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Chemical additives affect sulfate reducing bacteria biofilm properties adsorbed on stainless steel 316L surface in circulating cooling water system

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Frontiers of Environmental Science & Engineering 2017年第2期11卷 143-156页

作者： yu qi Jin li Rui liang Sitong Ji Jianxiang li Meng liu Research Center for Aqueous Organic Pollutants Control and Water Quality Security Beijing Key Laboratory Beijing Jiaotong University Beijing 100044 China

This paper studied the biofilm properties and corrosion behavior of sulfate reducing bacteria （SRB） on stainless steel 316L （SS316L） surface in circulating cooling water system with and without additives including hydroxy ethyl fork phosphonic acid （HEDP）, dodecyl dimethyl benzyl anunonium chlotide （1227） and NaClO. Biochemical technique, electrochemical technology, X-ray photoelectron spectroscopy （XPS） and scanning electron microscope （SEM） were used. The results show that the extracellular polymeric substance （EPS） in biofilm attached on the SS316L surface mainly contain proteins and polysaccharides, the contents are 98 ***-2 and ***-2, respectively. The polysaccharides were cut by 1227 about 80%, while 55% by NaCIO. The proteins were reduced by NaCIO about 53%, while only 30% by 1227. The potentiodynamic polarization shows that the corrosion potential of SS316L was enhanced from -0.495 V to -0.390 V by the chemical additive delaying the occurrence of the corrosion. And the corrosion rate was also reduced from 5.19 × 10^-3 mm·a^-1 to 2.42 × 10^-3 mm＇a . But NaCIO stdl caused pitting corrosion after stenhzmg the bacteria, while 1227 can form a protective film on the surface of SS316L. Though HEDP contribute to the bacteria activity, it can enhance the breakdown potential. XPS results confirmed that 1227 can change the value of C：O in the biofilm attached on metal surface, and NaCIO can eliminate the existence of amidogen. This study would provide some recommendations for the selection of chemical additives in the thermal power plant.

关键词： Sulfate reducing bacteria (SRB)Chemical additivesBiofilmExtracellular polymeric substance (EPS)Microbe conosion

AquaSee: Predict Load and Cooling System Faults of Supercomputers Using Chilled Water Data

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Journal of Computer Science & Technology 2020年第1期35卷 221-230页

作者： yu-qi li li-Quan Xiao Jing-Hua Feng Bin Xu Jian Zhang National Supercomputer Center in Tianjin Tianjin 300450China College of Computer National University of Defense TechnologyChangsha 410073China

An analysis of real-world operational data of Tianhe-1A(TH-1A)supercomputer system shows that chilled water data not only can reflect the status of a chiller system but also are related to supercomputer *** study proposes AquaSee,a method that can predict the load and cooling system faults of supercomputers by using chilled water pressure and temperature *** method is validated on the basis of real-world operational data of the TH-1A supercomputer system at the National Supercomputer Center in *** with various compositions are used to construct the prediction model,which is also established using different prediction sequence *** results show that the method that uses a combination of pressure and temperature data performs more effectively than that only consisting of either pressure or temperature *** best inference sequence length is two ***,an anomaly monitoring system is set up by using chilled water data to help engineers detect chiller system anomalies.

关键词： supercomputer chilled water data sensor network load prediction

Synthesis and antitumor activity of 9-methyl-10-hydroxycamptothecin

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Chinese Chemical Letters 2008年第8期19卷 918-920页

作者： Sheng Wang yu Yan li qi Dong You Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A novel camptothecin analogue, 9-methyl-10-hydroxycamptothecin （4）, was unexpectedly synthesized from 10-hydroxycamptothecin in two steps. The key step included an efficient Mannich-type reaction. The overall yield was 47.2%. An ether analogue of 4, 9-methyl-10-benzylaminomethoxycamptothecin （5）, was also prepared. These new camptothecin analogues were evaluated for in vitro cytotoxicity against four human cancer cell lines, and exhibited more potent antitumor activities than contrals camptothecin and topotecan against several cancer cells.

关键词： Synthesis Camptothecin 10-Hydroxycamptothecin Cytotoxicity

Microsatellite Variation in the Oyster Crassostrea plicatula Along the Coast of China

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Journal of Ocean University of China 2008年第4期7卷 432-438页

作者： yu Hong, li qi yu Ruihai College of Fisheries Ocean University of China Qingdao 266003 P. R. China

Genetic diversity and differentiation of the oyster Crassostrea plicatula populations from China’s coast were studied based on seven microsatellite loci. All loci showed high polymorphism for all five C. plicatula populations,with an average number of allele per locus of 19.3-27.9 and an average expected heterozygosity of 0.889-0.952. Significant departures from Hardy-Weinberg equilib-rium and deficits of heterozygotes were observed over most populations at each locus,which were fully explained by null alleles. Microsatellite analysis revealed significant subdivision in the C. plicatula populations. According to the neighbor-joining tree con-structed on the basis of the DA distance,the five populations fell into three regional groups,showing a relatively homogeneous genetic structure in geographically close populations. Assignation tests correctly assigned high percentages of individuals to their original populations and groups,and also confirmed the existence of genetic differentiation among C. plicatula populations. The results ob-tained in this study will facilitate the formulation of appropriate fisheries management programs,stock identification and conservation of biodiversity for the species.

关键词： Crassostrea plicatula microsatellites genetic diversity population structure

Role of vascular endothelial growth factor B in nonalcoholic fatty liver disease and its potential value

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World Journal of Hepatology 2023年第6期15卷 786-796页

作者： yu-qi li Lei Xin yu-Chi Zhao Shang-qi li Ya-Nuo li Department of Pathophysiology School of Basic MedicineBinzhou Medical UniversityYantai 264000Shandong ProvinceChina Department of Gastrointestinal Surgery Yantaishan HospitalYantai 264000Shandong ProvinceChina Department of Surgery Yantaishan HospitalYantai 264000Shandong ProvinceChina The First School of Clinical Medicine Binzhou Medical UniversityYantai 264000ShandongChinaYantai 264000Shandong ProvinceChina

Nonalcoholic fatty liver disease(NAFLD)refers to fatty liver disease caused by liver injury factors other than *** disease is characterized by diffuse fat infiltration,including simple steatosis(no inflammatory fat deposition),nonalcoholic fatty hepatitis,liver fibrosis,and so on,which may cause liver cirrhosis,liver failure,and even liver cancer in the later stage of disease *** present,the pathogenesis of NAFLD is still being ***"two-hit"theory,represented by lipid metabolism disorder and inflammatory reactions,is gradually enriched by the"multiple-hit"theory,which includes multiple factors,such as insulin resistance and adipocyte *** recent years,vascular endothelial growth factor B(VEGFB)has been reported to have the potential to regulate lipid metabolism and is expected to become a novel target for ameliorating metabolic diseases,such as obesity and type 2 *** review summarizes the regulatory role of VEGFB in the onset and development of NAFLD and illustrates its underlying molecular *** conclusion,the signaling pathway mediated by VEGFB in the liver may provide an innovative approach to the diagnosis and treatment of NAFLD.

关键词： Nonalcoholic fatty liver disease Vascular endothelial growth factor B "Twohit"theory "Multiple-hit"theory Obesity

Facile Synthesis and Adsorption Properties of Phosphonated Cellulose Beads for Selective Removal of Low-density lipoprotein

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Chinese Chemical Letters 2006年第9期17卷 1193-1196页

作者： Hao Feng yu Guo qi FU li liU Bing lin HE The Key Laboratory of Functional Polymer Materials of Ministry of Education Institute of Polymer Chemistry Nankai University Tianjin 300071

A novel low-density lipoprotein adsorbent was prepared simply by directly phosphonating porous cellulose beads. Tests in vitro demonstrated that this adsorbent showed quite good adsorption performance for selective removal of low-density lipoprotein from human plasma. The effects of preparation conditions on the lipoprotein sorption properties of the resulted adsorbent were investigated. The adsorption dynamics was also examined.

关键词： Cellulose beads phosphonation low-density lipoprotein adsorption hyperlipemia

Vascular endothelial growth factor B improves impaired glucose tolerance through insulin-mediated inhibition of glucagon secretion

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World Journal of Diabetes 2023年第11期14卷 1643-1658页

作者： yu-qi li Lu-Yang Zhang yu-Chi Zhao Fang Xu Zhi-Yong Hu qi-Hao Wu Wen-Hao li Ya-Nuo li Department of Pathophysiology School of Basic MedicineBinzhou Medical UniversityYantai 264000Shandong ProvinceChina Department of Rheumatology and Immunology Yantaishan HospitalYantai 264000Shandong ProvinceChina Department of Surgery Yantaishan HospitalYantai 264000Shandong ProvinceChina School of Public Health and Management Binzhou Medical UniversityYantai 264000Shandong ProvinceChina The First School of Clinical Medicine Binzhou Medical UniversityYantai 264000Shandong ProvinceChina

BACKGROUND Impaired glucose tolerance(IGT)is a homeostatic state between euglycemia and hyperglycemia and is considered an early high-risk state of *** IGT occurs,insulin sensitivity decreases,causing a reduction in insulin secretion and an increase in glucagon ***,vascular endothelial growth factor B(VEGFB)has been demonstrated to play a positive role in improving glucose metabolism and insulin ***,we constructed a mouse model of IGT through high-fat diet feeding and speculated that VEGFB can regulate hyperglycemia in IGT by influencing insulin-mediated glucagon secretion,thus contributing to the prevention and cure of *** To explore the potential molecular mechanism and regulatory effects of VEGFB on insulin-mediated glucagon in mice with *** We conducted in vivo experiments through systematic VEGFB knockout and pancreatic-specific VEGFB *** and glucagon secretions were detected via enzyme-linked immunosorbent assay,and the protein expression of phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)was determined using western ***,mRNA expression of forkhead box protein O1,phosphoenolpyruvate carboxykinase,and glucose-6 phosphatase was detected via quantitative polymerase chain reaction,and the correlation between the expression of proteins was analyzed via *** In mice with IGT and VEGFB knockout,glucagon secretion increased,and the protein expression of PI3K/AKT decreased ***,in mice with VEGFB overexpression,glucagon levels declined,with the activation of the PI3K/AKT signaling *** VEGFB/vascular endothelial growth factor receptor 1 can promote insulin-mediated glucagon secretion by activating the PI3K/AKT signaling pathway to regulate glucose metabolism disorders in mice with IGT.

关键词： Vascular endothelial growth factor B Insulin-mediated Glucagon secretion Prediabetes Impaired glucose tolerance

A reliability-oriented genetic algorithm-levenberg marquardt model for leak risk assessment based on time-frequency features

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Petroleum Science 2023年第5期20卷 3194-3209页

作者： Ying-Ying Wang Hai-Bo Sun Jin Yang Shi-De Wu Wen-Ming Wang yu-qi li Ze-qing lin College of Safety and Ocean Engineering China University of PetroleumBeijing102249China College of Mechanical and Transportation Engineering China University of PetroleumBeijing102249China College of Instrument Science and Engineering Harbin Institute of TechnologyHarbin150006HeilongjiangChina

Since leaks in high-pressure pipelines transporting crude oil can cause severe economic losses,a reliable leak risk assessment can assist in developing an effective pipeline maintenance plan and avoiding unexpected *** fast and accurate leak detection methods are essential for maintaining pipeline safety in pipeline reliability *** oil pipeline leakage signals are insufficient for feature extraction,while the training time for traditional leakage prediction models is too long.A new leak detection method is proposed based on time-frequency features and the Genetic Algorithm-Levenberg Marquardt(GA-LM)classification model for predicting the leakage status of oil *** signal that has been processed is transformed to the time and frequency domain,allowing full expression of the original *** traditional Back Propagation(BP)neural network is optimized by the Genetic Algorithm(GA)and Levenberg Marquardt(LM)*** results show that the recognition effect of a combined feature parameter is superior to that of a single feature *** Accuracy,Precision,Recall,and F1score of the GA-LM model is 95%,93.5%,96.7%,and 95.1%,respectively,which proves that the GA-LM model has a good predictive effect and excellent stability for positive and negative *** proposed GA-LM model can obviously reduce training time and improve recognition *** addition,considering that a large number of samples are required for model training,a wavelet threshold method is proposed to generate sample data with higher *** research results can provide an effective theoretical and technical reference for the leakage risk assessment of the actual oil pipelines.

关键词： Leak risk assessment Oil pipeline GA-LM model Data derivation Time-frequency features

Seasonal Variation of the Glycogen Enzyme Activity in Diploid and Triploid Pacific Oyster Gonad During Sexual Maturation

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Journal of Ocean University of China 2007年第4期6卷 383-386页

作者： KONG lingfeng WANG Zhaoping yu Ruihai li qi WANG Rucai College of Fisheries Ocean University of China Qingdao 266003 P. R. China

The glycogen content and the activities of two key enzymes in glycogen metabolism, glycogen phosphorylase and gly- cogen synthetase, in the gonad of diploid and triploid Pacific oysters (Crassostrea gigas) were compared during maturation. The glycogen content in the gonad of diploids decreased with gametogenesis (by 85.7%), but the glycogen content in the gonad of trip- loids did not vary significantly. Activity of glycogen phosphorylase (GP) in the gonad of diploids decreased with gametogenesis (by 55.5%), while GP activity of triploids did not vary significantly during maturation. Activity of glycogen synthetase (GS) in the gonad of diploids increased slightly with gametogenesis, reaching a peak in June. Activity of GS declined sharply from June to July, which might be due to gonad spawning. GS activity of triploid oysters in spawning time (July and August) was significantly higher than that in other months, which might be explained with a ‘compensating’ mechanism for the higher glycogen content in triploids.

关键词： Pacific oyster diploid triploid glycogen metabolism gametogenesis