检索结果-南通市图书馆

Heme oxygenase-1 promotes Caco-2 cell proliferation and migration by targeting CTNND1

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第16期126卷 3057-3063页

作者： ZHANG li liU yu-lin CHEN Guang-xiang CUI Bin WANG Jin-shen SHI yu-long li Le-ping GUO Xiao-bo Department of Gastrointestinal Surgery Provincial Hospital Affiliatedto Shandong University Jinan Shandong 250021 China

Background Heme oxygenase-1 （HO-1） can be induced by inflammatory cytokines,oxidation,ischemia,hypoxia,and *** a ＂graft survival protective gene,＂ HO-1 is a hot spot in organ transplantation ***,the role of HO-1 gene expression in the function of human colon adenocarcinoma cell line （Caco-2） cells has not been reported *** The role of HO-1 in the proliferation and migration of Caco-2 cells was analyzed using a stable HO-1 expression *** constructed a recombinant adeno-associated virus plasmid containing the HO-1 gene,heme oxygenase 1 （HMOX1）,which was transfected into Caco-2 intestinal *** identified a number of target genes by global microarray analysis combined with real-time polymerase chain reaction （PCR） and chromatin immunoprecipitation *** Our results showed that significant HO-1 upregulation was demonstrated in the Caco-2 cells after HO-1 *** of HO-1 expression promoted proliferation and invasion in *** CTNND1 gene,a member of the armadillo protein family,was identified as a direct HO-1 target *** Overexpression of HO-1 promotes Caco-2 cell proliferation and migration by targeting the CTNND1 gene.

关键词： heme oxygenase-1 Caco-2 cells microarray CTNND1

CRISPR-mediated BnaIDAediting prevents silique shattering, floral organ abscission, and spreading of Sclerotinia sclerotiorum in Brassica napus

在线全文

学校读者我要写书评

暂无评论

Plant Communications 2022年第6期3卷 127-130页

作者： Rui Geng yue Shan Lei li Chun-lin Shi Wei Zhang Jin Wang Rehman Sarwar Yi-Xuan Xue yu-long li Ke-Ming Zhu Zheng Wang li-Zhang Xu Reidunn B.Aalen Xiao-li Tan School of life Sciences Jiangsu UniversityZhenjiang 212013China ANGENOVO 1414 VikenNorway Key Laboratory for Theory and Technology of Intelligent Agricultural Machinery and Equipment Jiangsu UniversityZhenjiang 212013China Department of Biosciences University of Oslo0316 OsloNorway

Dear Editor,Rapeseed(Brassica napus)oil is a major source of vegetable oil around the *** rot disease caused by the necrotrophic fungus Sclerotinia sclerotiorum and silique shattering during harvest are two major contributors to yield loss in ***(Zhang et al.,2021).Infection by *** occurs when ascospores land on detached petals where they germinate and form mycelia that ultimately infects the leaves(Ding et al.,2021).Consistent with this mode of infection,reduced damage from stem rot has been achieved by generating apetalous rapeseed that are resistant to petal-mediated infection(yu et al.,2016).We propose that preventing petal shedding should also reduce leaf ***,attached floral organs will promote rapeseed flower tourism and provide an additional economic benefit.

关键词： attached generating organs

Microstructure and mechanical properties of pulsed laser welded Al/steel dissimilar joint

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2016年第4期26卷 994-1002页

作者：杨瑾李玉龙张华南昌大学机电工程学院江西省机器人及焊接自动化重点实验室南昌330031

Pulsed laser welding was used in joining pure aluminum to stainless steel in a lap joint configuration. It is found that the mechanical properties of the laser joints were closely correlated with the bead geometry, i.e., penetration depth. In order to study the correlation, two typical laser welds with different penetration depths were analyzed. In high penetration depth (354 μm) joint, Al-rich Fe?Al IMCs with microcracks were formed at the Al/fusion zone (FZ) interface. The joint strength was found to be (27.2±1.7) N/mm and three failure modes were observed near the Al/FZ interface. In low penetration depth (108 μm) joint, Fe-rich Fe?Al IMCs without any defect were formed at the Al/FZ interface. The joint strength was found to be (46.2±1.9) N/mm and one failure mode was observed across the FZ.

关键词： pulsed laser welding steel aluminum microstructure mechanical property

The pharmacodynamics experiment of Xinkang injection protect action of ADR-induced toxin myocarditisin mice

在线全文

学校读者我要写书评

暂无评论

沈阳药科大学学报 2008年第S1期25卷 95-96页

作者： ZHANG Hong,DU Jia-lin,li Xin-hua,XIANG Shao-jie,JIA Dong,BAO yu-long,li Kun(liaoning University of Traditional Chinese Medicine,Shenyang 110034,China)

Objective The experiment is to study the protective effects of Xinkang Injection on ADR-induced toxin myocarditisin *** The test of Xinkang Injection on ADR-induced toxin myocarditisin ***,the animal of obnormal,weight and death ***,the influnences of cardiogram of ADR-induced toxin myocarditisin ***,the influnences of lactate dehydrogenase(LDH),creatine kinase(CK)and glutamic oxaloacetic transaminasw(GOT)of ADR-induced toxin myocarditisin ***,the influnences of changes of cardioc pathological mechanism of ADR-induced toxin myocarditisin ***,the influnces of the caidioc ultrastructural of ADR-induced toxin myocarditisin *** Firstly,to ADR-induced toxin myocarditisin mice,the weight of middle dose and high dose of Xinkang injection had declined obviosly which contrast with the constraction model mice *** the mean time,the weight of Xinkang injection team had obviosly changde which contrast with contrastion mice team(Plined the activity of LDH and CK(P<0.01).Fouthly,to ADR-induced toxin myocarditisin mice,the low dose,the middle dose and high dose of Xinkang injection team can contrast with injured on toxic myocarditisin mice ***,to ADR-induced toxin myocarditisin mice,the low dose,the middle dose and high dose of Xinkang injection team have effect of allevite the injection of the cardioc ulteasteuctural of ADR-induced toxin myocarditisin *** Xinkang injection can protect t

关键词： Xinkang injection ADR toxin myocarditisin

Angiosarcoma around Hip Joint Prosthesis

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2016年第21期129卷 2642-2643页

作者： Wei Zhu Bin Feng Qi Ma yu-long li Xi-Tao Song Xi-Sheng Weng Department of Orthopaedics Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Angiosarcoma,a rare and malignant tumor,is known to be associated with prosthesis and *** to now,only a few cases related to knee prosthesis and fewer cases related to hip prosthesis have been reported.

关键词： Angiosarcoma Arthroplasty Hematoma Hip Prosthesis

Relationship between different skin incisions and the injury of the infrapatellar branch of the saphenous nerve during anterior cruciate ligament reconstruction

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2007年第13期120卷 1127-1130页

作者： LUO Hao yu Jia-Kuo AO Ying-fang yu Chang-long PENG li-bin liN Chun-yang ZHANG Ji-ying FU Xin Institute of Sports Medicine of Peking University Third Hospital Beijing 100083 China

Background After anterior cruciate ligament （ACL） reconstruction, some patients suffered from sensory disturbance around the surgical incision of the leg. This research was aimed to investigate the relationship between the different skin incisions and the injury of the infrapatellar branch of the saphenous nerve （IPBSN） post ACL reconstruction.Methods ACL reconstructions were performed with quadruple hamstring tendon for 60 patients. Sensory disturbance around the skin incision was followed up at an average of 14.5±4.7 months post operation. Among the 60 patients, vertical incision for 35 patients and oblique incision for 25 patients were used for graft taking during ACL reconstruction. The lengths of the incisions were measured. The patients were asked to mark the sensory disturbance zone at follow up time, and then the marked area was measured. The IPBSN of 15 cadaver knees were anatomized. The distance between the IPBSN and the upper edge of the pes anserinus tendon at the middle point of the incision was measured. independent-samples t-test, chi-square and Mann-Whitney tests were used for statistical analyses. Results The patients＇ age （P=0.329）, the follow-up time （P=0.661）, and the incision length （P=0.732） between the two groups had no significant difference. Twenty-three patients （65.7%） in the vertical incision group had IPBSN injury compared with 6 patients （24.0%） in oblique incision group （P=0.002）. The average sensory disturbance area in vertical incision group （（48.0±75.3） cm^2） was significantly larger （P=0.004） than that in the oblique group （（8.4±19.4） cm^2）. The anatomy measurement showed the average distance between IPBSN and the upper edge of the pes anserinus tendon was 0.6 cm at the incision. Conclusions Oblique incision with less risk of damage for IPBSN may be better for graft harvesting in ACL reconstruction. As the IPBSN is so near and parallel to the hamstring tendons, damage to the IPBSN is one of the potential complications for gra

关键词： anterior cruciate ligament reconstructive surgical procedures saphenous nerve nerve injury

A 30p Production Experiment being Planned at CRIB/CNS of University of Tokyo

在线全文

学校读者我要写书评

暂无评论

近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 64-65页

作者： Xu Shiwei He Jianjun Hu Jun yu Xiangqing li long Zhang liyong

Three-dimensional Printed Scaffolds with Gelatin and Platelets Enhance In vitro Preosteoblast Growth Behavior and the Sustained-release Effect of Growth Factors

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2016年第21期129卷 2576-2581页

作者： Wei Zhu Chi Xu Bu-Peng Ma Zhi-Bo Zheng yu-long li Qi Ma Guo-liang Wu Xi-Sheng Weng Department of Orthopaedic Surgery Peking Union Medical College Hospital Beijing 100730 China Department of Clinical Medicine Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China

Background：Three-dimensional （3D） printing technology holds great promise for treating diseases or injuries that affect human bones with enhanced performance over traditional *** patterns of design can lead to various mechanical properties and biocompatibility to various ***,there is still a long way to go before we can fully take advantage of 3D printing ***：This study tailored 3D printed scaffolds with gelatin and platelets to maximize bone *** scaffolds were designed with special internal porous structures that can allow bone tissue and large molecules to infiltrate better into the *** were then treated with gelatin and platelets via thermo-crosslinking and freeze-drying,*** endothelial growth factor （VEGF） and transforming growth factor （TGF）-β1 were measured at different time points after the scaffolds had been *** proliferation and cytotoxicity were determined via cell counting kit-8 （CCK-8） ***：There was a massive boost in the level of VEGF and TGF-β1 released by the scaffolds with gelatin and platelets compared to that of scaffolds with only *** 21 days of culture,the CCK-8 cell counts of the control group and treated group were significantly higher than that of the blank group （P 〈 0.05）.The cytotoxicity test also indicated the safety of the ***：Our experiments confirmed that the 3D printed scaffolds we had designed could provide a sustained-release effect for growth factors and improve the proliferation of preosteoblasts with little cytotoxicity in *** may hold promise as bone graft substitute materials in the future.

关键词： Growth Factor Platelet Scaffold Three-dimensional Print Titaniunl

2-N-邻苯二甲酰亚胺壳聚糖基手性固定相的制备及手性识别能力研究

在线全文

学校读者我要写书评

暂无评论

高分子学报 2016年第11期26卷 1555-1562页

作者：张丽丽沈军岡本佳男李玉龙哈尔滨工程大学材料科学与化学工程学院超轻材料与表面技术教育部重点实验室哈尔滨150001 Nagoya University Furo-choChikusa-kuNagoya 464-8603Japan

为了开发具有高效手性识别能力的新型多糖类手性固定相,合成了5种糖单元2-位具有邻苯二甲酰亚胺,而3,6-位同时具有4种不同苯基氨基甲酸酯基团(2-氯、3-氯、4-氯和3,5二氯取代的苯基氨基甲酸酯)和一种无取代的苯基氨基甲酸酯基团的壳聚... 详细信息

为了开发具有高效手性识别能力的新型多糖类手性固定相,合成了5种糖单元2-位具有邻苯二甲酰亚胺,而3,6-位同时具有4种不同苯基氨基甲酸酯基团(2-氯、3-氯、4-氯和3,5二氯取代的苯基氨基甲酸酯)和一种无取代的苯基氨基甲酸酯基团的壳聚糖类衍生物,并将其涂覆在氨丙基硅胶表面制备成HPLC手性固定相.利用红外光谱和核磁氢谱对所合成的衍生物进行结构表征与分析,并应用HPLC法评价其对10种对映体的手性识别能力.研究结果表明:这些新型壳聚糖类手性固定相的手性识别能力受苯基氨基甲酸酯取代基中芳环上侧基的引入位置、数量和空间位阻的影响较大.同时色谱测试中所使用流动相的成分对该类手性固定相的识别能力也具有较大影响.进一步探讨了这些衍生物的氨基甲酸酯残基核磁氢谱中N—H质子的化学位移和红外光谱中N—H波数与手性识别能力之间的关系.

关键词：壳聚糖 2-N-邻苯二甲酰亚胺苯基氨基甲酸酯手性固定相手性识别能力