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An Alternating Direction Method of Multipliers for MCP-penalized Regression with High-dimensional Data

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Acta Mathematica Sinica,English Series 2018年第12期34卷 1892-1906页

作者： yue Yong SHI yu ling jiao Yong Xiu CAO Yan Yan LIU School of Economics and Management China University of Geosciences Wuhan 430074 P. R. China Center for Resources and Environmental Economic Research China University of Geosciences Wuhan 430074 P. R. China School of Statistics and Mathematics Zhongnan University of Economics and Law Wuhan 430073 P. R. China School of Mathematics and Statistics Wuhan University Wuhan 430072 P. R. China

The minimax concave penalty （MCP） has been demonstrated theoretically and practical- ly to be effective in nonconvex penalization for variable selection and parameter estimation. In this paper, we develop an efficient alternating direction method of multipliers （ADMM） with continuation algorithm for solving the MCP-penalized least squares problem in high dimensions. Under some mild conditions, we study the convergence properties and the Karush-Kuhn-Tucker （KKT） optimality con- ditions of the proposed method. A high-dimensional BIC is developed to select the optimal tuning parameters. Simulations and a real data example are presented to illustrate the efficiency and accuracy of the proposed method.

关键词： Alternating direction method of multipliers coordinate descent continuation high-dimen-sional BIC minimax concave penalty penalized least squares

High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun Zhang Xiaoyun Wang Shuai Wang Yan Li Libo Chen Handong jiao Zhijing yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (LiMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** LiMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and Li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of LiMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of LiMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable LiMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： Lithium manganese iron phosphate High energy density Lithium-ion batteries Reaction mechanism Tap density

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑yuan yu Jing Wu Guang Yin Fan‑Zhen jiao Zhong‑Zhen yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

2012~2019年某口腔医院抗菌药物临床应用的阶段性评估

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中国当代医药 2021年第4期28卷 203-207页

作者：于皎凌大连市口腔医院药剂科辽宁大连116021

目的统计大连市口腔医院2012~2019年的抗菌药物临床应用数据,分析开展抗菌药物专项治理以来的阶段性成果。方法从大连市口腔医院信息系统中调取2012~2019年抗菌药物临床应用相关监测数据,对全院抗菌药物的使用率、住院患者抗菌药物使用... 详细信息

目的统计大连市口腔医院2012~2019年的抗菌药物临床应用数据,分析开展抗菌药物专项治理以来的阶段性成果。方法从大连市口腔医院信息系统中调取2012~2019年抗菌药物临床应用相关监测数据,对全院抗菌药物的使用率、住院患者抗菌药物使用强度、各类抗菌药物使用情况、Ⅰ类切口手术预防使用抗菌药物情况、接受抗菌药物治疗的住院患者抗菌药物使用前微生物送检率,用药金额排序/用药频度排序比等指标进行统计分析。结果与2012年比较,2019年医院门诊、急诊、住院患者抗菌药物使用率分别降低了9.44%、14.56%、35.22%,住院患者抗菌药物使用强度降低了63.26 DDDs/(100人·d),住院患者静脉输液占比、人均抗菌药物使用金额分别下降了41.68%和46.84%,接受抗菌药物治疗前微生物送检率逐年增加,Ⅰ类手术切口连续5年未预防用药。用药金额排序/用药频度排序比中硝基咪唑类、大环内酯类、一代头孢类连续8年排所用药物前3名。结论2012~2019年的数据反映本院抗菌药物使用已趋于合理,但是仍然要加强管理,防止反弹,继续巩固并提高合理用药水平。

关键词：口腔医院抗菌药物合理用药使用强度

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康复新液治疗复发性口腔溃疡的临床疗效观察

中国现代药物应用 2021年第4期15卷 139-142页

作者：于皎凌那婕大连市口腔医院药剂科 116021 联勤保障部队第967医院药剂科 116000

目的分析康复新液治疗复发性口腔溃疡的临床疗效。方法136例复发性口腔溃疡患者,按照计算机分组法分为对照组与实验组,各68例。对照组使用生理盐水治疗,实验组使用康复新液治疗。对比两组疗效、治疗后相关指标变化、临床症状评分及链球... 详细信息

目的分析康复新液治疗复发性口腔溃疡的临床疗效。方法136例复发性口腔溃疡患者,按照计算机分组法分为对照组与实验组,各68例。对照组使用生理盐水治疗,实验组使用康复新液治疗。对比两组疗效、治疗后相关指标变化、临床症状评分及链球菌、韦荣菌与奈瑟菌检测结果。结果实验组患者治疗优良率为97.06%,高于对照组的86.76%,差异有统计学意义(P<0.05)。治疗后,实验组CD3^+、CD4^+、CD8^+、肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)、白细胞介素-10(IL-10)水平均优于对照组,差异有统计学意义(P<0.05)。实验组患者溃疡面积、溃疡个数、渗出、充血、疼痛、烧灼感疼痛评分均低于对照组,差异有统计学意义(P<0.05)。实验组患者链球菌、韦荣菌与奈瑟菌检测结果分别为(8.00±0.30)、(8.10±0.31)、(8.51±0.35)拷贝/ml,均优于对照组的(7.54±0.26)、(7.71±0.28)、(8.98±0.38)拷贝/ml,差异有统计学意义(P<0.05)。结论康复新液治疗复发性口腔溃疡的疗效显著,可快速缓解疾病症状,具有推广价值。

关键词：康复新液复发性口腔溃疡淋巴细胞炎性因子

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高迁移率族蛋白B1与慢性非细菌性前列腺炎

安徽医药 2012年第5期16卷 571-573页

作者：于皎凌陈真中国药科大学药学医学基础实验教学中心江苏南京210009

高迁移率族蛋白B1(HMGB1)是一种高度保守的核蛋白,具有调控DNA稳定、复制、转录及翻译等功能。慢性非细菌性前列腺炎的发病和多种细胞因子的表达有关,由于HMGB1不同于TNF-α等早期细胞因子,发病后24 h才上升达到高峰,其可能成为慢性非... 详细信息

高迁移率族蛋白B1(HMGB1)是一种高度保守的核蛋白,具有调控DNA稳定、复制、转录及翻译等功能。慢性非细菌性前列腺炎的发病和多种细胞因子的表达有关,由于HMGB1不同于TNF-α等早期细胞因子,发病后24 h才上升达到高峰,其可能成为慢性非细菌性前列腺炎治疗的新靶点,因此该文就HMGB1参与调控细胞因子及在慢性非细菌性前列腺炎中的作用,做一综述。

关键词：高迁移率族蛋白B1 慢性非细菌性前列腺炎细胞因子

噬菌体展示布鲁氏菌蛋白文库构建及差减筛选融合蛋白

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中国人兽共患病学报 2019年第5期35卷 376-381页

作者：王阔鹏于凌娇刘倩宏刘麒张履冰吉林农业科技学院动物科技学院吉林132100

目的建立噬菌体展示羊型布鲁氏菌16M株表面蛋白文库,差减筛选具有良好特异性、亲和力及反应原性的蛋白,为确定新型诊断用抗原奠定基础。方法利用噬菌粒载体pYW01构建重组羊型布鲁氏菌16M株基因文库,辅助噬菌体VCSM13感染基因文库进而构... 详细信息

目的建立噬菌体展示羊型布鲁氏菌16M株表面蛋白文库,差减筛选具有良好特异性、亲和力及反应原性的蛋白,为确定新型诊断用抗原奠定基础。方法利用噬菌粒载体pYW01构建重组羊型布鲁氏菌16M株基因文库,辅助噬菌体VCSM13感染基因文库进而构建噬菌体展示羊型布鲁氏菌16M蛋白文库。利用PEG纯化后,扩增蛋白文库。随机挑取单克隆,提取质粒,测序鉴定蛋白文库。通过差减筛选,选择具有良好特异性、亲和力及反应原性的表面蛋白,为确定诊断用抗原奠定基础。结果通过DNA重组技术,构建羊型布鲁氏菌16M基因文库,库容量达到10~8pfu/mL,并且随机性良好。利用辅助噬菌体VCSM13包装基因文库,随机挑取蛋白文库中单克隆,提取质粒,经测序鉴定,成功构建噬菌体展示羊型布鲁氏菌16M株表面蛋白文库。利用免疫血清及感染血清对噬菌体展示蛋白文库进行差减淘选,筛选出6个噬菌体融合蛋白。经Western-blot分析6个噬菌体融合蛋白均具有较好的反应原性及特异性。结论成功构建噬菌体展示布鲁氏菌蛋白文库,差减筛选出6个具有较好反应原性及特异性的融合蛋白,为后续新型血清学诊断制剂筛选奠定基础。

关键词：布鲁氏菌噬菌体展示融合蛋白差减筛选

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan jiao lingyan Meng Kang Du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

SensFL:Privacy-Preserving Vertical Federated Learning with Sensitive Regularization

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 385-404页

作者： Chongzhen Zhang Zhichen Liu Xiangrui Xu Fuqiang Hu jiao Dai Baigen Cai Wei Wang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing100044China Shuohuang Railway Development Co. Ltd.National Energy GroupCangzhou062350China Beijing Key Laboratory of Security and Privacy in Intelligent Transportation School of Computer Science and TechnologyBeijing Jiaotong UniversityBeijing100044China

In the realm of Intelligent Railway Transportation Systems,effective multi-party collaboration is crucial due to concerns over privacy and data *** Federated Learning(VFL)has emerged as a promising approach to facilitate such collaboration,allowing diverse entities to collectively enhance machine learning models without the need to share sensitive training ***,existing works have highlighted VFL’s susceptibility to privacy inference attacks,where an honest but curious server could potentially reconstruct a client’s raw data from embeddings uploaded by the *** vulnerability poses a significant threat to VFL-based intelligent railway transportation *** this paper,we introduce SensFL,a novel privacy-enhancing method to against privacy inference attacks in ***,SensFL integrates regularization of the sensitivity of embeddings to the original data into the model training process,effectively limiting the information contained in shared *** reducing the sensitivity of embeddings to the original data,SensFL can effectively resist reverse privacy attacks and prevent the reconstruction of the original data from the *** experiments were conducted on four distinct datasets and three different models to demonstrate the efficacy of *** results show that SensFL can effectively mitigate privacy inference attacks while maintaining the accuracy of the primary learning *** results underscore SensFL’s potential to advance privacy protection technologies within VFL-based intelligent railway systems,addressing critical security concerns in collaborative learning environments.

关键词： Vertical federated learning privacy defenses