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内体分选转运复合体:确保有丝分裂正确进行的分子机器

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中国医学科学院学报 2024年第2期46卷 287-292页

作者：高吴陆怡杨玉张鹏霞商宇佳木斯大学基础医学院微生态-免疫调节网络与相关疾病重点实验室黑龙江佳木斯154007

有丝分裂是真核细胞增殖的重要环节。内体分选转运复合体是与膜剪切过程密切相关的多蛋白复合体,其功能涉及内体成熟、病毒出芽、自噬等过程,其结构和功能异常与癌症等疾病发生发展密切相关。本文总结了内体分选转运复合体在细胞有丝分... 详细信息

有丝分裂是真核细胞增殖的重要环节。内体分选转运复合体是与膜剪切过程密切相关的多蛋白复合体,其功能涉及内体成熟、病毒出芽、自噬等过程,其结构和功能异常与癌症等疾病发生发展密切相关。本文总结了内体分选转运复合体在细胞有丝分裂不同阶段所发挥的作用,以及内体分选转运复合体调控有丝分裂作用在疾病方面的研究进展。

关键词：有丝分裂内体分选转运复合体纺锤体检查点癌症

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中药熏蒸技术联合中药塌渍法治疗急性附睾炎的临床疗效与观察

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中华男科学杂志 2024年第7期30卷 648-652页

作者：赵欣郁郁李傲梅商玮东部战区总医院中医科

目的:探究中药熏蒸技术联合中药塌渍法治疗急性附睾炎的临床疗效。方法:以2021年12月至2023年12月于我院就诊的急性附睾炎患者为研究对象，采用单盲法，按照随机数字法将入组患者随机分为试验组和对照组，两组患者各37例。两组均接受抗... 详细信息

目的:探究中药熏蒸技术联合中药塌渍法治疗急性附睾炎的临床疗效。方法:以2021年12月至2023年12月于我院就诊的急性附睾炎患者为研究对象，采用单盲法，按照随机数字法将入组患者随机分为试验组和对照组，两组患者各37例。两组均接受抗生素常规治疗，试验组在常规治疗的基础上采用中药熏蒸联合中药塌渍法进行治疗，对照组使用染色纯净水熏蒸加中药塌渍进行对照，比较两组的治疗效果。结果:治疗前，试验组和对照组患者疼痛评分分别为(6.85±1.25)分、(6.79±1.38)分；附睾最大直径分别为(1.59±0.42)cm、(1.61±0.39) cm,均无明显差异(P>0.05)。治疗后，两组患者在治疗第3天疼痛评分(4.45±1.87)分、(4.63±0.95)分，无明显差异(P>0.05),治疗第7天疼痛评分(1.02±0.36)分、(3.78±1.03)分，试验组较对照组疼痛评分更低、总体治疗有效率(91.89%)也较对照组(75.68%)明显升高，差异有统计学意义(P0.05)。结论:在常规治疗基础上，中药熏蒸联合中药塌渍大部分在治疗后7d即取得较好疗效，能够快速、有效缓解附睾炎患者疼痛，减轻局部肿胀，加速患者的康复，缩短治疗时间，值得在临床中推广应用。

关键词：附睾炎中药塌渍中药熏蒸疼痛

TANK结合激酶1在PINK1/Parkin依赖性和非依赖性线粒体自噬中的作用研究进展

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生理学报 2024年第1期76卷 161-172页

作者：邓豪夏志尚画雨成都体育学院运动医学与健康学院成都610041 温州大学体育与健康学院温州325035 井冈山大学体育学院吉安343009

线粒体自噬是一种清除受损或多余线粒体的过程,在调节细胞内线粒体质量和维持线粒体能量代谢等方面发挥重要作用。TANK结合激酶1(TANK-binding kinase 1,TBK1)是一种多功能的丝氨酸/苏氨酸蛋白激酶,同时参与调控PTEN诱导假定激酶1(PTEN-... 详细信息

线粒体自噬是一种清除受损或多余线粒体的过程,在调节细胞内线粒体质量和维持线粒体能量代谢等方面发挥重要作用。TANK结合激酶1(TANK-binding kinase 1,TBK1)是一种多功能的丝氨酸/苏氨酸蛋白激酶,同时参与调控PTEN诱导假定激酶1(PTEN-induced putative kinase 1,PINK1)/Parkin依赖性和非依赖性线粒体自噬过程。近期研究表明,TBK1可磷酸化视神经蛋白(optineurin,OPTN)、p62/sequestosome-1、Ras相关GTP结合蛋白7(Ras-related GTP binding protein 7,Rab7)等自噬相关蛋白,并介导核点蛋白52(nuclear dot protein 52,NDP52)与UNC-51样自噬激活激酶1(UNC-51 like autophagy activating kinase 1,ULK1)复合物相结合,以及TAX1结合蛋白1(TAX1-binding protein 1,TAX1BP1)与微管相关蛋白1轻链3(microtubule-associated protein 1 light chain 3,LC3)相结合,从而增强PINK1/Parkin依赖性线粒体自噬。TBK1亦可作为AMP活化蛋白激酶(AMP-activatedproteinkinase,AMPK)/ULK1自噬通路的作用底物而被激活,再通过磷酸化动力相关蛋白1(dynamin-related protein 1,Drp1)、Rab7促进PINK1/Parkin非依赖性线粒体自噬。本文对TBK1在PINK1/Parkin依赖性和非依赖性线粒体自噬中的作用及机制进行了综述。

关键词：线粒体线粒体自噬 TANK结合激酶1 PTEN诱导假定激酶1 Parkin

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Precise capture of circulating endometrial cells in endometriosis

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中华医学杂志(英文版) 2024年第14期137卷 2024 Apr 29页

作者： Wang shang Cheng Hongyan Zhu Honglan yu Xiaoming Ye Xue Chang Xiaohong Department of Obstetrics and Gynecology Peking University People’s Hospital Beijing China Reproductive Medicine Center Peking University People’s Hospital Beijing China

Background: Endometriosis (EM) is a complex benign gynecological disease, but it has malignant biological behavior and can invade any part of the body. Clinical manifestations include pelvic pain, dysmenorrhea, infertility, pelvic nodules, and masses. Our previous study successfully detected circulating endometrial cells (CECs) in the peripheral blood of patients with EM. The purpose of this study is to overcome the limitation of cell size in the previous microfluidic chip method, to further accurately capture CECs, understand the characteristics of these cells, and explore the relationship between CECs and the clinical course characteristics of patients with ***: Human peripheral venous blood used to detect CECs and circulating vascular endothelial cells (CVECs) was taken from EM patients (n = 34) hospitalized in the Peking University People’s Hospital. We used the subtraction enrichment and immunostaining fluorescencein situ hybridization (SE-iFISH) method to exclude the interference of red blood cells, white blood cells, and CVECs, so as to accurately capture the CECs in the peripheral blood of patients with EM. Then we clarified the size and ploidy number of chromosome 8 of CECs, and a second grouping of patients was performed based on clinical characteristics to determine the relationship between CECs and clinical course ***: The peripheral blood of 34 EM patients and 12 non-EM patients was evaluated by SE-iFISH. Overall, 34 eligible EM patients were enrolled. The results showed that the detection rates of CECs were 58.8% in EM patients and 16.7% in the control group. However, after classification according to clinical characteristics, more CECs could be detected in the peripheral blood of patients with rapidly progressive EM, with a detection rate of 94.4% (17/18). In total, 63.5% (40/63) of these cells were small cells with diameters below 5 μm, and 44.4% (28/63) were aneuploid cells. No significant association was found between the

关键词： Endometriosis Circulating endometrial cells Clinical symptoms Dysmenorrhea Circulating vascular endothelial cells

Geochemical characteristics and exploration significance of ultra-deep Sinian oil and gas from Well Tashen 5,Tarim Basin,NW China

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Energy Geoscience 2024年第1期5卷 24-36页

作者： Zicheng Cao Anlai Ma Qinqi Xu Quanyong Pan Kai shang Fan Feng Yongli Liu Northwest Petroleum Oilfield Company SINOPECUrumqi830011China Petroleum Exploration and Production Research Institute SINOPEC102260BeijingChina

The Well Tashen 5(TS5),drilled and completed at a vertical depth of 9017 m in the Tabei Uplift of the Tarim Basin,NW China,is the deepest well in *** has been producing both oil and gas from the Sinian at a depth of 8780e8840 m,also the deepest in Asia in terms of oil *** this paper,the geochemical characteristics of Sinian oil and gas from the well were investigated and compared with those of Cambrian oil and gas discovered in the same *** oil samples,with Pr/Ph ratio of 0.78 and a whole oil carbon isotopic value of31.6‰,have geochemical characteristics similar to those of Ordovician oils from the No.1 fault in the North Shuntuoguole area(also named Shunbei area)and the Middle Cambrian oil from wells Zhongshen 1(ZS1)and Zhongshen 5(ZS5)of Tazhong *** maturity of light hydrocarbons,diamondoids and aromatic fractions all suggest an approximate maturity of 1.5%e1.7%Ro for the ***(4-+3-)methyldiamantane concentration of the samples is 113.5 mg/g,indicating intense cracking with a cracking degree of about 80%,which is consistent with the high bottom hole temperature(179℃).The Sinian gas samples are dry with a dryness coefficient of *** gas is a mixture of kerogen-cracking gas and oil-cracking gas and has Ro values ranging between 1.5%and 1.7%,and methane carbon isotopic values of41.6‰.Based on the equivalent vitrinite reflectance(R_(eqv)=1.51%e1.61%)and the thermal evolution of source rocks from the Cambrian yu'ertusi Formation of the same well,it is proposed that the Sinian oil and gas be mainly sourced from the Cambrian yu'ertusi Formation during the Himalayan period but probably also be joined by hydrocarbon of higher maturity that migrated from other source rocks in deeper *** discovery of Sinian oil and gas from Well TS5 suggests that the ancient ultra-deep strata in the northern Tarim Basin have the potential for finding volatile oil or condensate reservoirs.

关键词： Ultra-deep Sinian oil and gas Oil-cracking Well Tashen 5 Tarim Basin

基于现行规范的型钢混凝土柱侧力-位移曲线预测方法研究

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建筑钢结构进展 2024年第7期26卷 51-59页

作者：尚崇新薛亦聪杨勇于云龙西安建筑科技大学土木工程学院西安710055 东南大学混凝土及预应力混凝土结构教育部重点实验室南京210096

型钢混凝土(steel reinforced concrete,SRC)柱因承载力高、刚度大和耐久性能好等优点而被广泛应用于高层结构中。然而,现阶段SRC结构设计普遍基于承载力设计法,基于性能的抗震设计法在SRC结构方面的应用仍待完善。作为基于性能(位移)... 详细信息

型钢混凝土(steel reinforced concrete,SRC)柱因承载力高、刚度大和耐久性能好等优点而被广泛应用于高层结构中。然而,现阶段SRC结构设计普遍基于承载力设计法,基于性能的抗震设计法在SRC结构方面的应用仍待完善。作为基于性能(位移)的抗震设计方法中最重要的一环,现阶段SRC构件的侧力-位移关系评估缺乏规范指导。基于美国现行规范ASCE/SEI 41-17中针对钢筋混凝土构件的相关规定,结合SRC构件的受力与变形特征,提出了发生弯曲破坏的SRC柱在地震作用下的侧力-位移曲线建模方法。该曲线采用约束混凝土强度计算SRC构件的峰值承载力;使用刚度折减法考虑型钢与混凝土之间的黏结滑移;基于SRC构件的变形特征考虑了纵向受力钢材端部滑移对柱顶侧移的贡献。最后,通过与28根SRC柱试验结果的比较证明了曲线的适用性。计算结果表明:所提出的曲线能合理预测发生弯曲破坏的SRC柱的开裂荷载、开裂位移、峰值荷载、峰值位移和强度退化,可为SRC结构的性能化抗震设计提供参考。

关键词：型钢混凝土柱抗震性能基于性能的抗震设计侧力-位移曲线

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Teaching Research and Effect Observation on the Integration of Clinical Medicine Integrated Course and Ideological and Political Elements from the Perspective of“Sanquan Education”

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Journal of Contemporary Educational Research 2024年第4期8卷 270-275页

作者： Wensi Liu Chunyan Zhao Xiangying Kong Zhiwu Ji Cuicui yu Fuxiang Song Jincai shang Jiamusi University Jiamusi 154002Heilongjiang ProvinceChina

Purpose:To analyze the application path of the integration of clinical medicine integrated courses with the elements of ideology and politics under the theory of“Sanquan Education,”and to provide references for the promotion of educational reform in medical ***:60 clinical medicine undergraduates at Jiamusi University in 2018 and 2019 were randomly selected as research *** the basis of the analysis of students’characteristics and pre-study content,the students were divided into the integration group and the traditional group,each with 30 *** in the integration group carried out clinical medicine integrated class with the integration of ideological and political *** in the traditional group carried out the traditional clinical medicine integrated *** evaluation scales,anonymous questionnaires,and interviews were used to conduct research,collect data,and compare and observe the application ***:After carrying out different modes of clinical medicine integrated courses,the undergraduates of the Excellent Physician Class in the integration group were higher than those in the traditional group in terms of teaching satisfaction,comprehensive quality,basic knowledge test,and case analysis scores through questionnaire analysis(P<0.05).In the evaluation of the effect of ideological education,the undergraduates of the Excellent Physician Class of the integration group were higher than the traditional group in terms of the acceptance of doctor-patient communication,the correct rate of mastering the history of the discipline,and the correct rate of mastering the frontiers and policies(P<0.05).Conclusion:Through the integration of clinical medicine integrated course and ideological and political elements,we can help students establish correct values while teaching them professional knowledge,improve the implementation of moral education in medical schools,cultivate excellent medical workers with high morality

关键词： Sanquan Education Clinical medicine integrated course Ideological and political elements Teaching

基于ELM的超声多特征融合螺栓应力测量方法

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仪器仪表学报 2024年第4期45卷 46-56页

作者：陈平商秋仙余鑫尹爱军重庆大学机械与运载工程学院重庆400044

针对传统超声波螺栓应力测量中存在的非线性和不适定性问题,提出一种基于极限学习机(ELM)的超声多特征融合螺栓应力测量方法。首先基于声弹性理论和散射理论,根据超声回波信号提取声时差及瑞利散射范围内多晶体材料中纵波的衰减系数等... 详细信息

针对传统超声波螺栓应力测量中存在的非线性和不适定性问题,提出一种基于极限学习机(ELM)的超声多特征融合螺栓应力测量方法。首先基于声弹性理论和散射理论,根据超声回波信号提取声时差及瑞利散射范围内多晶体材料中纵波的衰减系数等超声波特征参数。然后通过向量降维选择声时差、衰减系数和有效受力长度作为模型输入特征向量,建立了基于ELM的超声多特征融合螺栓应力测量模型。搭建螺栓轴向应力超声波测量实验平台,对不同材料和规格的螺栓进行螺栓应力的测量,并对比了使用传统的超声测量方法的测量结果,验证了传统超声检测方法的局限性。对比了ELM与其他机器学习方法包括BP、支持向量回归(SVR)的测量结果和精度。结果表明,提出的方法有效克服了传统超声测量方法的不足,能实现不同材料不同规格的螺栓应力测量,并且测量精度更高(平均相对误差为3.86%),泛化能力更好。

关键词：螺栓应力超声波测量向量降维 ELM 多特征融合

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Simple bone cysts of the proximal humerus presented with limb length discrepancy:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1130-1137页

作者： Cing Syue Lin shang Ming Lin Syang-Peng Rwei Chin-Wen Chen Tsung-yu Lan Department of Orthopedic Surgery Far Eastern Memorial HospitalNew Taipei City 220Taiwan Department of Materials and Textiles Asia Eastern University of Science and TechnologyNew Taipei City 220Taiwan Institute of Organic and Polymeric Materials National Taipei University of TechnologyTaipei City 10608Taiwan

BACKGROUND Simple bone cysts(SBC)are benign tumor-like bone lesions typically identified in *** SBC may lead to growth disturbances or growth arrest,such cases are *** mechanisms behind these observations remain ***,research on the etiology of SBC remains inconclusive,and there has been no consensus on the appropriate timing and methodology for *** SUMMARY Here,we present our experience in the successful surgical management of a 10-year-old girl with SBC,who presented with a pathological fracture complicated by malunion of the displaced fracture,varus deformity,and limb length *** hypothesized two possible etiologies for the patient’s growth arrest and subsequent humerus varus deformity:(1)Direct disruption of the physis by fluid from the cyst itself;and(2)damage to the epiphysis due to repetitive pathological fractures associated with *** addressing this case,surgical intervention was undertaken to correct the proximal humerus varus *** approach offered the advantages of simultaneously correcting angular abnormalities,achieving mild limb lengthening,providing definitive SBC treatment,and reducing the overall treatment *** As per current literature,acute correction of acute angular deformity in proximal humeral SBC is not well ***,in this specific case,acute correction was considered an optimal solution.

关键词： Bone cyst Solitary cysts Benign Humerus Growth arrest Limb length discrepancy Case report