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Long non-coding RNA H19 regulates neurogenesis of induced neural stem cells in a mouse model of closed head injury

Neural Regeneration Research 2024年第4期19卷 872-880页

作者： mou Gao qin Dong Zhijun Yang Dan Zou Yajuan Han Zhanfeng Chen Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People's HospitalSchool of MedicineUniversity of Electronic Science and Technology of China Department of Neurosurgery Chinese PLA General Hospital Zhongsai Stem Cell Genetic Engineering Co. Ltd. Department of Neurology Fu Xing HospitalCapital Medical University

Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head *** previously reported that induced neural stem cells exert beneficial effects on neural regeneration via cell ***,the neural regeneration efficiency of induced neural stem cells remains *** this study,we explored differentially expressed genes and long non-coding RNAs to clarify the mechanism underlying the neurogenesis of induced neural stem *** found that H19 was the most downregulated neurogenesis-associated lnc RNA in induced neural stem cells compared with induced pluripotent stem ***,we demonstrated that H19 levels in induced neural stem cells were markedly lower than those in induced pluripotent stem cells and were substantially higher than those in induced neural stem cell-derived *** predicted the target genes of H19 and discovered that H19 directly interacts with mi R-325-3p,which directly interacts with Ctbp2 in induced pluripotent stem cells and induced neural stem *** H19 or Ctbp2 impaired induced neural stem cell proliferation,and mi R-325-3p suppression restored the effect of H19 inhibition but not the effect of Ctbp2 ***,H19 silencing substantially promoted the neural differentiation of induced neural stem cells and did not induce apoptosis of induced neural stem ***,silencing H19 in induced neural stem cell grafts markedly accelerated the neurological recovery of closed head injury *** results reveal that H19 regulates the neurogenesis of induced neural stem cells.H19 inhibition may promote the neural differentiation of induced neural stem cells,which is closely associated with neurological recovery following closed head injury.

关键词： closed head injury Ctbp2 induced neural stem cell lncRNA H19 miR-325-3p neurogenesis

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Learning in games:a systematic review

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Science China(Information Sciences) 2024年第7期67卷 133-159页

作者： Rong-Jun qin Yang yu National Key Laboratory for Novel Software Technology Nanjing University Polixir Technologies

Game theory studies the mathematical models for self-interested individuals. Nash equilibrium is arguably the most central solution in game theory. While finding the Nash equilibrium in general is known as polynomial parity arguments on directed graphs(PPAD)-complete, learning in games provides an alternative to approximate Nash equilibrium, which iteratively updates the player's strategy through interactions with other players. Rules and models have been developed for learning in games, such as fictitious play and no-regret learning. Particularly, with recent advances in online learning and deep reinforcement learning,techniques from these fields greatly boost the breakthroughs in learning in games from theory to *** a result, we have witnessed many superhuman game AI systems. The techniques used in these systems evolve from conventional search and learning to purely reinforcement learning(RL)-style learning methods,gradually getting rid of the domain knowledge. In this article, we systematically review the above techniques,discuss the trend of basic learning rules towards a unified framework, and recap applications in large ***, we discuss some future directions and make the prospect of future game AI systems. We hope this article will give some insights into designing novel approaches.

关键词： non-cooperative games learning in games no-regret learning reinforcement learning superhuman AI

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Effect of Iron on the Stability of Rhodochrosite at the Topmost Lower Mantle Conditions

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Journal of Earth Science 2024年第2期35卷 504-513页

作者： Tianlei Zhai Fei qin Shengxuan Huang Shan qin yu Gong Key Laboratory of Orogenic Belts and Crustal Evolution Ministry of EducationSchool of Earth and Space SciencesPeking UniversityBeijing100871China School of Earth Sciences and Resources China University of GeosciencesBeijing100083China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China

Carbonates are viewed as the principal oxidized carbon carriers during subduction,and thus the stability of subducted carbonates has significant implications for the deep carbon *** we investigate the high pressure-temperature behaviors of rhodochrosite in the presence of iron up to∼34 GPa by in-situ X-ray diffraction and ex-situ Raman *** relatively low temperature below∼1500 K,MnCO_(3)breaks down into MnO and CO_(2).Upon heating to∼1800 K,however,the MnCO_(3)-Fe^(0)reactions occur with the formation of Mn_(3)O_(4),Fe^(O)and reduced carbon.A'three-stage'reaction mechanism is proposed to understand the kinetics of the carbon-iron-manganese redox *** results suggest that Fe^(0)can serve as a reductant to greatly affect the stability of rhodochrosite,which implies that the effect of Fe-metal should be seriously considered for the high pressure-temperature behaviors of other predominant carbonates at Earth's mantle conditions,particularly at depths greater than∼250 km.

关键词： deep carbon cycle rhodochrosite reduced mantle diamond formation high pressure tectonics geochemistry

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Preparation and Characterization of pH-Responsive Charge Reversal Nanocomposite for miRNA Delivery

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 1048-1052页

作者：余丹 YE Liyuan LI Binbin mou Fangzhi 殷义霞 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hainan Institute Wuhan University of TechnologySanya 572000China Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of TechnologyWuhan 430070China

pH-responsive charge reversal loaded miRNA nanocomposite was prepared by electrostatic *** morphology,particle size and zeta potential of the nanocomposites were analyzed by transmission electron microscopy and dynamic light *** synthesis of the polymer was analyzed by^(1)*** zeta-potential changes and cellular uptake effects of the nanocomplexes under different pH environments were *** experimental results show that the surface morphology of the nanocomposite is spherical,and the average particle size is about 135 *** the pH value of the solution gradually decreases,the surface charge of the nanocomposite reverses from negative charge to positive charge(from-9.4 to+17.1 mV).Cellular uptake mediated by pH-responsive nanocomposite is selective for tumor cells,and the cellular uptake effect in tumor cells at pH 6.5 was approximately 3 times higher than that at pH *** pH responsive charge reversal nanocomposite has promising application prospects for gene delivery in the weak acid environment of tumors.

关键词： charge conversion siRNA delivery pH responsive cancer therapy

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L_(1)-Smooth SVM with Distributed Adaptive Proximal Stochastic Gradient Descent with Momentum for Fast Brain Tumor Detection

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Computers, Materials & Continua 2024年第5期79卷 1975-1994页

作者： Chuandong qin yu Cao Liqun Meng School of Mathematics and Information Science North Minzu UniversityYinchuan750021China Ningxia Key Laboratory of Intelligent Information and Big Data Processing Yinchuan750021China

Brain tumors come in various types,each with distinct characteristics and treatment approaches,making manual detection a time-consuming and potentially ambiguous *** tumor detection is a valuable tool for gaining a deeper understanding of tumors and improving treatment *** learning models have become key players in automating brain tumor *** descent methods are the mainstream algorithms for solving machine learning *** this paper,we propose a novel distributed proximal stochastic gradient descent approach to solve the L_(1)-Smooth Support Vector Machine(SVM)classifier for brain tumor ***,the smooth hinge loss is introduced to be used as the loss function of *** avoids the issue of nondifferentiability at the zero point encountered by the traditional hinge loss function during gradient descent ***,the L_(1) regularization method is employed to sparsify features and enhance the robustness of the ***,adaptive proximal stochastic gradient descent(PGD)with momentum,and distributed adaptive PGDwithmomentum(DPGD)are proposed and applied to the L_(1)-Smooth *** computing is crucial in large-scale data analysis,with its value manifested in extending algorithms to distributed clusters,thus enabling more efficient processing ofmassive amounts of *** DPGD algorithm leverages Spark,enabling full utilization of the computer’s multi-core *** to its sparsity induced by L_(1) regularization on parameters,it exhibits significantly accelerated convergence *** the perspective of loss reduction,DPGD converges faster than *** experimental results show that adaptive PGD withmomentumand its variants have achieved cutting-edge accuracy and efficiency in brain tumor ***-trained models,both the PGD andDPGD outperform other models,boasting an accuracy of 95.21%.

关键词： Support vector machine proximal stochastic gradient descent brain tumor detection distributed computing

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Unveiling the Contribution of Lactic Acid to the Passivation Behavior of Ti-6Al-4V Fabricated by Laser Powder Bed Fusion in Hank’s Solution

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Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 102-118页

作者： yu-Hang Chu Liang-yu Chen Bo-yuan qin Wenbin Gao Fanmin Shang Hong-yu Yang Lina Zhang Peng qin Lai-Chang Zhang School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang212100China Foshan(Southern China)Institute for New Materials Foshan528200China Key Laboratory of Automobile Materials Ministry of Education and Department of Materials Science and EngineeringJilin UniversityChangchun130025China Centre for Advanced Materials and Manufacturing School of EngineeringEdith Cowan University270 Joondalup DriveJoondalupPerthWA6027Australia

In actual physiological environments,bacteria can activate the immune system and release lactic ***,the detailed contribution of lactic acid to the passivation behavior of titanium(Ti)alloys is still *** current work investigated the in vitro passivation behavior of Ti-6Al-4V(TC4)alloys fabricated by laser powder bed fusion in Hank's solution with and without adding lactic *** methods,inductively coupled plasma atomic emission spectrometer,and X-ray photoelectron spectroscopy were jointly *** lactic acid decreases the corrosion resistance of samples by degrading the formed passive *** film formed in the(lactic acid)-containing solution exhibits a higher level of oxygen vacancies and a lower thickness,attributed to the suppressed formation of Ti^(4+)transformed from Ti^(3+)and Ti^(2+).Moreover,the presence of lactic acid would increase the open circuit potential,relieve the ions release,and hinder the deposition of calcium phosphates within 24 h immersion.

关键词： Titanium alloy Corrosion behavior Passive film Lactic acid Laser powder bed fusion

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Type one autoimmune pancreatitis based on clinical diagnosis: A case report

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World Journal of Clinical Cases 2024年第14期12卷 2438-2444页

作者： Bi-yu Zhang mou-Wang Liang Shuang-Xi Zhang Department of Gastroenterology Guangzhou University of Chinese Medicine Shunde HospitalFoshan 528300Guangdong ProvinceChina Department of Gastroenterology Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina

BACKGROUND Autoimmune pancreatitis(AIP)is a rare form of autoimmune-mediated pancrea-titis,which is easily misdiagnosed as pancreatic cancer and thus treated *** studied the diagnosis and treatment of a patient with type 1 AIP recent-ly admitted to our hospital,and reviewed the literature to provide a reference for clinical diagnosis of *** SUMMARY The chief complaint was yellowing of the body,eyes and urine for 21 *** pa-tient's clinical presentation was obstructive jaundice and imaging suggested pan-creatic *** was difficult to distinguish between inflammation and *** immunoglobulin G4(IgG4)was markedly ***4 is an important serological marker for type 1 *** patient was diagnosed with AIP,IgG4-related cholangitis,acute cholecystitis and hepatic *** applying hormonal therapy,the patient's symptoms improved *** the same time,imaging suggested that pancreatic swelling subsided,and liver function and other biochemical indicators *** treatment was *** In patients with pancreatic swelling,the possibility of AIP should be considered.

关键词： Autoimmune pancreatitis Characteristics Diagnosis Immunoglobulin G4 Case report

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Pullout of the Cylindrical Helicoidal Fiber

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Acta Mechanica Solida Sinica 2024年第3期37卷 444-456页

作者： Chenhan Hu Weihao Tao Hongjun yu qinghua qin Jianshan Wang Department of Mechanics Tianjin UniversityTianjin300054China Department of Astronautic Science and Mechanics Harbin Institute of TechnologyHarbin150001China Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen518172China

The multi-layer cylindrical helicoidal fiber structure(MCHFS)exists widely in biological materials such as bone and wood at the *** typically function as reinforcing elements to enhance the toughness of *** this study,we establish a shear lag-based pullout model of the cylindrical helicoidal fiber(CHF)for investigating interlayer stress transfer and debonding behaviors,with implications regarding the underlying toughening mechanism of *** on the shear lag assumptions,analytical solutions for the stress and displacement fields of the MCHFS during the pullout are derived by considering the CHF as a cylindrically monoclinic material and verified through the 3D finite element *** is found that the helical winding of CHF results in both axial and hoop interlayer shear *** the helical winding angle and the elastic moduli of the fiber and matrix have significant influences on interlayer stress *** work reveals a new interlayer stress transfer mechanism in the MCHFS existing widely in biological materials.

关键词： Cylindrical helicoidal fiber structure Cylindrically monoclinic material Helical winding of fiber Pullout Interlayer stress transfer

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Regulatable Orthotropic 3D Hybrid Continuous Carbon Networks for Efficient Bi-Directional Thermal Conduction

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Nano-Micro Letters 2024年第10期16卷 136-148页

作者： Huitao yu Lianqiang Peng Can Chen Mengmeng qin Wei Feng School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional MaterialsTianjin UniversityTianjin 300350People's Republic of China

Vertically oriented carbon structures constructed from low-dimen-sional carbon materials are ideal frameworks for high-performance thermal inter-face materials(TIMs).However,improving the interfacial heat-transfer efficiency of vertically oriented carbon structures is a challenging ***,an orthotropic three-dimensional(3D)hybrid carbon network(VSCG)is fabricated by depositing vertically aligned carbon nanotubes(VACNTs)on the surface of a horizontally oriented graphene film(HOGF).The interfacial interaction between the VACNTs and HOGF is then optimized through an annealing *** regulating the orientation structure of the VACNTs and filling the VSCG with polydimethylsi-loxane(PDMS),VSCG/PDMS composites with excellent 3D thermal conductive properties are *** highest in-plane and through-plane thermal conduc-tivities of the composites are 113.61 and 24.37 W m^(-1)K^(-1),*** high contact area of HOGF and good compressibility of VACNTs imbue the VSCG/PDMS composite with low thermal *** addition,the interfacial heat-transfer efficiency of VSCG/PDMS composite in the TIM performance was improved by 71.3%compared to that of a state-of-the-art thermal *** new structural design can potentially realize high-performance TIMs that meet the need for high thermal conductivity and low contact thermal resistance in interfacial heat-transfer processes.

关键词： Orthotropic continuous structures Hybrid carbon networks Carbon/polymer composites Thermal interface materials

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Sequence-Controlled Synthesis of Alternating Poly(ester amide)s using Water as Control Agent in One-Pot

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Chinese Journal of Polymer Science 2024年第8期42卷 1015-1020页

作者： Tao Liu Fang-Fang Niu Kan Cheng yu-Min Xia Bo-mou Ma Xue-Li Wang Jian-Yong yu Yong He State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Innovation Center for Textile Science and Technology Donghua UniversityShanghai 201620China

Poly(ester amide)s(PEAs)attract much attention as a new kind of biodegradable ***,the synthesis of PEAs with sequence-regulated chain structures is still complicated due to the multistep polymerization,high monomer purity,as well as the usage of organic solvents,which greatly inhibits its development and ***,a one-pot strategy without solvent was developed to synthesize the alternating PEA fromα,ω-amino alcohol and dicarboxylic acid by sequential polycondensation,where water was used as the controlling agent for amidation and ***,the amidation and esterification were controlled to proceed in turn by adding or removing water,realizing the one-pot preparation of alternating *** resultant PEA is characterized by^1H-and^(13)C-NMR,and its chain structure is confirmed to be highly quasi-alternating similar to alternating PEAs prepared by classical methods The evaluations from DSC and DMA demonstrate that the properties of quasi-alternating PEA(T_(m)=102℃,ΔH_(m)=30J·g^(-1))are far superior to those of random PEA(T_(m)=72℃,ΔH_(m)<1 J·g^(-1)).

关键词： Biodegradable macromolecules Polymer architectures Sequence-controlled synthesis One-pot polymerization

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