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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui yu yan Xie Jian yu kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

可溶液加工的聚(多金属氧簇降冰片烯)和聚(己酸降冰片烯)嵌段和无规共聚物的合成及催化功能的研究

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高分子学报 2017年第7期27卷 1159-1168页

作者：成恰苗文科颜雨坤王维南开大学化学学院功能高分子材料教育部重点实验室高分子化学研究所天津300071 天津化学化工协同创新中心南开大学天津300071

将一种可有机功能化的Wells-Dawson POM与降冰片烯相连接,制备了多金属氧簇降冰片烯单体.再利用活性可控的开环易位聚合方法(ROMP),在Grubbs 3^(rd)催化剂的作用下,合成了聚(多金属氧簇降冰片烯)-聚(己酸降冰片烯)的杂化嵌段和无规共聚... 详细信息

将一种可有机功能化的Wells-Dawson POM与降冰片烯相连接,制备了多金属氧簇降冰片烯单体.再利用活性可控的开环易位聚合方法(ROMP),在Grubbs 3^(rd)催化剂的作用下,合成了聚(多金属氧簇降冰片烯)-聚(己酸降冰片烯)的杂化嵌段和无规共聚物(H-CPs),分别简写为Poly(POM)_m-b-Poly(COOH)_n和Poly(POM)_m-r-Poly(COOH)_n.采用~1H-NMR、^(31)P-NMR和FTIR等方法对共聚物结构进行表征,确认我们成功地合成了由共价键连接这2种单体形成的H-CPs.最后,利用带有光散射和红外探测器的凝胶渗透色谱(SEC)测定聚合物的绝对分子量和分子量分布,证明所得到的H-CPs不仅分子量可控,而且分子量分布系数较窄.最后,研究了H-CPs催化氧化四氢噻吩(THT)成环丁亚砜(THTO)反应,结果表明,相比于聚(多金属氧簇)的均聚物(Poly(POM)),H-CPs的催化活性有所下降,原因是POM催化剂含量较低以及H-CPs在催化介质中溶解性的差异.

关键词：多金属氧簇聚(多金属氧簇) 共聚物 ROMP 催化性能

符号的本体意义与文论扩容——兼谈“强制阐释”与“本体阐释”

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Silk damping in scalar-induced gravitational waves: a novel probe for new physics

文艺理论 2016年第1期 143-150页

作者：王坤喻言Wang kun,yu yan

文论扩容是文艺学强大生命力的表现。西方文论扩容过程中的“强制阐释”一提出，就引起学界高度关注。与其相对的“本体阐释”，密切关联着本体论问题，这也是中国当代文论的瓶颈。现在基本定论的本质主义，终究是以自然本体论为依据的... 详细信息

文论扩容是文艺学强大生命力的表现。西方文论扩容过程中的“强制阐释”一提出，就引起学界高度关注。与其相对的“本体阐释”，密切关联着本体论问题，这也是中国当代文论的瓶颈。现在基本定论的本质主义，终究是以自然本体论为依据的。反本质主义思路中，既有西方的引入，亦有本土的贡献。理论创造中最重要的本体论建构，在起步处恰恰是最简单的：从日常生活中的常见现象入手。西方文论的基础，在从自然本体论到社会本体论的演变过程中，现象学与符号学居功至伟。在当代丰盈社会，衣食无忧不再是人们追求的理想生活；人类劳动产品的使用价值与符号价值的关系，正在发生前所未有之巨变。后者地位的直线上升，深刻地改变了当下社会，亦为文论扩容带来全新机遇。“强制阐释”现象产生的原因，在于存在两种本体论、两种文论与两种文学。异域理论对中国当代文论扩容具有参考价值与借鉴意义，但难以直接套用。“强制阐释”的提出，有助于促进中国当代文论认清并突破本体论瓶颈。

关键词：文论扩容两种本体论两种文论两种文学强制阐释

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 79-85页

作者： yan-Heng yu Sai Wang Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences School of Physics University of Chinese Academy of Sciences

Silk damping is well known in the study of cosmic microwave background（CMB） and accounts for suppression of the angular power spectrum of CMB on large angular multipoles. In this article, we study the effect of Silk damping on the scalar-induced gravitational waves（SIGWs）. Resulting from the dissipation of cosmic fluid, the Silk damping notably suppresses the energydensity spectrum of SIGWs on scales comparable to a diffusion scale at the decoupling time of weakly-interacting particles. The effect offers a novel observable for probing the underlying particle interaction, especially for those mediated by heavy gauge bosons beyond the standard model of particles. We anticipate that pulsar timing arrays are sensitive to gauge bosons with mass ～10～3-10～4 GeV, while space-and ground-based interferometers to those with mass ～10～7-1012GeV, leading to essential complements to on-going and future experiments of high-energy physics.

关键词： scalar-induced gravitational waves Silk damping new physics

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng Wen Qin Xuebing yan kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

糖皮质激素联合沙丁胺醇雾化吸入对急性加重期慢性阻塞性肺疾病患者通气功能及炎症因子的影响

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四川解剖学杂志 2023年第3期31卷 32-35页

作者：玉彦坤滑县中心医院呼吸内科安阳456400

目的:分析急性加重期慢性阻塞性肺疾病(简称慢阻肺)患者联用糖皮质激素与沙丁胺醇治疗的效果.方法:选取2022年1月至2022年12月期间本院收治的急性加重期慢阻肺患者80例作为研究对象,采用抽签法分为研究组和对照组,各40例.在常规治疗基础... 详细信息

目的:分析急性加重期慢性阻塞性肺疾病(简称慢阻肺)患者联用糖皮质激素与沙丁胺醇治疗的效果.方法:选取2022年1月至2022年12月期间本院收治的急性加重期慢阻肺患者80例作为研究对象,采用抽签法分为研究组和对照组,各40例.在常规治疗基础上,研究组雾化吸入加沙丁胺醇的糖皮质激素治疗,对照组仅雾化吸入糖皮质激素治疗,对比两组效果.结果:与对照组比较,研究组治疗后总有效率和比气道传导率(sGAW)更高,比气道阻力(sRAW)、气道阻力(RAW)更低,差异有统计学意义(P0.05).结论:糖皮质激素与沙丁胺醇联用的临床疗效确切,可有效调节机体炎性因子水平,改善患者通气和血气状况,且安全性高.

关键词：急性加重期糖皮质激素通气功能慢阻肺沙丁胺醇

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尼洛替尼的合成研究

化学试剂 2011年第3期33卷 266-268页

作者：禹艳坤王超刘爱霞冀亚飞华东理工大学药学院上海200237

3-乙酰基吡啶与N,N-二甲基甲酰胺二甲缩醛反应制得(E)-3-二甲胺基-1-(3-吡啶基)-2-丙烯-1-酮,接下来与硝酸胍环合得4-(3-吡啶基)-2-胺基嘧啶,然后与3-溴-4-甲基苯甲酸乙酯缩合再经水解反应制得关键中间体4-甲基-3-[[4-(3-吡啶基)-2-嘧啶... 详细信息

3-乙酰基吡啶与N,N-二甲基甲酰胺二甲缩醛反应制得(E)-3-二甲胺基-1-(3-吡啶基)-2-丙烯-1-酮,接下来与硝酸胍环合得4-(3-吡啶基)-2-胺基嘧啶,然后与3-溴-4-甲基苯甲酸乙酯缩合再经水解反应制得关键中间体4-甲基-3-[[4-(3-吡啶基)-2-嘧啶基]胺基]苯甲酸。此关键中间体直接与3-三氟甲基-5-(4-甲基-1H-1-咪唑基)苯胺进行酰胺化反应,最终制得高选择性酪氨酸激酶抑制剂尼洛替尼,总收率约39.4%。

关键词：尼洛替尼酪氨酸激酶抑制剂抗白血病药合成

High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun Zhang Xiaoyun Wang Shuai Wang yan Li Libo Chen Handong Jiao Zhijing yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (LiMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** LiMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and Li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of LiMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of LiMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable LiMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： Lithium manganese iron phosphate High energy density Lithium-ion batteries Reaction mechanism Tap density

6-氟-3-(4-哌啶基)-1,2-苯并异噁唑盐酸盐的合成

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化学世界 2011年第6期52卷 352-354页

作者：王超刘爱霞禹艳坤冀亚飞华东理工大学药学院 363信箱上海200237

4-哌啶甲酸(2)与乙酐反应制得N-乙酰基-4-哌啶甲酸(3),3经历酰氯化、与间二氟苯Friedel-Crafts反应得到N-乙酰基-4-(2,4-二氟苯甲酰基)哌啶(4)。4脱保护产物5与盐酸羟胺进行缩合反应生成(2,4-二氟苯基)-(4-哌啶基)甲酮肟盐酸盐(6)。最... 详细信息

4-哌啶甲酸(2)与乙酐反应制得N-乙酰基-4-哌啶甲酸(3),3经历酰氯化、与间二氟苯Friedel-Crafts反应得到N-乙酰基-4-(2,4-二氟苯甲酰基)哌啶(4)。4脱保护产物5与盐酸羟胺进行缩合反应生成(2,4-二氟苯基)-(4-哌啶基)甲酮肟盐酸盐(6)。最后,6经分子内环合、成盐反应得精神病治疗药的中间体(1),总收率49.5%。

关键词：利培酮帕潘立酮精神病治疗药药物中间体合成