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Long-Term Outcome of A Large Series of Gastric Cancer Patients in China

Chinese Journal of Cancer Research 2010年第3期22卷 167-175页

作者： Ai-wen wu Jia-fu Ji Hong Yang Yan-ning li Shuang-xi li lian-hai Zhang Zi-yu li Xiao-jiang wu Xiang-long Zong Zhao-de Bu Ji Zhang Xiang-qian Su Yi Wang Guang-wei Xu Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department ofGastrointestinal Surgery Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing100142 China

Objective：The outcome of gastric cancer treatment in China is relatively poor compared with those in Japan and *** factors are not quite clear till *** aim of this study is to present data on gastric cancer patients from a single high volume cancer center of China and to illuminate relevant factors regarding unsatisfactory ***：A total of 2312 consecutive pathologically proven gastric carcinoma patients were treated in Beijing Cancer Hospital from January 1995 to December *** information including demographic information,tumor characteristics,therapeutic experience and survival was retrieved from the Database specially designed for Gastric Cancer Collaborative Group,Beijing Cancer ***：There were 1633 males and 679 females with a median age of 58.8 years（range 19-89）.Merely 181 patients were in the early stage（7.8%）.Curative resection was performed in less than 72% of the *** number of lymph nodes harvested varied from 0 to 71（average 9） while the median number of positive lymph node was 2（0-37）.Only in 650 patients the number of lymph nodes harvested was more than *** the end of follow-up,874 patients were still alive while 1132 *** 1,2,5,10-year overall survival were 68.50%,51.88%,36.83%,and 30.49%,*** analysis demonstrated that TNM stage,tumor location,tumor size,surgery,and vascular invasion were independent prognostic ***：The outcome of gastric cancer in China is not as good as *** detection and standardized curative resection should be prompted at present to improve the outcome.

关键词： Gastric cancer Management Outcome

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Endometrial Mucin-1 and Pinopode in Peri-implantation Phase in Ovarian High Responders during Controlled Ovarian Hyperstimulation Cycles

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Journal of Reproduction and Contraception 2007年第3期18卷 187-196页

作者： Qiu-ju CHEN Xiao-xi SUN Lu li Xiao-hong GAO yu wu li-nan CHENG Department of Reproductive Medicine International Peace Maternity and Child Health Hospital Shanghai200030 China

Objective To investigate effects of ovarian high response on endometrial mucin-1 （MUC1） and pinopode in peri-implantation phase in controlled ovarian hyperstimulation （COH） cycles. Methods Ovarian high response was defined as serum E2 〉 15 000 pmol/L on the day of hCG administration in COH cycle using GnRH agonist and recombinant FSH （n=8）. Healthy and fertile women were used as the natural control （n=10）. Endometrial biopsies were performed on the day of LH＋ 7/hCG＋ 7. Pinopode formation was observed by scanning electron microscope. Expression of MUC1 was detected with quantitative Real-time PCR and immunohistochemistry. Results In high response group, the lumen surface was covered with variant pinopodes and microvillous. The expression of MUC1 mRNA in high response group was lower than that in the natural control （P〈0.05）. Immunostaining for MUC1 protein in glandular and luminal epithelium in high response group was lower than that in the natural control （P〈0. 05）. Conclusion Asynchronized pinopode appearance and lower expression of MUC1 during peri-implantation period were the characteristics of endometrium in high response group, Which may provide a clue of decreased endometrial receptivity in the supraphysiological hormone milieu.

关键词： endometrium controlled ovarian hyperstimulation high response mucin-1 pinopode

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao yu-Gui Peng Peng wu Zong-lin li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

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Different effects of nine clausenamide ennatiomers on liver glutathione biosynthesis and glutathione S-transferase activity in mice

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Acta Pharmacologica Sinica 2006年第8期27卷 1024-1028页

作者： yu-qun wu li-de liU Hua-ling WEI Geng-tao liU~1 Department of Pharmacology,Institute of Materia Medica,Peking Union Medical College & Chinese Academy of Medical Sciences.Beijing 100050.China Department of Pharmacology Institute of Materia Medica Peking Union Medical College & Chinese Academy of Medical Sciences Beijing China

Aim:To study the effects of nine synthetic clausenamide with different stereostructures on liver glutathione(GSH)biosynthesis and glutathione S-transferase(GST)activity in ***:The nine test compounds were racemic mixturesand their ennatiomers of clausenamide,neoclausenamide and *** were administered clausenamide 250 mg/kg once daily for 3 consecutivedays,ig,and were killed 24 h after the last *** mouse liver cytosol GSHand GST were determined with related biochemical ***:Nineclausenamides exhibited different effects on liver GSH and *** nineclausenamides,only(+)and(±)clausenamide markedly increased liver cytosolGSH *** mechanism of increasing liver GSH content of(+)clausenamideis mainly due to stimulating the key limiting enzyme γ-glutamylcysteine synthetase(γ-GCS)activity for GSH *** other test clausenamides had no sucheffect on liver *** of the nine clausenamides induced a significant increaseof GST ***:The effects of clausenamide ennatiomers on liverGST and GSH varied with the alterations of their spatial structures.(+)Clausena-mide stimulated liver GSH biosynthesis through enhancing γ-GCS activity.

关键词： clausenamide glutathione γ-glutamylcysteine synthetase glutathione S-transferase

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K-M花样分析法测定薄晶体厚度和消光距离的不确定度评定

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物理学报 2022年第14期71卷 210-219页

作者：娄艳芝李玉武中国航发北京航空材料研究院北京100095 国家环境分析测试中心北京100029

本文通过分析200 kV加速电压条件下,单晶Si薄膜样品的透射电子显微镜(TEM)双束会聚束衍射(CBED)Kossel-Mollenstedt(K-M)花样,测定了单晶Si薄膜样品的局部厚度和Si晶体(400)晶面的消光距离ζ400.分析了影响测量不确定度的因素,并运用一... 详细信息

本文通过分析200 kV加速电压条件下,单晶Si薄膜样品的透射电子显微镜(TEM)双束会聚束衍射(CBED)Kossel-Mollenstedt(K-M)花样,测定了单晶Si薄膜样品的局部厚度和Si晶体(400)晶面的消光距离ζ400.分析了影响测量不确定度的因素,并运用一阶偏导的方法讨论了各个因素对测量不确定度的影响系数,依据GB/T 27418-2017《测量不确定度评定与表示》对实验估计值进行了不确定度评定.结论如下:被测Si晶体局部厚度的实验估计值为239 nm,其合成标准不确定度为5 nm,相对标准不确定度为2.2%;包含概率为0.95时,包含因子为2.07,扩展不确定度为11 nm;加速电压为200 kV时,Si晶体(400)晶面的消光距离ζ400的实验估计值为194 nm,合成标准不确定度为20 nm;包含概率为0.85时,包含因子为1.49,扩展不确定度为30 nm.影响试样厚度合成标准不确定度的主要因素是相机常数、加速电压和试样厚度;影响消光距离合成标准不确定度的主要因素是相机常数、加速电压和消光距离.双束K-M花样测量数据的测量不确定度u(Δθi)对消光距离不确定度的影响约是对试样厚度不确定度影响的ni(ζ/t^(3))(ni为正整数,ni≥1)倍,对拟合直线斜率的不确定度的影响是对截距不确定度影响的倍.如果试样有一定厚度,即ni>1,则用TEM双束会聚束衍射K-M花样分析薄晶体厚度的不确定度较小,而用此方法分析消光距离的不确定度较大.

关键词：会聚束电子衍射厚度测定消光距离不确定度

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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan li Xi liu Wenping liang yu li liyong wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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大掺量粉煤灰混凝土配比计算模型的建立与应用

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江西师范大学学报（自然科学版） 2009年第6期33卷 687-691页

作者：余丽武南京工程学院建筑工程学院江苏南京211167

引入粉煤灰胶凝系数β的概念,把粉煤灰作为混凝土的一个独立组分,并区分其在混凝土中的不同作用.提出大掺量粉煤灰混凝土配合比设计的4个基本参数,推导确定4个参数的理论公式,建立了大掺量粉煤灰混凝土配合比设计计算模型,并通过实验考... 详细信息

引入粉煤灰胶凝系数β的概念,把粉煤灰作为混凝土的一个独立组分,并区分其在混凝土中的不同作用.提出大掺量粉煤灰混凝土配合比设计的4个基本参数,推导确定4个参数的理论公式,建立了大掺量粉煤灰混凝土配合比设计计算模型,并通过实验考察配合比设计方法的合理性.结果表明:试验结果与原设计要求能较好地符合;粉煤灰掺量越高,混凝土各龄期的强度则越低;HFCC的抗压强度与胶凝系数β成正比,与灰胶比K成反比.

关键词：大掺量粉煤灰混凝土配合比设计胶凝系数计算模型力学性能

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Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： yuanwei li Xiaoxiao Xu Xuan wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

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Anti-tumor immune responses induced by gene transfer of 4-1BBL into human tongue squamons cell Tca8113 in vitro study

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中国口腔颌面外科杂志 2008年第B5期6卷 184-185页

作者： Hong yu Yang li wu Zheng Juan Luo Roger A.Zwahlen Mei Chu Department of Oral & Maxillofacial Surgery Shenzhen HospitalPeking University. Shenzhen 518036China

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Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： yun li Junfang wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

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