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Synthesis of 5-functionalized-1,2,3-triazoles via a one-pot aerobic oxidative coupling reaction of alkynes and azides

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Chinese Chemical Letters 2014年第8期25卷 1161-1164页

作者： Ling-Jun Li yu-qin zhang Yang zhang An-Lian Zhu Gui-Sheng zhang School of Chemistry and Chemical Engineering Key Laboratory of Green Chemical Media and Reactions Ministry of EducationCollaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals Henan Normal University

In this paper, an efficient synthesis of 5-alkynyl-1,2,3-triazoles through a one-pot aerobic oxidative coupling reaction of various alkynes and azides has been developed. Further derivatization of 5-alkynyl-1,2,3-triazoles readily yielded 5-carbonyl-1,2,3-triazoles, 5-carboxylic-1,2,3-triazole, 5-hydroxyalkyl-1,2,3-triazoles and 5-quinoxaline-1,2,3-triazole, which provided an entry into structurally diverse 5-functionalized-1,2,3-triazoles.

关键词： Alkyne Azide 1,2,3-Triazole Copper catalysis

Unveiling the twinning and dynamic recrystallization behavior and the resultant texture evolution in the extruded Mg-Bi binary alloys during hot compression

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Journal of Materials Science & Technology 2022年第10期105卷 274-285页

作者： yu-qin zhang Wei-li Cheng Hui yu Hong-xia Wang Xiao-feng Niu Li-fei Wang Hang Li School of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of Education Taiyuan University of TechnologyTaiyuan 030024China School of Materials Science and Engineering Hebei University of TechnologyTianjin 300132China

The twinning behavior, dynamic recrystallization(DRX) mechanism and the resultant texture evolution of the extruded Mg-xBi(x=0.5 wt.%, 2.0 wt.%) alloys were systematically investigated during hot compression at the strain rate of 10 s^(-1) and temperature of 200℃. The results indicate that the types and intensities of the texture are greatly dependent on the twining behavior and DRX mechanism. At the initial stage, the evolution of texture is mainly domination by the formation and variation of {1012} extension twins, which is benefcial to the compression direction(CD)-tilted basal texture. With an increase in the strain, the texture evolution is more greatly regulated by the DRX mechanism. Besides, the pyramidal slip and basal slip are activated during the compression process, resulting in the Schmid factors(SF) of pyramidal slip remain at ~0.4 and the average SFs for basal slip increase from 0.2 to0.34 as the strain increase. These fndings provide a new insight into controlling the texture of wrought Mg-Bi-based alloys during hot deformation processing.

关键词： Wrought Mg-Bi alloys Hot deformation Twinning Dynamic recrystallization Dislocation slip Texture

Characterizations on Mechanical Properties and In Vitro Bioactivity of Biomedical Ti–Nb–Zr–CPP Composites Fabricated by Spark Plasma Sintering

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Acta Metallurgica Sinica(English Letters) 2016年第11期29卷 1073-1080页

作者： Zheng-yuan He Lei zhang Wen-Rui Shan yu-qin zhang Ye-Hua Jiang Rong Zhou Jun Tan School of Materials Science and Engineering Kunming University of Science and Technology Kunming 650093China National-local Joint Engineering Laboratory of Metal Advanced Solidification Forming and Equipment Technology Kunming 650093 China Engineering Technology Research Center of Titanium Products and Application of yunnan Province Kunming 650093 China IFW Dresden Institute for Complex MaterialsP.O. Box 27 01 16 01171 Dresden Germany

To alleviate the bio-inert of Ti alloys as hard tissue implants, Ti–35Nb–7Zr–xCPP（calcium pyrophosphate,x = 5, 10, 15, 20 wt%） composites were prepared by mechanical alloying（MA） and following spark plasma sintering（SPS）. Mechanical behaviours and in vitro bioactivity of these composites were investigated systematically. Results showed that the composites consisted of β-Ti matrix, α-Ti, and metal–ceramic phases such as CaO, CaTiO3, CaZrO3, and TixPy. With increasing CPP content, the composites had higher strength（over 1500 MPa） and higher elastic modulus, but suffered almost zero plastic deformation together with lower relative density. When the CPP contents were 5 and 10 wt%,the compressive elastic moduli were 44 and 48 GPa, respectively, which were close to those of natural bones. However, the compressive elastic modulus of the composites increased significantly when CPP contents exceed 10 wt%, thus deteriorating the mechanical compatibility of the composites owing to more α-Ti and metal–ceramic phases. Besides, the surface of Ti–35Nb–7Zr–10CPP composite was deposited as a homogeneous apatite layer during soaking in simulated body fluid（SBF）. It indicates a good bioactivity between the implant materials and living bones.

关键词： Composites Spark plasma sintering Microstructure Mechanical behaviours Bioactivity

Removal of Fulvic Acids from Aqueous Solutions via Surfactant Modified Zeolite

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Chemical Research in Chinese Universities 2006年第5期22卷 566-570页

作者： WANG Shu-guang GONG Wen-xin LIU Xian-wei GAO Bao-yu yuE qin-yan zhang Dong-hua School of Environmental Science and Engineering Shandong University Jinan 250100 P. R. China

A surfactant modified zeolite（ SMZ）, i. e. , a zeolite modified by using hexadecyl trimethyl ammonium bromide （HDTMA） was used to remove fulvic acids（FA） from aqueous solution. The effects of the relevant parameters, such as the loading level of HDTMA, the contact time, the initial FA concentration, the pH, and the types of the metal carious and organics were examined. The results show that SMZ with an HDTMA loading-level of 120% of the external cation exchange capacity（ECEC） of zeolite exhibits the best performance. Although the removal of fulvic acids by SMZ occurs rapidly within the first 30 min of the contact time, a contact time of at least 4 h is required to attain the adsorption equilibrium. The removal capacity of FA by SMZ decreases with the increase of the initial FA concentration. The pH has an effect on the FA removal efficiency because it can influence the characteristics of the FA molecules. The removal of FA is considerably enhanced by Ca^2＋ or Mg^2＋ ions and is adversely affected by phenol or pentachlorophenol（PCP）. Under the optimum conditions, 98% of FA could be removed by SMZ. Furthermore, the desorption of FA and the regeneration of SMZ were studied. The results show that a 30% ethanol solution is sufficient for the regeneration of SMZ.

关键词： Surfactant modified zeolite(SMZ) Fulvic acids(FA) removal Adsorption Desorption

Oxcarbazepine oral suspension in pediatric patients with partial seizures and/or generalized tonic-clonic seizures: a multi-center, single arm, observational study in China

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World Journal of Pediatrics 2017年第6期13卷 551-559页

作者： Yi Wang Yin-Bo Chen yu-qin zhang Rong Luo Hua Wang Jun-Lan Lv Dong Wang Sui-Qiang Zhu Zhong-Dong Lin Jiong qin Department of Neurology Children's Hospital of Fudan UniversityShanghaiChina Department of Pediatric Neurology The First Bethune Hospital of Jilin UniversityChangchunChina Department of Neurology Tianjin Children's HospitalTianjinChina Department of Pediatric Neurology West China Second University Hospital of Sichuan UniversityChengduChina Department of Pediatric Neurology Shengjing Hospital of China Medical UniversityShenyangChina Department of Neurology Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Neurology Xi'an Children's HospitalXi'anChina Department of Neurology Tongji HospitalTongji Medical College of Huazhong University of Science&TechnologyWuhanChina Department of Pediatric Neurology The 2nd Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Department of Pediatrics Peking University People's HospitalBeijingChina

Background:To assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-16 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in ***:This 26-week,single arm,multicenter and observational study recruited patients aged 2-16 years with PS or GTCS suitable for OXC oral suspension *** patients received OXC oral suspension treatment for 26 *** endpoints included mean seizure frequency at the end of the treatment and mean seizure frequency reduction at the end of the treatment *** efficacy-related endpoints and safety parameters were also ***:Nine hundred and eighty-seven pediatric patients were enrolled and 912 (92.4%) completed the *** mean seizure frequencies at baseline and the end of week 26 were 13.40±64.92 and 1.62±19.47 times/month,*** mean seizure frequency reduction was 10.03±63.67 times/month and the mean seizure frequency reduction percentage was 90.02%±5127.0% (P<0.0001).After 26 weeks of treatment,82.36%,7.24% and 3.86% of the patients became controlled,significantly improved and improved,*** events (AEs) were reported in 74 (7.65%) *** was the most common *** efficacy of OXC was not affected by seizure types,age or ***:This study confirms the efficacy and good safety profile of OXC oral suspension in Chinese pediatric patients aged 2-16 years with PS and/or GTCS.

关键词： children efficacy generalized tonic-clonic seizures oxcarbazepine oral suspension partial seizures

Influence of PPV,PRV and PRRSV on Efficacy of the Lapinized Hog Cholera Vaccine and Pathogenicity of Classical swine fever virus

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Journal of Integrative Agriculture 2012年第11期11卷 1892-1897页

作者： NING Yi-bao ZHAO yun WANG qin FAN Xue-zheng qin yu-ming zhang Guang-chuan XU Lu QIU Hui-shen WANG Zai-shi SONG Li SHEN qing-chun ZHAO Qi-zu China National Classical Swine Fever Reference Laboratory/China Institute of Veterinary Drug Control Beijing 100081 P.R. China

Classical swine fever caused by Classical swine fever virus （CSFV） is a serious problem for swine industries in developing countries, which successful control of the disease have been relying on vaccination. However, classical swine fever still occurs in some immunized swine herds for various reasons. In this study, we conducted animal experiments to examine the influence of single or mixed infection with Porcine parvo virus （PPV）, Pseudorabies virus （PRV） and Porcine reproductive and respiratory syndrome virus （PRRSV） on the protective immunity induced by the Lapinized hog cholera virus （HCLV） vaccine and the pathogenicity of CSFV. In experiment 1, pigs were first inoculated with PPV, PRV or PRRSV, then immunized with HCLV, and finally challenged with a highly virulent CSFV Shimen strain. All of the pigs immunized with HCLV survived after the challenge, while all of the pigs in the non-immunized control group died after the challenge. The pigs in the group immunized with HCLV did not show any clinical symptoms of classical swine fever and were negative with CSFV after the challenge. The pigs infected with the non-CSFV before HCLV immunization did not display any clinical symptoms after the challenge with CSFV Shiman strain, but 11 of the 12 pigs were positive with CSFV. In experiment 2, pre-infections with PPV, PRV, and PRRSV were followed by inoculation with a low-virulence CSFV strain （CSFV 39）, and then the pigs were challenged with the CSFV Shimen strain. Infections by either PPV, PRV or PRRSV did not enhance the virulence of CSFV-39, but pigs infected by a mixture of the 3 viruses developed clinical symptoms after inoculation with CSFV-39. The mixed infection also increased mortality caused by the challenge with the CSFV Shimen strain. Together, these results showed PPV, PRV and PRRSV infections in pigs can reduce the efficacy of the HCLV vaccine and enhance the pathogenicity of CSFV, which may partly explain the immunization failure against CSFV in some swine

关键词： Lapinized hog cholera virus vaccination pathogenicity mixed infection influence

Oxcarbazepine oral suspension in young pediatric patients with partial seizures and/or generalized tonic-clonic seizures in routine clinical practice in China: a prospective observational study

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World Journal of Pediatrics 2018年第3期14卷 280-289页

作者： Jiong qin Yi Wang Xin-Fang Huang yu-qin zhang Fang Fang Yin-Bo Chen Zhong-Dong Lin Yan-Chun Deng Fei Yin Li Jiang Ye Wu Xiang-Shu Hu Department of Pediatrics Peking University People’s HospitalNo.11 Xi Zhi Men Nan Da JieXicheng DistrictBeijing 100044China Department ofP ediatrics Peking University First HospitalBeijingChina Department ofN eurology Children’s HospitalFudan UniversityShanghaiChina Department ofP ediatrics Quanzhou Women’s andChildren’s HospitalQuanzhouChina Department of N eurology Tianjin Children’s HospitalTianjinChina Department of N eurology Beijing Children’s HospitalBeijingChina Department of Pediatric Neurology The First Bethune HospitalJilin UniversityChangchunChina Department of Pediatric Neurology The 2nd Affi liated HospitalWenzhou Medical UniversityWenzhouChina Department of N eurology Xijing HospitalXi’anChina Department of P ediatrics Xiangya HospitalCentral South UniversityChangshaChina Department of N eurology Children’s HospitalChongqing Medical UniversityChongqingChina The third Department ofN eurology Guangdong 999 Brain HospitalGuangzhouChina

Background This study aimed to assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-5 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in China. Methods This 26-week, prospective, single-arm, multicenter, observational study recruited pediatric patients aged 2-5 years with PS or GTCS suitable for OXC oral suspension treatment based on physicians' judgments from 11 medical centers in China. Enrolled subjects started OXC oral suspension treatment as monotherapy or in combination with other antiepileptic drugs. Primary efficacy outcome was the percentage of pediatric subjects achieving ≥ 50% seizure frequency reduction at the end of the 26-week treatment. Secondary efficacy-related parameters and safety parameters such as adverse events (AEs) and serious AEs (SAEs) were also monitored during the 26-week treatment period. Results Six hundred and six pediatric patients were enrolled and 531 (87.6%) completed the study. After 26 weeks of treat-ment, 93.3% subjects achieved ≥ 50% seizure frequency reduction, and 81.8% achieved 100% seizure frequency reduction compared to baseline. Among diff erent seizure types, OXC was eff ective in all subjects with simple PS and in > 90% of subject with other type of seizure present in the study. AEs were observed in 49 (8.1%) subjects. Only three subjects expe-rienced SAE. Rash (n = 18, 2.97%) was the most common AE. Only 17 subjects discontinued due to AEs. Conclusion This study, reporting the real-world data, further confi rms the efficacy and good safety profi le of OXC oral suspension in Chinese pediatric patients aged 2-5 years with PS and/or GTCS.

关键词： Antiepileptic drugs Generalized tonic-clonic seizures Oxcarbazepine oral suspension Partial seizures Pediatric patients

Diversity of fungal communities associated with biological soil crusts in the Shapotou Region,Tegger Desert,China

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Diversity of fungal communities associated with biological s...

Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

第五届全国微生物资源学术暨国家微生物资源平台运行服务研讨会

作者： Tao zhang yu-qin zhang Hong-yu Liu yu-Zhen Wei Li-Yan yu Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences & Peking Union Medical College

The diversity of fungal communities associated with biological soil crusts in arid and semiarid regions are one of the least explored *** particular,the Tegger desert in China remains mycologically poorly *** this study,we investigate the diversity of fungal communities associated with different crusts(i.e.,cyanobacterial crusts,moss crusts and lichen crusts) at five locations in Shapotou Region using cultivation and 454 pyrosequencing.A total of 300 isolates were recovered and 141 isolates were phylogenetically affiliated to 84 different taxa within 34 different genera with >50%of the total isolates belonging to Alternaria,Aspergillus,Chaetomium,Cladosporium,Coniothyrium, Cryptococcus,Emericella,Fusarium,Penicillium and Phoma.A total of 50,223 sequence reads were obtained with Ascomycota,Basidiomycota and Chytridiomycota encompassing >96%of the total sequences. Fungal communities showed high diversity;the 50,223 sequence reads belonged to 1362 *** these, 938 belonged to the phylum Ascomycota,121 to the phylum Basidiomycota,2 to the phylum Zygomycota, 9 to the phylum Chytridiomycota,and 292 to unknown *** detected fungi confirmed earlier trends in fungal diversity in other habitats,quite a number of sequences representing novel taxa were *** conclude that desert crusts in the Shapotou Region harbor a large diversity of fungal communities that varies with crust type and desert locations.

关键词： Biological soil crusts Fungi Cultivation 454 Pyrosequencing Shapotou Region

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di zhang Pengfei Lv Wei qin Xin He yuanhua He Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability