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Acta Metallurgica Sinica(English Letters) 2022年第5期35卷 745-756页

作者： yu-qing mao Ping Yang Li-Ming Ke Yang Xu yu-Hua Chen National Defence Key Discipline Laboratory of Light Alloy Processing Science and Technology Nanchang Hangkong UniversityNanchang330063China

Four tools with different pin centerline deviations were fabricated to friction stir weld(FSW)thick plates of Al-Mg-Zn-Cu *** results show that,compared with the pin without pin centerline deviation,the applying of pin centerline deviation is favorable to improve the flowability of plastic material,enlarging the size of nugget zone,refining the grains and reprecipitated phase particles,enhancing the degrees of dynamic recrystallization and quantity of high angle grain boundaries owing to higher temperature and bigger eccentric force,resulting in the increase of strain *** for the used pin with a centerline deviation of 0.2 mm,the highest average hardness and best metallurgical properties of thick FSW joints are produced,and which are consistent with the microstructure evolution and recrystallization ***,the fracture mode of the joints produced by the pins with centerline deviation from 0 mm to 0.3 mm changes gradually from a brittle fracture in the nugget zone(NZ)to a ductile failure in the HAZ.

关键词： Thick Al-Mg-Zn-Cu alloys Friction stir welding Pin centerline deviation Microstructure evolution Recrystallization behavior

A CCD OBSERVATIONAL METHOD TO DETERMINE PRECISELY THE BARYCENTRICPOSITIONS OF THE OUTER PLANETS(SATURN-NEPTUNE)

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紫金山天文台台刊 1998年第2期 78-83页

作者： Peng qing-yu mao Wei( yunnan Observatory, Chinese Academy of Sciences, Kunming 650011 )

This paper presents a new method to determine precisely the barycentric positions of the outer planets(Saturn - Neptune)by optical observations. It requires the CCD observations from a long focal distance telescope which is used to observe a planet and its satellites and ones from a meridian circle when it works in a CCD drift scanning manner. The key part of the method is tested by the observations with 1 meter telescope of yunnan Observatory. The result shows that the new method is feasible to carry out.

关键词： astrometry - natural satellites - planet position

Autophagy:A new therapeutic target for liver fibrosis

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World Journal of Hepatology 2015年第16期7卷 1982-1986页

作者： yu-qing mao Xiao-Ming Fan Department of Gastroenterology Jinshan Hospital of Fudan University Department of Internal Medicine Shanghai Medical College Fudan University

Hepatic fibrosis is a wound-healing response to liver injury and the result of imbalance of extracellular matrix(ECM) accumulation and degradation. The relentlessproduction and progressive accumulation of ECM can lead to end-stage liver disease. Although significant progress has been achieved in elucidating the mechanisms of fibrogenesis, effective anti-fibrotic strategies are still lacking. Autophagy is an intracellular process of self-digestion of defective organelles to provide material recycling or energy for cell survival. Autophagy has been implicated in the pathophysiology of many human disorders including hepatic fibrosis. However, the exact relationships between autophagy and hepatic fibrosis are not totally clear and need further investigations. A new therapeutic target for liver fibrosis could be developed with a better understanding of autophagy.

关键词： Autophagy Liver fibrosis Hepatic stellatecells Antifibrotic target

Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome

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World Journal of Gastroenterology 2024年第10期30卷 1431-1449页

作者： Zheng-Yang Li yu-qing mao Qian Hua Yong-Hong Sun Hai-Yan Wang Xuan-Guang Ye Jing-Xian Hu Ya-Jie Wang Miao Jiang Department of Gastroenterology Jinshan Hospital of Fudan UniversityShanghai 201508China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Gastroenterology Dalian Friendship HospitalDalian 116001Liaoning ProvinceChina Department of Pathology Jinshan Hospital of Fudan UniversityShanghai 201508China

BACKGROUND Serotonin receptor 2B(5-HT2B receptor)plays a critical role in many chronic pain *** possible involvement of the 5-HT2B receptor in the altered gut sensation of irritable bowel syndrome with diarrhea(IBS-D)was investigated in the present *** To investigate the possible involvement of 5-HT2B receptor in the altered gut sensation in rat model and patients with *** Rectosigmoid biopsies were collected from 18 patients with IBS-D and 10 patients with irritable bowel syndrome with constipation who fulfilled the Rome IV criteria and 15 healthy *** expression level of the 5-HT2B receptor in colon tissue was measured using an enzyme-linked immunosorbent assay and correlated with abdominal pain *** IBS-D rat model was induced by intracolonic instillation of acetic acid and wrap *** in visceral sensitivity and 5-HT2B receptor and transient receptor potential vanilloid type 1(TRPV1)expression were examined following 5-HT2B receptor antagonist *** in visceral sensitivity after administration of the TRPV1 antago-INTRODUCTION Irritable bowel syndrome(IBS)is a chronic functional bowel disorder characterized by recurrent abdominal pain with altered bowel habits that affects approximately 15%of the population worldwide[1].IBS significantly impacts the quality of life of *** the pathogenesis of IBS is not completely understood,the role of abnormal visceral sensitivity in IBS has recently emerged[2,3].5-Hydroxytryptamine(5-HT)is known to play a key role in the physiological states of the gastrointestinal *** 5-HT levels in IBS with diarrhea(IBS-D)patients were greater than those in healthy controls[4],suggesting a possible role of 5-HT in the pathogenesis of *** serotonin receptor 2(5-HT2 receptor)family comprises three subtypes:5-HT2A,5-HT2B,and *** 5-HT2 receptors exhibit 46%-50%overall sequence identity,and all of these receptors preferentially bind to Gq/

关键词： Diarrhea-predominant irritable bowel syndrome Serotonin receptor 2B Transient receptor potential vanilloid type-1 Visceral hypersensitivity Abdominal pain

Activity of HDV ribozymes to trans-cleave HCV RNA

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World Journal of Gastroenterology 2002年第4期8卷 694-698页

作者： yue-Cheng yu qing mao Chang-Hai Gu Qi-Fen Li yu-Ming Wang Institute of Infectious Diseases of Chinese PLA,Southwest Hospital,Third Military Medical University,Chongqing 400038,China Institute of Infectious Diseases of Chinese PLA Southwest Hospital Third Military Medical University Chongqing 400038China. yuechengyu212001@***

AIM: To explore whether HDV ribozymes have the abilityto trans-cleave ***: Three HDV genomic ribozymes weredesigned and named RzC1, RzC2 and RzC3. Thesubstrate RNA contained HCVRNA 5'-noncoding regionand 5'-fragment of C region (5'-NCR-C). All theribozymes and HCV RNA 5'-NCR-C were obtained bytranscription in vibo from their DNA templates, and HCVRNA 5'-NCR-C was radiolabelled at its 5'-end Undercertain pH, temperature, appropriate concentration ofMg2+ and deionized formamide, these ribozymes wererespectively or simultaneously mixed with HCVRNA 5'-NCR-C and reacted for a certain time. The trans-cleavage reaction was stopped at different time points,and the products were separated with polyacrylamidegel electrophoresis (PAGE), displayed byautoradiography. Percentage of trans-deaved productswas measured to indicate the activity of HDV ***: RzC1 and RzC2 could trans-cleave 26 % and21.8 % of HCV RNA 5'-NCR-C under our reactionconditions with 2.5 mol. L-1 deionized formamiderespectively. The percentage of HCV RNA 5'-NCR-Ctrans-cleaved by RzC1, RzC2 or combined usage of thethree ribozymes increased with time, up to 24.9 %, 20.3 %and 37.3 % respectively at 90 min point. Almost noproduct from RzC3 was ***: HDV ribozymes are able to trans-cleavespecifically HCV RNA at certain sites under appropriateconditions, and combination of several ribozymesaiming at different target sites can trans-cleave thesubstrate more efficiently than using only one of them.

关键词：丁型肝炎病毒核酸重组丙型肝炎病毒 RNA活性

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连续级配饱和破碎岩石压实特性试验研究

煤炭学报 2016年第9期41卷 2195-2202页

作者：冯梅梅吴疆宇陈占清茅献彪郁邦永中国矿业大学深部岩土力学与地下工程国家重点实验室江苏徐州221116 中国矿业大学力学与建筑工程学院江苏徐州221116

为研究满足连续级配的饱和破碎岩石压实特性及压实前后岩石粒径的分布规律,利用MTS816.03岩石力学试验系统及自制装置对满足Talbol分布的饱和破碎岩石进行压实试验研究。分析了Talbol指数对割线模量、切线模量、孔隙率、碎胀系数和压实... 详细信息

为研究满足连续级配的饱和破碎岩石压实特性及压实前后岩石粒径的分布规律,利用MTS816.03岩石力学试验系统及自制装置对满足Talbol分布的饱和破碎岩石进行压实试验研究。分析了Talbol指数对割线模量、切线模量、孔隙率、碎胀系数和压实度的影响,讨论了分布系数r随Talbol指数和轴向应力的变化规律,建立了一种反映颗粒粒径分布变化的破碎岩石应力-应变关系。研究表明:破碎岩样在承载过程中,割线模量、切线模量、孔隙率、碎胀系数、压实度与Talbol指数n呈负相关关系。分布系数r随轴向应力的增大而减小;且在轴向应力小于单轴抗压强度的50%时,分布系数r随n呈增大趋势;当轴向应力大于单轴抗压强度的50%时,破碎岩样分布系数r与n的关系出现波动;当轴向应力达到单轴抗压强度的90%后,不同n的破碎岩样分布系数r趋于一致。

关键词：岩石力学饱和破碎岩石压实连续级配 Talbol指数

MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self-Powered Motion Sensing

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： Wang, yu-Ze Wang, yu-Chang Liu, Ting-Ting Zhao, Quan-Liang Li, Chen-Sha Cao, mao-Sheng Beijing Inst Technol Sch Mat Sci & Engn Beijing 100081 Peoples R China Peking Univ Sch Mat Sci & Engn Beijing 100871 Peoples R China North China Univ Technol Sch Mech & Mat Engn Beijing 100144 Peoples R China Heilongjiang Univ Minist Educ Peoples Republ China Key Lab Funct Inorgan Mat Chem Harbin 150080 Peoples R China

Polymeric microwave actuators combining tissue-like softness with programmable microwave-responsive deformation hold great promise for mobile intelligent devices and bionic soft robots. However, their application is challenged by restricted electromagnetic sensitivity and intricate sensing coupling. In this study, a sensitized polymeric microwave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx (MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique space-charge polarization and interfacial polarization, resulting in significant improvements of 230% in the dielectric loss factor and 830% in the apparent efficiency of electromagnetic energy harvest. The sensitized microwave actuation demonstrates as the shortened response time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (up to 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combines driving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of similar to 3 mV) during actuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approach for developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

Ideal Bi-Based Hybrid Anode Material for Ultrafast Charging of Sodium-Ion Batteries at Extremely Low Temperatures

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NANO-MICRO LETTERS 2025年第1期17卷 1-16页

作者： Bai, Jie Jia, Jian Hui Wang, yu Yang, Chun Cheng Jiang, qing Jilin Univ Key Lab Automobile Mat Sch Mat Sci & Engn Minist Educ Changchun 130022 Peoples R China

Metallic nanoparticles with excellent size controllability and high loading rate are obtained via ultrafast high temperature shock *** Bi/CNRs-15 electrode exhibits an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, while the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C.A novel strategy of high-rate activation is proposed to obtain high capacity and superior stability at low temperature by creating new active sites for interfacial reaction. Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at - 20 degrees C or lower. However, the key capability of ultrafast charging at ultralow temperature for SIBs is rarely reported. Herein, a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue, which is synthesized via a high temperature shock method. Such a hybrid shows an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, outperforming all reported SIB anode materials. Coupled with a Na3V2(PO4)3 cathode, the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C. Based on this work, a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

生物制剂与炎症性肠病恶性肿瘤发生风险关系的研究进展

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世界华人消化杂志 2024年第3期32卷 221-227页

作者：毛雨晴孙少鹏吕宾范一宏浙江中医药大学附属第一医院消化内科浙江省杭州市310003

炎症性肠病(inflammation bowel disease,IBD)作为一种慢性疾病需终身治疗,使用生物制剂开展靶向治疗是当前IBD的主要治疗方法.随着IBD合并恶性肿瘤患者的逐渐增多,生物制剂与IBD患者恶性肿瘤的发生风险之间的关系日益引起关注.本文对... 详细信息

炎症性肠病(inflammation bowel disease,IBD)作为一种慢性疾病需终身治疗,使用生物制剂开展靶向治疗是当前IBD的主要治疗方法.随着IBD合并恶性肿瘤患者的逐渐增多,生物制剂与IBD患者恶性肿瘤的发生风险之间的关系日益引起关注.本文对生物制剂的使用与否与IBD患者恶性肿瘤的发生和发展风险进行综述,以期为IBD患者的临床用药决策提供参考.

关键词：生物制剂恶性肿瘤炎症性肠病溃疡性结肠炎克罗恩病,抗肿瘤坏死因子

Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients

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World Journal of Clinical Cases 2025年第4期13卷 18-27页

作者： Cheng-Cheng Wei yu-qing Huang Cheng-Hong yu Department of Cardiology Tongxiang First People's HospitalTongxiang 314500Zhejiang ProvinceChina Department of Cardiology Guangdong Cardiovascular InstituteGuangzhou 510080Guangdong ProvinceChina

BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained *** To investigate the link between longitudinal changes in lipid profiles and dyslipidemia and ischemic stroke in a hypertensive *** Between 2013 and 2014,6094 hypertension individuals were included in this,and ischemic stroke cases were documented to the end of *** changes of lipid were stratified into four groups:(1)Normal was transformed into normal group;(2)Abnormal was transformed into normal group;(3)Normal was transformed into abnormal group;and(4)Abnormal was transformed into abnormal *** examine the link between longitudinal changes in dyslipidemia along with its components and the risk of ischemic stroke,we utilized multivariate Cox proportional hazards models with hazard ratio(HR)and 95%*** The average age of the participants was 62.32 years±13.00 years,with 329 women making up 54.0%of the *** the course of a mean follow-up of 4.8 years,143 ischemic strokes *** normal was transformed into normal group was used as a reference,after full adjustments,the HR for dyslipidemia and ischemic stroke among abnormal was transformed into normal group,normal was transformed into abnormal group and abnormal was transformed into abnormal Wei CC et *** changed and ischemic stroke WJCC https://*** 2 February 6,2025 Volume 13 Issue 4 group were 1.089(95%CI:0.598-1.982;P=0.779),2.369(95%CI:1.424-3.941;P<0.001)and 1.448(95%CI:1.002-2.298;P=0.047)(P for trend was 0.233),*** In individuals with hypertension,longitudinal shifts from normal to abnormal in dyslipidemia-particularly in total and low-density lipoprotein cholesterol-were significantly associated with the risk of ischemic stroke.

关键词： Longitudinal change Hypertension Dyslipidemia Lipid profile Ischemic stroke