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Accelerated Cutaneous Wound Healing Using an Injectable Teicoplanin-loaded PLGA-PEG-PLGA Thermogel Dressing

Chinese Journal of Polymer Science 2019年第6期37卷 548-559页

作者： wei-Ke Xu Jing-yu Tang Zhang yuan Cai-yun Cai Xiao-Bin Chen Shu-Quan Cui Peng Liu Lin yu Kai-Yong Cai Jian-Dong Ding State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering Chongqing University

Bacterial infection is a very troublesome issue in wound treatment, which stimulates exudate formation and severely delays the healing process. Herein, a thermogelling dressing system composed of two triblock copolymers of poly(D,L-lactic acid-co-glycolic acid)-b-poly(ethylene glycol)-b-poly(D,L-lactic acid-co-glycolic acid)(PLGA-PEG-PLGA) with different block lengths was developed to deliver teicoplanin(TPN), a glycopeptide antibiotic, for cutaneous wound repair. The TPN-loaded thermogel was a free-flowing sol at room temperature and formed a semi-solid gel at physiological temperature. In vitro studies demonstrated that the TPN-loaded thermogel system exhibited desired tissue adhesiveness and realized the sustained release of TPN in a fast-followed-slow manner for over three weeks. Furthermore, a full-thickness excision wound model in Sprague-Dawley(SD) rats was constructed to assess the efficacy of TPNloaded thermogel formulation. Gross and histopathologic observations implied that treatment with the thermogel formulation reduced inflammation response, promoted disposition of collagen, enhanced angiogenesis, and accelerated wound closure and maturity of SD *** combination of the bioactivity of TPN and the acidic nature of the thermogel matrix was responsible for such an enhanced wound healing process. Consequently, the TPN-loaded PLGA-PEG-PLGA thermogel is a good candidate of wound dressing for full-thickness excision wound healing.

关键词： Wound dressing PLGA-PEG-PLGA thermogel Anti-infection Teicoplanin Sustained release

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Determination of Soil Parameters in Apple-Growing Regions by Near-and Mid-Infrared Spectroscopy

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Pedosphere 2011年第5期21卷 591-602页

作者： DONG Yi-wei YANG Shi-Qi XU Chun-Ying LI yu-Zhong BAI wei FAN Zhong-Nan WANG Ya-Nan LI Qiao-Zhen Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences Beijing 100081 (China) Key Laboratory of Agro-Environment and Climate Change Ministry of Agriculture Beijing 100081 (China) Key Laboratory of Dryland Farming and Water-Saving Agriculture Ministry of Agriculture Beijing 100081 (China)

Soil quality monitoring is important in precision *** study aimed to examine the possibility of assessing the soil parameters in apple-growing regions using spectroscopic methods.A total of 111 soil samples were collected from 11 typical sites of apple orchards,and the croplands surrounding ***-infrared(NIR) and mid-infrared(MIR) spectra,combined with partial least square regression,were used to predict the soil parameters,including organic matter(OM) content,pH,and the contents of As,Cu,Zn,Pb,and *** matter and pH were closely correlated with As and the heavy *** NIR model showed a high prediction accuracy for the determination of OM,pH,and As,with correlation coefficients(r) of 0.89,0.89,and 0.90,*** predictions of these three parameters by MIR showed reduced accuracy,with r values of 0.77,0.84,and 0.92,*** heavy metals could also be measured by spectroscopy due to their correlation with organic *** NIR and MIR had high correlation coefficients for the determination of Cu,Zn,and Cr,with standard errors of prediction of 2.95,10.48,and 9.49 mg kg-1 for NIR and 3.69,5.84,and 6.94 mg kg-1 for MIR,*** content behaved differently from the other *** NIR and MIR underestimated Pb content,with r values of 0.67 and 0.56 and standard errors of prediction of 3.46 and 2.99,*** and Zn had a higher correlation with OM and pH and were better predicted than Pb and ***,NIR spectra could accurately predict several soil parameters,metallic and nonmetallic,simultaneously,and were more feasible than MIR in analyzing soil parameters in the study area.

关键词： heavy metals partial least square regression prediction accuracy soil quality spectroscopic method

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Probing magnetic-proximity-effect enlarged valley splitting in monolayer WSe2 by photoluminescence

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Nano Research 2018年第12期11卷 6252-6259页

作者： Chenji Zou Chunxiao Cong Jingzhi Shang Chuan Zhao Mustafa Eginligil Lishu Wu yu Chen Hongbo Zhang Shun Feng Jing Zhang Hao Zeng wei Huang Ting yu Address correspondence to Ting yu yuting@ntu.edu.sg Chunxiao Cong cxcong@*** Hao Zeng haozeng@bufalo.edu wei Huang lamwhuang( ***

Possessing a valley degree of freedom and potential in information processing by manipulating valley features (such as valley splitting), group-VI monolayer transition metal dichalcogenides have attracted enormous interest. This valley splitting can be measured based on the difference between the peak energies of σ+ and σ− polarized emissions for excitons or trions in direct band gap monolayer transition metal dichalcogenides under perpendicular magnetic fields. In this work, a well-prepared heterostructure is formed by transferring exfoliated WSe2 onto a EuS substrate. Circular-polarization-resolved photoluminescence spectroscopy, one of the most facile and intuitive methods, is used to probe the difference of the gap energy in two valleys under an applied out-of-plane external magnetic field. Our results indicate that valley splitting can be enhanced when using a EuS substrate, as compared to a SiO2/Si substrate. The enhanced valley splitting of the WSe2/EuS heterostructure can be understood as a result of an interfacial magnetic exchange field originating from the magnetic proximity effect. The value of this magnetic exchange field, based on our estimation, is approximately 9 T. Our findings will stimulate further studies on the magnetic exchange field at the interface of similar heterostructures.

关键词： valley splitting transition metal dichalcogenides magnetic proximity effect heterostructure magnetic exchange field

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Evaluating effectiveness and safety of combined percutaneous transhepatic gallbladder drainage and laparoscopic cholecystectomy in acute cholecystitis patients:Meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1407-1419页

作者： yu Li wei-Ke Xiao Xiao-Jun Li Hui-yuan Dong Department of General Surgery No.942 Hospital of PLAYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Acute cholecystitis(AC)is a common disease in general *** cholecystectomy(LC)is widely recognized as the"gold standard"surgical procedure for treating *** low-risk patients without complications,LC is the recommended treatment plan,but there is still controversy regarding the treatment strategy for moderate AC patients,which relies more on the surgeon's experience and the medical platform of the visiting *** transhepatic gallbladder puncture drainage(PTGBD)can effectively alleviate gallbladder inflammation,reduce gallbladder wall edema and adhesion around the gallbladder,and create a"time window"for elective *** To compare the clinical efficacy and safety of LC or PTGBD combined with LC for treating AC patients,providing a theoretical basis for choosing reasonable surgical methods for AC *** In this study,we conducted a clinical investigation regarding the combined use of PTGBD tubes for the treatment of gastric cancer patients with *** performed searches in the following databases:PubMed,Web of Science,EMBASE,Cochrane Library,China National Knowledge Infrastructure,and Wanfang *** search encompassed literature published from the inception of these databases to the ***,relevant data were extracted,and a meta-analysis was conducted using RevMan 5.3 *** A comprehensive analysis was conducted,encompassing 24 studies involving a total of 2564 *** patients were categorized into two groups:1371 in the LC group and 1193 in the PTGBD+LC *** outcomes of the meta-analysis revealed noteworthy disparities between the PTGBD+LC group and the LC group in multiple dimensions:(1)Operative time:Mean difference(MD)=17.51,95%CI:9.53-25.49,P<0.01;(2)Conversion to open surgery rate:Odds ratio(OR)=2.95,95%CI:1.90-4.58,P<0.01;(3)Intraoperative bleeding loss:MD=32.27,95%CI:23.03-41.50,P<0.01;(4)Postoperative hospital stay:MD=1.44,95%CI:0.14-2.73,P=0.03;(5)Overall posto

关键词： Acute cholecystitis Laparoscopic cholecystectomy Percutaneous transhepatic gallbladder drainage Metaanalysis Efficacy

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Parametric stability analysis for planar bicircular restricted four-body problem

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Astrodynamics 2018年第2期2卷 147-159页

作者： Ying-Jing Qian Lei-yu Yang Xiao-Dong Yang wei Zhang Beijing Key Laboratory of Nonlinear Vibrations and Strength of Mechanical Structures College of Mechanical EngineeringBeijing University of TechnologyBeijing 100124China

Stability for the notn-autonomous bicircular four-body model is analytically investigated in this *** gowerning equation is derived from Newton's law of *** the distance between the infnitesimal mass and the third primary is expanded as Taylor expansions,the governing equation can be regarded 3 two parts:the unperturbed conservative system and the small periodically parametric *** unperturbed system's natural frequency and paramettic frequency are analyzed for the posibility of principal parametric *** method of multiple scales is applied directly to the governing *** stability conditions are obtained analytically for the principal pararmetric *** method demonstrates the efflciency of the analytical results.

关键词： bicircular four-body model parametric resonance libration points

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Expression and Distribution Characteristics of Human Ortholog of Mammalian Enabled (hMena) in Glioma

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Chinese Journal of Cancer Research 2011年第4期23卷 312-316页

作者： Xue-tao Dong Xue-jun Yang Hua-min Wang wei Wang Li yu Bin Zhang Sheng-ping yu Hao-lang Ming Department of Neurosurgery Tianjin Medical University General Hospital Tianjin Neurological Institute Tianjin 300052 China

Objective: To investigate the utility of hMena, a family of enabled/vasodilator-stimulated phosphoprotein (Ena/VASP), we sought to characterize the expression profile and distribution characteristics of hMena in a large panel of glioma samples and determine whether hMena expression levels might correlate with the pathological grade of glioma. Methods: Sixty-five specimens of glioma with different pathological grades and five control brain tissues were collected. In 6 of the 21 glioblastoma patients, multi-specimens were obtained respectively from the main tumor mass, the junction zone between the tumor and the normal tissue, and adjacent brain tissue 1.5 cm away from the tumor boundary under assistance of neuronavigation system during the operation. Immunohistochemistry was used to detect the expression and distribution characteristics of hMena. hMena expression was analyzed by Western blot in 20 specimens. Results: The hMena expression was negative in control brain tissue but positive in different grades of glioma. The expression rate of hMena was positively correlated with the increasing grade of the World Health Orgnization (WHO) classification (rs=0.682, P=0.000). hMena was located in cytoplasm. Positive cells only distributed around the vessels within the tumor mass in low grade glioma, while in high grade glioma, these cells were able to be detected not only in the tumor but also in the boundary zone and adjacent brain parenchyma. In the tumor mass, hMena expressed highly and diffusedly. In the junction zone, hMena positive cells formed radiolitic pattern around the vessels. In adjacent brain parenchyma, single positive cell was scattered. hMena expression was markedly elevated in Grade III and IV glioma compared with Grade II and I. Conclusion: Our data suggested that the expression of hMena is closely related to malignant grade of glioma. hMena can label the migrating cells, and indicate the migrating path of glioma cells from the tumor to adjacent tissue al

关键词： Glioma hMena Migration Immunohistochemistry

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Research and development of a 0.5-m-long helical superconducting undulator prototype

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Nuclear Science and Techniques 2024年第10期35卷 86-95页

作者： Xiang-Chen Yang Xiao-Wu yu Jun-Hao wei Xiang-Zhen Zhang Zi-Lin Chen Xiao-Juan Bian He-Ting Li Guang-Yao Feng yu-Hui Li National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Plasma Physics Chinese Academy of Sciences(ASIPP)Hefei 230031China China Spallation Neutron Source Institute of High Energy PhysicsChinese Academy of SciencesDongguan 523000China

The helical undulator is in high demand in synchrotron radiation facilities for circular polarization *** to the higher field strength provided by the superconducting undulator compared to the conventional permanent-magnet undulator,greater research efforts should be directed toward this *** helical superconducting undulator holds great potential in synchrotron radiation facilities,especially in low-energy storage rings that seek circularly polarized radiation with the highest possible radiation *** the successful development of planar superconducting undulators,the Institute of High Energy Physics conducted research and development for the helical superconducting undulator.A 0.5-m-long Deltatype superconducting undulator prototype was developed and *** information on the design,fabrication,and cryogenic testing of the prototype is presented and discussed.

关键词： Helical Superconducting undulator Delta

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Subclinical paraganglioma of the retroperitoneum:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2672-2677页

作者： Li-Min Kang Fa-Kun yu Fu-wei Zhang Lei Xu Department of Hepatobiliary and Pancreatic Surgery Puer People's HospitalPuer 665000Yunnan ProvinceChina

BACKGROUND Paraganglioma(PGL)located in the retroperitoneum presents challenges in diagnosis and treatment due to its hidden location,lack of specific symptoms in the early stages,and absence of distinctive manifestations on *** SUMMARY A 56-year-old woman presented with a left upper abdominal mass discovered 1 wk ago during a physical *** did not have a history of smoking,alcohol consumption,or other harmful habits,no surgical procedures or infectious diseases,and had a 4-year history of *** admission,she did not exhibit fever,vomiting,or abdominal *** examination indicated mild percussion pain in the left upper abdomen,with no palpable enlargement of the liver or *** tests and tumor markers showed no significant *** computed tomography and magnetic resonance imaging of the upper abdomen revealed a cystic solid mass in the left epigastrium measuring approximately 6.5 cm×4.5 cm,with inhomogeneous enhancement in the arterial phase,closely associated with the lesser curvature of the stomach and the *** patient underwent laparoscopic resection of the retroperitoneal mass,which was successfully removed without tumor rupture.A 12-month postoperative follow-up period showed good *** This case report details the successful laparoscopic resection of a retroperitoneal subclinical PGL,resulting in a good recovery observed at the 12-month ***,the patient also experienced unexpected cure of hypertensive disease.

关键词： Paraganglioma Retroperitoneal anatomy Subclinical Pheochromocytoma Laparoscopy Case report

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MiR-22 as a metabolic silencer and liver tumor suppressor

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Liver Research 2020年第2期4卷 74-80页

作者： Lijun Wang yu-Shiuan Wang Eko Mugiyanto wei-Chiao Chang yu-Jui Yvonne Wan Department of Pathology and Laboratory Medicine University of California DavisSacramentoCA The College of Life Science Yangtze UniversityJingzhouHubei PhD Program in Clinical Drug Development of Chinese Herbal Medicine College of PharmacyTaipei Medical UniversityTaipei Department of Clinical Pharmacy School of PharmacyTaipei Medical UniversityTaipei

With obesity rate consistently increasing,a strong relationship between obesity and fatty liver disease has been *** than 90%of bariatric surgery patients also have non-alcoholic fatty liver diseases(NAFLDs).NAFLD and non-alcoholic steatohepatitis(NASH),which are the hepatic manifesta-tions of metabolic syndrome,can lead to liver ***,there is no effective medicine that can be used to treat NASH or liver ***,it is critically important to understand the mechanism underlying the development of these *** evidence suggests that microRNA 22(miR-22)can be a diagnostic marker for liver diseases as well as a treatment *** review paper focuses on the roles of miR-22 in metabolism,steatosis,and liver *** search is limited based on the publications included in the PubMed database in the recent 10 years.

关键词： MicroRNA-22(miR-22) Cancer Liver Metabolism Steatosis Non-alcoholic steatohepatitis Hepatitis

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Functional Capsules Encapsulating Molecular-Recognizable Nanogels for Facile Removal of Organic Micro-Pollutants from Water

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Engineering 2021年第5期7卷 636-646页

作者： Wen-Ying Liu Xiao-Jie Ju Xing-Qun Pu Quan-wei Cai yu-Qiong Liu Zhuang Liu wei Wang Rui Xie Liang-Yin Chu School of Chemical Engineering&State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China

A novel method has been successfully developed for the facile and efficient removal of organic micro-pollutants(OMP)from water based on novel functional capsules encapsulating molecular-recognizable *** functional capsules are composed of ultrathin calcium alginate(Ca-Alg)hydrogel shells as semipermeable membranes and encapsulated poly(N-isopropylacrylamide-co-acrylic acid-g-mono-(6-ethanediamine-6-deoxy)-β-cyclodextrin)(PNCD)nanogels withβ-cyclodextrin(CD)moieties as OMP *** semipermeable membranes of the capsules enable the free transfer of OMP and water molecules across the capsule shells,but confine the encapsulated PNCD nanogels within the *** A(BPA),an endocrine-disrupting chemical that is released from many plastic water containers,was chosen as a model OMP molecule in this *** on the host–guest recognition complexation,the CD moieties in the PNCD nanogels can efficiently capture BPA ***,the facile and efficient removal of BPA from water can be achieved by immersing the proposed functional capsules into BPA-containing aqueous solutions and then simply removing them,which is easily done due to the capsules’characteristically large size of up to several *** kinetics of adsorption of BPA molecules by the capsules is well described by a pseudo-second-order kinetic model,and the isothermal adsorption thermodynamics align well with the Freundlich and Langmuir isothermal adsorption *** regeneration of capsules can be achieved simply by washing them with water at temperatures above the volume phase transition temperature of the PNCD ***,the proposed functional capsules encapsulating molecular-recognizable nanogels provide a novel strategy for the facile and efficient removal of OMP from water.

关键词： Functional capsules Molecular-recognizable nanogels Organic micro-pollutants Host-guest complexation Separations

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