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The implementation of rapid acquisition algorithm for GPS weak signal by using FPGA

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The implementation of rapid acquisition algorithm for GPS we...

Hot Deformation Behavior and Flow Stress Prediction of Ultra Purified 17% Cr Ferritic Stainless Steel Stabilized with Nb and Ti

第五届中国卫星导航学术年会

作者： Wang yuanlei gao yang Wang meng Space Star Technology Co. Ltd

ISBN: (纸本)9783642547362

The traditional acquisition technology of low oribit GPS signal has been widely applied in the design of GPS navigation receiver. However, navigation receiver can only accept the navigation signal which comes from the other end of the earth when running above the navigation constellation, which results the decline of GPS navigation visibility and signal power , and the navigation signal power from high oribit navigation receiver will reduce 10dB at least than low oribit navigation receiver and traditional fast acquisition design can not meet design requirements of high oribit navigation receiver. Therefore, this paper present a design which increase times of coherent integration to improve ratio of carrier and noise of received signal, at the same time, it uses full link simulation by simulink to vertify feasibility of the design, the final design of weak signal acquisition, through the test of Xilinkcompany Virtex4 series FPGA chip based on the weak signal acquisition sensitivity up to -176dB. Because the GLONASS navigation system and BDS navigation and GPS navigation system using spread spectrum communication system, different with GPS navigation system in production of presucode ratio and presurange and the carrier frequence paramaters. Therefore, this fast acquisition algorithm for GPS weak signal adapt to the design of GLONASS navigation reciver and BDS navigation reciever.

关键词： GPS. Weak Signal. fast acquisition. High Orabit

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Journal of Iron and Steel Research International 2015年第9期22卷 827-836页

作者： Fei gao Fu-xiao yu Hai-tao LIU Zhen-yu LIU School of Materials & Metallurgy Northeastern Unversity State Key Laboratory of Rolling and Automation Northeastern University

The hot deformation behavior of ultra purified 17% Cr ferritic stainless steel stabilized with Nb and Ti was investigated using axisymmetric hot compression tests on a thermomechanical *** deformation was carried out at the temperatures ranging from 700 to 1 100℃ and strain rates from 1to *** microstructure was investigated using electron backscattering *** effects of temperature and strain rate on deformation behavior were represented by Zener-Hollomon parameter in an exponent type *** effect of strain was incorporated in the constitutive equation by establishing polynomial relationship between the material constants and strain.A sixth order polynomial was suitable to represent the effect of *** modified constitutive equation considering the effect of strain was developed and could predict the flow stress throughout the deformation conditions except at800℃in 1s-1 and at 700℃in 5and *** the reliability of the modified constitutive equation was possibly ascribed to the increase in average Taylor factor at 800℃in 1s-1 and the increase in temperature at 700℃in 5and10s-1 during hot *** optimum window for improving product quality of the ferritic stainless steels was identified as hot rolling at a low finisher entry temperature of 700℃,which can be achieved in practical production.

关键词： 17%Cr ferritic stainless steel hot deformation flow stress constitutive equation strain compensation

伴下腔静脉滤器经上腔静脉路径成功消融右侧旁路1例

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临床心血管病杂志 2024年第1期40卷 78-80页

作者：陈东冯俊江永进高玉周高亮卢冬雨合肥市第二人民医院(安徽医科大学附属合肥医院)心血管内科合肥230011

患者因反复胸闷胸痛7年、心悸2 h入院。临床诊断为阵发性室上性心动过速(PSVT)。患者于20年前植入下腔静脉滤器。电生理检查明确诊断为右侧隐匿性旁道介导的房室折返性心动过速(顺向性)。后通过上腔静脉入路成功消融。对于难以通过下腔... 详细信息

患者因反复胸闷胸痛7年、心悸2 h入院。临床诊断为阵发性室上性心动过速(PSVT)。患者于20年前植入下腔静脉滤器。电生理检查明确诊断为右侧隐匿性旁道介导的房室折返性心动过速(顺向性)。后通过上腔静脉入路成功消融。对于难以通过下腔静脉入路消融的患者来说,上腔静脉入路可能是一种安全、有效和可行的方法。

关键词：下腔静脉滤器上腔静脉入路导管消融右侧隐匿性旁道

儿童阻塞性睡眠呼吸暂停对颌面发育的影响和机制

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临床耳鼻咽喉头颈外科杂志 2024年第8期38卷 758-761,768页

作者：高菡冰管明浙江中医药大学第四临床医学院杭州310051 浙江大学医学院附属杭州市第一人民医院耳鼻咽喉头颈外科

近年来,大量的研究证实儿童阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)会使儿童颌面部发育异常,而颌面部的异常发育可能导致OSA病情持续发展以及颌面部的持续异常发育,对孩子身心造成不利影响。了解OSA对儿童颌面发育的影响和机... 详细信息

近年来,大量的研究证实儿童阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)会使儿童颌面部发育异常,而颌面部的异常发育可能导致OSA病情持续发展以及颌面部的持续异常发育,对孩子身心造成不利影响。了解OSA对儿童颌面发育的影响和机制,有助于更好地预防及治疗儿童OSA以及颌面发育不良问题。

关键词：阻塞性睡眠呼吸暂停儿童颌面部发育机制

NCTD通过调控PPP5C影响人白血病细胞增殖和凋亡的机制研究

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中国比较医学杂志 2024年第4期34卷 11-19页

作者：张鑫崔冰洁于国兴王飞赵靓高娜杜静滨州医学院第一临床医学院血液内科山东滨州256603 滨州医学院附属医院医学研究中心山东滨州256603 滨州市人民医院肿瘤科山东滨州256603

目的研究去甲斑蝥素(norcantharidin,NCTD)通过调控磷酸蛋白磷酸酶催化亚基5C(protein phosphatase 5 catalytic subunit,PPP5C)对人白血病NB4、K562细胞增殖、凋亡能力的影响及机制的初步研究。方法体外培养NB4、K562细胞,电转PC3.1和PPP5C-PC3.1质粒至NB4、K562细胞,遗传霉素(geneticin,G418)筛选NB4、K562稳转细胞系。Western blot和RT-qPCR实验检测PPP5C蛋白和mRNA表达水平。采用CCK-8、迁移实验、Live&Dead^(TM)动物细胞活力/毒性检测试剂盒分别检测NB4、K562细胞的增殖能力、迁移能力和死细胞、活细胞的数量。将NB4、K562稳转细胞分为0μg/mL NCTD组和不同浓度NCTD组,分别用含有0、8、16、32μg/mL NCTD的1640培养基培养;Live&Dead^(TM)动物细胞活力/毒性检测试剂盒检测死细胞率并对细胞形态进行拍照;Western blot检测各组细胞caspase 3、Cleaved caspase 3、JNK、p-JNK、p38、p-p38和α-Tubulin蛋白表达水平。结果NB4、K562细胞转染后PPP5C表达水平显著提高,细胞增殖能力、迁移能力、抗凋亡能力显著增强;与0μg/mL NCTD组相比,NCTD各浓度组会促进细胞凋亡,且呈剂量依赖性;PPP5C过表达拮抗NCTD对白血病细胞的杀伤作用;机制研究发现PPP5C通过去磷酸化修饰降低p-JNK的蛋白水平进而调控与细胞凋亡相关蛋白Cleaved caspase 3的表达。结论NCTD能够通过调控PPP5C分子促进NB4、K562细胞凋亡,抑制细胞的增殖。

关键词： PPP5C 去甲斑蝥素人白血病细胞增殖凋亡

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西藏墨脱苔藓植物多样性初步研究

亚热带植物科学 2024年第1期53卷 53-59页

作者：马和平司孟鑫高智远西藏农牧学院高原生态研究所/西藏高原森林生态教育部重点实验室/西藏林芝高山森林生态系统国家野外科学观测研究站/西藏自治区高寒植被生态安全重点实验室西藏林芝860000

墨脱因其特殊的地理位置和巨大的海拔高差使得该地区拥有丰富的植物种类,其独特的自然地理和独特的气候条件为苔藓植物的分布孕育了多种多样的生境,形成了多样化的苔藓植物群落。为研究西藏墨脱苔藓植物多样性及其生活型组成特征,采用... 详细信息

墨脱因其特殊的地理位置和巨大的海拔高差使得该地区拥有丰富的植物种类,其独特的自然地理和独特的气候条件为苔藓植物的分布孕育了多种多样的生境,形成了多样化的苔藓植物群落。为研究西藏墨脱苔藓植物多样性及其生活型组成特征,采用线路采集的方式对该地区苔藓植物进行调查和标本采集,物种鉴定和相关分析。结果表明:(1)墨脱共有苔藓植物83科239属631种(含变种、亚种),其中,角苔2科2属2种,苔类植物38科68属217种,藓类植物43科169属412种。该区苔藓植物有19个优势科,26个优势属和19个优势种。(2)墨脱不同基质苔藓植物群落类型特征中,岩面薄土生群落共有苔藓植物327种,占该区苔藓植物总数的51.83%;石生群落共有苔藓植物216种,占该区苔藓植物总数的34.23%;土生群落共有苔藓植物173种,占该区苔藓植物总数的27.42%;树附生群落共有苔藓植物97种,占该区苔藓植物总数的15.37%,叶附生群落共有苔藓植物21种,占该区苔藓植物总数的3.32%。总体分析,墨脱良好的自然环境条件为丰富的苔藓植物生存提供了保障。

关键词：苔藓植物物种多样性群落特征生活型墨脱

Platinum-coordinated graphitic carbon nitride nanosheet used for targeted inhibition of amyloid β-peptide aggregation

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Nano Research 2016年第8期9卷 2411-2423页

作者： meng Li Yijia Guan Zhaowei Chen Nan gao Jinsong Ren Kai Dong Xiaogang Qu Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Science Changchun 130022 China University of Chinese Academy of Sciences Beijing 100039 China

Amyloid β-peptide （Aβ） aggregation is a critical step in the pathogenesis of Alzheimer＇s disease （AD）. Inhibition of A[3 production, dissolution of existing aggregates and clearance of Aβ represent valid therapeutic strategies against AD. Herein, a novel platinum（II）-coordinated graphitic carbon nitride （g-C3N4） nanosheet （g-C3N4@Pt） has been designed to covalently bind to Aβ and modulate the peptide＇s aggregation and toxicity. Furthermore, g-CBN4@Pt nanosheets possess high photocatalytic activity and can oxygenate Aβ upon visible light irradiation, remarkably attenuating both the aggregation potency and neurotoxicity of Aβ Due to its ability to cross the blood-brain barrier （BBB） and its good biocompatibility, g-C3N4@Pt nanosheet is a promising inhibitor of Aβ aggregation. This study may serve as a model for the engineering of novel multifunctional nanomaterials used for the treatment of AD.

关键词： amyloid disease platinum graphitic carbon nitridenanosheet photooxygenation amyloid β-peptide (Aβ)inhibitors

Regulation of RDN on Th1/ILC1 cell imbalance in HFMD patients caused by EV71 infection

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Chinese Journal of Natural Medicines 2021年第3期19卷 205-211页

作者： WANG Yi-meng TIAN Ye LI Qian-Wen BIAN Zheng-Ying gao yue ZEN yu TANG Lei TANG Tie-Jun GUO Wei YAO Wen-Bing Jiangsu Key Laboratory of Druggability of Biopharmaceuticals School of Life Science and TechnologyChina Pharmaceutical UniversityNanjing 210009China Children’s Hospital of Nanjing Medical University Nanjing 210009China

Enterovirus 71(EV71)infection is more likely to cause hand,foot and mouth disease(HFMD)in children,which can lead to neurogenic complications and higher *** a commonly used clinical medicine,Reduning injection(RDN)helps to shorten the symptoms of patients with HFMD and facilitate the early recovery of ***,the regulatory mechanism of RDN on the HFMD immune system disorder caused by EV71 remains to be *** study collected detailed treatment data of56 children with HFMD who entered the affiliated Children’s Hospital of Nanjing Medical University during *** analysis of clinical data showed that the symptoms of the RDN treatment group were improved compared with the untreated *** explore its mechanism,the relevant detection indicators were detected by flow cytometry,enzyme-linked immunosorbent assay and realtime quantitative *** was found that the number and function of innate immune(ILCs)and adaptive immunity(Th1,Th2 and secreted cytokines)were reduced,suggesting that RDN plays a role by regulating cellular *** in vitro differentiation inhibition test further confirmed that RDN affected Th1 differentiation by inhibiting the expression of transcription factors on the basis of Th1 cell differentiation in vitro.

关键词： Enterovirus 71(EV71) Hand,foot and mouth disease(HFMD) Reduning injection(RDN) Th1 differentiated in vitro Innate immunity

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多动物链球菌诱导巨噬细胞驯化的免疫活性

中国兽医学报 2024年第8期44卷 1645-1650页

作者：都心怡高宇骆雪月杨勇军刘真真吉林大学动物医学学院吉林长春130062

旨在筛选分离驯化巨噬细胞的细菌,并鉴定其驯化效应分子。从牛、羊粪便中分离和纯化细菌、制备发酵上清,并通过小鼠腹腔巨噬细胞模型,进行一氧化氮(NO)测定和肿瘤坏死因子-α(TNF-α)的ELISA分析来研究驯化活性,活性细菌进行16S rRNA基... 详细信息

旨在筛选分离驯化巨噬细胞的细菌,并鉴定其驯化效应分子。从牛、羊粪便中分离和纯化细菌、制备发酵上清,并通过小鼠腹腔巨噬细胞模型,进行一氧化氮(NO)测定和肿瘤坏死因子-α(TNF-α)的ELISA分析来研究驯化活性,活性细菌进行16S rRNA基因序列鉴定、生长曲线测定,并经饱和硫酸铵沉淀进行NO测定和TNF-α的ELISA分析来研究驯化后巨噬细胞对金黄色葡萄球菌的吞噬能力。结果显示,筛选获得1株具有驯化免疫作用的菌株ED-8,经16S rRNA基因序列比对显示其与多动物链球菌具有99.86%的相似性,分类为多动物链球菌。其发酵上清可显著提高巨噬细胞NO和TNF-α的分泌,驯化后巨噬细胞对金黄色葡萄球菌的吞噬能力也增强,且经粗提处理后仍保留此效应,表明具有免疫调节活性。结果表明,本试验成功分离到多动物链球菌ED-8,其分泌物能够诱导巨噬细胞的免疫驯化,增强其吞噬活性。

关键词：多动物链球菌驯化免疫巨噬细胞