction monitoring parameters (tR, ion-pairs, and collision energy). Furthermore, we quantified 514 acylcarnitines in human plasma and urine, mouse kidney, liver, heart, lung, and muscle. This provides a rapid method for quantifying acylcarnitines in multiple biological matrices.

关键词： Acylcarnitine UPLC-MS/MS Quantitative structure-retention relationship Molecular phenotype

Chemical Composition, Pharmacological Effects and Clinical Applications of Cinobufacini

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Chinese Journal of Integrative Medicine 2024年第4期30卷 366-378页

作者： ZUO Qian XU Ding-qiao yuE shi-jun FU Rui-jia tang yu-ping Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese MedicineXi'an(712046)China

Chinese medicine cinobufacini is an extract from the dried skin of Bufo bufo gargarizans Cantor,with active ingredients of bufadienolides and indole alkaloids.With further research and clinical applications,it is found that cinobufacini alone or in combination with other therapeutic methods can play an anti-tumor role by controlling proliferation of tumor cells,promoting apoptosis,inhibiting formation of tumor neovascularization,reversing multidrug resistance,and regulating immune response;it also has the functions of relieving cancer pain and regulating immune function.In this paper,the chemical composition,pharmacological effects,clinical applications,and adverse reactions of cinobufacini are summarized.However,the extraction of monomer components of cinobufacini,the relationship between different mechanisms,and the causes of adverse reactions need to be further studied.Also,high-quality clinical studies should be conducted.

关键词： cinobufacini chemical composition Chinese medicine pharmacological effect clinical application adverse effect

Reducing Subspaces of Toeplitz Operators Induced by a Class of Non-analytic Monomials over the Unit Ball

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1767-1777页

作者： Yan yue shi Bo ZHANG Xu tang yu Feng LU School of Mathematical Sciences Ocean University of China School of Mathematics and Information Sciences Yantai University School of Mathematical Sciences Space Engineering University School of Mathematical Sciences Dalian University of Technology

In this paper, we describe the minimal reducing subspaces of Toeplitz operators induced by non-analytic monomials on the weighted Bergman spaces and Dirichlet spaces over the unit ball B2. It is proved that each minimal reducing subspace M is finite dimensional, and if dim M ≥ 3,then M is induced by a monomial. Furthermore, the structure of commutant algebra ■ is determined by N and the two dimensional minimal reducing subspaces of ■. We also give some interesting examples.

关键词： Reducing subspace operator-weighted shifts Toeplitz operator von Neumann algebra 47B35 47B37

Applications of gastric peroral endoscopic myotomy in the treatment of upper gastrointestinal tract disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 658-669页

作者： shi-yu Chang Guo-Hua Jin Hai-Bo Sun Dong Yang Tong-yu tang Department of Gastroenterology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

Gastric peroral endoscopic myotomy(G-POME)is an emerging minimally invasive endoscopic technique involving the establishment of a submucosal tun-nel around the pyloric sphincter.In 2013,Khashab et al used G-POME for the first time in the treatment of gastroparesis with enhanced therapeutic efficacy,prov-iding a new direction for the treatment of gastroparesis.With the recent and rapid development of G-POME therapy technology,progress has been made in the treatment of gastroparesis and other upper digestive tract diseases,such as congenital hypertrophic pyloric stenosis and gastric sleeve stricture,with G-POME.This article reviews the research progress and future prospects of G-POME for the treatment of upper digestive tract gastrointestinal diseases.

关键词： Gastric peroral endoscopic myotomy Upper digestive tract diseases Gastroparesis Congenital hypertrophic pyloric stenosis Gastric sleeve stricture

Cronkhite-Canada syndrome with esophagus involvement and sixyear follow-up:A case report

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World Journal of Gastroenterology 2024年第8期30卷 984-990页

作者： yu-Chen tang Department of Endocrinology The First Affiliated Hospital of Ningbo UniversityNingbo 315000Zhejiang ProvinceChina

BACKGROUND Cronkhite-Canada syndrome(CCS)is a rare,noninherited disease characterized by gastrointestinal polyposis with diarrhea and ectodermal abnormalities.CCS polyps are distributed through the whole digestive tract,and they are common in the stomach and colon but very uncommon in the esophagus.CASE SUMMARY Here,we present a case of a 63-year-old man with skin hyperpigmentation accompanied by diarrhea,alopecia,and loss of his fingernails.Laboratory data indicated anemia,hypoalbuminemia,hypocalcemia,hypokalemia,and positive fecal occult blood.Endoscopy showed numerous polyps scattered throughout the digestive tract,including the esophagus.He was treated with nutritional support and glucocorticoids with remission of his symptoms.CONCLUSION Comprehensive treatment led by hormonal therapy can result in partial or full remission of clinical symptoms.Treatment should be individualized for each patient according to their therapy response.Surveillance endoscopy is necessary for assessing mucosal disease activity and detecting malignant transformation.

关键词： Cronkhite-Canada syndrome Gastrointestinal polyposis Hormonal therapy Prognosis Case report

Process metallurgy and data-driven prediction and feedback of blast furnace heat indicators

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1228-1240页

作者： Quan shi Jue tang Mansheng Chu School of Metallurgy Northeastern UniversityShenyang 110819China Institute for Frontier Technologies of Low-carbon Steelmaking Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

The prediction and control of furnace heat indicators are of great importance for improving the heat levels and conditions of the complex and difficult-to-operate hour-class delay blast furnace(BF)system.In this work,a prediction and feedback model of furnace heat indicators based on the fusion of data-driven and BF ironmaking processes was proposed.The data on raw and fuel materials,process op-eration,smelting state,and slag and iron discharge during the whole BF process comprised 171 variables with 9223 groups of data and were comprehensively analyzed.A novel method for the delay analysis of furnace heat indicators was established.The extracted delay variables were found to play an important role in modeling.The method that combined the genetic algorithm and stacking efficiently im-proved performance compared with the traditional machine learning algorithm in improving the hit ratio of the furnace heat prediction model.The hit ratio for predicting the temperature of hot metal in the error range of±10℃ was 92.4%,and that for the chemical heat of hot metal in the error range of±0.1wt%was 93.3%.On the basis of the furnace heat prediction model and expert experience,a feedback model of furnace heat operation was established to obtain quantitative operation suggestions for stabilizing BF heat levels.These sugges-tions were highly accepted by BF operators.Finally,the comprehensive and dynamic model proposed in this work was successfully ap-plied in a practical BF system.It improved the BF temperature level remarkably,increasing the furnace temperature stability rate from 54.9%to 84.9%.This improvement achieved considerable economic benefits.

关键词： blast furnace furnace heat genetic algorithm stacking prediction and feedback

Large magnetostriction of Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93)/epoxy composites in a wide temperature range

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Journal of Rare Earths 2024年第4期42卷 705-709页

作者： Hehe Ding Yangguang shi Shaolong tang MIIT Key Laboratory of Aerospace Information Materials and Physics Department of Applied PhysicsNanjing University of Aeronautics and AstronauticsNanjing210016China National Laboratory of Solid State Microstructures Nanjing UniversityNanjing210093China

We report the magnetostrictive performance of the Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93)/epoxy composites.Measurement of M?ssbauer spectra and the XRD results indicate that the easy magnetic direction of the Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93)compound is alongdirection with spontaneous magnetostrictionλ111 of1900 ppm.The-oriented Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93)/epoxy composites with particle volume fractions of20 vol%-55 vol%were prepared.Magnetization measurements demonstrate that the composite is highly anisotropic.The raw material cost of Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93)is about 85%of that of the Terfenol-D(Tb_(0.3)Dy_(0.7)Fe_(2))composition.Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93)/epoxy composites possess comparable magnetostriction with those composites made of Tb_(0.3)Dy_(0.7)Fe_(2)particles.At room temperature,the magnetostrictionλ_Ⅱof the Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93)/epoxy composite reaches 420 ppm at a low field of 80 kA/m and about1000 ppm at 239 kA/m.In addition,the composite exhibits a large saturation magnetostrictionλ_Ⅱover1200 ppm from 300 to 100 K,suggesting its potential applications as a low-cost magnetostrictive material in a wide temperature range.Therefore,the current study offers an opportunity to widen the operating temperature range of the magnetostrictive composite.

关键词： Magnetostrictive composite Nd_(0.2)Tb_(0.3)Dy_(0.5)Fe_(1.93) Wide temperaturerange Laves phase Rare earths

The Enhanced Period Map and Equivariant Deformation Quantizations of Nilpotent Orbits

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Acta Mathematica Sinica,English Series 2024年第3期40卷 885-934页

作者： shi Lin yu Department of Mathematics School of Mathematical SciencesXiamen UniversityXiamen 361005P.R.China

In a previous paper,the author and his collaborator studied the problem of lifting Hamil-tonian group actions on symplectic varieties and Lagrangian subvarieties to their graded deformation quantizations and apply the general results to coadjoint orbit method for semisimple Lie groups.Only even quantizations were considered there.In this paper,these results are generalized to the case of general quantizations with arbitrary periods.The key step is to introduce an enhanced version of the(truncated)period map defined by Bezrukavnikov and Kaledin for quantizations of any smooth sym-plectic variety X,with values in the space of Picard Lie algebroid over X.As an application,we study quantizations of nilpotent orbits of real semisimple groups satisfying certain codimension condition.

关键词： Coadjoint orbit method deformation quantization Harish-Chandra modules semisimple Liegroups

Data-driven modeling on anisotropic mechanical behavior of brain tissue with internal pressure

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Defence Technology（防务技术） 2024年第3期33卷 55-65页

作者： Zhiyuan tang yu Wang Khalil I.Elkhodary Zefeng yu Shan tang Dan Peng State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of Technology116023DalianPR China The Department of Mechanical Engineering The American University in CairoNew Cairo11835Egypt Department of Neurology The Second Hospital of Dalian Medical UniversityDalian116023PR China

Brain tissue is one of the softest parts of the human body,composed of white matter and grey matter.The mechanical behavior of the brain tissue plays an essential role in regulating brain morphology and brain function.Besides,traumatic brain injury(TBI)and various brain diseases are also greatly influenced by the brain's mechanical properties.Whether white matter or grey matter,brain tissue contains multiscale structures composed of neurons,glial cells,fibers,blood vessels,etc.,each with different mechanical properties.As such,brain tissue exhibits complex mechanical behavior,usually with strong nonlinearity,heterogeneity,and directional dependence.Building a constitutive law for multiscale brain tissue using traditional function-based approaches can be very challenging.Instead,this paper proposes a data-driven approach to establish the desired mechanical model of brain tissue.We focus on blood vessels with internal pressure embedded in a white or grey matter matrix material to demonstrate our approach.The matrix is described by an isotropic or anisotropic nonlinear elastic model.A representative unit cell(RUC)with blood vessels is built,which is used to generate the stress-strain data under different internal blood pressure and various proportional displacement loading paths.The generated stress-strain data is then used to train a mechanical law using artificial neural networks to predict the macroscopic mechanical response of brain tissue under different internal pressures.Finally,the trained material model is implemented into finite element software to predict the mechanical behavior of a whole brain under intracranial pressure and distributed body forces.Compared with a direct numerical simulation that employs a reference material model,our proposed approach greatly reduces the computational cost and improves modeling efficiency.The predictions made by our trained model demonstrate sufficient accuracy.Specifically,we find that the level of internal blood pressure can greatly influence stress distribution and

关键词： Data driven Constitutive law Anisotropy Brain tissue Internal pressure

Recent Advances in Mechanistic Understanding of Metal-Free Carbon Thermocatalysis and Electrocatalysis with Model Molecules

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Nano-Micro Letters 2024年第7期16卷 74-97页

作者： Wei Guo Linhui yu Ling tang Yan Wan Yangming Lin CAS Key Laboratory of Design and Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002People’s Republic of China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamen 361021People’s Republic of China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002People’s Republic of China Institute of Urban Environment Chinese Academy of SciencesXiamen 361021People’s Republic of China

Metal-free carbon,as the most representative heterogeneous metal-free catalysts,have received considerable interests in electro-and thermo-catalytic reac-tions due to their impressive performance and sustainability.Over the past decade,well-designed carbon catalysts with tunable structures and heteroatom groups coupled with various characterization techniques have proposed numerous reaction mechanisms.However,active sites,key intermediate species,precise structure-activity relationships and dynamic evolution processes of carbon catalysts are still rife with controversies due to the monotony and limitation of used experimental methods.In this Review,we sum-marize the extensive efforts on model catalysts since the 2000s,particularly in the past decade,to overcome the influences of material and structure limitations in metal-free carbon catalysis.Using both nanomolecule model and bulk model,the real contribution of each alien species,defect and edge configuration to a series of fundamentally important reactions,such as thermocatalytic reactions,electrocatalytic reactions,were systematically studied.Combined with in situ techniques,isotope labeling and size control,the detailed reaction mechanisms,the precise 2D structure-activity relationships and the rate-determining steps were revealed at a molecular level.Furthermore,the outlook of model carbon catalysis has also been proposed in this work.

关键词： Metal-free carbon catalysts Model catalyst Electrocatalysis Active site Reaction mechanisms