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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Super Weak Compactness and Uniform Eberlein Compacta

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Acta Mathematica Sinica,English Series 2017年第4期33卷 545-553页

作者： Zhi Tao yang yu Feng LU qing Jin CHENG School of Mathematical Sciences Dalian University of Technology School of Mathematical Sciences Qinzhou University School of Mathematical Sciences Xiamen University

We prove that a topological space is uniform Eberlein compact iff it is homeomorphic to a super weakly compact subset C of a Banach space such that the closed convex hull coC of C is super weakly compact. We also show that a Banach space X is super weakly compactly generated iff the dual unit ball B;of X;in its weak star topology is affinely homeomorphic to a super weakly compactly convex subset of a Banach space.

关键词： Banach space uniform Eberlein compactas super weak compactness

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Influence of Extrusion Joint on Microstructural Evolution and Properties of Mg Alloy Sheet

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Acta Metallurgica Sinica(English Letters) 2016年第5期29卷 475-482页

作者： qing-Shan yang Zu-Jian yu Hu-Cheng Pan qing-Wei Dai Jian-Hui Li School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing 401331China Chongqing Academy of Science and Technology Chongqing 401123China Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education) Northeastern UniversityShenyang 110819China

The mechanical behaviour of AZ31 magnesium alloy sheet with the extrusion joint （EJ） was evaluated. Extruded joint of AZ31 alloy sheets was obtained by the hot extrusion process. Tensile tests were carried out along the extrusion direction at room temperature, and both the non-uniform plastic deformation and the fracture behaviour were studied. It is found that the samples with EJ present significantly deteriorated mechanical properties compared with the EJ- free counterpart. Inhomogeneous rnicrostructure distribution around EJ zone brings in the uncoordinated deformation due to the high density of {1012} twins which were readily activated during plastic deformation.

关键词： Mg alloy Microstructure Twin Texture Extrusion joint

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Syntheses,Crystal Structures and Luminescent Properties of Three New Gallium Complexes Containing Pyridine-2,6-dicarboxylic Acid

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Chemical Research in Chinese Universities 2012年第6期28卷 936-941页

作者： ZHOU Guang-peng yang yu-lin FAN Rui-qing Department of Chemistry Harbin Institute of Technology Harbin 150001 P. R. China

Three new gallium complexes formulated as [Ga（PDA）2 ][Ga（H2O）（PDA）（phen）]·4H2O（1）,[Ga（PDA） 2]·（H2IN）·2H2O（2） and [Ga（OH）（PDA）（H2O）] 2（3）（H2PDA=pyridine-2,6-dicarboxylic acid;phen=1,10-phenanthroline;HIN=isonicotinic acid） have been synthesized under hydrothermal *** the mixed-ligand system of complex 1,PDA2 and phen are connected to the central Ga 3＋ cation as tri-and bi-dentate ligands,*** complex 2,each Ga 3＋ cation is six-coordinated by two PDA 2 anions *** 3 shows a binuclear structure,with the bond distance of Ga1― Ga2 being 0.30061（3） *** 3D supramolecular structures of the three complexes are constructed via hydrogen bonds and aromatic π-π packing *** the three complexes exhibit intense blue emission at room temperature in the solid state,which are attributed to π＊-π transition centered on the ligands.

关键词： Gallium complex Crystal structure Luminescent property

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Free-standing two-dimensional Au films

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Rare Metals 2022年第12期41卷 4235-4240页

作者： Shi-Zhuang Gao Mu yang qing-yun Xiang yu Wang Huan Zhang yang Bai Wen-qing Yao Jiang-Li Cao Institute of Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Corrosion-Erosion and Surface Technology Beijing Key Laboratory Beijing 100083China Department of Applied Physics Hong Kong Polytechnic UniversityHong KongChina Department of Chemistry Tsinghua UniversityBejing 100084China

Free-standing two-dimensional(FS-2D) materials of covalent or ionic bonds can be prepared through mechanical exfoliation by virtue of their intrinsic layered crystal ***,following this strategy,it was reported the fabrication of large-area FS-2D Au films with controllable lattice orientations via an electrochemical hydrogen-detaching *** was further characterized the catalytic properties of FS-2D ***(111)-oriented FS-2D Au with 20 nm in thickness shows a catalytic conversion up to 43.8% for the oxidation of cyclohexane as a model reaction system,a result of more than double of generally reported *** exceptionally high catalytic activity could be attributed to the flexible structure of the FS-2D Au catalyst,which differs from the rigid structure of general *** results give useful implications for large-scale productions of a variety of FS-2D metals with controllable orientations,by which their applications may not be confined to catalysis chemistry.

关键词： Free-standing two-dimensional Au thin films Eelectrochemical hydrogen-detaching method Catalysis

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毛细管电泳叠加对比法测定复方降压片中5组分含量

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沈阳药科大学学报 2002年第4期19卷 265-268页

作者：孙国祥孙毓庆李阳沈阳药科大学药学院辽宁沈阳110016

目的建立复方降压片 (二方 )的高效毛细管电泳多组分同时定量方法。方法用高效毛细管电泳叠加对比法 ,采用石英毛细管 ( 6 5cm× 75 μmI.D .)有效长度 5 0cm ,5 0mmol/L硼砂溶液为背景电解质 ,重力进样 1 0s(高度 7cm) ,检测温度 ( 2 4... 详细信息

目的建立复方降压片 (二方 )的高效毛细管电泳多组分同时定量方法。方法用高效毛细管电泳叠加对比法 ,采用石英毛细管 ( 6 5cm× 75 μmI.D .)有效长度 5 0cm ,5 0mmol/L硼砂溶液为背景电解质 ,重力进样 1 0s(高度 7cm) ,检测温度 ( 2 4± 1 )℃ ,紫外检测波长 2 4 6nm。结果测定复方降压片中维生素B1、磷酸氯喹、氢氯噻嗪、维生素B6和芦丁 5组分的相对峰面积的RSD不大于2 4 % ,回收率为 96 8%～ 1 0 4 2 % ,标示百分含量均在 96 7%～ 1 0 3 5 %。结论该法可同时分离测定复方降压片中

关键词： CZE 叠加法维生素B1 磷酸氯喹氢氯噻嗪维生素B6 芦丁

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An experimental study on seepage behavior of sandstone material with different gas pressures

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Acta Mechanica Sinica 2015年第6期31卷 837-844页

作者： Sheng-Qi yang Yan-Hua Huang yu-Yong Jiao Wei Zeng qing-Lei yu State Key Laboratory for Geomechanics and Deep Underground Engineering School of Mechanics and Civil Engineering China University of Mining and Technology Institute of Rock and Soil Mechanics Chinese Academy of Sciences School of Resource and Civil Engineering Northeastern University

The seepage evolution characteristic of brittle rock materials is very significant for the stability and safety of rock engineering. In this research, a series of conventional triaxial compression and gas seepage tests were carded out on sandstone specimens with a rock mechanics servo-controlled testing system. Based on the experimental results, the relationship between permeability and deformation is firstly analyzed in detail. The results show that the permeabilityaxial strain curve can be divided into the following five phases： the phase of micro-defects closure, the phase of linear elastic deformation, the phase of nonlinear deformation, the phase of post-peak stress softening and the phase of residual strength. The seepage evolution characteristic is also closely correlated with the volumetric deformation according to the relationship between permeability and volumetric strain. It is found that the gas seepage pressure has a great effect on the permeability evolution, i.e. permeability coefficients increase with increasing gas seepage pressures. Finally, the influence of gas seepage pressures on the failure behavior of brittle sandstone specimens is discussed.

关键词： Rock mechanics · Sandstone · Gas seepage ·Volumetric deformation · Permeability

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Temperature-dependent β-Crystal Growth in Isotactic Polypropylene with β-Nucleating Agent after Shear Flow

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Chinese Journal of Polymer Science 2017年第12期35卷 1540-1551页

作者：陈妍慧 Hao-qing yang Song yang Qiu-yu Zhang Zhong-ming Li Department of Applied Chemistry School of Science Northwestern Polytechnical University College of Polymer Science and Engineering and State Key Laboratory of Polymer Materials Engineering Sichuan University

In our current work, the effect of the shear temperature on the growth of β-crystal in isotactic polypropylene（iPP） with β-nucleating agent is investigated by means of in situ two-dimensional wide-angle X-ray diffraction（2 D-WAXD）. At low shear temperatures, the formed shear-induced oriented precursors are hard to relax back to random coiled state due to the weak mobility of molecular chains. Therefore, plenty of oriented α-crystals are induced by shear-induced oriented precursors, while β-crystal is greatly depressed. As the shear temperature increases, oriented β-crystal gradually increases along with the decrease of α-crystal. It is deduced that the shear temperature at which the content of β-crystal increases to the（maximum） value found in quiescent crystallization is almost the same as that at which the accelerating effect of flow on crystallization kinetics is completely erased. Our work manifests its significance in regulating β-crystal and thus in the structure and property manipulation of i PP.

关键词： Isotactic polypropylene β-Crystal Crystallization Shear temperature

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Controllable synthesis of nanorod/nanodisk TiO_2 from titanium-containing electric furnace molten slag

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Rare Metals 2015年第4期34卷 267-275页

作者： Zai-qing Que yang Li Hai-yang yu Feng Zheng Mei Zhang Min Guo State Key Laboratory of Advanced Metallurgy School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

Nanostructured TiO2 with different morphologies and crystal phases was successfully synthesized from titanium-containing electric furnace molten slag by using a hydrothermal method followed by reflux process in acid solution. The effects of acid concentration, reflux time, and acid type on the formation of TiO2 were systematically investigated by scanning electron microscopy, X-ray dif- fraction （XRD）, transmission electron microscopy （TEM）, high-resolution transmission electron microscopy （HRTEM）, and X-ray fluorescence （XRF）. It is indicated that TiO2 nanorod with rutile phase is achieved in nitric or hydrochloric acid, while anatase TiO2 nanodisk is formed in sulfuric acid. With the increase of the concentration of hydrochloric acid from 0.3 to 1.5 mol-L-1, the dispersibility and crystallinity of the final product can be improved. With prolonging the reflux time from 6 to 14 h, the rutile TiO2 nanorod with uniform crystal size and high crystallinity is obtained. The growth mechanism of TiO2 nanorod and nanodisk prepared under different conditions was also discussed.

关键词： Titanium-containing electric furnace molten slag TiO2 Nanorod Nanodisk Hydrothermal method

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氟噻唑吡乙酮原药的高效液相色谱分析

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农药 2017年第4期56卷 260-261页

作者：张立黄成田于保青杨国军李慧超胥维昌梅宝贵沈阳化工研究院有限公司沈阳110021 沈阳中化农药化工研发有限公司新农药创制与开发国家重点实验室沈阳110021

[目的]建立一种高效液相色谱测定氟噻唑吡乙酮原药的定量分析方法。[方法]采用高效液相色谱法,使用COSMOSIL Packed Column 5 C_(18)-AR-Ⅱ色谱柱,以乙腈-水(体积比65:35)为流动相,紫外检测器检测波长为260 nm,对氟噻唑吡乙酮原药进行... 详细信息

[目的]建立一种高效液相色谱测定氟噻唑吡乙酮原药的定量分析方法。[方法]采用高效液相色谱法,使用COSMOSIL Packed Column 5 C_(18)-AR-Ⅱ色谱柱,以乙腈-水(体积比65:35)为流动相,紫外检测器检测波长为260 nm,对氟噻唑吡乙酮原药进行分离和测定。[结果]当氟噻唑吡乙酮质量浓度为10.0~1000 mg/L时,氟噻唑吡乙酮的线性相关系数为0.999 868,标准偏差为0.15,变异系数为0.16%,平均回收率为99.95%。[结论]该方法准确、快速、分离效果好,适合于氟噻唑吡乙酮原药的定量分析。

关键词：氟噻唑吡乙酮高效液相色谱定量分析

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