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Total Saponins of Panax notoginseng Activate Akt/mTOR Pathway and Exhibit Neuroprotection in vitro and in vivo against Ischemic Damage

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Chinese Journal of Integrative Medicine 2022年第5期28卷 410-418页

作者： PAN yu-wei WU Dong-ping LIANG Hua-feng TANG Gen-yun FAN Chun-lin SHI Lei YE Wen-cai LI Man-mei JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research Jinan UniversityGuangzhou(510632)China Department of TCM Preventive Medicine Tianhe District Hospital of Traditional Chinese MedicineGuangzhou(510632)China Institute of Traditional Chinese Medicine and Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollege of PharmacyJinan UniversityGuangzhou(510632)China

Objective:To reveal the neuroprotective effect and the underlying mechanisms of a mixture of the main components of Panax notoginseng saponins(TSPN)on cerebral ischemia-reperfusion injury and oxygenglucose deprivation/reoxygenation(OGD/R)of cultured cortical ***:The neuroprotective effect of TSPN was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT)assay,flow cytometry and live/dead cell *** morphology of dendrites was detected by *** cerebral artery occlusion(MCAO)was developed in rats as a model of cerebral *** neuroprotective effect of TSPN was evaluated by neurological scoring,tail suspension test,2,3,5-triphenyltetrazolium chloride(TTC)and Nissl *** blot analysis,immunohistochemistry and immunofluorescence were used to measure the changes in the Akt/mammalian target of rapamycin(mTOR)signaling ***:MTT showed that TSPN(50,25 and 12.5μg/m L)protected cortical neurons after OGD/R treatment(P<0.01 or P<0.05).Flow cytometry and live/dead cell assays indicated that 25μg/m L TSPN decreased neuronal apoptosis(P<0.05),and immunofluorescence showed that 25μg/m L TSPN restored the dendritic morphology of damaged neurons(P<0.05).Moreover,12.5μg/m L TSPN downregulated the expression of Beclin-1,Cleaved-caspase 3 and LC3 B-Ⅱ/LC3 B-Ⅰ,and upregulated the levels of phosphorylated(p)-Akt and p-mTOR(P<0.01 or P<0.05).In the MCAO model,50μg/m L TSPN improved defective neurological behavior and reduced infarct volume(P<0.05).Moreover,the expression of Beclin-1 and LC3 B in cerebral ischemic penumbra was downregulated after 50μg/m L TSPN treatment,whereas the p-mTOR level was upregulated(P<0.05 or P<0.01).Conclusions:TSPN promoted neuronal survival and protected dendrite integrity after OGD/R and had a potential therapeutic effect by alleviating neurological deficits and reversing neuronal *** promoted p-mTOR and inhibited Beclin-1 to alleviate ischemic damage,

关键词： total saponins of Panax notoginseng oxygen-glucose deprivation and reoxygenation neuroprotection ischemia-reperfusion Akt/mTOR pathway Chinese medicine

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Superconductivity in chromium nitrides Pr3Cr10-xN11 with strong electron correlations

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National Science Review 2020年第1期7卷 21-26页

作者： Wei Wu Kai Liu Yanjie Li Zhenhai yu Desheng Wu yuting Shao Shihang Na Gang Li Ruizhen huang Tao Xiang Jianlin Luo Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials & Micro-nano Devices Renmin University of China School of Physical Science and Technology Shanghai Tech University Songshan Lake Materials Laboratory Kavli Institute for Theoretical Sciences

Exploration of superconductivity in Cr-based compounds has attracted considerable interest because only a few Cr-based superconductors(CrAs, A2Cr3As3and ACr3As3（A = K, Rb, Cs, Na）) have been discovered so far and they show an unconventional pairing mechanism. We report the discovery of bulk superconductivity at 5.25 K in chromium nitride in Pr3Cr10-xN11with a cubic lattice structure. A relatively large upper critical field of Hc2（0）～12.6 T is determined, which is larger than the estimated Pauli-paramagnetic pair-breaking magnetic field. The material has a large electronic specific-heat coefficient of 170 mJ K-2mol-1—about 10 times larger than that estimated by the electronic structure calculation,which suggests that correlations between 3d electrons are very strong in Pr3Cr10-xN11, and thus quantum fluctuations might be involved. Electronic structure calculations show that the density of states at the Fermi energy are contributed predominantly by Cr 3d electrons, implying that the superconductivity results mainly from the condensation of Cr 3d electrons. Pr3Cr10-xN11represents a rare example of possible unconventional superconductivity emerging in a 3D system with strong electron correlations. Nevertheless,clarification of the specific pairing symmetry needs more investigation.

关键词： Cr-based superconductors nitrides strong electron correlations unconventional superconductivity

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Alternative technique to save ischemic bowel segment in management of neonatal short bowel syndrome: A case report

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World Journal of Clinical Cases 2019年第20期7卷 3353-3357页

作者： Lei Geng Lei Zhou Guo-Jian Ding Xiao-Liang Xu yu-mei Wu Ji-Jun Liu Ting-Liang Fu Department of Pediatric Surgery Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina Department of Hepatobiliary Surgery Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina Department of Neonatology Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina Department of Anorectal Surgery Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina

BACKGROUND Congenital short bowel syndrome(SBS)associated with malrotation,gut volvulus and jejuno-ileal atresia is a very rare *** is a severe challenge for surgeons to preserve residual ischemic bowel segment in the management of short bowel syndrome,especially in *** SUMMARY We report a newborn baby with gut malrotation associated with jejuno-ileal atresia,congenital SBS and jejunal *** and abdominal distention were *** laparotomy,malrotation associated with jejuno-ileal atresia,congenital SBS and jenunal volvulus was *** total length of the small bowel was 63 cm with proximal jejunal bowel segment measuring 38 cm,including 18 cm necrotic segment below the Treitz’s ligament and 20 cm severe ischemic *** distal part of the small bowel was 25 cm in length and only about 0.8 cm in ***’s procedure,necrotic segment resection and end-to-back duodeno-ileal anastomosis were *** residual severe ischemic jejunum was preserved with single proximal stoma and distal end *** months later,to restore the continuity of the isolated gut segment,end-to-end duodeno-jejunal and jejuno-ileal anastomosis was *** entire functional small bowel length increased to 80 *** fluid therapy and parenteral nutrition were discontinued on the 10th day *** months later,her body weight was 9.5 *** Isolation of severe ischemic bowel segment and staged anastomosis to restore the gut continuity for infants with SBS are safe and feasible.

关键词： Ischemic bowel segment Short bowel syndrome Bowel isolation technique Staged salvaging procedure Case report

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Cobalt/nitrogen co-carved carbon nanorod for efficient Fenton-like reaction:Degradation efficacy,reaction mechanism and singlet oxygen generation

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Journal of Materials Science & Technology 2023年第6期137卷 67-78页

作者： Meng Li Ke Zheng yu-Ting Jin Zhao-Xin Zhang Ji-Liang Cheng Long-Wei huang Ce-Hui Mo Shao-Qi Zhou Guangdong Provincial Research Center for Environment Pollution Control and Remediation Materials College of Life Science and TechnologyJinan UniversityGuangzhou 510632China College of Environment and Energy Guangzhou Higher Education Mega CentreSouth China University of TechnologyGuangzhou 510006China Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina School of Civil Engineering and Transportation South China University of TechnologyGuangzhou 510640China Thrust of Sustainable Energy&Environment The Hong Kong University of Science and TechnologyGuangzhou 511458China College of Resources and Environmental Engineering Guizhou UniversityGuiyang 550025China

The Fenton-like process shows promising potential to generate reactive oxygen species for the reme-diation of increasingly environmental ***,the slow development of high-activity cata-lysts with strong stability and low leaching of metal ions has greatly inhibited scale-up application of this ***,cobalt(Co)/nitrogen(N)atom co-curved carbon nanorod(CoNC)containing highly uniform CoN_(x)active sites is developed as a Fenton-like catalyst for the effective catalytic oxidation of various organics via peroxymonosulfate(PMS)activation with high *** confirmed by the exper-imental results,singlet oxygen(^(1)O_(2))is the dominant active species for the degradation of the organ-ics,with a proportion of 100%.Furthermore,density functional theory calculations indicate that CoN_(2)C_(2)is the most effective ligand structure with more negative adsorption energy for PMS and the shortest length Co-O bond,while the most reasonable generation pathway for^(1)O_(2)was CoN_(2)C_(2)-PMS→CoN_(2)C_(2)-OH∗→2O∗→^(1)O_(2).Further studies demonstrate that the electron can be transferred from the highest occupied molecular orbitals of the organics to the lowest unoccupied molecular orbitals of the PMS via CoN_(2)C_(2)*** addition,the CoNC presents strong resistance to inorganic ions and natural organic matter in the Fenton-like catalysis *** presence of CoN_(2)C_(2)active centre can significantly shorten the migration distance of the^(1)O_(2)generated from PMS activation,which further enhances the Fenton-like catalytic activity in terms of mineralising various organic contaminants with high efficiency over a wide pH range.

关键词： Non-radical pathway Singlet oxygen Co/N co-carved carbon nanorod Fenton-like catalysis

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Regulating the electrolyte solvation structure by weakening the solvating power of solvents for stable lithium metal batteries

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Science China Chemistry 2023年第12期66卷 3620-3627页

作者： Jia-Lin Liang Shu-yu Sun Nan Yao Zhao Zheng Qian-Kui Zhang Bo-Quan Li Xue-Qiang Zhang Jia-Qi huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China Department of Chemical Engineering Tsinghua UniversityBeijing 100081China

Rational electrolyte design is essential for stabilizing high-energy-density lithium(Li)metal batteries but is plagued by poor understanding on the effect of electrolyte component properties on solvation structure and interfacial ***,regulating the solvation structure in localized high-concentration electrolytes(LHCE)by weakening the solvating power of solvents is proposed for high-performance LHCE.1,3-dimethoxypropane(DMP)solvent has relatively weak solvating power but maintains the high solubility of Li salts,thus impelling the formation of nanometric aggregates where an anion coordinates to more than two Li-ions(referred to AGG-n)in *** decomposition of AGG-n increases the Li F content in solid electrolyte interphase(SEI),further enabling uniform Li *** cycle life of Li metal batteries with DMP-based LHCE is 2.1 times(386 cycles)as that of advanced ether-based LHCE under demanding ***,a Li metal pouch cell of 462Wh kg^(-1)undergoes 58 cycles with the DMP-based LHCE *** work inspires ingenious solvating power regulation to design high-performance electrolytes for practical Li metal batteries.

关键词： lithium metal anodes solvation structure 1,3-dimethoxypropane nanometric aggregates pouch cells

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Estimation for ammonia emissions at county level in China from 2013 to 2018

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Science China Earth Sciences 2022年第6期65卷 1116-1127页

作者： Wenling LIAO Mingxu LIU Xin huang Tiantian WANG Zhenying XU Fang SHANG yu SONG Xuhui CAI Hongsheng ZHANG Ling KANG Tong ZHU State Key Joint Laboratory of Environmental Simulation and Pollution Control Department of Environmental SciencePeking UniversityBeijing 100871China Joint International Research Laboratory of Atmospheric and Earth System Sciences School of Atmospheric SciencesNanjing UniversityNanjing 210023China Laboratory for Atmosphere-Ocean Studies Department of Atmospheric and Oceanic ScienceSchool of PhysicsPeking UniversityBeijing 100871China

Ammonia (NH_(3)) can interact with other trace chemicals in the atmosphere,significantly impacting atmospheric chemistry and global climate *** is a largely agricultural country with high consumption of nitrogen fertilizer and large livestock herds,resulting in high NH_(3) *** this study,a comprehensive county-level inventory of Chinese NH_(3) emissions from 2013 to 2018 was *** on previous research,an estimate of NH_(3) emissions from household coal combustion was added to the *** estimation of emissions from open biomass burning was improved by using a method based on fire radiative energy (FRE).The total NH_(3) emissions in China increased from 2013 (9.64 Tg) to 2015 (9.75 Tg),and then decreased to 9.12 Tg in *** from fossil fuels reached a peak value in 2018,accounting for 8.4%of total emissions,while fertilizer application and livestock waste were responsible for fewer emissions than in previous years,accounting for 27.7%and 49.9%of the total from non-fossil fuel sources,*** highest emission rates were in central and southwestern ***,NH_(3) emissions peaked in spring and *** inventory had a 1-km spatial resolution and a monthly temporal resolution,which confirmed its suitability for global and regional air quality simulations.

关键词： Ammonia emission Seasonal variations Spatial distribution Policy Suggestions China

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Solid-pseudopapillary tumor of the pancreas: Clinical experience and literature review

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World Journal of Gastroenterology 2005年第9期11卷 1403-1409页

作者： Hsueh-Lien huang Shou-Chuan Shih Wen-Hsiung Chang Tsang-En Wang Ming-Jen Chen yu-Jan Chan Division of Gastroenterology

AIM: To evaluate the clinical presentations of solidpseudopapillary tumor of the pancreas (SPT) and examine the diagnosis, treatment, low grade malignant potential of this rare ***: We retrospectively reviewed a series of seven patients with SPT managed in our hospital between July 1990 and October 2003. Six females and one male with mean age of 31 years (range 13 to 50 years) were diagnosed with SPT at our ***: Clinical presentation included a palpable abdominal mass in two patients and vague abdominal discomfort in another two. Two patients were asymptomatic;their tumors were found incidentally on abdominal sonographic examination for other reasons. The final patient was admitted with hemoperitoneum secondary to tumor rupture. The mean diameter of the tumors in the seven patients was 10.5 cm (range 5 to 20 cm). The lesions were located in the body and tail in five cases and in the head of the pancreas in two. Surgical procedures included distal pancreatectomy (3), distal pancreatectomy with splenectomy (2), pancreaticoduodenectomy (1) and a pylorus-preserving Whipple procedure (1). There were gross adhesions or histological evidence of infiltration to the adjacent pancreas and/or splenic capsule in four cases. None of the patients received adjuvant *** mean follow up was 7 years (range 0.5 to 14 years).One patient developed multiple liver metastases after 14 years of follow ***: SPT is a rare tumor that behaves less aggressively than other pancreatic tumor. However, in cases with local invasion, long-term follow up is advisable.

关键词： Solid-pseudopapillary tumor of the pancreas Distal pancreatectomy Pancreaticoduodenectomy

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Reflection Talbot Effect and Application

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贵州科学 2013年第4期31卷 3-5页

作者： ZHONG-mei huang WEN-Bo Hu WEI-Qi huang Institute of Nanophotonic Physics Guizhou University

The reflection Talbot effect under the illumination of Gaussian spherical wave and plane wave is observed on 1D and 2D photonic crystal of silicon prepared by nanosecond laser. It is found that the distance between two adjacent Talbot images increases lineally with increasing of image distance as well as amplification of Talbot images under the illumination of Gaussian spherical wave. The result of theory is coincident with that of experiment, which shows that selecting suitable wavefront shape of input field can enlarge the amplification rate and improve the resolution of Talbot imaging. The reflection Talbot effect will have a lot of good application in microscopy of micro-fabrication on silicon, such as detecting period structures of plasma on line of PLD fabricating.

关键词：复合水凝胶力学性能吸水率抑菌性

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Unique catalysis of Ni-Al hydrotalcite derived catalyst in CO_2 methanation: cooperative effect between Ni nanoparticles and a basic support

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Journal of Energy Chemistry 2014年第5期23卷 587-592页

作者： Lei He Qingquan Lin yu Liu Yanqiang huang State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of Sciences

Ni-Al hydrotalcite derived catalyst （Ni-Al2O3-HT） exhibited a narrow Ni particle-size distribution with an average particle size of 4.0 nm. Methanation of CO2 over this catalyst initiated at 225℃ and reached 82.5% CO2 conversion with 99.5% CH4 selectivity at 350℃, which was much better than its impregnated counterpart. Characterizations by means of CO2 microcalorimetry and 27 Al NMR indicated that large amount of strong basic sites existed on Ni-Al2O3-HT, originated from the formation of Ni-O-Al structure. The existence of strong basic sites facilitated the activation of CO2 and consequently promoted the activity. The combination of highly dispersed Ni with strong basic support led to its unique and high efficiency for this reaction. Keywords

关键词： CO2 methanation hydrotalcite NiJA1203 basic support Ni-O-Al

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Influence of Ⅴ/Ⅲ ratio on QD size distribution

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Frontiers of Optoelectronics 2011年第4期4卷 364-368页

作者： Zhongwei SHI Lirong huang Yi yu Peng TIAN Hanchao WANG Wuhan National Laboratory for Optoelectronics College of Optoelectonic Science and Engineering Huazhong University of Science and Technology

The influence of Ⅴ/Ⅲ ratio on the formation of quantum dots(QDs) grown by metal-organic chemical vapor deposition(MOCVD) is investigated by atomic force microscopy(AFM) and photoluminescence(PL)measurements. As Ⅴ/Ⅲ ratio increases, the density of QDs decreases accompanied by the transition of QD size distribution from bimodal(at Ⅴ/Ⅲ = 9) to single-modal(at Ⅴ/Ⅲ = 15), and then to bimodal(at Ⅴ/Ⅲ = 25) again,which is attributed to the change of the indium-species migration length at different Ⅴ/Ⅲ ratios. There are PL spectrum redshifts and the PL peak intensity decreases as Ⅴ/Ⅲ ratio increases.

关键词： quantum dots (QDs) V/III ratio QD size distribution photoluminescence (PL)

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