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Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-Hong Zhong Jiang-Shan Huang Fei-Long Guo Jing-yu wu Mao-Xiu yuan Jia-Fu Zhu Wen-Wei Lin Sui Chen Zhen-Yang Zhang Jiang-Bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

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风电占比提高对电网接地距离保护Ⅱ段整定全局影响分析

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电力系统及其自动化学报 2025年第2期37卷 20-28页

作者：谢钰武志刚华南理工大学电力学院广州510640

从风电与电网间关系的角度研究风电占比提高短路电流分布变化对传统电力系统运行规则的影响。以接地距离保护Ⅱ段整定为例,首先结合风机的限流特性与继保整定规则分析风电占比提高对线路整定配合的影响;其次定义反映线路失配风险的指标... 详细信息

从风电与电网间关系的角度研究风电占比提高短路电流分布变化对传统电力系统运行规则的影响。以接地距离保护Ⅱ段整定为例,首先结合风机的限流特性与继保整定规则分析风电占比提高对线路整定配合的影响;其次定义反映线路失配风险的指标——失配系数,并通过失配系数分析线路失配的影响因素;最后计算广东电网中线路的失配系数,并对受影响区域与网架、风电并网情况的关系进行分析。通过研究风电占比提高对实际电网整定的全局影响,从完善电源出力组合的角度提出了线路易失配时的解决方法。

关键词：短路电流继电保护接地距离保护Ⅱ段风电失配系数

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黏膜免疫系统及黏膜疫苗研究的挑战

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中华微生物学和免疫学杂志 2025年第1期45卷 78-83页

作者：于霞丽吴疆北京市疾病预防控制中心免疫预防所北京100013

黏膜免疫系统是机体免疫系统的重要组成部分,广泛分布于呼吸道、消化道、泌尿生殖道的黏膜组织是局部特异性免疫应答发生的主要场所。黏膜表面是与外界病原直接接触的门户,大部分病原体经黏膜感染,因此黏膜免疫是机体抵抗病原体感染的... 详细信息

黏膜免疫系统是机体免疫系统的重要组成部分,广泛分布于呼吸道、消化道、泌尿生殖道的黏膜组织是局部特异性免疫应答发生的主要场所。黏膜表面是与外界病原直接接触的门户,大部分病原体经黏膜感染,因此黏膜免疫是机体抵抗病原体感染的第一道防线。黏膜疫苗提供了在病原体感染的主要部位产生强大的保护性免疫应答的潜力,但是目前上市的黏膜疫苗非常有限。本文综述黏膜免疫系统的组成、抗原摄取以及黏膜疫苗研发面临的挑战,为预防和控制传染性疾病黏膜疫苗研究提供思路。

关键词：黏膜免疫黏膜疫苗微皱褶细胞

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Integration of urchin-like MnCo_(2)O_(4)@C core–shell nanowire arrays within porous copper current collector for superior performance Li-ion battery anodes

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Rare Metals 2024年第2期43卷 599-611页

作者： Xue-Ru Zhang qiong wu Yong Zhang Xi-Fei Li Ting Xie yu-Cheng wu Instrumental Analysis Center Hefei University of TechnologyHefei230009China Key Laboratory of Advanced Functional Materials and Devices of Anhui Province Hefei230009China School of Materials Science and Engineering Hefei University of TechnologyHefei230009China Institute of Advanced Electrochemical Energy Xi’an University of TechnologyXi’an710048China

Spinel MnCo_(2)O_(4) is a promising energy storage candidate as anode materials in lithium-ion batteries owing to synergistic effects of two intrinsic solid-state redox ***,low conductivity,poor rate capacity and rapid capacity fading have seriously impaired its practical *** overcome the inferiorities,urchin-like MnCo_(2)O_(4)@C core–shell nanowire arrays have been fabricated directly within a porous copper current collector via a facile hydrothermal method followed by a chemical vapor deposition carbonization *** a typical nanowire,the core is composed of interconnected MnCo_(2)O_(4)nanoparticles and the shell shows as a thin amorphous carbon *** integrated MnCo_(2)O_(4)@C/Cu structure could act as working anodes without using additives or polymer *** MnCo_(2)O_(4)@C/Cu possesses slightly longer Li-ion insertion/desertion pathway than that of MnCo_(2)O_(4)/Cu,the carbon shell could effectively prevent the pulverization of MnCo_(2)O_(4) and lower down charge transfer resistance and actively participate in Li-ion *** rearrangement of carbon atoms during lithiation/delithiation cycling could inhibit the formation of passive solid electrolyte interphase *** a result,the MnCo_(2)O_(4)@C/Cu electrode presents superior rate capacity(600 mAh·g^(−1) at 1 A·g^(−1)) and better stability(797 mAh·g^(−1) after 200 cycles at 100 mA·g^(−1)).The excellent reversible Li ion storage capacity,cycling stability and rate capacity endow MnCo_(2)O_(4)@C/Cu great potential as stable and high output integrated anode materials in Li-ion batteries.

关键词： MnCo_(2)O_(4)@C Urchin-like nanowire arrays Core-shell Integrated anode materials Lithium-ion batteries

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-yu Tang Chun-Mao yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng yun-Dong wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines(Chinese Academy of Sciences) Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical OncogenomicsPeking University Shenzhen Graduate SchoolShenzhen 518055China Shenzhen Bay Laboratory Shenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Microbial Metabolism School of Life Sciences&BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201China yunnan Key Laboratory for Wild Plant Resources Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical SciencesBeijing 100730China

In the intricate process of natural product biosynthesis,a metabolon can enhance metabolic flux by associating sequential enzymes.A fungal metabolon,comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G,is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide *** notoamide E as a substance,Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation,followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium ***,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol *** provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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Analysis on Pseudo Excitation of Random Vibration for Structure of Time Flight Counter

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Chinese Journal of Mechanical Engineering 2015年第2期28卷 325-330页

作者： wu qiong LI Dapeng Beijing Engineering Technological Research Center of High-efficient & Green CNC Machining Process and Equipment Beihang University

Traditional computing method is inefficient for getting key dynamical parameters of complicated *** Excitation Method（PEM）is an effective method for calculation of random *** to complicated and coupling random vibration in rocket or shuttle launching,the new staging white noise mathematical model is deduced according to the practical launch *** deduced model is applied for PEM to calculate the specific structure of Time of Flight Counter（ToFC）.The responses of power spectral density and the relevant dynamic characteristic parameters of ToFC are obtained in terms of the flight acceptance test *** stiffness of fixture structure,the random vibration experiments are conducted in three directions to compare with the revised *** experimental results show the structure can bear the random vibration caused by launch without any damage and key dynamical parameters of ToFC are *** revised PEM is similar with random vibration experiment in dynamical parameters and responses are proved by comparative *** maximum error is within 9%.The reasons of errors are analyzed to improve reliability of *** research provides an effective method for solutions of computing dynamical characteristic parameters of complicated structure in the process of rocket or shuttle launching.

关键词： pseudo excitation method power spectral density random processes dynamic response vibration

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In vivo self-assembled bispecific fluorescence probe for early detection of bladder cancer and metastasis

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Science Bulletin 2025年第3期70卷 407-418页

作者： Da-Yong Hou Ni-yuan Zhang Peng Zhang Xiang-Peng Li Jiong-Cheng wu Mei-yu Lv Zhi-Jia Wang Xing-Jie Hu Jian-Xiao Liang Hong-Lei Wang yue-Ze Wang Hui-Hui You Hong-Wei An Hao Wang Wanhai Xu NHC Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in UrologyHarbin Medical UniversityHarbin 150001China Department of PET-CT/MRI Harbin Medical University Cancer HospitalHarbin 150001China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Tumor metastasis accounts for over 90%of tumor-related deaths,prompting the development of fluorescently labeled tumor-specific molecular imaging agents for differentiating tumors from normal ***,early detection of metastasis lesions by tracking tumor markers alone has proven to be ***,we reported a glycopeptide-based bispecific fluorescence probe(bsProbe)for earlier detection of bladder cancer and *** simultaneously recognition(tumor&tumor microenvironment)and in vivo self-assembly,the tumor accumulation of bsProbe(12.3%ID/g)was obviously increased by∼6 fold compared with that in CXCR4 specific fluorescence probe(sProbe),indicating the obvious advantages of bsProbe over existing tumor metastasis detection ***,bsProbe substantially broadens the tumor diagnosis window and enhances the detection signal to noise ratio(SNR:approximately 9.5),permitting early diagnosis of lung micro-metastasis(∼1 mm),precise identifying of tumor boundaries and micro-tumors in orthotopic tumor *** importantly,bsProbe was demonstrated to distinguish malignant from benign specimen with a specificity of 90.48%and sensitivity of 92.22%in 195 clinical specimens of bladder cancer *** together,this novel synergetic targeting(CD206×CXCR4)strategy provides an attractive method for earlier detection of bladder cancer and metastasis,which might be further extended to the imaging-guided surgery of clinical invisible tumors.

关键词： Self-assembly Peptide Nanomaterial Fluorescence imaging Bladder cancer

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工业互联网平台如何助力制造企业绿色转型？——数字技术可供性视角的案例研究

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研究与发展管理 2025年第1期37卷 98-112页

作者：郭波武成琼文王梦莹中南大学商学院浙江工商大学经济学院

工业互联网作为新型工业化的数字底座和发展新质生产力的关键驱动力，日益成为制造企业绿色转型的重要基石。本文基于数字技术可供性视角，通过海尔“可持续灯塔工厂”建设的案例研究，提出了工业互联网平台助力制造企业绿色转型的理论... 详细信息

工业互联网作为新型工业化的数字底座和发展新质生产力的关键驱动力，日益成为制造企业绿色转型的重要基石。本文基于数字技术可供性视角，通过海尔“可持续灯塔工厂”建设的案例研究，提出了工业互联网平台助力制造企业绿色转型的理论框架。研究发现：数字技术应用特征和组织转型目标的交互形成数字技术可供性机制形成的条件；数字技术可供性的内部呈叠加聚合的关系，二级数字技术可供性的叠加聚合形成了对内部生产要素、生产关系和生产能力的优势叠加与功能聚合效应；企业绿色转型主要体现为工业互联网平台助力生产要素、生产关系和生产能力三个层面的绿色变革。生产资源层面，工业互联网平台通过融合生成和组织记忆两大功能可供性，推动实现绿色生产要素建构；生产关系层面，工业互联网平台通过感知学习和联动协作两大关系可供性，推动实现绿色生产关系互联；生产能力层面，工业互联网平台通过流程管理和社会交互两大结构可供性，推动实现绿色生产能力撬动。研究结论丰富了企业绿色转型和数字技术可供性理论，并为我国制造企业利用工业互联网平台实现绿色转型提供实践启示。

关键词：绿色转型工业互联网平台数字技术可供性可持续灯塔工厂

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侵彻爆炸联合作用下超高性能混凝土遮弹层设计

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爆炸与冲击 2025年第1期45卷 88-101页

作者：程月华吴昊岑国华张瑜同济大学土木工程学院上海200092

为了准确评估超高性能混凝土(ultra-high performance concrete,UHPC)遮弹层在战斗部侵彻爆炸作用下的损伤破坏并建立可靠的计算方法,首先,开展了UHPC靶体抗105 mm口径弹体侵彻和5 kg TNT炸药爆炸联合作用试验,获取了侵彻作用后以及侵... 详细信息

为了准确评估超高性能混凝土(ultra-high performance concrete,UHPC)遮弹层在战斗部侵彻爆炸作用下的损伤破坏并建立可靠的计算方法,首先,开展了UHPC靶体抗105 mm口径弹体侵彻和5 kg TNT炸药爆炸联合作用试验,获取了侵彻作用后以及侵彻与爆炸联合作用后弹靶的损伤破坏数据;然后,建立了UHPC靶体抗弹体侵彻与爆炸作用的有限元模型,通过对上述试验和已有的有限厚UHPC板埋置装药爆炸试验进行数值仿真分析,验证了有限元模型和分析方法的可靠性;最后,对比了SDB、WDU-43/B和BLU-109/B等3种典型原型战斗部侵彻与爆炸联合作用下,UHPC遮弹层和普通混凝土遮弹层的临界贯彻和震塌厚度。结果表明:3种战斗部侵彻爆炸联合作用下,遮弹层的临界贯穿厚度和震塌厚度范围分别为1.30~2.60 m和1.70~5.00 m,相应的临界贯穿系数和震塌系数范围分别为1.81~2.17和2.46~4.17;与普通混凝土遮弹层对比,3种战斗部侵彻爆炸联合作用下UHPC遮弹层的开坑直径减小了34.4%~42.4%,临界贯穿和震塌厚度分别减小了7.1%~31.6%和39.7%~52.8%。研究结果可为UHPC遮弹层的抗力评估和设计提供参考。

关键词：超高性能混凝土遮弹层侵彻爆炸防护设计

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Ultralow-Vertical-Current Magnetization Switching Effect in an All Van Der Waals 2D Heterostructure

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Chinese Physics Letters 2025年第2期42卷 239-248页

作者： Hao wu Li Yang Gaojie Zhang Wen Jin Jie yu Bichen Xiao Ahmed Annas Wenfeng Zhang Haixin Chang Center for Joining and Electronic Packaging State Key Laboratory of Material Processing and Die&Mold TechnologySchool of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China wuhan National High Magnetic Field Center and Institute for Quantum Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China Shenzhen R&D Center of Huazhong University of Science and Technology Shenzhen 518000China

The manipulation of magnetization and spin polarization using electrical currents represents a fundamental breakthrough in *** has formed the foundation for data storage and next-generation computing ***-transfer torque(STT)and spin-orbit torque(SOT)have emerged as prominent mechanisms in current-driven magnetization ***,these approaches typically require critical current densities in the range of 10^(6) to 10^(9) A·cm^(-2),resulting in significant heat generation during data writing ***,we report the discovery of an ultralow-vertical-current magnetization switching effect in a van der Waals ferromagnetic/ferroelectric heterostructure based on the modulation of the critical magnetic field(H_(C))using small vertical currents,with a critical current density as low as 1.81A·cm^(-2) and an average effective field(H_(eff)/J_(C))as high as 150.3mT·A^(-1)·cm^(2).This unique magnetization switching effect with ultralow-critical-vertical-current densities typically six to nine orders of magnitude lower than those of the STT and SOT provides a new transformative and viable pathway for developing next-generation spintronic and quantum technologies.

关键词： magnetization critical typically

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