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Laparoscopic treatment of a calcium fluorophosphate stone within a seminal vesicle cyst

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Asian Journal of Andrology 2008年第2期10卷 337-340页

作者： Ping Han yu-ru yang Xin-yuan Zhang Qiang Wei Department of Urology West China Hospital Analytical and Testing Center Sichuan University Chengdu 610044 China

Stones in the seminal vesicles are extremely rare. We present a 62-year-old patient with a stone within a seminal vesicle cyst, who was cured by laparoscopic treatment. The operative time was 80 rnin, and the estimated blood loss was 90 mL. Scanning electron microscope examination of the stone showed a compact crystal image externally and sparse spherical crystal structure in kernel. Composition of the stone was calcium fluorophosphate on X-ray diffractometer. The follow-up time was 15 months with no recurrence of cyst or stone. To our knowledge, this case is the first to describe laparoscopic removal of a stone within a seminal vesicle cyst, and the first to describe calcium fluorophosphate as the composition of seminal vesicle stones. （Asian JAndro12008 Mar; 10： 337-340）

关键词： calcium phosphates calculi fluoride laparoscopy seminal vesicles sex organs, accessory, male water pollutants, chemical

Risk factors for prostatic inflammation extent and infection in benign prostatic hyperplasia

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Asian Journal of Andrology 2006年第5期8卷 621-627页

作者： Fa-Xian Yi Qiang Wei Hong Li Xiang Li Ming Shi Qiang Dong yu-ru yang Department of Urology West China Hospital West China Medical School Sichuan University Chengdu Sichuan 610041 China

Aim： To investigate the risk factors for prostatic inflammation extent and infection in patients with benign prostatic hyperplasia （BPH） so as to manage prostatic inflammation more efficiently. Methods： Sixty patients with BPH undergoing TURP between September 2005 and December 2005 in West China Hospital of Sichuan University were studied. Prostate fluid （PF） was collected for the measurement of secretory IgA （SIgA） and complement 3 （C3）. Prostate tissue were collected for testing bacterial 16S rDNA by real-time PCR, examining SIgA in the tissue and examining the inflammation. The possible clinical and immune risk factors for prostatic inflammation or infection were analyzed by using the logistic regression method. Results： Abnormal white blood cell count in urinalysis, prostatic infection and a high concentration of C3 in PF are the risk factors for prostatic inflammation extent （P = 0.025, 0.034 and 0.035, respectively and odds ratio [OR] = 18.269, 8.284 and 1.508, respectively）. Risk factors for prostatic infection include the C3 concentration and the concentration of SIgA in PF （P = 0.003 and 0.013, respectively, and OR=1.645 and 0.993, respectively）. Conclusion： The present study suggests that prostatic inflammation is associated with urinary tract infection, prostatic infection and the activated complement and that prostatic infection is associated with the activated complement and downregulated mucosal immunity in prostates of the patients with BPH. It is also suggested that individual immune regulation should be considered in the treatment of prostatic inflammation and infection of patients with BPH.

关键词： inflammation infection logistic regression benign prostatic hyperplasia prostate

Efficacy of maximal androgen blockade versus castration alone in the treatment of advanced prostate cancer： a retrospective clinical experience from a Chinese medical centre

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Asian Journal of Andrology 2010年第5期12卷 718-727页

作者： Xue-Qin Chen Ying Huang Xiang Li Peng Zhang rui Huang Juan Xia Ni Chen Qiang Wei yu-Chun Zhu yu-ru yang Hao Zeng Laboratory and Department of Pathology West China Hospital Sichuan University Chengdu 610041 China Department of Urology West China Hospital Sichuan University Chengdu 610041 China Department of Nuclear Medicine West China Hospital Sichuan University Chengdu 610041 China

In this retrospective study, we evaluated and compared the efficacy and toxicities of maximal androgen blockade （MAB） versus castration alone in Chinese patients with advanced prostate cancer. From 1996 to 2004, 608 patients with advanced prostate cancer were included in the study. Patients were retrospectively divided into two groups according to different therapeutic regimens. Of the 608 patients, 300 patients were treated with MAB （castration plus nonsteroidal antiandrogens） and the remaining 308 were treated with castration alone. The 2- and 5-year overall survival rates of these patients were 73.7% and 56%, respectively. Multivariate analysis showed that, in patients with metastatic prostate cancer, MAB was associated with not only the improvement of progression-free survival （PFS）（increased by 10 months） but also a 20.6% reduction in mortality risk compared with castration alone. In contrast, the efficacy of MAB was not superior to castration alone for patients with nonmetastatic prostate cancer. Interestingly, among patients with MAB, those using bicalutamide had a longer PFS than those using flutamide; this was especially so in patients with metastatic prostate cancer. Almost all of the toxicities due to the hormone therapy were mild to moderate and manageable. To conclude, in China, hormone therapies, including MAB and castration alone, have been standard treatments for advanced prostate cancer. For patients with nonmetastatic prostate cancer, castration alone might be adequately practical and efficient. In patients with metastatic prostate cancer, however, MAB has superior efficacy over castration alone. It is clear that MAB should be considered the first-line standard treatment for patients with metastatic prostate cancer.

关键词： bicalutamide castration alone maximal androgen blockade prostate cancer

Effects of varicocele on testosterone, apoptosis and expression of StAR mRNA in rat Leydig cells

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Asian Journal of Andrology 2011年第2期13卷 287-291页

作者： De-Yi Luo Gang yang Jian-Jun Liu yu-ru yang Qiang Dong Department of Urology West China Hospital Sichuan University Chengdu 610041 China Department of Pediatric Surgery West China Hospital Sichuan University Chengdo 610041 China Department of Urology People＇s Hospital Henan 450003 China

The aim of this study was to explore the effects of varicocele on the morphology and function of Leydig cells in the rat testis. Forty male Sprague-Dawley rats were divided into two groups： the experimental group underwent surgery to create a left varicocele （VC）, and the control group underwent a sham operation. Serum testosterone and intratesticular testosterone levels were measured using a radioimmunoassay after 4 and 8 weeks of operation. Leydig cells were studied for apoptosis and expression of steroidogenetic acute regulatory （STAR） protein mRNA levels. Serum testosterone levels declined after 4 and 8 weeks of operation but were not significant （P〉0.05）. However, the intratesticular testosterone levels after 8 weeks were significantly decreased compared with the control group （P〈0.01）. The mean apoptosis index of Leydig cells in the experimental group was significantly higher than that in the control group after 4 or 8 weeks （P〈0.01）. StAR mRNA levels in the Leydig cells of the experimental group were significantly lower compared to those of the control group （P〈0.01）. Our data show that varicocele did impair Leydig cell function by increasing apoptosis and suppressing the expression of the StAR protein.

关键词： apoptosis Leydig cell steroidogenic acute regulatory protein testosterone varicocele

The correlation between molecular structure parameters of O-ethyl N-isopropyl phosphoro(thioureido)thioates and their retention data in RP-HPLC

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Chinese Journal of Chemistry 1993年第1期11卷 76-80页

作者： WANG,Qin-Sun GAO,ru-yu yang,Hua-Zheng YAN,Bing-Wen National Laboratory.of Elemento-Organic Chemistry,Nankai University,Tianjin 300071 National Laboratory of Elemento‐Organic Chemistry Namkai University Tianjin 300071

A retention prediction system(RPS)of seven O-ethyl N-isopropyl phosphoro(thioureido)- thioates in reversed phase HPLC was *** system is based on the solvent selectivity triangle *** molecular structure parameters(hydrophobicity Ⅱ,substituent length L, and substituent maximum width B_5)were used to describe the quantitative structure-retention relation- *** these quantitative relationships,the retention behaviours of other eight homologs for different mobile phase composition were *** predicted values were consistent with the measured values within relative error of 10%,which means that it is possible to apply the reported method to predict retention values for qualitative purposes for different mobile phase compositions.

关键词： The correlation between molecular structure parameters of O-ethyl N-isopropyl phosphoro thioureido)thioates and their retention data in RP-HPLC data

"Source-Diagenesis-Accumulation" enrichment and accumulation regularity of marine shale gas in southern China

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China Geology 2018年第3期1卷 319-330页

作者： Gang-yi Zhai yu-fang Wang Zhi Zhou Guo-heng Liu yu-ru yang Juan Li Oil and Gas Survey China Geological SurveyBeijing 100029China Unconventional oil and gas geology laboratory China Geological SurveyBeijing 100029China

After the breakthrough of shale gas exploration and development in the Ordovician Wufeng Formation (Fm.) and Silurian Longmaxi Fm. of Chongqing Jiaoshiba area,Changning-Weiyuan area,etc. in Sichuan basin,a series of discovery and breakthrough were obtained by China Geological Survey in the Cambrian Niutitang Fm. and Sinian Doushantuo Fm. shale of the areas with complicated structure outside Sichuan basin. Based on the understanding of the law of shale gas enrichment in Longmaxi Fm. in the basin,this paper puts forward three elements of the formation and enrichment of shale gas,which are the “Source”,the “Diagenesis ” and the “Accumulation ”,after deeply studying the law shale gas enrichment and accumulation in Sinian-Cambrian reservoir of the complex structure area outside the basin. The “Source”means the sedimentary environment and petrological characteristics of organic *** “Diagenesis ”means the basin tectonic subsidence and hydrocarbon generation and expulsion process of organic *** “Accumulation” means the tectonic uplift and shale gas preservation. It is proposed that the Sinian-Cambrian and Ordovician-Silurian black shale series in the middle and upper yangtze region of southern China were both formed in the deep-water shelf environment of rift trough and foreland basin *** dessert intervals were formed in the strong reduction environment under transgressive system *** shale lithology belongs to calcium-siliceous and charcoal-siliceous respectively. Based on the summary of structural evolution in yangtze area,the correlation of structural burial depth with shale diagenesis and the coupling evolution of organic matter with pore structure are discussed. Combining with structural styles,the preservation conditions of shale gas are discussed. Five types of shale gas reservoir control models are further described. Two types of future exploration directions,which are reverse fault syncline and paleo-uplift margin in complex structura

关键词： Shale gas Exploration and development Enrichment and accumulation Reservoir controlling models Exploration direction

A review and research on comprehensive characterization of microscopic shale gas reservoir space

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China Geology 2019年第4期2卷 541-556页

作者： yu-ru yang Xiao-chen Liu Hui Zhang Gang-yi Zhai Jiao-dong Zhang Zhi-fang Hu Shu-jing Bao Cong Zhang Xiang-hua Wang Xiao yang Zheng-zhuang Liu Ting Xie Juan Chen Liyu Fang Li-juan Qin Oil and Gas Survey China Geological SurveyBeijing 100083China Unconventional Petroleum Geology Laboratory of Oil and Gas Survey Ministry of Natural ResourcesChina Geological SurveyBeijing 100094China SGS-CSTC Standards Technical Services Co. Ltd.Beijing 100176China School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China

In this paper,substantial domestic and foreign research results of microscopic shale reservoir space were systemically reviewed,the research history consisting of simple observation and qualitative classification,quantitative research,the combination of qualitative and quantitative research successively as well as the characteristics of each research stage were *** addition,the current problems existing in the characterization methods of shale reservoir space were also ***,based on massive actual detection of typical core samples obtained from more than 50 global shale gas wells and relevant practical experience,a comprehensive characterization method of combining qualitative with the semiquantitative characterization was put *** detail,the indicators of the qualitative characterization include pore combination type and organic-matter microscopic morphology type,while the core elements of the semi-quantitative characterization include the percentage of the organic-matter area and the plane porosity of the pores of different *** on the reference of the naming and classification of rocks,the three-end-member diagram method was used to characterize microscopic shale reservoir *** is achieved by plotting the three end-member diagram of 3 kinds of first-order critical reservoir spaces,i.e.,organic-matter pores,matrix pores,and micro-fractures,in order to intuitively present the features of the microscopic pore ***,statistic histograms of organic-matter microscopic morphology type and the plane porosity of different types of pores were adopted to characterize the development degree of second-order pores *** this comprehensive characterization method,the importance of both pore combination and the microscopic morphology of organic matter were emphasized,revealing the control of organic-matter microscopic morphology over the organic-matter *** is more,high-resolution FE-SEM was adopted t

关键词： Shale Shale gas Reservoir space Research status Types of pore combinations Oil-gas exploration engineering Longmaxi Formation Niutitang Formation Shahejie Formation Yanchang Formation China USA

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia yang Qian-ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

基于用户行为的扫地机器人APP体验优化方法研究

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包装工程 2022年第2期43卷 90-97页

作者：于入洋王江涛何人可马超民湖南大学长沙410082

目的通过对家用情境下用户使用扫地机器人的行为分析获取用户各项需求被满足情况,从而有针对性地制定扫地机器人交互体验优化策略,提升用户交互体验。方法首先,基于桌面研究、清洁行为观察分析等方法得到家用扫地机器人APP现有功能与用... 详细信息

目的通过对家用情境下用户使用扫地机器人的行为分析获取用户各项需求被满足情况,从而有针对性地制定扫地机器人交互体验优化策略,提升用户交互体验。方法首先,基于桌面研究、清洁行为观察分析等方法得到家用扫地机器人APP现有功能与用户潜在需求功能,通过KANO模型对功能集进行优先层级排序;然后,对现有功能中优先级较高的进行可用性水平测试,并针对可用性不足的功能进行情境下交互行为分析,挖掘扫地机器人APP现有功能中影响交互体验的具体问题。从而形成交互体验优化策略并通过设计实践案例进行有效性验证。结果优化后的扫地机器人APP可用性因子有不同程度的提高,证明了方法的有效性。结论该方法可以帮助开发者科学、高效、准确地选择产品功能优化对象,并系统地获取用户在与扫地机器人交互中的不足,辅助扫地机器人交互迭代设计,提升用户体验。

关键词：行为分析扫地机器人交互体验需求分析可用性量化