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Ascending aorta dilatation reduces the influence of elevated pulse pressure on left ventricular hypertrophy:findings from a Chinese elderly hypertensive population

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Journal of Geriatric Cardiology 2023年第2期20卷 100-108页

作者： yu-qi jiang Huan-Rui ZHANG Bo-Nan LIU Tian-Wen LI Jun-Feng jiang Wen TIAN Department of Geriatrics the First Hospital of China Medical UniversityShenyangChina

OBJECTIVE To determine the role of ascending aorta dilatation in the relationship between pulse pressure(PP)and left ventricular(LV)*** A total of 1556 Chinese elderly hypertensive patients were retrospectively *** echocardiography was used to obtain the aortic and cardiac structure *** addition,brachial blood pressure was measured,and total arterial compliance,systemic vascular resistance,arterial elastance,and end-systolic LV elastance were *** participants were divided into four groups according to the status of ascending aortic diameter and *** LV mass index increased in succession in the four groups,i.e.,the group with the normal aorta and lower PP,with the normal aorta and higher PP,with aortic dilatation and lower PP,and with aortic dilatation and higher PP(Ptrend<0.001).Total arterial compliance−1,arterial elastance,and end-systolic LV elastance were slightly higher in the individuals with normal aorta compared to those with aortic dilatation,regardless of PP being lower or higher(P<0.01).Compared to the group with the normal aorta and lower PP,individuals with aortic dilatation had a significantly increased multivariable adjusted risk of LV hypertrophy,and higher PP further exacerbated this risk[aortic dilatation with lower PP(OR=1.75,95%CI:1.01–3.04)and aortic dilatation with higher PP(OR=3.42,95%CI:2.03–5.77)].In the relation between PP and LV mass index(β=0.095,P<0.001),-41.3%of the total effect was attributable to mediation by ascending aortic diameter(P<0.0001).CONCLUSIONS In Chinese elderly patients with hypertension,ascending aorta dilatation could reduce the influence of elevated PP on LV hypertrophy.

关键词： elevated hypertensive hypertrophy

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On-treatment monitoring of liver fibrosis with serum hepatitis B core-related antigen in chronic hepatitis B

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World Journal of Gastroenterology 2019年第32期25卷 4764-4778页

作者： Xiu-Juan Chang Chao Sun Yan Chen Xiao-Dong Li Zu-jiang yu Zheng Dong Wen-Lin Bai Xiao-Dong Wang Zhi-qin Li Da Chen Wen-Juan Du Hao Liao qi-yu jiang Li-Jun Sun Yin-Yin Li Cui-Hong Zhang Dong-Ping Xu Yong-Ping Chen qin Li Yong-Ping Yang Chinese PLA Medical School Chinese PLA General HospitalBeijing 100853China Department of Therapeutic Research for Liver Cancer the Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Peking University 302 Clinical Medical School Beijing 100039China Department of Research for Clinical Medicine the Fifth Medical center of Chinese PLA General HospitalBeijing 100039China Department of Infectious Disease the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Infectious and Liver Diseases Liver Research Centerthe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Fuzhou Infectious Diseases Hospital Fuzhou 350025Fujian ProvinceChina Medical Department Training Graduate Office Chinese PLA General HospitalBeijing 100853China Department of Microbiology&Infectious Disease Center School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

BACKGROUND Non-invasive evaluation for liver fibrosis is clinically important,especially in patients with undetectable hepatitis B virus(HBV)DNA treated with nucleoside *** To clarify the monitoring power of hepatitis B core-related antigen(HBcrAg)for hepatic histologic changes in patients with chronic hepatitis B(CHB)treated with *** This prospective multicenter study used multiple ordinal and multivariate logistics regression analysis to assess variables associated with Ishak fibrosis score and regression for fibrosis regression,respectively,in 403 CHB patients,including 374 with entecavir for 72 weeks(291 underwent paired liver biopsy)and 29 as *** Level of HBcrAg correlated negatively with liver fibrosis staging(γ=-0.357,P6.33 log IU/mL at baseline and logarithmic reduction>1.03 log IU/mL at week 72 were associated with a higher chance of regression of liver fibrosis and histological improvement,*** HBcrAg level is associated with liver fibrosis *** is an excellent monitor of hepatic histological changes,especially in CHB patients treated with nucleoside analogs.

关键词： Hepatitis B core-related antigen Liver fibrosis Cirrhosis On-treatment monitoring

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Realization of Communication Protocols of RFID R/W Device Based on CPLD

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The Journal of China Universities of Posts and Telecommunications 2002年第2期9卷 57-61页

作者： yu Xing qi, jiang Mei long, DENG Wei chun, SHEN Shu qun (Beijing University of Posts and Telecommunications, Beijing 100876, P.R.China) Beijing University of Posts and Telecommunications Beijing 100876 P.R.China

The function of the communication module of Radio FrequencyIdentification(RFID)system is de- scribed. Based on Electronic DesignAutomation(EDA), the implementation of digital module of RFID usingXIL- INX XC9500 series Complex Programmable Logic Device(CPLD)isintroduced modularized and layering methods In communicationprotocols of RFID systems are employed to enhance the systemperformance and facilitate the de- Sign. To ensure the security andreliability of data transmission, a new method of combing encryptionand error cor- Rection is employed and described in detail.

关键词： RFID EDA CPLD Very High Speed Integrated Circuit Hardware DescriptionLanguage(VHDL)

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui yu Yan Xie Jian yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-qi Zhang yu-Ying Tan Li Zhang Wen-Tao jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong Yang Haochen Shen Xiaoming Xiao Zhichao Li qi Zhou Wei Yang Bin jiang Yongli Sun Luhong Zhang Zhenhua Yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting

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Correlation analyse between thyroid hormone levels and severity of schizophrenia symptoms

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World Journal of Psychiatry 2025年第1期15卷 63-71页

作者： qi-Hui jiang Wei-Dong Gong Department of Endocrinology and Metabolism Hengyang Central HospitalHengyang 421000Hunan ProvinceChina Breast Tumor Surgical Outpatient Hengyang Central HospitalHengyang 421000Hunan ProvinceChina

BACKGROUND The imbalance of hormone levels in the body is closely related to the occurrence and progression of schizophrenia,especially thyroid *** To study the relationship between triiodothyronine(T3),thyroxine(T4),free T3(FT3),free T4(FT4),thyroid stimulating hormone(TSH)and *** In this study,100 schizophrenia patients were selected from our hospital between April 2022 and April *** clinical data were analyzed *** on the Positive and Negative Syndrome Scale(PANSS)score,patients were divided into mild(1-3 points,n=39),moderate(4 points,n=45),and severe groups(5-7 points,n=16).Additionally,55 healthy individuals served as a control *** blood samples were collected to measure T3,T4,FT3,FT4,TSH,and cortisol concentrations,analyzing their relationship with PANSS *** The serum levels of T3,FT3,FT4,TSH and cortisol in the schizophrenia group were lower than those in the control group(P<0.05).With the increase of the severity of the disease,the concentrations of T3 and T4 decreased,while the con-centrations of TSH and cortisol increased(P<0.05).The concentrations of TSH and cortisol were positively correlated with the PANSS score,while T3 and T4 were negatively correlated with the PANSS score(P<0.05).The receiver ope-rating characteristic curve results showed that T3,T4,TSH,and cortisol had good efficacy in the diagnosis of *** results showed that decreased T3 level,decreased T4 level,decreased TSH level and increased cortisol level may be independent risk factors for *** Thyroid hormone levels are associated with the severity of schizophrenia symptoms,which can provide new solutions for the diagnosis and treatment of schizophrenia.

关键词： Thyroid hormone Schizophrenia Symptom severity Positive and Negative Syndrome Scale score Cortisol

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Study on Fuzzy Self-tuning PID Cascade Control Algorithm for Temperature of Active Solar House Heating System

Study on Fuzzy Self-tuning PID Cascade Control Algorithm for...

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2010 Chinese Control and Decision Conference

作者： Jun-qi yu,jiang Zhou,Yan-Feng Liu,Tao Ai School of Information and Control Engineering,Xi'' an University of Architecture & Technology,Xi'' an,710055

＜正＞Aiming at the control to temperature of Active Solar House Heating System,which has large time-delay, time-varying and model *** Self-tuning PID Cascade Control algorithm is *** takes the advantage of cascade control algorithm to overcome dynamic characteristics of controlled parameter,a self-tuning PID control for achieving perfect control *** simulation shows that the algorithm is better than the conventional PID cascade control,it has better adaptabilities for the parameters’ variation,lower overshoot and better anti-interference ability.

关键词： Temperature Active Solar House Fuzzy Cascade Control Heating system

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节水灌溉稻田杂草群落多样性分析

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中国农村水利水电 2017年第2期 31-36页

作者：付浩龙罗玉峰余琪熊玉江乔伟长江科学院农业水利研究所武汉430010 河海大学水文水资源与水利工程科学国家重点实验室南京210098 武汉大学水资源与水电工程科学国家重点实验室武汉430072 长江水利委员会人事劳动局武汉430015

为了明确节水灌溉稻田杂草种类、发生密度及其群落多样性,以常规灌溉为对照,在2013年研究了高邮灌区水稻控制灌溉对稻田杂草群落多样性的影响。结果表明:控制灌溉稻田杂草种类共有10科13种,常规灌溉则有9科11种,控制灌溉稻田杂草物种丰... 详细信息

为了明确节水灌溉稻田杂草种类、发生密度及其群落多样性,以常规灌溉为对照,在2013年研究了高邮灌区水稻控制灌溉对稻田杂草群落多样性的影响。结果表明:控制灌溉稻田杂草种类共有10科13种,常规灌溉则有9科11种,控制灌溉稻田杂草物种丰富度要高于常规灌溉;常规灌溉稻田杂草各生育期发生密度总体大于控制灌溉,且部分生育期差异显著;同时控制灌溉稻田杂草危害优势种少于常规灌溉;虽然不同灌溉模式下杂草Shannon-Wiener多样性指数随生育期变化不大且无显著差异,但控制灌溉稻田杂草Pielou均匀度在生育后期整体要大于常规灌溉,杂草群落相对稳定。由此可见,控制灌溉对稻田杂草密度和危害优势种具有一定的控制作用,可以有效地抑制部分杂草的爆发,对维护稻田杂草多样性及稻田生态平衡具有重要的意义。

关键词：节水灌溉稻田杂草群落多样性稻田生态平衡

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Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

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Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao jiang Zengxin qi Huixian Zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan jiang Wangrui yuan Xin Cao Liang Chen qianxing Zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

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Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： Ke jiang Zhi Chen Ji yu Chen Zheng Shan Huang Ming Wang Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

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