检索结果-南通市图书馆

Neiguan(PC6) acupoint stimulation for preventing chemotherapy-induced nausea and vomiting: a cost-effective supplement in guideline-inconsistent chemotherapy-induced nausea and vomiting prophylaxis subgroup

引用

Journal of Traditional Chinese Medicine 2024年第3期44卷 581-585页

作者： yu Wenxi TANG Lina LI Hongtao WANG Yonggang shen Zan Department of Oncology Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200233China

OBJECTIVE: To assess the efficacy and safety of Neiguan(PC6) acupoint acustimulation in preventing chemotherapy-induced nausea and vomiting(CINV),especially for patients with guideline-inconsistent CINV prophylaxis(GICP) due to personal reasons METHODS: From January 2021 to December 2021, 373 patients suffered from solid malignancy were recruited according to the inclusion criteria. Complete response(no emesis and no rescue medication use) rate during the overall phase(0-120 h of each chemo-cycle) was the primary assessment of CINV control. The Functional Living Index-Emesis(FLIE) questionnaire was investigated among these patients as a secondary 'quality of life' objective to assess the impact of CINV on patients' daily life by recording score of nausea and vomiting. RESULTS: With acustimulation of Neiguan(PC6) acupuncture point through a portable, noninvasive and user-friendly device, in terms of complete response rate and scores in nausea/vomiting by FLIE questionnaire, patients achieve a better outcome in highly emetogenic chemotherapy(HEC) induced CINV, especially GICP subgroup. Meanwhile, analysis also demonstrated this tendency existed in other patients with HEC/GCCP(guideline consistent CINV prophylaxis) and moderate emetogenic chemotherapy, although the difference was not significant. CONCLUSION: Considering advantages of Neiguan(PC6) acustimulation such as noninvasive, covered by medical insurance and few side effects, we believe it would be an ideal auxiliary tool in CINV control, especially in patients who receive highly emetogenic chemoprotocol and are reluctant to GCCP for economic reasons.

关键词： acupuncture acustimulation tumor chemotherapy-induced nausea and vomiting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Search for a lighter Higgs boson in the Next-to-Minimal Supersymmetric Standard Model

引用

Chinese Physics C 2018年第10期42卷 51-58页

作者： Jun-Quan Tao M.Aamir Shahzad Si-Jing Zhang Chu Wang yu-qiao shen Guo-Ming Chen He-sheng Chen S.Gascon-Shotkina L.Finco C.Camen Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Institut de Physique Nucleaire de Lyon Universite de LyonUniversite Claude Bernard Lyon 1CNRS-IN2P3Villeurbanne 69622France Changzhou Institute of Technology Changzhou 213032China

Following the discovery of the Higgs boson with a mass of approximately 125 GeV at the LHC, many studies have been performed from both the theoretical and experimental viewpoints to search for a new Higgs Boson that is lighter than 125 GeV. We explore the possibility of constraining a lighter neutral scalar Higgs boson hi and a lighter pseudo-scalar Higgs boson al in the Next-to-Minimal Supersymmetric Standard Model by restricting the next-to-lightest scalar Higgs boson h2 to be the one observed at the LHC after applying the phenomenological constraints and those from experimental measurements. Such lighter particles are not yet completely excluded by the latest results of the search for a lighter Higgs boson in the diphoton decay channel from LHC data. Our results show that some new constraints on the Next-to-Minimal Supersymmetric Standard Model could be obtained for a lighter scalar Higgs boson at the LHC if such a search is performed by experimental collaborations and more data. The potentials of discovery for other interesting decay channels of such a lighter neutral scalar or pseudo-scalar particle are also discussed.

关键词： Next-to-Minimal Supersymmetric Standard Model lighter Higgs boson discovery potentials

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Robust tantalum tuned perovskite oxygen electrode for reversible protonic ceramic electrochemical cells

引用

Rare Metals 2024年第7期43卷 3055-3065页

作者： yu-Shi Feng yu shen Fang Wang Chuan Tian Qin-Yi Hu Qian Duan Jing-Wei Li Di Bao School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China Zhongshan Institute of Changchun University of Science and Technology Zhongshan528437China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022China Key Laboratory of Preparation and Applications of Environmental Friendly Materials Ministry of EducationJilin Normal UniversityChangchun 130103China

Perovskite oxides with diverse composition and structure have exhibited grand advances in boosting the oxygen reduction and evolution reaction(ORR/OER),which are essential for the reversible protonic ceramic electrochemical cell(R-PCEC)toward the sustainable hydrogen production and ***,enhancement of their activity and stability remains ***,we develop the Ta-regulated BaCo_(0.7)Fe_(0.3)O_(3-δ)perovskite oxygen electrode(Ba(Co_(0.7)Fe_(0.3))_(1-x)Ta_xO_(3-δ))with abundant oxygen defects and achieve the simultaneous enhancement in the electrocatalytic activity and stability toward ORR and ***-fabricated R-PCEC with(Ba(Co_(0.7)Fe_(0.3))_(0.9)Ta_(0.1)O_(3-δ))(BCFT10)oxygen electrode performs high power density of 1.47 W·cm^(-2)at 650℃in fuel cell mode,and the current density is up to-2.11 A·cm^(-2)at 1.4 V at 650℃in electrolysis mode,as well as the good stability in both the fuel cell and electrolysis ***,the cell also demonstrates a stable cycling operation between fuel cell and electrolysis mode,suggesting a great potential of BCFT10 as oxygen electrode material for R-PCECs.

关键词： Reversible protonic ceramic electrochemical cells Perovskite oxide Oxygen electrode Ta element doping Oxygen defects

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research on Hepatocyte Regulation of PCSK9-LDLR and Its Related Drug Targets

引用

Chinese Journal of Integrative Medicine 2024年第7期30卷 664-672页

作者： LIU Su-su yu Tong qiao Yan-fang GU Shu-xiao CHAI Xin-lou School of Traditional Chinese Medicine Beijing University of Traditional Chinese MedicineBeijing102401China

The prevalence of hyperlipidemia has increased significantly due to genetic, dietary, nutritional and pharmacological factors, and has become one of the most common pathological conditions in humans. Hyperlipidemia can lead to a range of diseases such as atherosclerosis, stroke, coronary heart disease, myocardial infarction, diabetes, and kidney failure, etc. High circulating low-density lipoprotein cholesterol (LDL-C) is one of the causes of hyperlipidemia. LDL-C in the blood binds to LDL receptor (LDLR) and regulates cholesterol homeostasis through endocytosis. In contrast, proprotein convertase subtilisin/kexin type 9 (PCSK9) mediates LDLR degradation via the intracellular and extracellular pathways, leading to hyperlipidemia. Targeting PCSK9-synthesizing transcription factors and downstream molecules are important for development of new lipid-lowering drugs. Clinical trials regarding PCSK9 inhibitors have demonstrated a reduction in atherosclerotic cardiovascular disease events. The purpose of this review was to explore the target and mechanism of intracellular and extracellular pathways in degradation of LDLR and related drugs by PCSK9 in order to open up a new pathway for the development of new lipid-lowering drugs.

关键词： hyperlipidemia proprotein convertase subtilisin/kexin type 9 low-density lipoprotein receptor intracellular pathway extracellular pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Unique citing documents Journal Impact Factor(Uniq-JIF)as a supplement for the standard Journal Impact Factor

引用

Journal of Data and Information Science 2024年第3期9卷 1-3页

作者： Zhesi shen Li Li yu Liao National Science Library Chinese Academy of SciencesBeijing 100190China

1 A new type of impact factor The Unique citing documents Journal Impact Factor(Uniq-JIF)is defined as follows:Uniq-JIF=Number of unique citing documents/Number of citable items(1)We note that formula(1)is given in a generic *** concrete applications,one must state the publication for which the Uniq-JIF is calculated(a journal,an edited book,a conference proceedings).

关键词： journal Impact Number

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The behaviors of gas-liquid two-phase flow under gas kick during horizontal drilling with oil-based muds

引用

Petroleum 2024年第1期10卷 49-67页

作者： yu Su Huiyun Ma Jianhua Guo Xinyu shen Zhaoliang Yang Jie Wu Engineering Technology Research Institute PetroChina Southwest Oil & Gas Field Company

Natural gas is easily soluble in oil-based muds(OBM), leading to complex flow behavior in wellbores,especially in horizontal wells. In this study, a new transient flow model considering wellbore-formation coupling and gas solubility on flow behavior is developed to simulate gas kicks during horizontal drilling with OBM. Furthermore, the effect of gas solubility on parameters such as bottom-hole pressure(BHP),gas void fraction and mixture velocity in the flow behavior is analyzed. Finally, several critical factors affecting flow behavior are investigated and compared to gas kicks in water-based muds(WBM) where the effect of solubility is neglected. The results show that the invading gas exists as dissolved gas in the OBM and as free gas in the WBM. Before the gas escapes from the OBM, the pit gain is zero and there is barely any change in the BHP, annulus return flow rate and mixture velocity, which means that detecting gas kicks through these warning signs can be challenging until they get very close to the surface and develop rapidly. However, in WBM drilling, these parameters change quickly with the increasing gas kick time. Additionally, for both cases, the longer the horizontal length and the greater reservoir permeability,the greater the decrease in BHP, and the shorter the time for gas to migrate from the bottom-hole to the wellhead. A larger flow rate contributes to a greater initial BHP and a lesser BHP reduction. This research is of value in characterizing gas kick behavior and identifying novel ways for early gas kick detection during horizontal drilling with OBM.

关键词： Flow behavior Gas solubility Gas kick Horizontal drilling Oil-based muds Water-based muds

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

GPa-level pressure-induced enhanced corrosion resistance in TiZrTaNbSn biomedical high-entropy alloy

引用

China Foundry 2024年第3期21卷 265-275页

作者： Xiao-hong Wang yu-lei Deng qiao-yu Li Zhi-xin Xu Teng-fei Ma Xing Yang Duo Dong Dong-dong Zhu Xiao-hong Yang Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000ZhejiangChina School of Materials Science and Engineering Taizhou UniversityTaizhou 318000ZhejiangChina

TiZrTaNb-based high-entropy alloys(HEAs)are research frontier of biomedical materials due to their high hardness,good yield strength,excellent wear resistance and corrosion ***,as an essential trace element in the human body that plays a significant role in physiological *** has stable chemical properties and a low elastic *** this study,a new material,TiZrTaNbSn HEAs,was proposed as a potential biomedical *** Ti_(35)Zr_(25)Ta_(15)Nb_(15)Sn_(10)biomedical high-entropy alloys(BHEAs)were successfully prepared through an arc melting furnace and then remelted using a German high-temperature and high-pressure apparatus under GPa-level(4 GPa and 7 GPa).The precipitation behavior of the needle-like HCP-Zr_(5)Sn_(3)phase that precipitates discontinuously at the grain boundary was successfully *** phase constitution,microstructure,and corrosion resistance of the alloy were *** results show that the needle-like HCP-Zr_(5)Sn_(3)phase is eliminated and the(Zr,Sn)-rich nano-precipitated phase is precipitated in the microstructure under high pressure,which leads to the narrowing of grain boundaries and consequently improves the corrosion resistance of the *** addition,the formation mechanisms of(Zr,Sn)-rich nanoprecipitates in BHEAs were *** Zr and Sn dissolve in the matrix due to the effect of high pressure,during the cooling process,they precipitate to form a(Zr,Sn)-rich nano-precipitated phase.

关键词： biomedical HEAs precipitation grain boundary corrosion resistance TiZrTaNbSn

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On the thermodynamics of plasticity during quasi-isentropic compression of metallic glass

引用

Matter and Radiation at Extremes 2024年第2期9卷 74-89页

作者： Kaiguo Chen Bo Chen Yinan Cui yuying yu Jidong yu Huayun Geng Dongdong Kang Jianhua Wu Yao shen Jiayu Dai College of Science National University of Defense TechnologyChangsha 410073People’s Republic of China Hunan Key Laboratory of Extreme Matter and Applications National University of Defense TechnologyChangsha 410073People’s Republic of China Applied Mechanics Laboratory Department of Engineering MechanicsSchool of AerospaceTsinghua UniversityBeijing 100084People’s Republic of China Institute of Fluid Physics China Academy of Engineering PhysicsMianyangPeople’s Republic of China Department of Material Science and Technology Shanghai Jiao Tong UniversityShanghaiPeople’s Republic of China

Entropy production in quasi-isentropic compression (QIC) is critically important for understanding the properties of materials under extremeconditions. However, the origin and accurate quantification of entropy in this situation remain long-standing challenges. In this work, a framework is established for the quantification of entropy production and partition, and their relation to microstructural change in QIC. Cu50Zr50is taken as a model material, and its compression is simulated by molecular dynamics. On the basis of atomistic simulation-informed physicalproperties and free energy, the thermodynamic path is recovered, and the entropy production and its relation to microstructural change aresuccessfully quantified by the proposed framework. Contrary to intuition, entropy production during QIC of metallic glasses is relativelyinsensitive to the strain rate ˙γ when ˙γ ranges from 7.5 × 10^(8) to 2 × 10^(9)/s, which are values reachable in QIC experiments, with a magnitudeof the order of 10^(−2)kB/atom per GPa. However, when ˙γ is extremely high (>2 × 10^(9)/s), a notable increase in entropy production rate with˙γ is observed. The Taylor–Quinney factor is found to vary with strain but not with strain rate in the simulated regime. It is demonstrated thatentropy production is dominated by the configurational part, compared with the vibrational part. In the rate-insensitive regime, the increase inconfigurational entropy exhibits a linear relation to the Shannon-entropic quantification of microstructural change, and a stretched exponential relation to the Taylor–Quinney factor. The quantification of entropy is expected to provide thermodynamic insights into the fundamentalrelation between microstructure evolution and plastic dissipation.

关键词： entropy metallic regime

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Poly(3-hexylthio) thiophene Field-effect Transistor Device Performance: Impact of the Content of Hexylthio Side Chain on Backbone

引用

Chinese Journal of Polymer Science 2024年第1期42卷 14-23,I0005页

作者： Hao-yu Liu Lian-He Han Ling-Wei Kong Li-Ping Zhu Xiao-Lan qiao Mei-Fang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Regioregular poly(3-hexylthio)thiopene(P3HTT) has emerged tremendous potential in organic electronic applications due to the strong noncovalent interactions from the sulfur atom linked to thiophene. However, P3HTT generally exhibits low charge mobility mostly due to poor solution processability attributed to dense arrangement of hexylthio side chain in polymer, which led to strong noncovalent interactions among sulfur atoms. To balance the nonvalent interaction and aggregation for P3HTT, herein, we systematically study the effect of hexylthio side chain content in polymer backbone on the structure and properties. A series of regioregular P3HTT-based homopolymers(P3HTT, P3HTT-50,P3HTT-33 and P3HTT-25) were prepared via Kumada catalyst transfer polycondensation method from a set of mono-, bi-, ter-and quarterthiophenes containing different contents of hexylthio side chain. The DFT calculation shows the planarity of polymers backbone could be improved through reducing the density of hexylthio side chain in polymer mainchain. And significant changes in their crystallinity, aggregation and optical properties were observed with the content of hexylthio side chain reducing. The P3HTT-33 displayed the highest field-effect transistor hole mobility of 2.83×10^(-2) cm^(2)·V^(-1)·s^(-1) resulting from a balance between the crystallinity and planarity. This study demonstrates modulating the content of hexylthio side chain in P3HTT is an effective strategy to optimize the opto-electronic properties of polymer obtaining excellent semiconductor device performance.

关键词： Conjugated polymer Polythiophene Noncovalent interaction Molecular aggregation Organic field-effect transistor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SmartEagleEye:A Cloud-Oriented Webshell Detection System Based on Dynamic Gray-Box and Deep Learning

引用

Tsinghua Science and Technology 2024年第3期29卷 766-783页

作者： Xin Liu Yingli Zhang Qingchen yu Jiajun Min Jun shen Rui Zhou Qingguo Zhou School of Information Science and Engineering Lanzhou UniversityLanzhou 730000China College of Computer Science and Technology Zhejiang UniversityHangzhou 310058China School of Computing and Information Technology University of WollongongWollongong 2500Australia

Compared with traditional environments,the cloud environment exposes online services to additional vulnerabilities and threats of cyber attacks,and the cyber security of cloud platforms is becoming increasingly prominent.A piece of code,known as a Webshell,is usually uploaded to the target servers to achieve multiple *** Webshell attacks has become a hot spot in current ***,the traditional Webshell detectors are not built for the cloud,making it highly difficult to play a defensive role in the cloud ***,a Webshell detection system based on deep learning that is successfully applied in various scenarios,is proposed in this *** system contains two important components:gray-box and neural network *** gray-box analyzer defines a series of rules and algorithms for extracting static and dynamic behaviors from the code to make the decision *** neural network analyzer transforms suspicious code into Operation Code(OPCODE)sequences,turning the detection task into a classification *** experiment results show that SmartEagleEye achieves an encouraging high detection rate and an acceptable false-positive rate,which indicate its capability to provide good protection for the cloud environment.

关键词： Webshell detection cloud web security deep learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：