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Optical scheme for realization of optimal unambiguous state discrimination of the JS limit

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Science China(Physics,Mechanics & Astronomy) 2013年第3期56卷 606-609页

作者： zhang WenHai yu LongBao CAO ZhuoLiang YE Liu Department of Physics Huainan Normal University Department of Physics and Electronic Engineering Hefei Normal University School of Physics and Material Science Anhui University

We exploit optimal probabilistic cloning to rederive the JS *** on the formulation given by the optimal probabilistic cloning,the explicit transformation of a measure of the JS limit is *** on linear optical devices,we propose an experimentally feasible scheme to implement the JS limit measure of a general pair of two nonorthogonal quantum *** success probability of the proposed scheme is unity.

关键词： quantum state discrimination optimal unambiguous discrimination JS limit optimal probabilistic quantum cloning

The DNMT1-PAS1-PH20 axis drives breast cancer growth and metastasis

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1311-1321页

作者： Yenan Fu Xi zhang Xiao Liu Peng Wang Wenhui Chu Wei Zhao yunling Wang Guangbiao Zhou yu yu Hongquan zhang Program for Cancer and Cell Biology Department of Human AnatomyHistology and EmbryologySchool of Basic Medical SciencesPKU International Cancer InstituteMOE Key Laboratory of Carcinogenesis and Translational Research and State Key Laboratory of Natural and Biomimetic DrugsPeking University Health Science CenterBeijing 100191China Department of Orthopedics Peking University Third HospitalBeijing 100191China Institute for Cardiovascular Research Peking UniversityBeijing 100191China State Key Laboratory of Molecular Oncology National Cancer CenterNational Clinical Research Center for CancerCancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

PH20 is a member of the human hyaluronidase family that degrades hyaluronan in the extracellular matrix and controls tumor *** of DNA methyltransferases(DNMTs)leads to elevated hyaluronan levels;however,whether DNMT inhibitors control PH20 remains ***,we report that the DNMT1 inhibitor,decitabine,suppresses PH20 expression by activating the long non-coding RNA PHACTR2-AS1(PAS1).PAS1 forms a tripartite complex with the RNA-binding protein vigilin and histone methyltransferase *** interaction between PAS1 and vigilin maintains the stability of ***,PAS1 recruits SUV39H1 to trigger the H3K9 methylation of PH20,resulting in its ***,PAS1 inhibits breast cancer growth and metastasis,at least partially,by suppressing *** therapy of decitabine and PAS1-30nt-RNA,which directly binds to SUV39H1,effectively blocked breast cancer growth and metastasis in *** together,DNMT1,PAS1,and PH20 comprise a regulatory axis to control breast cancer growth and *** findings reveal that the DNMT1-PAS1-PH20 axis is a potential therapeutic target for breast cancer.

关键词： metastasis breast DNMT1

Synthesis and photochemistry of novel bromo substituted stilbene derivatives as triplet state sensitizers for the generation of singlet oxygen

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Chinese Chemical Letters 2009年第12期20卷 1415-1418页

作者： Hong Ru Li qin yuan Guo Ting Xie Fang Gao Sheng Tao zhang College of Chemistry and Chemical Engineering Chongqing University Chongqing 400044 China

We have presented the synthesis and characterization of three new bromo substituted stilbene derivatives, p-3,4,5-trimethoxy-p′- 2,3,4,5,6-pentabromostilbene （C1）, p-N,N-dimethylamino-p′-2,3,4,5,6-pentabromostilbene （C2） and p-N,N-diphenylamino-p′- 2,3,4,5,6-pentabromostilbene （C3） in this letter. The UV/vis absorption and photoluminescence were investigated in various solvents. The maximal absorption wavelength of C1 exhibited blue-shift to those of C2 and C3 in different solvents. No florescence emission could be detected for these compounds at room temperature. Singlet oxygen could be efficiently produced with these sensitizers under near-ultraviolet and visible light irradiation.

关键词： Synthesis Photochemistry Triplet state Bromo substitution Singlet oxygen

Synthesis, Crystal Structure, Physical Properties, and Application of a Series of Functional Dibenzo[d,f][1,3]dioxepine Derivatives

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Chemical Research in Chinese Universities 2008年第6期24卷 798-804页

作者： zhang Hai-quan zhang Cheng-bo ZHENG Yan YANG Bing MA yu-guang State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao 066004 P. R. China State Key Lab for Supramolecular Structure and Materials Jilin University Changchun 130012 P. R. China

The twisted aromatics, functional dibenzo[d,f][1,3]dioxepine derivatives were synthesized in high yields from reactions of 5,5＇-dibromo-2,2＇-biphenol with corresponding ketal or ketone compounds under acid catalysis. The structures of these compounds were characterized by ^1H NMR, elemental analysis, UV-Vis absorption spectrum and X-ray diffraction analysis. The conformation of O--C--O bridged biphenyl derivatives with varied substitute groups on 6,6＇-position was studied by X-ray crystallography and force-field simulation. The result of calculations by UNIVERSAL 1.02 force field in Cerius2 package（4.6） indicates that dibenzo[d,f][1,3]dioxepine derivatives show twisted conformations and the twisted angle between the phenyl rings is about 40°, which is accordant with the result from crystal structure determination, though the obtained angles in the crystal of dibenzo[d,f][1,3]dioxepine derivatives with the varied substitute groups on 6,6＇-position are shown to be slightly shifted to 40° owing to intermolecular interactions in crystal stacking. DSC studies exhibit that the substitute groups on 6,6＇-position can induce a large variation of endothermic peaks ranging from 80 to 135 ℃. The conjugated polymers based on dibenzo[d,f][1,3]dioxepine derivatives, which have ultraviolet emitting with a quantum efficiency of 10%, were obtained by Yamamoto coupling.

关键词： Dibenzo[d,f]dioxepine Twisted angle Crystal structure Twisted conformation Ultraviolet emission

Robust frequency-upconversion lasing operated at 400 K from inorganic perovskites microcavity

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Nano Research 2022年第1期15卷 492-501页

作者： Zhifeng Shi Fei zhang Jingjing Yan yuan zhang Xu Chen Shu Chen Di Wu Xinjian Li yu zhang Chongxin Shan Key Laboratory of Materials Physics of Ministry of Education School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityQianjin Street 2699Changchun 130012China

Multi-photon-pumped lasing based on metal-halide perovskites is promising for nonlinear optics and practical frequency-upconversion devices in integrated photonic ***,at present almost all the multi-photon-pumped lasing emissions from perovskite microcavities were limited for two-photon excitation,and also suffered from a compromise in room temperature or low temperature operation *** this study,based on the vapor-phase epitaxial CsPbBr3 microplatelets with high crystallinity,self-formed high-quality microcavities,and great thermal stability,low-threshold and high-quality factor whispering gallery mode lasing was realized under single-,two-,and three-photon excitation,and the lasing action is very stable under continuous pulsed laser irradiation(~3.6×10^(7) laser shots).More importantly,the three-photon-pumped lasing can be efficiently sustained at a high temperature of~400 K,and the characteristic temperature was determined to be as high as~152.6 K,indicating the highly temperature-insensitive gain *** that this is the first report on high-temperature three-photon-pumped lasing on perovskite ***,an aggressive thermal cycling test(two cycles,290-400-290 K)was further performed to indicate the stability and repeatability of the multi-photon-pumped lasing *** can be anticipated that the results obtained represent a significant step toward the temperature-insensitive frequency-upconversion lasing,inspiring the exploitation of advantageous perovskites for novel applications.

关键词： frequency-upconversion lasing perovskite microcavity high-temperature characteristic temperature stability

Structures and macrosegregation of a 2024 aluminum alloy fabricated by direct chill casting with double cooling field

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China Foundry 2022年第1期19卷 1-8页

作者： Cheng Zhu Zhi-hao Zhao qing-feng Zhu Gao-song Wang yu-bo Zuo Gao-wu qin Research Center for Metallic Wires School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China Key Laboratory of Anisotropy and Texture of Materials Ministry of EducationNortheastern UniversityShenyang 110819China

Central region coarse grains and centerline segregation are common defects in aluminum ingots fabricated by direct chill(DC)casting.A double cooling field was introduced into the DC casting process to reduce these defects,whereby the external cooling was supplied by the mold and water jets,and intercooling was achieved by inserting a rod of the same alloy into the molten pool along the central axis of the *** than forming a good metallurgical interface during solid-liquid compound casting,in the present work,the purpose of inserting the rod is to enforce internal cooling and consequently decrease the sump ***,the insertion provides more nucleation sites with the unmoltenα-Al *** structure and the macrosegregation of 2024 Al alloy ingots prepared by DC casting with and without the inserts were *** show that when the inserting position is 50 mm above the upper edge of the graphite ring,significant grain refinement in the central region of the ingot and a reduced centerline segregation are achieved.

关键词： aluminum alloy direct chill casting double cooling field grain refinement macrosegregation

Resident Prrxl lineage stromal cells promote T cell survival in the spleen

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Journal of Molecular Cell Biology 2019年第2期11卷 182-184页

作者： Wanyao zhang Qian yu Huijuan Liu Baojie Li Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education Shanghai Jiao Tong UniversityShanghai 200240 China

Dear Editor, Spleen is a sec on dary lymphoid organ (SLO). It is composed of white pulps, lymph node-like structures that contain T and B cells, and red pulps, which filter effete red blood cells. The architecture of spleen is supported by stromal cells that can be classified into at least four subtypes based on expression of CD31 and podoplanin (gp38): lymphatic endothelial cells (LECs, CD31^+ gp38^+), blood endothelial cells (BECs, CD31^+ gp38^-), fibroblastic reticular cells (FRCs, CD31^- gp38^+), and double-negative stromal cells (DNSCs, CD31^- gp38^-)(Link et al., 2007). The stromal cells form a physical framework that supports compartmentation of SLOs (Astarita et al, 2015). In addition, growing evidence indicates that stromal cells also play critical roles in immune cell homeostasis (Mueller and Germain, 2009). Stromal cells in SLOs can secrete cytokines, e.g. IL7, CCL19, and CCL21, to regulate proliferation, apoptosis, and migration of immune cells (Roozendaal and Mebius, 2011).

关键词： T cell survival spleen Prrxl lineage stromal cells

Control on β conformation of poly(9,9-di-n-octylfluorene)via solvent annealing

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Chinese Physics B 2019年第7期28卷 345-348页

作者： Zhi Chao zhang Bing yue zhang yu Yan Weng Tian Hui zhang Center for Soft Condensed Matter Physics and Interdisciplinary Research and College of Physics Soochow University Suzhou 215006 China National Laboratory of Solid State Microstructures Nanjing University Nanjing 210093 China

Films of poly(9,9-dioctylfluorene)(PFO) are of great importance in fabricating light emitting *** practice, theβ-phase of PFO is expected due to its high efficiency in the transport of charge *** promote the formation of β-phase,PFO films are immersed and annealed in the mixture of solvent/*** effects of temperature, solvent/nonsolvent ratio, and annealing time are examined *** is found that the fraction of β-phase can be highly improved by increasing the ratio of solvent/*** reconfiguration of PFO molecules for β-phase in annealing is generally finished in 10 *** finding in this study demonstrates that solvent-assisted annealing offers a fast and economic approach for mass annealing.

关键词： organic crystal conjugated polymer solvent annealing

Inhibitory effect of synthetic small interfering RNAs on glial fibrillary acidic expression in astrocytes

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Neural Regeneration Research 2008年第9期3卷 950-953页

作者： Mingzhu zhang qing Zhao Xin Tang Guangrong yu Department of Orthopedics First Affiliated Hospital of Dalian Medical University Dalian 116011 Liaoning Province China Depratment of Orthopedics Tongji Hospital of Tongji University Shanghai 200065 China

BACKGROUND： Glial fibritlary acidic protein （GFAP） expression highly correlates with spinal glial scar formation, and is regarded as an important target for scar therapy. Efficient inhibition of expression could benefit recovery from spinal cord injury. OBJECTIVE： To investigate the inhibitory effects of synthetic small interfering RNAs （siRNAs） on astrocytic GFAP expression in rats. DESIGN, TIME AND SETTING： A randomized, controlled, animal experiment at the cellular and molecular level was performed at the First Hospital of Dalian Medical University between June 2005 and February 2006. MATERIALS： A total of 100 seven-day-old, Sprague Dawley rats were selected. GAPDH siRNA was purchased from Ambion, USA, And TransMessengerTM Transfection Reagent from DAKO, Carpinteria, CA. METHODS： Rat astrocytes were isolated and cultured. Three pairs of 21-nucleotide （nt） siRNAs specific to rats GFAP mRNA, 401,404 and 854, were synthesized and transfected in primary astrocytes at 1, 2, 3, and 4 g/L using TransMessengerTM Transfection Reagent. Non-transfected astrocytes served as the blank group. Cells transfected with siRNA were regarded as the negative control group, with GAPDH siRNA as the positive control group, and 401 siRNA, 404 siRNA, and 854 siRNA as experimental groups. MAIN OUTCOME MEASURES： GFAP mRNA and protein expression were assessed by RT-PCR and Western blot, respectively, at 24, 48, and 72 hours of culture. RESULTS： GFAP mRNA expression in the positive control group was significantly less than the negative control group （P 〈 0.01）. GFAP mRNA expression in astrocytes from three pairs of siRNA was significantly less than the blank group after 48 hours （P 〈 0.01 ）, while no differences were detected between the negative control and blank groups （P 〉 0.05）. GFAP protein expression was remarkably less in siRNA-transfected astrocytes compared to the blank control （P 〈 0.01 ）. CONCLUSION： Transfected siRNAs could significantly inhibit GFAP gene expression in astrocytes a

关键词： glial fibrillary acidic protein RNA interference spinal cord injury