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circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling

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World Journal of Gastroenterology 2018年第3期24卷 323-337页

作者： Xing-Ya Guo Fang Sun Jian-Neng Chen yu-qin wang qin Pan Jian-Gao Fan Department of Gastroenterology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China Department of Hepatology Zhengxing HospitalZhangzhou 363000Fujian ProvinceChina Shanghai Key Laboratory of Children’s Digestion and Nutrition Shanghai 200092China

AIM To investigate micro(mi)R-34 a-antagonizing circular(circ)RNA that underlies hepatocellular *** The effect of circ RNA on mi R-34 a was recognized by the mi RNA response element(MRE), and validated by the dual-luciferase reporter assay. Its association with hepatocellular steatosis was investigated in Hep G2-based hepatocellular steatosis induced by free fatty acids(FFAs; 2:1 oleate:palmitate) stimulation. After normalization of the steatosis-related circRNA by expression vector, analysis of mi R-34 a activity,peroxisome proliferator-activated receptor(PPAR)α level, and expression of downstream genes were carried out so as to reveal its impact on the mi R-34 a/PPARα regulatory system. Both triglyceride(TG) assessment and cytopathological manifestations uncovered the role of circRNA in miR-34 a-dependent *** Bioinformatic and functional analysis verified circRNA_0046366 to antagonize the activity of mi R-34 a via MRE-based complementation. In contrast to its lowered level during FFA-induced hepatocellular steatosis, circ RNA_0046366 up-regulation abolished the mi R-34 a-dependent inhibition of PPARα that played a critical role in metabolic signaling pathways. PPARα restoration exerted transcriptional improvement to multiple genes responsible for lipid metabolism. TGspecific lipolytic genes [carnitine palmitoyltransferase 1 A(CPT1 A) and solute-carrier family 27 A(SLC27 A)] among these showed significant increase in their expression levels. The circ RNA_0046366-related rebalancing of lipid homeostasis led to dramatic reduction of TG content, and resulted in the ameliorated phenotype of hepatocellular *** Dysregulation of circ RNA_0046366/mi R-34 a/PPARα signaling may be a novel epigenetic mechanism underlying hepatocellular steatosis. circ RNA_0046366 serves as a potential target for the treatment of hepatic steatosis.

关键词： hepatocytes steatosis circRNA_0046366 miR-34a peroxisome proliferator-activated receptorα

A self-management application“painhousekeeper”to control cancer pain:a randomized controlled trial study protocol

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Frontiers of Nursing 2020年第3期7卷 257-267页

作者： Qian Liu Xiao-Man Zhang Pei-yu Liu Ya-Ling wang yu-qin wang School of Nursing Xuzhou Medical UniversityXuzhouJiangsu 221000China Department of General Surgery Affiliated HospitalXuzhou Medical UniversityXuzhouJiangsu 221000China

Objective:Pain is a prevalent and distressing symptom in patients with cancer which has a significant impact on patients’physical health,psychological well-being,and quality of life(QOL).Deficiency of pain care,inadequate pain communication,and reluctance toward pain medication contribute to the difficulties in improving the situation of patients with cancer ***,the integration of self-management and professional healthcare provides new opportunities for patients with cancer ***:A two-arm randomized controlled trial will be conducted to assess the effectiveness of self-management application compared with routine care among patients with cancer *** on Orem’s self-care theory and Naylor’s transitional care theory,cancer pain self-management application“Pain-housekeeper”was developed with dual client:patient client and medical client.A total of 120 patients with cancer pain are recruited from two university-affiliated tertiary public hospitals in *** are randomly assigned to the control group and the intervention *** patients in the control group get routine care while the patients in the intervention group get routine care and Pain-housekeeper *** intervention is delivered by registered doctors,nurses,and postgraduate nursing students specialized in pain *** measurements for both groups are carried out with questionnaires at baseline(T0),after 4 weeks(T1)and after 12 weeks(T2).The primary outcomes include pain condition,self-efficacy,and *** secondary outcomes include pain medication adherence,satisfaction,anxiety,and *** of data submission,economic evaluation,usage,and clinical data are also considered in the *** for the evaluation are gathered continuously during the study ***:This article provides insight into the effectiveness of a theory-based self-management mobile application intervention delivered to patients with uncontrolled cancer *** results are used to he

关键词： cancer pain self-management application pain condition quality of life self-efficacy•randomized controlled trial

Localization of Inhibin in Some Rat Tissues and Exploration of Its Transport Mechanism

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Agricultural Sciences in China 2006年第9期5卷 718-724页

作者： ZHANG Zhong-xia XU Lu DI He-shuang YAN yu-qin wang Gen-lin College of Animal Science and Technology Nanjing Agricultural University Nanjing 210095 P.R.China

The aims of the study were to determine the distribution of inhibin and its α subunit in some rat tissues by an immunohistochemical method of streptavidin-biotin complex （SABC） and to assess the transport mechanism of inhibin by investigating the localization of inhibin and α subunits in the central nervous system （mainly in hypothalamus and pituitary） of ovariectomized rats. Investigations on the extragonadal tissues of ovariectomized rats showed positive expression of inhibin and its α subunit in heart, kidney, spleen, pancreatic gland cells, but no positive reaction sites were seen in lung, liver, submaxillary gland, and adrenal gland. After injection with inhibin α subunit fragment or inhibin extract, positive reaction sites were observed in hypothalamus and pituitary of ovariectomized rats by SABC. Inhibin and its subunit was present in a wide variety of nonreproductive organs and tissues, and its expression was tissue specific, which indicated that inhibin might play a role in regulating tissue function through autocrine/paracrine mechanisms. Inhibin dimer and α subunit could be transported through the BBB by the method of “separation and reconstruction”.

关键词： inhibin inhibin α subunit blood-brain barrier (BBB) immunohistochemical localization

Progress in the treatment of advanced hepatocellular carcinoma with immune combination therapy

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 273-286页

作者： Di Pan Hao-Nan Liu Peng-Fei Qu Xiao Ma Lu-Yao Ma Xiao-Xiao Chen yu-qin wang Xiao-Bing qin Zheng-Xiang Han Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

Advanced hepatocellular carcinoma(HCC)is a severe malignancy that poses a serious threat to human *** to challenges in early diagnosis,most patients lose the opportunity for radical treatment when ***,recent advancements in cancer immunotherapy provide new directions for the treatment of *** instance,monoclonal antibodies against immune check-point inhibitors(ICIs)such as programmed cell death protein 1/death ligand-1 inhibitors and cytotoxic t-lymphocyte associated antigen-4 significantly improved the prognosis of patients with ***,tumor cells can evade the immune system through various *** the rapid development of genetic engineering and molecular biology,various new immunotherapies have been used to treat HCC,including ICIs,chimeric antigen receptor T cells,engineered cytokines,and certain cancer *** review summarizes the current status,research progress,and future directions of different immunotherapy strategies in the treatment of HCC.

关键词： Hepatocellular carcinoma Immunotherapies Immune checkpoint inhibitor Clinical efficacy Adverse reactions

Impact of baseline body mass index on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

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World Journal of Gastroenterology 2024年第37期30卷 4132-4148页

作者： yu-qin wang Di Pan Zhi-yuan Yao yu-Qi Li Peng-Fei Qu Run-Bang wang qing-Hao Gu Jie Jiang Zheng-Xiang Han Hao-Nan Liu Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina The First College of Clinical Medicine Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Oncology Suining County People’s HospitalXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Primary liver cancer is the sixth most common cancer worldwide,with hepato-cellular carcinoma(HCC)being the most prevalent *** the current availability of multiple immune or immune combination treatment options,the prognosis is still poor,so how to identify a more suitable population is extremely *** To evaluate the clinical effectiveness of combining lenvatinib with camrelizumab for patients with hepatitis B virus(HBV)-related HCC in Barcelona Clinic Liver Cancer(BCLC)stages B/C,considering various body mass index(BMI)in diffe-rent *** Retrospective data were collected from 126 HCC patients treated with lenvatinib plus *** were divided into two groups based on BMI:The non-overweight group(BMI<25 kg/m2,n=51)and the overweight/obese group(BMI≥25 kg/m2,n=75).Short-term prognosis was evaluated using mRECIST criteria,with subgroup analyses for non-overweight(BMI:18.5-24.9 kg/m2),overweight(BMI:25-30 kg/m2),and obese(BMI≥30 kg/m2)patients.A Cox proportional hazards regression analysis identified independent prognostic factors for overall survival(OS),leading to the development of a column-line graph *** subgroup analyses for non-overweight(BMI:18.5-24.9 kg/m2),overweight(BMI:25-30 kg/m2),and obese(BMI≥30 kg/m2)patients.A Cox proportional hazards regression analysis identified independent prognostic factors for overall survival(OS),leading to the development of a column-line graph *** Median progression-free survival was significantly longer in the obese/overweight group compared to the non-overweight ***,the median OS was significantly prolonged in the obese/overweight group than in the non-overweight *** objective remission rate and disease control rate for the two groups of patients were,respectively,objective remission rate(5.88%vs 28.00%)and disease control rate(39.22%vs 62.67%).Fatigue was more prevalent in the obese/overweight group,while other adverse effects showed n

关键词： Hepatocellular carcinoma Camrelizumab Lenvatinib Efficacy Safety

Engineering layered/spinel heterostructure via molybdenum doping towards highly stable Li-rich cathodes

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Tungsten 2022年第4期4卷 323-335页

作者： Kun-Qi Geng Meng-Qian Yang Jun-Xia Meng Ling-Fei Zhou yu-qin wang Sydorov Dmytro Qian Zhang Sheng-Wen Zhong Quan-Xin Ma Key Laboratory of Power Battery and Materials Faculty of Materials Metallurgy and ChemistryJiangxi University of Science and TechnologyGanzhou341000China School of Physics and Electronics Gannan Normal UniversityGanzhou341000China

Li-rich layered oxide(LLO),e.g.,Li_(1.12)[Mn_(0.56)Ni_(0.16)Co_(0.08)]O_(2)(LRMO),is considered as a promising cathode material due to its superior Li-storage ***,the poor cycling stability and large voltage decay,which are related to the phase transition,limit its industrialization ***,a Mo-doped LRMO(Li_(1.12)[Mn_(0.56)Ni_(0.16)Co_(0.08)]_(0.98)Mo_(0.02)O_(2),LRMO-Mo2.0%)was successfully synthesized via a simple combination of co-precipitation with high-temperature calcination for solving the mentioned *** with the pristine counterpart,the as-prepared LRMO-Mo2.0%shows more excellent electrochemical performance in terms of rate capability(reversible capacity of 118 mA·h·g^(−1) at 5 C),cyclic ability(94.3%capacity retention after 100 cycles at 0.2 C)and discharge midpoint voltage decay(0.11 V after 100 cycles).Systematic investigation of structural evolution and electrochemical kinetics elucidate that the synergic effect of robust oxygen framework and layered/spinel heterostructure is the key to its performance *** synergy helps to stabilize the layered structure by curbing the structural transformation and oxygen escaping during the electrochemical *** work paved the way for the simple and efficient preparation of highly stable LLO cathode materials.

关键词： Li-rich layered oxide Mo doping Layered/spinel heterostructure High rate performance Cycling stability

Relationship of left heart size and left ventricular mass with exercise capacity in chronic heart failure

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Chinese Medical Journal 2011年第16期124卷 2485-2489页

作者： SHEN yu-qin wang Le-min CHE Lin SONG Hao-ming ZHANG Qi-ping Department of Cardiology Shanghai Tongji Hospital Affiliated toTongji University Shanghai 200065 China

Background Impaired exercise capacity is one of the most common clinical manifestations in patients with chronic heart failure （CHF）. The severity of reduced exercise capacity is an indicator of disease prognosis. The aim of the current study was to investigate the association between left heart size and mass with exercise capacity. Methods A total of 74 patients were enrolled in the study, with 37 having congestive heart failure （left ventricular ejection fraction （LVEF）〈0.45） and the other 37 with coronary heart disease （by coronary angiography） serving as the control group （LVEF 〉0.55）. Echocardiography and cardiopulmonary exercise test were performed. The multiply linear regression model was used to evaluate the association between echocardiogrphic indices and exercise capacities. Results The study showed that left ventricular end diastolic / systolic diameter （LVEDD/LVESD）, left atrial diameter （LAD） and left ventricular mass index （LVMI） were significantly enlarged in patients with chronic heart failure compared with controls （P 〈0.01）. The VO2AT, Peak VO2, Load AT, and Load Peak in chronic heart failure patients were also significantly reduced compared with controls （P 〈0.05）, VENCO2 slope was increased in patients with chronic heart failure （P 〈0.01）. Multivariate linear regression analysis indicated that the patients＇ exercise capacity was significantly associated with the left heart size and mass, however, the direction and/or strength of the associations sometimes varied in chronic heart failure patients and controls. Load AT correlated negatively with LVEDD in chronic heart failure patients （P=0.012）, while Load AT correlated positively with LVEDD in control patients （P=0.006）. VENCO2 slope correlated positively with LAD （B=0.477, P 〈0.0001） in chronic heart failure patients, while the VENCO2 slope correlated negatively with LAD in control patients （P=0.009）. Conclusion The study indicates that the size of LVEDD and LAD are important determinants of exe

关键词： echocardiography exercise tolerance exercise test heart failure systolic

Entering the duodenal diverticulum:A method for cannulation of the intradiverticular papilla

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World Journal of Gastroenterology 2012年第48期18卷 7394-7396页

作者： Bao-Can wang Wei-Bin Shi Wen-Jie Zhang Jun Gu Yi-Jing Tao yu-qin wang Xue-Feng wang Department of Gastroenterology Xinhua HospitalShanghai Jiaotong University School of Medicine Department of General Surgery Xinhua HospitalShanghai Jiaotong University School of Medicine

Successful cannulation of the common bile duct may be difficult in patients in whom the papilla is located entirely within a *** this study,we report successful biliary cannulation in three patients following intubation of the distal tip of the duodenoscope into the duodenal diverticulum and locating the major *** complications occurred during the operation or during the postoperative *** method didn't need second incubation an endoscope and might lower the burden of *** this skill is useful to deal with the papilla hidden inside the large diverticulum because of its safety and convenience.

关键词： Endoscopic retrograde cholangiopancrea-tography Intradiverticular papilla Duodenoscope

STUDIES ON STEREOSELECTIVE SYNTHESIS OF 4R,6R,4-ACETOXY-6-PENTYLVALEROLACTONE

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Chinese Chemical Letters 1992年第8期3卷 607-610页

作者： Li Bing yu Zhi qin wang Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Ling Ling Road,Shanghai 200032

The title compound has been synthesized from the chiral building block 2 through five steps.

关键词： ppm STUDIES ON STEREOSELECTIVE SYNTHESIS OF 4R,6R,4-ACETOXY-6-PENTYLVALEROLACTONE