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Effects of Glutamine Supplementation on Patients Undergoing Abdominal Surgery

Chinese Medical Sciences Journal 2009年第1期24卷 55-59页

作者： yue-Dina Fan Jian-chun yu Wei-ming kang Qun Zhang Department of Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To evaluate the effects of supplementation of glutamine （GLN） on maintaining glu- tathione （GSH） level, immune system function, liver function, and clinical outcome of patients receiving abdominal operation. Methods Forty patients undergoing elective abdominal surgical treatment were randomly divided into 2 groups： study group （n=20） and control group （n=20）. All patients received total parenteral nutrition （TPN） for up to 7 days during perioperative period. The study group received TPN supplemented with GLN dipeptide while the control group received TPN without GLN dipeptide. Patients in both groups received equivalent nitrogen and caloric intake. Blood sample was taken on preoperative day, and the 1st, 3rd, 6th postoperative day to measure GSH level, immune indexes, and liver function indexes. Results The decrease of GSH level in plasma and red blood cell （RBC） in study group was less than that in control group during postoperative period. Ratio of GSH/glutathione disulfide （GSSG） in plasma in study grouP was higher than that in control group on the 3rd postoperative day （52.53±11.46 vs. 31.43±7.27, P = 0.001）. Albumin level in study group was higher than that in control group on the 3rd postoperative day （37.7±3.8 g/L vs. 33.8±4.2 g/L, P = 0.02）. There was no significant difference in the levels of immunoglobin （IgG, IgM, IgA） or T lymphocyte subgroup （CD4, CD8, CD4/CD8） in both groups during postoperative period. There was one case with infectious complication in control group, while none in study group. A trend of shortened hospital stay was observed in study group compared with control group （22.3±2.1 d vs. 24.9±1.7 d,P= 0.32）. Conclusions Supplementation of GLN-enriched TPN has beneficial effects on maintaining GSH levels in plasma and RBC, sustaining GSH/GSSG ratio and albumin level, and keeping antioxidant abilities during postoperative period in patients with abdominal operation, with the trends of decreasing incidence of infectious complicati

关键词： glutamine dipepfide glutathione total parenteral nutrition abdominal operation

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Chronic Intracerebroventricular Infusion of Metformin Inhibits Salt-Sensitive Hypertension via Attenuation of Oxidative Stress and Neurohormonal Excitation in Rat Paraventricular Nucleus

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Neuroscience Bulletin 2019年第1期35卷 57-66页

作者： Xiao-Jing yu Ya-Nan Zhao Yi-kang Hou Hong-Bao Li Wen-Jie Xia Hong-Li Gao Kai-Li Liu Qing Su Hui-yu Yang Bin Liang Wen-Sheng Chen Wei Cui Ying Li Guo-Qing Zhu Zhi-ming Yang yu-ming kang Department of Physiology and Pathophysiology Xi’an Jiaotong University School of Basic Medical SciencesMinistry of Education Key Laboratory of Environment and Genes Related to DiseasesXi’an Jiaotong UniversityXi’an 710061China Department of Cardiology Second Affiliated Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Respiratory Medicine Affiliated Jiangyin Hospital of Southeast University Medical SchoolJiangyin 214400China Department of Cardiovascular Surgery Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Endocrinology and Metabolism First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an Jiaotong University Health Science CenterXi’an 710061China Department of Plastic and Cosmetic Surgery Gansu Provincial HospitalLanzhou 730000China Key Laboratory of Cardiovascular Disease and Molecular Intervention Department of PhysiologyNanjing Medical UniversityNanjing 210029China

Metformin(MET), an antidiabetic agent, also has antioxidative effects in metabolic-related *** study was designed to determine whether MET has anti-hypertensive effects in salt-sensitive hypertensive rats by inhibiting oxidative stress in the hypothalamic paraventricular nucleus(PVN). Salt-sensitive rats received a highsalt(HS) diet to induce hypertension, or a normal-salt(NS)diet as control. At the same time, they received intracerebroventricular(ICV) infusion of MET or vehicle for 6 weeks. We found that HS rats had higher oxidative stress levels and mean arterial pressure(MAP) than NS rats. ICV infusion of MET attenuated MAP and reduced plasma norepinephrine levels in HS rats. It also decreased reactive oxygen species and the expression of subunits of NAD(P)H oxidase, improved the superoxide dismutase activity,reduced components of the renin-angiotensin system, and altered neurotransmitters in the PVN. Our findings suggest that central MET administration lowers MAP in saltsensitive hypertension via attenuating oxidative stress,inhibiting the renin-angiotensin system, and restoring the balance between excitatory and inhibitory neurotransmitters in the PVN.

关键词： Hypertension Paraventricular nucleus Sympathoexcitation Metformin Oxidative stress

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Blockade of c-Src Within the Paraventricular Nucleus Attenuates Inflammatory Cytokines and Oxidative Stress in the Mechanism of the TLR4 Signal Pathway in Salt-Induced Hypertension

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Neuroscience Bulletin 2020年第4期36卷 385-395页

作者： Qing Yang Xiao-Jing yu Qing Su Qiu-yue Yi Xin-Ai Song Xiao-Lian Shi Hong-Bao Li Jie Qi Guo-Qing Zhu yu-ming kang Department of Physiology and Pathophysiology Xi'an Jiaotong University School of Basic Medical SciencesKey Laboratory of Environment and Genes Related to Diseases of the Ministry of EducationXi'an Jiaotong UniversityXi’an 710061China Department of Cardiovascular Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Department of Pharmacology School of Basic Medical SciencesXi’an Jiaotong University Health Science CenterXi’an 710061China Key Laboratory of Cardiovascular Disease and Molecular Intervention Department of PhysiologyNanjing Medical UniversityNanjing 210029China

Toll-like receptor 4 (TLR4) and cellular Src (cSrc) are closely associated with inflammatory cytokines and oxidative stress in hypertension, so we designed this study to explore the exact role of c-Src in the mechanism of action of the TLR4 signaling pathway in salt-induced hypertension. Salt-sensitive rats were given a high salt diet for 10 weeks to induce hypertension. This resulted in higher levels of TLR4, activated c-Src, pro-inflammatory cytokines, oxidative stress, and arterial pressure. Infusion of a TLR4 blocker into the hypothalamic paraventricular nucleus (PVN) decreased the activated c-Src, while microinjection of a c-Src inhibitor attenuated the PVN levels of nuclear factor-kappa B, pro-inflammatory cytokines, and oxidative stress. Our findings suggest that a longterm high-salt diet increases TLR4 expression in the PVN and this promotes the activation of c-Src, which upregulates the expression of pro-inflammatory cytokines and results in the overproduction of reactive oxygen ***, inhibiting central c-Src activity may be a new target for treating hypertension.

关键词： Toll-like receptor 4 Cellular Src Inflammatory cytokines Oxidative stress Hypothalamic paraventricular nucleus Salt-induced hypertension

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Angiotensin Type 1 Receptors and Superoxide Anion Production in Hypothalamic Paraventricular Nucleus Contribute to Capsaicin-Induced Excitatory Renal Reflex and Sympathetic Activation

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Neuroscience Bulletin 2020年第5期36卷 463-474页

作者： yun Qiu Fen Zheng Chao Ye Ai-Dong Chen Jue-Jin Wang Qi Chen yue-Hua Li yu-ming kang Guo-Qing Zhu Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center of Translational Medicine for Cardiovascular Diseaseand Department of PhysiologyNanjing Medical UniversityNanjing 211166China Department of Pathophysiology Nanjing Medical UniversityNanjing 211166China Department of Physiology and Pathophysiology Cardiovascular Research CenterXi'an Jiaotong University School of MedicineXi'an 710061China

Chemical stimulation of the kidney increases sympathetic activity and blood pressure in *** hypothalamic paraventricular nucleus(PVN)is important in mediating the excitatory renal reflex(ERR).In this study,we examined the role of molecular signaling in the PVN in mediating the capsaicin-induced ERR and sympathetic *** PVN microinjections were performed in rats under *** ERR was elicited by infusion of capsaicin into the cortico-medullary border of the right *** reflex was evaluated as the capsaicin-induced changes in left renal sympathetic nerve activity and mean arterial *** of angiotensin type 1 receptors with losartan or inhibition of angiotensin-converting enzyme with captopril in the PVN abolished the capsaicin-induced *** infusion of capsaicin significantly increased NAD(P)H oxidase activity and superoxide anion production in the PVN,which were prevented by ipsilateral renal denervation or microinjection of losartan into the ***,either scavenging of superoxide anions or inhibition of NAD(P)H oxidase in the PVN abolished the capsaicin-induced *** conclude that the ERR induced by renal infusion of capsaicin is mediated by angiotensin type 1 receptor-related NAD(P)H oxidase activation and superoxide anion production within the PVN.

关键词： Renal reflex Sympathetic activity Blood pressure Paraventricular nucleus Angiotensin Reactive oxygen species

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Blockade of Endogenous Angiotensin-(1–7) in Hypothalamic Paraventricular Nucleus Attenuates High Salt-Induced Sympathoexcitation and Hypertension

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Neuroscience Bulletin 2019年第1期35卷 47-56页

作者： Xiao-Jing yu yu-Wang Miao Hong-Bao Li Qing Su Kai-Li Liu Li-Yan Fu Yi-kang Hou Xiao-Lian Shi Ying Li Jian-Jun Mu Wen-Sheng Chen Wei Cui Guo-Qing Zhu Philip J.Ebenezer Joseph Francis yu-ming kang Department of Physiology and Pathophysiology Xi’an Jiaotong University School of Basic Medical SciencesKey Laboratory of Environment and Genes Related to DiseasesMinistry of EducationXi’an 710061China Comparative Biomedical Sciences School of Veterinary MedicineLouisiana State UniversityBaton RougeLA 70803USA Genetic Engineering Laboratory College of BiotechnologyXi’an UniversityXi’an 710065China Department of Plastic and Cosmetic Surgery Gansu Provincial HospitalLanzhou 730000China Department of Pharmacology School of Basic Medical SciencesXi’an Jiaotong University Health Science CenterXi’an 710061China Department of Cardiovascular Medicine First Affiliated Hospital of the Medical College of Xi’an Jiaotong UniversityXi’an 710061China Department of Cardiovascular Surgery Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Endocrinology and Metabolism The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an Jiaotong University Health Science CenterXi’an 710061China Key Laboratory of Cardiovascular Disease and Molecular Intervention Department of PhysiologyNanjing Medical UniversityNanjing 210029China

Angiotensin(Ang)-(1–7) is an important biologically-active peptide of the renin-angiotensin system. This study was designed to determine whether inhibition of Ang-(1–7) in the hypothalamic paraventricular nucleus(PVN) attenuates sympathetic activity and elevates blood pressure by modulating pro-inflammatory cytokines(PICs)and oxidative stress in the PVN in salt-induced hypertension. Rats were fed either a high-salt(8% NaCl) or a normal salt diet(0.3% NaCl) for 10 weeks, followed by bilateral microinjections of the Ang-(1–7) antagonist A-779 or vehicle into the PVN. We found that the mean arterial pressure(MAP), renal sympathetic nerve activity(RSNA), and plasma norepinephrine(NE) were significantly increased in salt-induced hypertensive rats. The high-salt diet also resulted in higher levels of the PICs interleukin-6, interleukin-1 beta, tumor necrosis factor alpha, and monocyte chemotactic protein-1, as well as higher gp91 phoxexpression and superoxide production in the PVN. Microinjection of A-779(3 nmol/50 nL) into the bilateral PVN of hypertensive rats not only attenuated MAP, RSNA, and NE, but also decreased the PICs and oxidative stress in the PVN. These results suggest that the increased MAP and sympathetic activity in salt-induced hypertension can be suppressed by blockade of endogenous Ang-(1–7) in the PVN, through modulation of PICs and oxidative stress.

关键词： High-salt diet Hypertension Angiotensin(1–7) Paraventricular nucleus Pro-inflammatory cytokines

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Chemical Stimulation of Renal Tissue Induces Sympathetic Activation and a Pressor Response via the Paraventricular Nucleus in Rats

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Neuroscience Bulletin 2020年第2期36卷 143-152页

作者： Chao Ye yun Qiu Feng Zhang Ai-Dong Chen Hong Zhou Jue-Jin Wang Qi Chen yue-Hua Li yu-ming kang Guo-Qing Zhu Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center of Translational Medicine for Cardiovascular Diseaseand Department of PhysiologyNanjing Medical UniversityNanjing 211166China Department of Physiology Nanjing Medical UniversityNanjing 211166China Department of Physiology and Pathophysiology Cardiovascular Research CenterXi’an Jiaotong University School of MedicineXi’an 710061China

Sympathetic activation and the kidney play critical roles in hypertension and chronic heart *** role of the kidney in sympathetic activation is still not well *** this study,we revealed an excitatory renal reflex(ERR)in rats induced by chemical stimulation of the kidney that regulated sympathetic activity and blood *** ERR was induced by renal infusion of capsaicin,and evaluated by the changes in renal sympathetic outflow,blood pressure,and heart *** infusion of capsaicin dose-dependently increased the contralateral renal sympathetic nerve activity,mean arterial pressure,and heart *** in the corticomedullary border had greater effects than in the cortex or *** infusion of capsaicin had no significant *** effects of renal infusion of capsaicin were abolished by ipsilateral renal denervation,but were not affected by bilateral sinoaortic *** infusion of capsaicin increased the ipsilateral renal afferent *** ERR was also induced by renal infusion of bradykinin,adenosine,and angiotensin II,but not by *** infusion of capsaicin increased c-Fos expression in the paraventricular nucleus(PVN)of *** of neurons in the PVN with kainic acid abolished the capsaicin-induced *** findings indicate that chemical stimulation of kidney causes an excitatory reflex,leading to sympathetic activation,pressor response,and accelerated heart *** PVN is an important central nucleus in the pathway of the ERR.

关键词： Sympathetic activity Blood pressure Renal afferents Renal reflex Paraventricular nucleus

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Laparoscopic Partial Splenectomy for Giant Hemangioma Misdiagnosed as Splenic Cyst:a Case Report

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Chinese Medical Sciences Journal 2010年第3期25卷 189-192页

作者： Jin Wang Jian-chun yu Wei-ming kang Zhi-qiang Ma Department of General Surgery Peking Union Medical College Hospital ChineseAcademy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

ALTHOUGH unusual, hemangioma is the most common type of primary splenic neoplasm.1 Usually, splenic hemangioma appears as solid mass, but sometimes it presents cystic corn-ponent as well, which is difficult to discriminate from some other lesions, such as abscess, simple cyst, parasitic cyst, and lymphangioma.2 Preoperative diagnosis of splenic hemangioma mainly depends on imaging study （e.g. ultrasonography, CT, MRI）.

关键词： splenic hemangioma splenic cyst laparoscopic partial splenectomy misdiagnosis

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基于ARM的超声洁牙设备智能化检测系统的设计

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中国医疗器械杂志 2007年第3期31卷 189-191页

作者：余明康电子科技大学生命科学与技术学院四川成都610054

介绍一种新型的基于ARM嵌入式技术开发的超声洁牙设备检测系统。该系统以PHILIPS公司LPC2132芯片为核心,集温度、压力、频率和振幅模拟放大电路,以及步进电机驱动单元为一体。在硬件平台上移植μC/OS-Ⅱ嵌入式实时操作系统,实现多路信... 详细信息

介绍一种新型的基于ARM嵌入式技术开发的超声洁牙设备检测系统。该系统以PHILIPS公司LPC2132芯片为核心,集温度、压力、频率和振幅模拟放大电路,以及步进电机驱动单元为一体。在硬件平台上移植μC/OS-Ⅱ嵌入式实时操作系统,实现多路信号的实时采集与显示。系统精度高,可靠性好,可以满足用户对超声洁牙设备检测的要求。

关键词： ARM 洁牙设备步进电机嵌入式 μC /OS-Ⅱ

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Leptin receptor of the hind brain nuclei is involved in the conditioned taste preference of rats

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中国应用生理学杂志 2015年第6期31卷 549-555页

作者： Cai-xia LIN Shao-yun ZHANG Ke CHEN Xiao LUO Bo SUN yu-ming kang Jian-qun YAN Department of Physiology and Pathophysiology Xi'an Jiaotong University School of Basic Medical Science

Objective: Conditioned taste preference(CTP) is a taste learning reflex by which an animal learns to prefer a substance which tastes not well and has been studied with much interest in recent years. However, the neural substrates of CTP are less known. This study aimed to determine the possible neural pathways of CTP and whether serum leptin level and the leptin receptor(OB-Rb) in the hind brain are involved following CTP formation. Methods: We established CTP of quinine in rats with a 2-bottle preference test. The serum leptin concentrations were detected, the expression of c-fos in the rat brain was tested to determine the nuclei in relation with establishment of CTP. Finally, the OB-Rb m RNA expression was examined by RT-q PCR assay in parabrachial nucleus(PBN) and the nucleus of the solitary tract(NST) of the hind brain. Results: Compared with control group, the level of serum leptin was higher in the CTP group(4.58 ± 0.52 vs 1.67 ± 0.25 μg/L, P<0. 01); increased c-fos positive cells were found in the anterior hypothalamus(AH, 221.75 ± 4.96 vs. 178.50±6.63 cells/mm^2, P<0.05), the basal lateral amygdala(BLA, 70.75±6.17 vs 56.50±3.62 cells/mm^2, P<0.05) and the nucleus of the solitary tract(NST, 41.25±1.32 vs 32.50±1.02 cells/mm^2, P<0.05). But in ventromedial nucleus of the hypothalamus(VMH, 20.75±2.73 vs 38.5±1.54 per 1 mm^2, P<005), PBN(21.50 ±2.24 vs 36.25±1.49 cells/mm^2, P<0.05) and the central nucleus of the amygdala(Ce A, 22.25±1.53 vs 35.50 ±2.11 cells/mm^2, P<0.05), the number of c-fos positive cells was decreased in the CTP group. In addition, we found OB-Rb m RNA expression in PBN of CTP group rats was higher than that of control group(0.95±0.055 vs 0.57± 0.034, P<0.05), while there was no significant difference of OB-Rb m RNA expression in NST between the two groups. Conclusion: Nuclei AH, BLA, NST, VMH, PBN and Ce A participate in the formation of CTP. Leptin and its receptor in PBN may be involved in the formation and maintenance of CTP.

关键词：瘦素受体大鼠脑偏好味觉 c-fos表达核受体 OB-Rb 阳性细胞

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不同轧制比纯钨1250～1350℃下的再结晶行为

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材料热处理学报 2017年第7期38卷 50-56页

作者：余明王康昝祥罗来马吴玉程合肥工业大学材料科学与工程学院安徽合肥230009 合肥工业大学工业与装备技术研究院安徽合肥230009 安徽省有色金属材料与加工工程实验室安徽合肥230009

在1250、1300和1350℃下对50%(W50)、67%(W67)和90%(W90)轧制量的纯钨进行了等温退火实验。运用显微硬度测试和显微组织分析,研究了温度和轧制量对纯钨再结晶过程的影响。通过Arrhenius关系式拟合计算出W50、W67和W90表观再结晶激活能Q... 详细信息

在1250、1300和1350℃下对50%(W50)、67%(W67)和90%(W90)轧制量的纯钨进行了等温退火实验。运用显微硬度测试和显微组织分析,研究了温度和轧制量对纯钨再结晶过程的影响。通过Arrhenius关系式拟合计算出W50、W67和W90表观再结晶激活能Q分别为478、496和447 kJ/mol,并通过外推预测出在900℃时,W50、W67和W90的使用寿命分别为172.7、72.3和8.5年。通过对1350℃等温退火后的纯钨样品完全再结晶晶粒统计分析发现,完全再结晶平均晶粒尺寸随轧制量的增加而逐渐减小。

关键词：纯钨轧制等温退火再结晶定量金相分析

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