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汇率变动对自贸区企业进出口行为的传递效应:微观测度和机理研究

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特区经济 2022年第12期 86-89页

作者：余杨青施洁瑾陶振蕊何倩浙江海洋大学浙江舟山316000

自21世纪初开始,人民币对美元的汇率逐步上升。目前,人民币升值的压力依旧存在。现如今我国拥有自贸区的省份有15个,分别为广东省、福建省、河北省、辽宁省、浙江省、湖北省、山东省、四川省、陕西省、海南省、河南省、江苏省、云南省... 详细信息

自21世纪初开始,人民币对美元的汇率逐步上升。目前,人民币升值的压力依旧存在。现如今我国拥有自贸区的省份有15个,分别为广东省、福建省、河北省、辽宁省、浙江省、湖北省、山东省、四川省、陕西省、海南省、河南省、江苏省、云南省、广西壮族自治区与黑龙江省,自贸区作为中国外贸的关键区域,对中国经济发展起着重要的作用,因此人民币汇率对自贸区企业的进出口贸易的影响,值得我们深入研究和分析。本文从实证角度研究了人民币实际汇率变动对自贸区企业进出口行为的影响并提出了相关建议和对策。

关键词：人民币实际汇率进出口贸易协整分析固定效应

Effect of adhesive on laser-arc hybrid welding of aluminum alloy to high-strength steel joint

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Journal of Iron and Steel Research International 2020年第9期27卷 1099-1107页

作者： Hong-yang Wang yu-qing Ma Li-ming Liu Key Laboratory of Liaoning Advanced Welding and Joining Technology School of Materials Science and EngineeringDalian University of TechnologyDalian 116024LiaoningChina

Aluminum alloy 6061 and high-strength steel Q460 were joined by laser-arc-adhesive hybrid welding technology successfully.A Cu alloy interlayer was added between Al alloy and high-strength *** effect of the adhesive on laser-arc-adhesive hybrid welding of Al alloy to high-strength steel was *** optical microscope,scanning electron microscope and electron probe micro-analysis were applied to observe the microstructural evolution and phase transition at Al-Fe interface of laser-arc-adhesive hybrid welded *** results showed the maximum tensile shear strength of the joint without adhesive was 256 *** adding adhesive,the maximum tensile shear strength reached 282 *** combination of the mechanical bonding and the metallurgical effect could improve the mechanical *** shape of the joint in Al alloy changed into a canine-like *** was no porosity in welds because the molten pool of Al alloy and the special keyhole phenomenon of laser welding provided a channel for the decomposed gas to escape from fusion zone.

关键词： Laser-arc welding Aluminum alloy High-strength steel Cu interlayer Adhesive

参莲提取物对LPS诱导的巨噬细胞炎症反应的影响

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中国实验方剂学杂志 2017年第10期23卷 85-91页

作者：刘思思李琦孙立东李玉洁杨庆朱晓新首都医科大学中医药学院北京100069 中国中医科学院中药研究所北京100700 安徽中医药大学合肥230031

目的:探讨参莲(SL)提取物在炎症调节中发挥的治疗性作用及其机制。方法:分别以小鼠巨噬细胞Raw264.7和小鼠腹腔巨噬细胞为实验对象,利用脂多糖(LPS)诱导炎症模型,SL提取物低、中、高剂量(5,10,20 mg·L^(-1))药物处理24 h,另设空白组,... 详细信息

目的:探讨参莲(SL)提取物在炎症调节中发挥的治疗性作用及其机制。方法:分别以小鼠巨噬细胞Raw264.7和小鼠腹腔巨噬细胞为实验对象,利用脂多糖(LPS)诱导炎症模型,SL提取物低、中、高剂量(5,10,20 mg·L^(-1))药物处理24 h,另设空白组,使用酶联免疫吸附测定(ELISA)法及实时荧光定量PCR(Real-time PCR)检测小鼠Raw264.7及腹腔巨噬细胞肿瘤坏死因子-α(TNF-α),白细胞介素-1β(IL-1β)含量及mRNA表达;使用蛋白质免疫印迹法(Western blot)对小鼠Raw264.7核转录因子-κB(NF-κB)信号通路中的p65及磷酸化p65(p-p65)蛋白表达情况进行检测,采用免疫荧光法对小鼠Raw264.7及腹腔巨噬细胞NF-κB p65分子进行亚细胞定位观察SL提取物是否能够影响其入核。结果:与空白组比较,模型组小鼠Raw264.7及腹腔巨噬细胞TNF-α,IL-1β含量及mRNA表达均显著升高,小鼠Raw264.7 p-p65/p65蛋白表达显著升高(P<0.01),免疫荧光观察显示模型组Raw264.7及腹腔巨噬细胞均可见明显入核行为;与模型组比较,SL提取物低、中、高剂量组明显降低小鼠Raw264.7及腹腔巨噬细胞TNF-α,IL-1β含量及mRNA表达(P<0.05,P<0.01),显著降低小鼠Raw264.7及p-p65蛋白(P<0.01),SL提取物中剂量组可明显减弱Raw264.7及腹腔巨噬细胞入核行为。结论:SL提取物能够抑制巨噬细胞的炎症反应,其机制可能与影响巨噬细胞炎性因子的分泌及NF-κB信号通路有关。

关键词：参莲提取物核转录因子-κB(NF-κB) 炎症巨噬细胞

静宁颗粒对注意缺陷多动障碍模型大鼠下丘脑-垂体-肾上腺轴及多巴胺的影响

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世界中西医结合杂志 2021年第12期16卷 2172-2175,2183页

作者：冯锴于庆洋邓家琳吴静静王俊宏刘玉清国家儿童医学中心首都医科大学附属北京儿童医院中医科北京100045 北京中医药大学东直门医院北京100700

目的探讨静宁颗粒对注意缺陷多动障碍(Attention-deficit hyperactivity disorder,ADHD)的作用机制。方法将50只雄性自发性高血压大鼠(SHR)按随机数字表法分为静宁颗粒高、中、低剂量组,盐酸哌甲酯组及模型组,每组10只。同时将10只同龄W... 详细信息

目的探讨静宁颗粒对注意缺陷多动障碍(Attention-deficit hyperactivity disorder,ADHD)的作用机制。方法将50只雄性自发性高血压大鼠(SHR)按随机数字表法分为静宁颗粒高、中、低剂量组,盐酸哌甲酯组及模型组,每组10只。同时将10只同龄Wistar大鼠设为正常组。正常组、模型组均按1 mg/100 g给予生理盐水;盐酸哌甲酯组按1 mg/100 g给予盐酸哌甲酯混悬液;静宁颗粒组按1 mg/100 g给予不同浓度的颗粒混悬液,具体浓度静宁颗粒高、中、低剂量组分别23.14 g/kg、11.57 g/kg、5.79 g/kg,1次/d,连续6周。运用高效液相法检测纹状体多巴胺(Dopamine,DA)及其代谢产物含量[二羟基苯乙酸(DOPAC)]。采用酶联免疫吸附测定法(Enzyme linked immunosorbent assay,ELISA)检测血清中促肾上腺皮质激素(Adrenocorticotropic hormone,ACTH)、皮质醇(Cortisol,COR)的表达量。结果与正常组比较,模型组大鼠纹状体DA及DOPAC含量下降,其中DA含量下降,差异有统计学意义(P0.05);与模型组比较,除静宁颗粒中剂量组外,各组COR含量均有明显提升(P<0.01)。结论静宁颗粒可能通过介导SHR大鼠HPA轴功能以调节纹状体DA水平,达到控制注意缺陷多动障碍临床症状的目的。

关键词：静宁颗粒注意缺陷多动障碍多巴胺下丘脑-垂体-肾上腺轴皮质醇

Effect of Hot Pressing on Microstructure and Mechanical Properties of Bulk Nanocrystalline Fe_3Al Materials Containing Manganese Element

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Journal of Iron and Steel Research International 2011年第3期18卷 65-71页

作者： LI yu-feng LA Pei-qing WEI yu-peng LU yang yang yang State Key Laboratory of Gansu Advanced Nonferrous Materials Lanzhou University of TechnologyLanzhou 730050GansuChina

Bulk nanocrystalline Fe3Al materials containing manganese of 10% were prepared by aluminothermic *** pressing of those materials was performed at different temperatures and *** microstructures of the alloy were investigated by optical microscope（OM） and electron probe microanalyzer（EPMA）.The grain sizes of the materials were analyzed by X-ray diffraction（XRD） and transmission electron microscope（TEM）.The results showed that the grain sizes of the materials increase after hot *** grain sizes of the materials decrease with increasing the hot pressing times at the same temperature and the grain sizes of the materials increase with increasing hot pressing temperatures at identical *** hardness and compressibility of the materials were also *** results showed that the hardness decreases with increasing hot pressing times at 800 ℃ and hardness increases with increasing the hot pressing *** variation of hardness with grain size of the nanocrystalline Fe3Al materials after hot pressing is contrary to the Hall-Petch *** materials are not broken during hot pressing and exhibit good plasticity and compressibility.

关键词： hot pressing Fe3Al nanostructure material microstructure mechanical property

IL-2/GM-CSF体外处理的外周血单个核细胞对再生障碍性贫血小鼠T淋巴细胞亚群及细胞因子的影响

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中国现代医学杂志 2020年第12期30卷 1-6页

作者：詹昱曲佳冯可欣杨郁青谭明珠谭雪芳杨德懋广州市第十二人民医院血液科广东广州510620

目的探讨白细胞介素-2(IL-2)/粒细胞-巨噬细胞集落刺激因子(GM-CSF)体外处理的外周血单个核细胞输注对再生障碍性贫血(以下简称再障)小鼠T淋巴细胞亚群和细胞因子的影响及其促造血作用。方法选取清洁级雌性BALB/c小鼠并复制免疫介导再... 详细信息

目的探讨白细胞介素-2(IL-2)/粒细胞-巨噬细胞集落刺激因子(GM-CSF)体外处理的外周血单个核细胞输注对再生障碍性贫血(以下简称再障)小鼠T淋巴细胞亚群和细胞因子的影响及其促造血作用。方法选取清洁级雌性BALB/c小鼠并复制免疫介导再障小鼠模型,设立对照组、模型组及干预组。干预组取正常同源小鼠外周血单个核细胞,在IL-2、GM-CSF等作用下培养48 h后进行尾静脉输注(模型复制第1、2、4及6天),模型组输注等体积生理盐水。全部小鼠分别于模型复制第7、14、21及28天断尾采血检测外周血白细胞、血红蛋白和血小板计数;于模型复制第28天或濒死时处死小鼠,计数骨髓有核细胞(粒系、红系、淋巴细胞比例及巨核细胞数),检测外周血CD3+CD4+(T辅助细胞、Th细胞)、CD3+CD8+(T抑制细胞、Ts细胞)及CD4+CD25+CD127-(调节性T细胞、T-regs)细胞比例,检测血清肿瘤坏死因子-α(TNF-α)、γ干扰素(IFN-γ)水平。结果模型组和干预组外周血WBC较对照组低(P<0.05),干预组在第21和28天较模型组高(P<0.05)。模型组和干预组外周血PLT较对照组低(P<0.05),干预组在第21和28天较模型组高(P<0.05)。模型组和干预组外周血Hb较对照组低(P<0.05),干预组在第28天较模型组高(P<0.05)。模型组和干预组粒系比例、红系比例及巨核细胞数较对照组低,淋巴细胞比例较对照组高(P<0.05),干预组骨髓粒系比例、红系比例及巨核细胞数较模型组高,淋巴细胞比例较模型组低(P<0.05)。模型组Th细胞比例、T-regs细胞比例较对照组低(P<0.05),Ts细胞比例较对照组高(P<0.05)。干预组Th细胞比例、T-regs细胞比例较模型组高,Ts细胞比例较模型组低(P<0.05)。模型组外周血TNF-α、IFN-γ水平较对照组高(P<0.05),干预组较模型组低(P<0.05)。结论IL-2/GM-CSF体外处理的外周血单个核细胞输注有助于调节再障小鼠T淋巴细胞亚群紊乱,下调造血负调控细胞因子,从而改善骨髓造血功能。

关键词：贫血,再生障碍性白细胞介素2 集落刺激因子单核细胞

Rare earth metal modified three dimensionally ordered macroporous MnO_x-CeO_2 catalyst for diesel soot combustion

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Journal of Rare Earths 2018年第1期36卷 64-71页

作者： qing tang jun du bin xie yu yang wenchong yu changyuan tao laboratory of green chemistry and chemical college of chemistry and chemical engineeringchongqing universityChongqing 400030，China

Three dimensionally ordered macroporous （3DOM） Ce-based catalysts were successfully prepared via a surfactant-assisted colloidal crystal template （CCT） route. The as-synthesized catalysts showed well- ordered structures with macropores and small interconnected pore windows. The Raman results indi- cate that the catalyst persists pure fluorite cubic phases until the molar ratio of Mn exceeds O.3, therefore MnOx particles form and impede the contact of the active site and the reagent and restraining soot combustion. The doping of Nd into MnOx-CeO2 enhances the catalytic activity because of increased oxygen vacancy, Mn4- content and stronger redox ability. Nd-doping also improves thermal stability of the catalyst due to less sintering and none phase separation after thermal aging. The flesh and aged ***2 catalysts show the maximum oxidation rate for soot at 331 and 355 ℃in the O2/N2 atmosphere, achieving a nearly 100% CO2 selectivity.

关键词： Neodymium dopingMnOx-CeO2Oxygen vacanciesSoot combustionThermal aging performanceThree dimensionally ordered macroporousstructure

Traditional Chinese medicine in the treatment of idiopathic pulmonary fibrosis based on syndrome differentiation:Study protocol of an exploratory trial

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Journal of Integrative Medicine 2020年第2期18卷 163-168页

作者： Xue-qing yu Shu-guang yang yang Xie Jian-sheng Li Department of Respiratory Diseases The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenan Province 450000China Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry of P.R.China Henan University of Chinese MedicineZhengzhouHenan Province 450046China Henan Key Laboratory of Chinese Medicine for Respiratory Diseases Henan University of Chinese MedicineZhengzhouHenan Province 450046China

Background: Idiopathic pulmonary fibrosis(IPF) has a poor prognosis and is often a kind of heavy financial burden to patients. Currently, few treatments are available for IPF. Clinical practice of traditional Chinese medicine(TCM), using a syndrome differentiation approach, offers some treatment success in IPF. However, there is no sufficient evidence-based study of the role of TCM in IPF management to make strong conclusions. This study evaluates the efficacy and safety of TCM in the treatment of *** and design: A multicenter, exploratory, randomized, double-blind and placebo-controlled trial is planned. A total of 80 patients will be enrolled in the study, which will include 26 weeks of *** will be randomly assigned into TCM group or control group in a 1:1 ratio. The TCM group will be given TCM granules based on syndrome differentiation. Formulae include Bao-fei Hua-xian granule for lung qi deficiency, Jin-shui Huan-xian granule for lung-kidney qi deficiency and yang-qing Kang-xian granule for yin deficiency and inner heat. The control group will be given a corresponding TCM granule placebo. The efficacy and safety of interventions will be evaluated by the outcome variables,including frequencies of acute exacerbations, pulmonary function, clinical symptoms, dyspnea, healthrelated quality of life(HRQo L), 6-minute walk distance and safety ***: It is hypothesized that TCM will decrease the frequency of adverse events, improve pulmonary function and HRQo L, based on our clinical experience. This trial is the first study of TCM treatment in IPF that is based on syndrome differentiation and will evaluate the efficacy and safety of TCM in IPF.

关键词： Idiopathic pulmonary fibrosis Traditional Chinese medicine Syndrome differentiation Protocol

应用LabVIEW开发非接触式压缩机叶片模态测试系统

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风机技术 2018年第1期60卷 53-60页

作者：杨青玉李朝峰杨树华孟继纲李凯华东北大学机械工程与自动化学院沈阳鼓风机集团股份有限公司

为了克服接触式模态测试方法中被测对象质量被改变以及敲击测试中随机因素造成的漏频问题,本文以非接触式电磁激振和激光拾振的方式应用Lab VIEW开发一套非接触式压缩机叶片模态测试系统。通过对该系统测得的实验结果与比利时LMS模态分... 详细信息

为了克服接触式模态测试方法中被测对象质量被改变以及敲击测试中随机因素造成的漏频问题,本文以非接触式电磁激振和激光拾振的方式应用Lab VIEW开发一套非接触式压缩机叶片模态测试系统。通过对该系统测得的实验结果与比利时LMS模态分析软件测得的实验结果进行对比,结果表明本系统可以更准确地测试出叶片的模态参数,针对文中的测试对象,最高测试频率达到11 000Hz。该系统基于稳态信号进行测试,理论上测得的结果更为准确,且具备操作简单、功能实用、无随机因素影响、可重复性强和无漏频等优势。

关键词：模态测试压缩机叶片非接触测量激光拾振