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On Orbit Followed Numerical Method for Ordinary Differential Equations

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On Orbit Followed Numerical Method for Ordinary Differential...

The　Synthesis　of　1－O－β－D－（5－Aryl－2－furoyl）AcetylatedSugarsbyPhaseTransferCatalysis

保结构算法2004

作者： yu-qi li and Zhen liu Academy of Mathematics and System Science, Chinese Academy of Sciences Beijing 100080, China Department of mathematics. Zhejiang University of Technology Hangzhou 310014, China Institute of Theoretical Physics. Chinese Academy of Sciences, Beijing 100080, China

＜正＞In this talk, we briefly introduce a kind of new numerical method for solving the ordinary differential equation. We show that this method has the similar capacity in simulating the global and structural dynamic... 详细信息

关键词： Symplectic algorithm Orbit followed method Adaptive orbit followed method

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合成化学 1996年第1期 5-7页

作者： Sun,Chang JunTo whom correspondence should be addressed. Wang,Yi Gui qi,yu Xin li,Hong Xiang Chen,Zai Cheng (Department of Chemistry,Shandong University,Jinan,250100) Xue,Peng (Department of Chemistry,Wuhan University,Wuhan,430072)

以相转移催化法使α－溴代乙酰基葡萄糖，α－溴代乙酰基木糖和α－溴代乙酰基葡萄糖醛酸甲酯与５－芳基－２－呋喃甲酸在水－有机相体系中反应，合成了１４个未见文献报道的糖酯类化合物，其结构经ＩＲ、１ＨＮＭＲ、ＭＳ等证实，生物... 详细信息

以相转移催化法使α－溴代乙酰基葡萄糖，α－溴代乙酰基木糖和α－溴代乙酰基葡萄糖醛酸甲酯与５－芳基－２－呋喃甲酸在水－有机相体系中反应，合成了１４个未见文献报道的糖酯类化合物，其结构经ＩＲ、１ＨＮＭＲ、ＭＳ等证实，生物活性实验正在进行之中

关键词：呋喃甲酸糖酯相转移催化抗癌药物

老年急性脑梗死患者血清Hcy、IMA水平与神经功能缺损程度和预后的关系

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川北医学院学报 2023年第4期38卷 470-473页

作者：范晓雪王超于琦莉于洪南方医科大学附属齐齐哈尔医院·齐齐哈尔市第一医院神经内科黑龙江齐齐哈尔161000 南方医科大学附属齐齐哈尔医院·齐齐哈尔市第一医院教育管理部黑龙江齐齐哈尔161000

目的:探讨老年急性脑梗死(ACI)患者血清同型半胱氨酸(Hcy)、缺血修饰蛋白(IMA)水平与神经功能缺损程度和预后的关系。方法:选取207例老年ACI患者为研究对象,根据美国国立卫生院卒中量表(NIHSS)评分分为神经缺损轻度组(NIHSS15分,n=52);... 详细信息

目的:探讨老年急性脑梗死(ACI)患者血清同型半胱氨酸(Hcy)、缺血修饰蛋白(IMA)水平与神经功能缺损程度和预后的关系。方法:选取207例老年ACI患者为研究对象,根据美国国立卫生院卒中量表(NIHSS)评分分为神经缺损轻度组(NIHSS15分,n=52);根据患者治疗1个月后改良Rankin量表(mRs)评分分为预后良好组(mRs≤2分,n=160)及预后不良组(mRs>2分,n=47)。比较不同程度神经缺损及不同预后患者血清Hcy、IMA水平,分析其与神经缺损程度的相关性及对ACI患者预后不良的预测诊断价值。结果:不同程度神经缺损组患者血清Hcy、IMA水平比较,差异有统计学意义(P中度组>轻度组。预后良好组患者血清Hcy、IMA水平低于预后不良组(P<0.05)。相关性分析显示,血清Hcy、IMA水平与老年ACI神经功能缺损程度呈正相关关系(r=0.326、0.513,P<0.05)。ROC曲线分析显示,血清Hcy(AUC=0.711)及IMA(AUC=0.829)对老年ACI患者预后不良均有良好的预测诊断价值,且两者联合检测的诊断效能更佳(AUC=0.861)。结论:血清Hcy、IMA水平不仅能反应老年ACI患者的神经缺损程度,还有助于评估近期预后状况。

关键词：急性脑梗死神经功能缺损程度预后 Spearman相关系数 ROC曲线

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汽车零部件供应商的评价与选择方法及软件实现

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物流科技 2006年第2期29卷 17-20页

作者：杜利珍余利琪陶德馨武汉理工大学湖北武汉430063 武汉警官职业学院湖北武汉430034

本文在介绍了汽车零部件供应商评价与选择的基本步骤和方法后,通过实际分析和研究建立了一套层次化的汽车零部件供应商评价体系,并根据层次分析法的基本原理在Matlab7.0软件平台上自主开发了一套SES(SuppliersEvaluation&Selection)系统... 详细信息

本文在介绍了汽车零部件供应商评价与选择的基本步骤和方法后,通过实际分析和研究建立了一套层次化的汽车零部件供应商评价体系,并根据层次分析法的基本原理在Matlab7.0软件平台上自主开发了一套SES(SuppliersEvaluation&Selection)系统,实现了供应商的评价与选择,为汽车制造厂选择最佳的零部件供应商提供了简便的操作工具和科学、客观的决策依据。

关键词：汽车零部件供应商评价 Matlab 7.0

Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： qi-Hong Zhong Jiang-Shan Huang Fei-Long Guo Jing-yu Wu Mao-Xiu yuan Jia-Fu Zhu Wen-Wei lin Sui Chen Zhen-Yang Zhang Jiang-Bo lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

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苯硝化工艺HAZOP分析的定量化研究

工业安全与环保 2016年第10期42卷 44-46,63页

作者：桂阳张明广虞奇李阳钱城江南京工业大学安全科学与工程学院南京210009

为提高危险化工工艺过程风险评估的准确性,通过工艺仿真模拟,研究工艺参数波动对生产装置安全性能的影响。以苯硝化工艺为例,采用危险与可操作性分析对该过程进行定性的风险评估;同时利用Aspen Plus建立苯硝化装置的模拟流程。结合HAZO... 详细信息

为提高危险化工工艺过程风险评估的准确性,通过工艺仿真模拟,研究工艺参数波动对生产装置安全性能的影响。以苯硝化工艺为例,采用危险与可操作性分析对该过程进行定性的风险评估;同时利用Aspen Plus建立苯硝化装置的模拟流程。结合HAZOP分析中偏差与模拟中硝化釜的流程变量之间的联系,以进料混酸的流量和1号硝化釜热负荷及出口温度为量化指标,观察混酸流量在正常操作点17.6 m3/h的±100%范围波动下1号硝化釜热负荷及出口温度的变化。研究结果表明,保持1号硝化釜温度为正常值,随着混酸流量的增大,硝化釜热负荷先增大后减小;保持硝化釜热负荷不变,随着混酸流量的增大,硝化釜温度先增大后减小。其中混酸流量值超过22.95 m3/h时,温度超过报警阈值60℃。

关键词： HAZOP分析仿真模拟苯硝化工段进料流量硝化釜散热量量化

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

一类具有Beverton-Holt出生函数和双时滞的阶段结构传染病模型的稳定性分析

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数学的实践与认识 2021年第10期51卷 291-299页

作者：于莉琦贺树立顾贞王强黑龙江东方学院数学教研室黑龙江哈尔滨150066 黑龙江东方学院计算机学部黑龙江哈尔滨150066

在一类以Beverton-Holt函数作为出生函数,且疾病仅在成年个体间传播的疾病模型中,考虑到时滞量对系统发展的重要作用,引入了两个时滞量,分别是幼年个体到成年个体的生长时滞和病毒在感染细胞内的繁殖时滞.以两个时滞为参数,研究了系统... 详细信息

在一类以Beverton-Holt函数作为出生函数,且疾病仅在成年个体间传播的疾病模型中,考虑到时滞量对系统发展的重要作用,引入了两个时滞量,分别是幼年个体到成年个体的生长时滞和病毒在感染细胞内的繁殖时滞.以两个时滞为参数,研究了系统的平衡点的局部稳定性.结果表明,随着参数的变化,系统平衡点发生了扰动,进而出现了周期解,并给出了分支存在条件的显示表达式.

关键词：传染病模型时滞局部稳定性 Hopf分支

Efficacy,safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart:A pilot study

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World Journal of Diabetes 2025年第1期16卷 65-73页

作者： Na Yang Lu Lv Shu-Meng Han li-yun He Zi-Yi li yu-Cheng Yang Fan Ping ling-ling Xu Wei li Hua-Bing Zhang yu-Xiu li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient data from the Chinese *** To demonstrate the efficacy,safety,and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus(T2DM).METHODS In this 12-week open-label,non-randomized,single-center,pilot study,patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin *** doses,hemoglobin A1c(HbA1c)levels,fasting blood glucose(FBG),hypoglycemic events,a Diabetes Treatment Satisfaction Questionnaire,and other parameters were assessed at baseline and *** This study included 21 participants.A marked enhancement was observed in the FBG level(P=0.02),daily total insulin dose(P=0.03),and overall diabetes treatment satisfaction(Plinical outcomes,particularly FBG levels,daily cumulative insulin dose,and overall satisfaction with diabetes treatment.

关键词： Insulin degludec/aspart Type 2 diabetes management Basal-bolus insulin therapy Pre-mixed insulin Diabetes treatment satisfaction questionnaire