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Method for Estimating the State of Health of Lithium-ion Batteries Based on Differential Thermal Voltammetry and Sparrow Search Algorithm-Elman Neural Network

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Energy Engineering 2025年第1期122卷 203-220页

作者： yu zhang Daoyu zhang TiezhouWu School of Electrical and Electronic Engineering Hubei University of TechnologyWuhan430068China

Precisely estimating the state of health(SOH)of lithium-ion batteries is essential for battery management systems(BMS),as it plays a key role in ensuring the safe and reliable operation of battery ***,current SOH estimation methods often overlook the valuable temperature information that can effectively characterize battery aging during capacity ***,the Elman neural network,which is commonly employed for SOH estimation,exhibits several drawbacks,including slow training speed,a tendency to become trapped in local minima,and the initialization of weights and thresholds using pseudo-random numbers,leading to unstable model *** address these issues,this study addresses the challenge of precise and effective SOH detection by proposing a method for estimating the SOH of lithium-ion batteries based on differential thermal voltammetry(DTV)and an SSA-Elman neural ***,two health features(HFs)considering temperature factors and battery voltage are extracted fromthe differential thermal voltammetry curves and incremental capacity ***,the Sparrow Search Algorithm(SSA)is employed to optimize the initial weights and thresholds of the Elman neural network,forming the SSA-Elman neural network *** validate the performance,various neural networks,including the proposed SSA-Elman network,are tested using the Oxford battery aging *** experimental results demonstrate that the method developed in this study achieves superior accuracy and robustness,with a mean absolute error(MAE)of less than 0.9%and a rootmean square error(RMSE)below 1.4%.

关键词： Lithium-ion battery state of health differential thermal voltammetry Sparrow Search Algorithm

Targeting A-type K+ channels in primary sensory neurons for bone cancer pain in a rat model

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Targeting A-type K+ channels in primary sensory neurons for ...

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Kai-Zheng DUAN~(1,*),Qian XU~(1,*),Xiao-Meng zhang~1,Zhi-Qi ZHAO~1,Yan-Ai MEI~2,yu-qiu zhang~(1,*) 1 Institute of Neurobiology,2 School of Life Sciences,Institutes of Brain Science and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032,China

The treatment of bone cancer pain remains a clinically challenging ***,we report that A-type K channels in primary sensory neurons are involved in the neuropathy of rat bone cancer pain and are a new target for diclofenac,a non-steroidal anti-inflammatory drug that can be used for therapy for this distinct *** injection of diclofenac dose-dependently attenuated bone cancer-induced spontaneous pain,mechanical allodynia and thermal hyperalgesia,all of which were reversed or prevented by administration of the A-type K channel blockers 4-AP or pandinotoxin-Kαor with siRNA targeted against Kv1.4 or ***,diclofenac significantly inhibited action potential firing and rapidly increased A-type K currents in IB4-positive small dorsal root ganglion (DRG) neurons in both normal and bone cancer ***,in bone cancer rats the A-type K currents were significantly increased on post-tumor day 14(PTD 14);they then faded,but they still remained at a higher level on PTD ***,the expression levels of the A-type K channels Kvl.4,Kv3.4,and Kv4.3 showed timedependent changes during bone cancer *** diclofenac administration not only decreased soft tissue swelling adjacent to the tumor but also attenuated bone *** results indicate that A-type K channel modulators may provide a novel mechanism-based therapeutic strategy for bone cancer pain.

关键词： A-type K+ currents bone cancer pain diclofenac dorsal root ganglion rat

Disrupting P2X7 receptors inhibited induction of long-term potentiation of C-fiber-evoked field potentials and Fos expression in spinal dorsal horn

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Disrupting P2X7 receptors inhibited induction of long-term p...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： yu-Xia CHU~(1,2),Ning LU~1,yu-qiu zhang~(1),Zhi-Qi ZHAO~(1,*) 1 Institute of Neurobiology,Institutes of Brain Science and State Key Laboratory of Medical Neurobiology,Fudan University,Shanghai 200032,China 2 College of Medicine,Jiaxing University,Jiaxing,314001,China

＜正＞Objective It has been shown that tetanically sciatic stimulation induces long-term potentiation（LTP） of C-fiberevoked field potentials in the spinal dorsal horn,which may be the substrate of inflammation- or nerve injury-produced central *** previous study showed that spinal glia was involved in the induction of *** that purinergic P2X7 receptor（P2X7R）is expressed by glia,the present study was to investigate the effects of P2X7R on tetanic stimulation-induced LTP and Fos expression in the dorsal horn of spinal *** The extracellular recording was performed on adult SD rats.C-fiber-evoked field potentials were induced by tetanic stimulation of the sciatic nerve（0.5 ms, 100 Hz,40V,10 trains of 2-s duration at 10-s intervals ）.The tetanic stimulation-induced expression of Fos and the distribution of P2X7R was identified by immunohistochemistry ***（1） Unilaterally tetanic stimuli elicited LTP of C-fiber-evoked field potentials.（2）The induction of spinal LTP was blocked by intrathecal（i.t.） administration of a specific antagonist of P2X7R Brilliant Blue G（20μM/10μl,i.t.） and a less specific oxidized ATP（300μM/10μl,i.t.） 0.5h prior to tetanic stimulation.（3）Intrathecal administration of Brilliant Blue G（20μM/10μl,i.t.） suppressed tetanic stimulation-induced spinal Fos expression.（4） Double immunofluorescence showed co-localization of P2X7R with OX42（microglia marker） and GFAP（astrocyte marker）,but not with NeuN（neuronal marker）.Conclusion Disruption of glial P2X7R may be associated with the inhibition of plastic change in spinal nociceptive *** of glial P2X7R may play an important role in the induction of tetanically sciatic stimulation-induced LTP.

关键词： LTP P2X7 spinal dorsal horn glial cells Fos

SIP30 in the anterior cingulated cortex contributes to the induction of pain-related negative affect in rat

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SIP30 in the anterior cingulated cortex contributes to the i...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Mei HAN~1 Yan zhang~1 Ru-Yi HUANG~2 Zhi-Qi ZHAO~1 yu-qiu zhang~(1 *) 1 Institutes of Neurobiology Institutes of Brain Science and State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032 China 2 Department of Life Science Fudan University Shanghai 200433 China

＜正＞Objective SNARE complex,including SNAβ-25,syntaxin and VAMP,plays an important role in presynaptic neurotransmitter ***β25 interacting protein of 30kD（SIP30）that was first identified in the cochlear hair cells of guinea pig organ of Corti is expressed in many organs but is most abundant in ***,its functional significance remains *** evidence demonstrates that the anterior cingulated cortex（ACC） is implicated in the affective response to noxious *** present study is to investigate whether SEP30 in the ACC play roles in pain-related negative affect in rat and its possible *** The localization of SEP30 was detected by *** chronic constriction injury（CCI） of sciatic nerve was used for neuropathic pain *** escape/avoidance paradigm （PEAβ） test was used to reflect the pain-related negative *** neural processing relating learning and memory was tested by conditioned place avoidance（CPA） induced by electric foot-shock or *** behavioral pain hypersensitivities were measured by Von Frey test for mechanical allodynia and Hargreves’test for thermal ***-ACC microinjection of SIP30 small interfering（siRNA） by letivirus as vector was used for knockdown the expression of SIP30. The efficiency of SIP30 knockdown in the ACC was tested by Western Blot and ***（1） SIP30 especially expressed on neuron not astrocyte or microglia in the rACC.（2） In the PEAβtest,the percentage of time spent in the light side of the chamber in the CCI group was much higher than that of sham group,which means PEA has occurred. （3） Compared with sham CCI group,SIP30 significantly upregulated in the rACC after PEAβtest in CCI group.（4） SIP30 knockdown in the rACC had no effect on CCI-induced pain hypersensitivities and innocuous stimuli-induced CPA.（5） Following SIP30 siRNA microinjected into the rACC,place escape/avoidance behavior to a noxious mechanical stimuli was attenua

关键词： SIP30 pain-related negative affect rACC rat

Constructing Pr-doped CoOOH catalytic sites for efficient electrooxidation of 5-hydroxymethylfurfural

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Journal of Energy Chemistry 2025年第1期100卷 234-244页

作者： Botao Fan Hao zhang Bang Gu Feng qiu qiue Cao Wenhao Fang School of Chemical Science and Technology Yunnan University National Center for International Research on Photoelectric and Energy Materials School of Materials and Energy Yunnan University

Electrocatalytic conversion of renewable biomass is emerging as a promising route for sustainable chemical production;hence it urgently calls for developing efficient electrocatalysts with low potentials and high current ***,a Pr-doped Co（OH）2hexagonal sheet （Pr/Co=1/9,in mole） is synthesized by electrodeposition as highly performant catalyst for 5-hydroxymethylfurfural （HMF） oxidation reaction（HMFOR） to produce 2,5-furandicarboxylic acid （FDCA）.This novel and low-cost catalyst possesses a rather low onset potential of 1.05 V （***） and requires only 1.10 V （***） to reach a current density of 10 mA cm-2for HMFOR,significantly outperforming Co（OH）2benchmark (i.e.,210 mV higher to reach10 m A cm-2).The origin of Pr promotion effect as well as the evolution of CoOOH catalytic sites and HMFOR process has been deeply elucidated by physical characterizations,kinetic experiments,in situ electrochemical techniques,and theoretical *** unique Pr-ameliorated CoOOH active centers enable 100%conversion of HMF,99.6%selectivity of FDCA,and 99.7%Faraday efficiency,with a superior cycling durability toward *** can be one of the most outstanding results for Co-based HMFOR catalysts to date in the *** this work can help open up new horizons for constructing novel and efficient Co-based electrocatalysts by the utilization of lanthanide elements.

关键词： Bioconversion

Activation of p38/MAPK in the anterior cingulate cortex contributes to pain-related negative emotion in rats

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Activation of p38/MAPK in the anterior cingulate cortex cont...

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Hong CAO~(1,2),Gen-Cheng WU~2,Zhi-Qi ZHAO~1,yu-qiu zhang~(1) 1 Institute of Neurobiology 2 Department of Integrative Medicine and Neurobiology,Institutes of Brain Research and State Key Laboratory of Medical Neurobiology Shanghai Medical College,Fudan University,Shanghai 200032,China

＜正＞Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, including a sensory-discriminative and an emotional-affective *** evidence from morphological, electrophysiological,neuroimaging,and behavioral studies as well as early clinical observation indicates that the anterior cingulate cortex（ACC） is involved in pain-related ***,little is known about the molecular and cellular mechanisms underlying pain-related aversion in *** previous studies showed that NMDAR-dependent ERK signaling cascade in rat ACC contributes to pain *** the present study we observed the role of p38,another member of MAP（mitogen-activated protein） kinase family,in ACC in pain-related negative emotion using Western Blot and behavioral ***-plantar injection of 5%formalin produced a robust increase in phosphorylated MKK3/6（pMKK3/6）,upstream of p38/MAPK,and phosphorylated p38（p-p38） in the bilateral rostral ACC（rACC）.Using formalin-induced conditioned place avoidance（F-CPA） in rats,which is believed to reflect the pain-related negative emotion,we found that blockade of p38/MAPK activation in the rACC with p38 inhibitor SB203580（0.1μg,1μg per side） but not low dose（0.01μg per side）,or another kind of p38 inhibitor SB239063（0.1μg,1μg per side） dose-dependently prevented the induction of ***,these blockades affected neither formalin-induced two-phase spontaneous pain nor low-intensity electric foot shock-induced CPA *** together,these results indicate that activation of p38/MAPK contributes to pain-related negative emotion,which will provide new molecule mechanisms underlying pain affect and bring new treatments for relieving emotional pain-related disturbance.

关键词： p38/MAPK formalin-induced conditioned place avoidance pain-related negative emotion anterior cingulate cortex rat

The MAPK pathway involves in the bone cancer pain

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The MAPK pathway involves in the bone cancer pain

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Ting-Ting LI~1,Chao BIAN~1,Zhi-Qi ZHAO~1,Ru-Rong JI~2,yu-qiu zhang~(1,*) 1 Institute of neurobiology,institutes of brain science and state key laboratory of medical neurobiology,Fudan University, shanghai 200032,China 2 Department of anesthesiology,Brigham and women''s hospital,Harvard medical school,Boston,Massachusetts 02115, USA

＜正＞Objective MAPKs are the evolutionally conserved molecules that play a critival role in intracellular signal transduction and consisit of extracellular signal-regulated protein kinase（ERK）,p38MAPK,c-Jun N-terminal kinase/ stress-activated protein kinase（JNK/SAPK）.It has been demonstrated that phosphorylated p38（p-p38） and phosphorylated extracellular signal-regulated kinasel/2（pERK1/2） are involved in inflammatory pain and neuropathic *** this study we futher investigate the role of two members of MAPKs in the cancer *** Walker256 mammary gland carcinoma cells were injected into the tibia medullary cavity to build a rat bone cancer pain *** method, behavioral test and histochemistry methods were used to test the development of bone cancer pain *** expression of p-p38 and pERK in the spinal dorsal horn of cancer pain model is tested by using immunohistochemistry and western blot ***（1） The significant bone destruction was observed on day 14 after the inoculation and the mechanical allodynia occurred in both hindpaws on day 8 and maintained to day 21 after inoculation.（2） p38 was activated mainly in neurons on the superficial of the spinal dorsal horn at 3 and 7 *** day 14,p-p38 was found in both neurons and microglia,but by day 21 predominantly in microglia.（3） ERK activation was found in neurons and microglia on the superficial of the spinal dorsal horn on day 3 after the ***,by 14 and 21 days after inoculation,all the neurons,astrocytes and microglia expressed pERK.（4） On day 14 after inoculation,the mechanical allodynia could be reduced by the administration of the inhibitors of p-p38 and pERK.（5） Microglia and astrocytes in the spinal dorsal horn were also activated on day 7 and lasted by day *** p-p38 and pERK as well as spinal glia cell activation are involved in bone cancer pain,and p-p38 and pERK may also play a role in spinal glia activation induced by cancer pain.

关键词： MAPK pathway spinal cord glia cells bone cancer pain

NMDAR-dependent AC-ERK-CREB signaling pathway in the anterior cingulate cortex contributes to pain-related negative emotion

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NMDAR-dependent AC-ERK-CREB signaling pathway in the anterio...

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Hong CAO~1,Yong-Jing GAO~1,Wen-Hua REN~1,Yihui CUI~2,Ting-Ling LI~1,Xiaohua CAO~2,Zhi-Qi ZHAO~1,Ru-Rong JI~1,yu-qiu zhang~(1) 1 Institute of Neurobiolgoy,Institutes of Brain Science,Fudan University,Shanghai,200032,China 2 Shanghai Institute of Brain Functional Genomics,The key laboratories of MOE and SSTC,East China Normal University, Shanghai,200062,China

＜正＞Pain is a multidimensional conscious experience including sensory and affective *** former has been extensively studied,while the latter is poorly *** evidence from morphological, electrophysiological,neuroimaging,and behavioral studies as well as clinical observations indicated that the anterior cingulated cortex（ACC） is a key structure that contributes to pain negative affect or *** of ERK （extracellular signal-regulated kinase）,a member of MAP（mitogen-activated protein） kinase family,in dorsal horn neurons of the spinal cord by peripheral noxious stimulation contributes to both short-term and long-term pain hypersensitivity. The overall goal of our study is to investigate the activation of ERK in the ACC and its contribution to persistent paininduced negative emotion using formalin-induced conditioned place avoidance（F-CPA） animal *** training, immunohistochemistry,Western blot,immunocytochemistry and eletrophysioloy methods were used in our experiments. Intraplantar（***.） injection of 5%formalin 50μ1 induced a rapid and sustained ERK activation in bilateral ACC neurons. Intra-ACC microinjection of MEK（MAP kinase kinase） inhibitor PD098059（0.2μg,2μg） or U0126（1μg） could significantly block the formation of F-CPA,but failed to affect formalin-induced nociceptive response and S-CPA（electric foot shockinduced conditioned place avoidance）,a fear conditioning *** of ACC slices with NMDA receptor agonist,NMDA（50μM）,Adenylyl cyclase（AC） activator,Forskolin（50μM） or cAMP-dependent protein kinase A（PKA） activator,Sp-cAMP（50μM） produced significant activation of ERK,which was suppressed by preincubation with corresponding respective antagonist APV（50μM） or 7-CK（50μM）,SQ22536（50μM） and Rp-cAMP（50μM）.Similarly,F-CPA was also blocked by premicroinjection in bilateral ACC of SQ22536（0.2μg,2μg） or Rp-cAMP（0.5μg,5μg）.Furthermore,formalin injection also produced significant CREB（cAMP response el

关键词： Anterior cingulate cortex ERK CREB F-CPA Pain emotion Rat

Visible-light-responsive homologous heterostructure of oxynitrides constructed to boost charge separation and water splitting

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Science China Chemistry 2025年第1期68卷 186-191页

作者： Hai Zou yunfeng Bao Xueshang Xin yu Qi Tengfeng Xie Fuxiang zhang State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences School of Chemistry and Chemical Engineering Liaoning Normal University College of Chemistry Jilin University

Constructing type II heterostructures represents a widely recognized strategy for enhancing charge separation and photocatalytic efficiency,but it remains challenging to fabricate homologous heterostructures based on visible-light-responsive semiconductors,especially for popularly investigated （oxy）nitrides with low thermal ***,we synthesized a homologous heterostructure （denoted as YTON＿H） based on the oxynitrides of YTaO4-xNyand YTa *** heterostructure exhibits type II band structure alignment and intimate interface achieved through a magnesium （Mg） powder-assisted nitridation *** with widely reported heterologous heterostructures,the as-obtained YTON＿H homologous heterostructure could similarly exhibit enhanced charge separation as well as photocatalytic water splitting performance with respect to its counterparts(YTaO4-xNyand YTaON2).Meanwhile,detailed structural characterizations and spectroscopy analysis have been made to confirm the formation of heterostructure and promotion of spatial charge separation.

关键词： charge separation heterostructure oxynitride photocatalysis visible light