检索结果-南通市图书馆

International Journal of Minerals,Metallurgy and Materials 2013年第7期20卷 636-644页

作者： yu-liang wu Ze-yi Jiang Xin-xin Zhang Peng Wang Xue-feng She School of Mechanical Engineering University of Science and Technology Beijing Beijing Engineering Research Center for Energy Saving and Environmental Protection University of Science and Technology Beijing Beijing Key Laboratory for Energy Saving and Emission Reduction of Metallurgical Industry University of Science and Technology Beijing

A mathematical model was established to describe the direct reduction of pellets in a rotary hearth furnace （RHF）. In the model, heat transfer, mass transfer, and gas-solid chemical reactions were taken into account. The behaviors of iron metallization and dezincification were analyzed by the numerical method, which was validated by experimental data of the direct reduction of pellets in a Si-Mo furnace. The simulation results show that if the production targets of iron metallization and dezincification are up to 80% and 90%, respectively, the furnace temperature for high-temperature sections must be set higher than 1300~ C. Moreover, an undersupply of secondary air by 20% will lead to a decline in iron metallization rate of discharged pellets by 10% and a decrease in dezincing rate by 13%. In addition, if the residence time of pellets in the furnace is over 20 min, its further extension will hardly lead to an obvious increase in production indexes under the same furnace temperature curve.

关键词： rotary hearth furnaces direct reduction process dust ore pellets dezincification numerical methods

Influence of Phosphatidylinositol-3-Kinase/Protein Kinase B-Mammalian Target of Rapamycin Signaling Pathway on the Neuropathic Pain Complicated by Nucleoside Reverse Transcriptase Inhibitors for the Treatment of HIV Infection

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2018年第15期131卷 1849-1856页

作者： Hao Cheng liang-yu wu Department of Anesthesiology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Background： Nucleoside reverse transcriptase inhibitors （NRTIs） are the earliest and most commonly used anti-human immunodeficiency virus drugs and play an important role in high active antiretroviral therapy. However, NRTI drug therapy can cause peripheral neuropathic pain. In this study, we aimed to investigate the mechanisms ofrapamycin on the pain sensitization of model mice by in vivo experiments to explore the effect of mammalian target of rapamycin （mTOR） in the pathogenesis ofneuropathic pain caused by NRTIs. Methods： Male Kun Ming （KM） mice weighing 20-2 g were divided into control, 2 mg/kg rapamycin, 12 mg/kg stavudine, and CMC-Na groups. Drugs were orally administered to mice for 42 consecutive days. The von Frey filament detection and thermal pain tests were conducted on day 7, 14, 21, 28, 35, and 42 after drug administration. After the last behavioral tests, immunohistochemistry and western blotting assay were used for the measurement of mTOR and other biomarkers. Multivariate analysis of variance was used. Results： The beneficial effects ofrapamycin on neuropathic pain were attributed to a reduction in mammalian target of rapamycin sensitive complex 1 （mTORC1）-positive cells （70.80± 2.41 vs. 112.30 ± 5.66, F = 34.36, P 〈 0.01 ） and mTORC1 activity in the mouse spinal cord. Mechanistic studies revealed that Protein Kinase B （Akt）/mTOR signaling pathway blockade with rapamycin prevented the phosphorylation of mTORC1 in stavudine-intoxicated mice （0.72 ± 0.04 vs. 0.86 ± 0.03, F=4.24, P = 0.045）, as well as decreased the expression of phospho-pTOS6K （0.47 ± 0.01 vs. 0.68 ± 0.03, F=6.01, P = 0.022） and phospho-4EBP1 （0.90 ± 0.04 vs. 0.94 ± 0.06, F= 0.28, P = 0.646）. Conclusions： Taken together, these results suggest that stavudine elevates the expression and activity of mTORC1 in the spinal cord through activating the Akt/mTOR signaling pathway. The data also provide evidence that rapamycin might be useful for the treatment of peripheral neuropathic pain.

关键词： Human lmmunodeficiency Vinls Infection Neuropathic Pain Nucleoside Reverse Transcriptase lnhibitors Phosphatidylinositol-3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway Rapamycin

Palladium-catalyzed late-stage mono-aroylation of the fully substituted pyrazoles via aromatic C-H bond activation

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2019年第3期30卷 702-706页

作者： Miao-Miao Chen Ling-Yan Shao Li-Jun Lun yu-liang wu Xiao-Pan Fu Ya-Fei Ji School of Pharmacy East China University of Science & Technology Shandong Keyuan Pharmaceutical Co. Ltd. Shandong Shanghe Economic Development Zone

The palladium-catalyzed late-stage aroylation of 4-methyl-1,5-diaryl-lH-pyrazole-3-carboxylates has been developed via direct and exclusive mono-Csp^2-H bond activation with broad substrate scope and good functional group tolerance. A dual-core dimeric palladacycle is confirmed by X-ray single crystal crystallography, and probably serves as an active species in the catalytic cycle.

关键词： Palladium-catalysis Late-stage functionalization AroYlation Fully substituted pyrazoles C-H bond activation Cyclopalladated intermediate

Numerical simulation on dynamic behaviors of bubbles flowing through bifurcate T-junction in microfluidic device

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2019年第10期28卷 417-427页

作者： liang-yu wu Ling-Bo Liu Xiao-Tian Han Qian-Wen Li Wei-Bo Yang School of Hydraulic Energyand Power EngineeringYangzhou UniversityYangzhou 225127China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Based on the volume of fluid(VOF) method, a numerical model of bubbles splitting in a microfluidic device with T-junction is developed and solved numerically. Various flow patterns are distinguished and the effects of bubble length,capillary number, and diameter ratio between the mother channel and branch are discussed. The break-up mechanism is explored in particular. The results indicate that the behaviors of the bubbles can be classified into two categories: break-up and non-break. Under the condition of slug flowing, the branches are obstructed by the bubbles that the pressure difference drives the bubbles into break-up state, while the bubbles that retain non-break state flow into an arbitrary branch under bubbling flow condition. The break-up of the short bubbles only occurs when the viscous force from the continuous phase overcomes the interfacial tension. The behavior of the bubbles transits from non-break to break-up with the increase of capillary number. In addition, the increasing of the diameter ratio is beneficial to the symmetrical break-up of the bubbles.

关键词： microfluidic T-junction bubble break-up numerical simulation

Sutureless Intestinal Anastomosis with a Novel Device of Magnetic Compression Anastomosis

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Sciences Journal 2011年第3期26卷 182-189页

作者： Chao Fan Jia Ma Hong-ke Zhang Rui Gao Jian-hui Li liang yu Zheng wu Yi Lv Department of Hepatobiliary Surgery the First Affiliated HospitalMedical School of Xi＇an Jiaotong UniversityXi＇an 710061China

Objective To explore the feasibility and efficiency of a novel magnetic compression anastomats(MCAs) in intestinal *** A total of 36 male mongrel canines underwent intestinal anastomosis using traditional hand-sewn(n=18) or a novel MCAs(n=18).We compared the anastomosis time,postoperative complications,bursting strength of anastomoses,gross appearance,and pathology between two groups at each time-point of *** The mean anastomosis time with MCAs was significantly less than that with hand-sewn(8.50±1.95 vs.31.1±4.32 minutes,P<0.001).The blood stools and intussusceptions occurred in both groups during follow-up *** 1 mongrel canine receiving intestinal anastomosis by MCAs experienced anastomotic *** average bursting pressure of anastomoses obtained from mongrel canines undergoing intestinal anastomosis by MCAs was significantly higher than that by traditional hand-sewn at 1 week's follow-up time(P<0.05).Gross appearance of the anastomoses constructed by MCAs was relatively smoother and *** evalution of anastomoses revealed that general inflammation was greater in hand-sewn anastomoses than magnetic *** The magnetic compression anastomat is a safe and effective device of sutureless intestinal anastomosis in canine models.

关键词： magnetic compression anastomosis bursting strength foreign body reaction

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan Li Xi Liu Wenping liang yu Li Liyong wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

Preparation of Co/S co-doped carbon catalysts for excellent methylene blue degradation

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 169-181页

作者： Haixu Li Haobo He Tiannan Jiang yunfei Du Zhichen wu liang Xu Xinjie Wang Xiaoguang Liu Wanhua yu Wendong Xue School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Beijing Jinyu Tongda Refractory Technologies Co. Ltd.Beijing 100085China

S and Co co-doped carbon catalysts were prepared via pyrolysis of MOF-71 and thiourea mixtures at 800℃at a mass ratio of MOF-71 to thiourea of 1:0.1 to effectively activate peroxymonosulfate(PMS)for methylene blue(MB)*** effects of two different mixing routes were identified on the MB degradation ***,the catalyst obtained by the alcohol solvent evaporation(MOF-AEP)mixing route could degrade 95.60%MB(50 mg/L)within 4 min(degradation rate:K=0.78 min^(-1)),which was faster than that derived from the direct grinding method(MOF-DGP,80.97%,K=0.39 min^(-1)).X-ray photoelectron spectroscopy revealed that the Co-S content of MOF-AEP(43.39at%)was less than that of MOF-DGP(54.73at%),and the proportion of C-S-C in MOF-AEP(13.56at%)was higher than that of MOF-DGP(10.67at%).Density functional theory calculations revealed that the adsorption energy of Co for PMS was -2.94 eV when sulfur was doped as C-S-C on the carbon skeleton,which was higher than that when sulfur was doped next to cobalt in the form of Co-S bond(-2.86 eV).Thus,the C-S-C sites might provide more contributions to activate PMS compared with ***,the degradation parameters,including pH and MOF-AEP dosage,were ***,radical quenching experiments and electron paramagnetic resonance(EPR)measurements revealed that ^(1)O_(2)might be the primary catalytic species,whereas·O~(2-)might be the secondary one in degrading MB.

关键词： advanced oxidation process alcohol solvent evaporation hydrogen bond S and Co co-doped carbon catalysts wastewater remediation

The Algorithm and Its Application of a Multi-Channel Adaptive Decision-Feedback Equalizer

在线全文

学校读者我要写书评

暂无评论

The Journal of China Universities of Posts and Telecommunications 2003年第4期10卷 59-64页

作者： ZHANG yu-liang,wu Wei-ling,TIAN Bao-yu,HE Zhi-qiang,GU Xin-yu(School of Information Engineering, Beijing University of Posts & Telecommunications, Beijing 100876, P.R.China) School of Information Engineering Beijing University of Posts & Telecommunications 北京 100876

In digital radio communication, diversity reception can combat flat fadingand adaptive equalization can combat Inter-Symbol Interference (ISI). In this paper, the structureand algorithm of a multi-channel equalizer with combined diversity reception and adaptiveequalization techniques are studied. Because Phase-Looked-Loops (PLL) are embedded in the equalizer,this equalizer is suitable for coherent communication in channels with high phase *** Carlo simulation is used to test its performance and the results show that a multi-channeldecision-feedback-equalizer has better performance than a single-channeldecision-feedback-equalizer, and the results of processing high-speed digital underwatercommunication signals demonstrate this farther.

关键词： multi-channel decision-feedback-equalizer diversity reception coherentcommunications

Superhydrophobic and corrosion-resistant siloxane-modified MgAl-LDHs coatings on magnesium alloy prepared under mild conditions

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 450-463页

作者： Wenxi Zhang Zhangzelong Zhuo Dan Xu liang wu Zhihui Xie Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringChina West Normal UniversityNanchong 637002China College of Materials Science and Engineering/National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China

We have developed a superhydrophobic and corrosion-resistant LDH-W/PFDTMS composite coating on the surface of Mg *** composite comprised a tungstate-intercalated(LDH-W)underlayer that was grown at low temperature(relative to hydrothermal reaction conditions)under atmospheric pressure and an outer polysiloxane layer created from a solution containing perfluorodecyltrimethoxysilane(PFDTMS)using a simple immersion *** successful intercalation of tungstate into the LDH phase and the following formation of the polysiloxane layer were confirmed through X-ray diffraction(XRD),Fourier transform infrared(FTIR)spectroscopy,and X-ray photoelectron spectroscopy(XPS).The corrosion resistance of the LDH-W film,both before and after the PFDTMS modification,was evaluated using electrochemical impedance spectroscopy(EIS),Tafel curves,and immersion *** results showed that Mg coated with LDH-W/PFDTMS exhibited significantly enhanced corrosion protection compared to the unmodified LDHW film,with no apparent signs of corrosion after exposure to 3.5wt%NaCl solution for 15 ***,the LDH-W/PFDTMS coating demonstrated superior superhydrophobicity and self-cleaning properties against water and several common beverages,as confirmed by static contact angle and water-repellency *** results offer valuable insights into preparing superhydrophobic and corrosion-resistant LDH-based composite coatings on Mg alloy surfaces under relatively mild reaction conditions.

关键词： Mg alloy corrosion coating layered double hydroxide

在线全文

学校读者我要写书评

暂无评论

铁在不同pH值的NaCl溶液中的腐蚀行为

腐蚀科学与防护技术 2008年第4期20卷 260-264页

作者：张震梁煜武华南理工大学化学科学学院广州510640

采用线性扫描伏安法(LSV)和Tafel方法测定铁的极化曲线,研究了铁电极在不同pH值NaC l溶液中,以及在不同浓度NaC l溶液中腐蚀规律.结果表明,酸的浓度越增加,铁的腐蚀越容易;C l-对铁有腐蚀促进作用.通过极化曲线得到腐蚀参数和动力学参数... 详细信息

采用线性扫描伏安法(LSV)和Tafel方法测定铁的极化曲线,研究了铁电极在不同pH值NaC l溶液中,以及在不同浓度NaC l溶液中腐蚀规律.结果表明,酸的浓度越增加,铁的腐蚀越容易;C l-对铁有腐蚀促进作用.通过极化曲线得到腐蚀参数和动力学参数,探讨了不同溶液中铁的腐蚀机理:氯离子的存在能够改变钝化膜的组织结构,提高膜的溶解速率.

关键词：线性扫描伏安法腐蚀参数腐蚀机理