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Application of quantitative estimates of fecal hemoglobin concentration for risk prediction of colorectal neoplasia

World Journal of Gastroenterology 2013年第45期19卷 8366-8372页

作者： Chao-Sheng Liao yu-min lin Hung-Chuen Chang yu-Hung Chen Lee-Won Chong Chun-Hao Chen yueh-Shih lin Kuo-Ching Yang Chia-Hui Shih Division of Gastroenterology Department of Internal Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei 111 Taiwan School of Medicine Fu Jen Catholic University New Taipei City 24205 Taiwan Department of Family Medicine Shin Kong Wu Ho-Su Memorial Hospital Taipei 111 Taiwan Health Management Center Shin Kong Wu HoSu Memorial Hospital Taipei 111 Taiwan Chang Gung Institute of Technology School of Nursing Tao-Yuan 333 Taiwan

AIM:To determine the role of the fecal immunochemical test(FIT),used to evaluate fecal hemoglobin concentration,in the prediction of histological grade and risk of colorectal ***:We enrolled 17881 individuals who attended the two-step colorectal cancer screening program in a single hospital between January 2010 and October *** was recommended to the participants with an FIT of≥12 ngHb/mL *** classified colorectal lesions as cancer(C),advanced adenoma(AA),adenoma(A),and others(O)by their colonoscopic and histological *** linear regression analysis adjusted for age and gender was used to determine the association between the FIT results and colorectal tumor *** risk of adenomatous neoplasia was estimated by calculating the positive predictive values for different FIT ***:The positive rate of the FIT was 10.9%(1948/17881).The attendance rate for colonoscopy was 63.1%(1229/1948).The number of false positive results was *** these 1229 cases,the numbers of O,A,AA,and C were 759,221,201,and 48,*** analysis revealed a positive association between histological grade and FIT concentration(β=0.088,Plinear relationship was found between the concentration and positive predictive value of the FIT for predicting colorectal tumors(R2>0.95,P<0.001).CONCLUSION:Higher FIT concentrations are associated with more advanced histological *** prediction for colorectal neoplasia based on individual FIT concentrations is significant and may help to improve the performance of screening programs.

关键词： Colorectal cancer Fecal immunochemical test Screening Risk prediction Performance

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Role of cyclooxygenase-2 signaling pathway dysfunction in unexplained recurrent spontaneous abortion

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Chinese Medical Journal 2010年第12期123卷 1543-1547页

作者： WANG yu ZHAO Ai-min lin Qi-de Department of Obstetrics & Gynecology Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China

Background Experimental evidence indicates that cyclooxygenase-2 （COX-2） plays a critical role in blastocyst implantation; however, little is known of the role of COX-2 in unexplained recurrent spontaneous abortion （URSA）. Methods We evaluated the expression level and potential signaling pathway of COX-2 in 30 cases of URSA who were excluded the abnormality of chromosomes, anatomy, endocrine, infectious, autoimmune diseases and in 30 normal pregnancies. Results The mRNA and the protein expression level of COX-2 in the URSA group （-0.238±0.848, 0.368±0.089, respectively） were significantly lower than that in the control group （1.943±3.845, 1.046±0.108, respectively）（both, P 〈0.01）. The expression of prostaglandins PGF2a, PGD2, PGE2, and PGI2, in the URSA group （（2326.0±295.6） pg/ml, （2164.0±240.5） pg/ml, （238.7±26.4） pg/ml, （2337.0±263.0） pg/ml, respectively） were significantly lower than that in the control group （（3450.0±421.7） pg/ml, （3174.0±415.6） pg/ml, （323.5±43.8） pg/ml, （3623.0±460.4） pg/ml, respectively）（P 〈0.05）. The mRNA expression level of PPARI3 and RXRa （0.859±0.653, -0.172±0.752, respectively） in URSA group was significantly lower than that in the control group （1.554±1.735, 0.777±2.482, respectively）（both P 〈0.05）. The mRNA and protein expression levels of vascular endothelial growth factor-A （VEGF-A） in the URSA group （2.010±1.522, 0.35±0.46） was significantly lower than that in the control group （4.569±2.430, 0.750±0.350）（both P 〈0.05）. Conclusions COX-2 and the COX-2-derived PGI2 signaling pathway possibly play an important role in successful embryo implantation, and their decreased expression may result in URSA. The decreased expression may influence the expression of VEGF-A which interferes with placental angiogenesis causing failure of embryo implantation, leading to spontaneous abortion.

关键词： unexplained recurrent spontaneous abortion cyclooxygenase-2 prostaglandin 12 proliferator-activated receptor β/retinoid X receptor a vascular endothelial growth factor-A blastocyst implantation

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Evaluation of the role of H pylori infection in pathogenesis of gastric cancer by immunoblot assay

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World Journal of Gastroenterology 2006年第43期12卷 7029-7032页

作者： Kuo-Ching Yang Alexander Chu Chao-Sheng Liao yu-min lin Gen-min Wang Division of Gastroenterology Department of Internal Medicine Shin Kong Wu Ho-Su MemorialHospitalTaipei Taiwan China Taipei Medical University Taipei TaiwanChina

AIM： To elucidate the different serological reactions to H pylori using the immunoblotting technique for further understanding of its pathogenic role in gastric cancer. METHODS： A total of 54 patients were divided into two groups after upper gastrointestinal endoscopy： normal control group （25 patients） and gastric cancer group （29 patients）. Both groups were further divided into Hpylori （＋） and H pylori （-） subgroups based on the results of CLO test, Giemsa staining and culture. Sera were further analyzed with the immunoblotting technique （HelicoBIot 2.0, Genelabs Diagnostics, Singapore）. RESULTS： The positive rate of the immunoblotting test was as high as 88.9% in the H pylori （-） gastric cancer group and only 14.3% in the H pylori （-） normal control group with a statistically significant difference. CONCLUSION： The prevalence of H pylori infection is higher in gastric cancer patients than in the normal controls, suggesting that H pylori may play a role in the pathogenesis of gastric cancer.

关键词： Western blot Immunoblotting Gastric cancer Hpylori Enzyme-linked immunosorbent assay

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Cost-effectiveness analysis of population-based screening of hepatocellular carcinoma: Comparing ultrasonography with two-stage screening

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World Journal of Gastroenterology 2016年第12期22卷 3460-3470页

作者： ming-Jeng Kuo Hsiu-Hsi Chen Chi-ling Chen Jean Ching-yuan Fann Sam Li-Sheng Chen Sherry yueh-Hsia Chiu yu-min lin Chao-Sheng Liao Hung-Chuen Chang yueh-Shih lin Amy ming-Fang Yen Department of Hepatogastroenterology Tainan Municipal Hospital Tainan 701 Taiwan Graduate Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei 100 Taiwan Graduate Institute of Clinical Medicine College of Medicine and Graduate Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei 100 Taiwan Department of Health Industry Management School of Healthcare Management Kainan University Taoyuan 338 Taiwan School of Oral Hygiene College of Oral Medicine Taipei Medical University Taipei 110 Taiwan Department and Graduate Institute of Health Care Management Chang Gung University Taoyuan 333 Taiwan Division of Gastroenterology Department of Internal Medicine Shin-Kong Wu Ho-Su Memorial Hospital Taipei 111 Taiwan angder Health Clinics Taipei 111 Taiwan

AIM: To assess the cost-effectiveness of two populationbased hepatocellular carcinoma(HCC) screening programs, two-stage biomarker-ultrasound method and mass screening using abdominal ultrasonography(AUS).METHODS: In this study, we applied a Markov decision model with a societal perspective and a lifetime horizon for the general population-based cohorts in an area with high HCC incidence, such as Taiwan. The accuracy of biomarkers and ultrasonography was estimated from published meta-analyses. The costs of surveillance, diagnosis, and treatment were based on a combination of published literature, Medicare payments, and medical expenditure at the National Taiwan University Hospital. The main outcome measure was cost per lifeyear gained with a 3% annual discount rate. RESULTS: The results show that the mass screening using AUS was associated with an incremental costeffectiveness ratio of USD39825 per life-year gained, whereas two-stage screening was associated with an incremental cost-effectiveness ratio of USD49733 per life-year gained, as compared with no screening. Screening programs with an initial screening age of 50 years old and biennial screening interval were the most cost-effective. These findings were sensitive to the costs of screening tools and the specificity of biomarker ***: Mass screening using AUS is more cost effective than two-stage biomarker-ultrasound screening. The most optimal strategy is an initial screening age at 50 years old with a 2-year inter-screening interval.

关键词： Two-stage biomarker-ultrasound screening One-stage abdominal ultrasonography screening Markov model Cost-effectiveness Sensitivity analysis Age

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Boosting bidirectional sulfur conversion enabled by introducing boron-doped atoms and phosphorus vacancies in Ni2P for lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 760-769页

作者： lin Peng yu Bai Hang Li Meixiu Qu Zhenhua Wang Kening Sun Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Beijing Key Laboratory of Chemical Power Source and Green Catalysis School of Chemistry and Chemical Engineering Beijing Institute of Technology

Lithium-sulfur （Li-S） batteries have gained great attention due to the high theoretical energy density and low cost,yet their further commercialization has been obstructed by the notorious shuttle effect and sluggish redox ***,we supply a strategy to optimize the electron structure of Ni2P by concurrently introducing B-doped atoms and P vacancies in Ni2P （Vp-B-Ni2P）,thereby enhancing the bidirectional sulfur *** study indicates that the simultaneous introduction of B-doped atoms and P vacancies in Ni2P causes the redistribution of electron around Ni atoms,bringing about the upward shift of d-band center of Ni atoms and effective d-p orbital hybridization between Ni atoms and sulfur species,thus strengthening the chemical anchoring for lithium polysulfides （LiPSs） as well as expediting the bidirectional conversion kinetics of sulfur ***,theoretical calculations reveal that the incorporation of B-doped atoms and P vacancies in Ni2P selectively promotes Li2S dissolution and nucleation ***,the Li-S batteries with Vp-B-Ni2P-separators present outstanding rate ability of 777 m A h g-1at 5 C and high areal capacity of 8.03 mA h cm-2under E/S of 5μL mg-1and sulfur loading of 7.20 mg *** work elucidates that introducing heteroatom and vacancy in metal phosphide collaboratively regulates the electron structure to accelerate bidirectional sulfur conversion.

关键词： Lithium sulfur batteries

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《无机材料化学》教学中多媒体课件的运用

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安庆师范学院学报（自然科学版） 2009年第2期15卷 104-105页

作者：闵宇霖安庆师范学院化学化工学院安徽安庆246011

尊重科学的认识规律,运用多媒体等现代化教学手段,是提高教学质量的重要保证。《无机材料化学》的教学实践证明:运用视听结合、直观对比的课件,有助于从感知上升到理论,有益于进行判断推理,因而也就有利于突破难点,夺取重点。

关键词：认识规律多媒体无机材料化学

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao yu-Gui Peng Peng Wu Zong-lin Li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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水热法制备二硫化钴空心微球

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化学世界 2009年第10期50卷 577-579,589页

作者：王敏闵宇霖张元广陈友存安庆师范学院功能配合物省级重点实验室安徽安庆246011

以CoCl2.6H2O和Na2S2O3.5H2O为原料,在150℃的水热条件下反应12 h制备了CoS2空心微球。利用X射线粉末衍射仪(XRD)、扫描电子显微镜(SEM)和透射电子显微镜(TEM)对产物进行了表征,探索了不同反应条件对合成产物的影响。结果表明,所得产物... 详细信息

以CoCl2.6H2O和Na2S2O3.5H2O为原料,在150℃的水热条件下反应12 h制备了CoS2空心微球。利用X射线粉末衍射仪(XRD)、扫描电子显微镜(SEM)和透射电子显微镜(TEM)对产物进行了表征,探索了不同反应条件对合成产物的影响。结果表明,所得产物为立方晶系的CoS2单相,呈空心球状,其直径约为2μm,壁厚约为100 nm。此外,反应物的量、反应温度和反应时间均对产物的形成有较大影响。

关键词： CoS2 水热法空心微球

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Nanostructured ZnO/BiVO_(4)I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： Yiling Li Xiaoyao yu Yingjie Zhou Yao lin Ying Wu Key Laboratory of the ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration

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用户定制主题聚焦爬虫的设计与实现

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计算机工程与设计 2015年第1期36卷 17-21页

作者：闵钰麟黄永峰清华大学电子工程系信息认知与智能系统研究所北京100084 清华大学信息科学与技术国家实验室北京100084

传统的聚焦爬虫在主题未知或者缺少相应训练集的情况下无法完成主题爬行。为让聚焦爬虫具有更好的主题适应性,提出基于聚类算法的自适应主题模型,指导聚焦爬虫在只有少量相同主题(主题未知)初始url的情况下完成主题爬行。通过对初始页... 详细信息

传统的聚焦爬虫在主题未知或者缺少相应训练集的情况下无法完成主题爬行。为让聚焦爬虫具有更好的主题适应性,提出基于聚类算法的自适应主题模型,指导聚焦爬虫在只有少量相同主题(主题未知)初始url的情况下完成主题爬行。通过对初始页面聚类得到主题中心向量,寻找相关网页更新主题中心位置;基于best-first策略实现url排序;基于该模型实现用户定制主题聚焦爬虫。通过对比实验验证了使用该模型的爬虫具有较高的收获比(havest rate)。

关键词：聚焦爬虫 k-means best-first策略自适应主题模型用户定制主题爬虫

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