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中枢神经系统相关水通道蛋白的研究进展

生理科学进展 2024年第1期55卷 34-42页

作者：郁凯琳朱宇杰吕叶辉奚盈盈陆怡颖杨明真童昉上海健康医学院基础医学院生理教研室上海201318 上海健康医学院基础医学院解剖与组胚教研室上海201318 上海健康医学院创面防治研究所上海201318 司法鉴定科学研究院上海市法医学重点实验室司法部司法鉴定重点实验室上海市司法鉴定专业技术服务平台上海200063 上海健康医学院附属周浦医院神经内科上海201318

水通道蛋白(aquaporins,AQPs)是一族表达于细胞膜上,对水分子高效通透的特异性孔道蛋白,其在全身广泛分布,与多个生物过程关系密切,同时也与较多神经系统疾病的发生发展存在联系。AQPs与中枢神经系统内的液体流动、能量代谢、神经修复... 详细信息

水通道蛋白(aquaporins,AQPs)是一族表达于细胞膜上,对水分子高效通透的特异性孔道蛋白,其在全身广泛分布,与多个生物过程关系密切,同时也与较多神经系统疾病的发生发展存在联系。AQPs与中枢神经系统内的液体流动、能量代谢、神经修复与发生、血脑屏障的发育与稳定、信号转导以及CSF的产生与循环密切相关。AQPs还与脑水肿、阿尔茨海默病、视神经脊髓炎、原发性颅内高压及帕金森病等中枢神经系统疾病的发生发展有关。在中枢神经系统中,虽然已经发现较多种类的AQPs存在,但研究成果主要集中于AQP1、AQP4及AQP9三个水通道蛋白上。对于AQPs的研究有助于加深中枢神经系统的认识,并提供疾病的潜在治疗靶点。本文综述了AQPs在中枢神经系统的表达分布、调节机制、生理功能及其与中枢神经系统疾病的关联,为相关神经科学研究提供新思路。

关键词：水通道蛋白中枢神经系统表达分布调节机制生理功能中枢神经系统疾病

小泉八云《怪读》的“双重书写”与“起源”概念（英文）

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文艺理论研究 2016年第6期36卷 169-183页

作者： Carlos yu-kai lin 宾夕法尼亚大学东亚语言文明系

对许多西方读者而言,小泉八云于年出版的《怪谈》经常被视为日本怪谈文学的重要文本。不过,此书原先以英文撰写并针对西方读者的事实,显示出在西方语境中作为一种文类的"怪谈"具有某种跨文化与翻译的特质,正因《怪谈》不仅仅是一本翻译... 详细信息

对许多西方读者而言,小泉八云于年出版的《怪谈》经常被视为日本怪谈文学的重要文本。不过,此书原先以英文撰写并针对西方读者的事实,显示出在西方语境中作为一种文类的"怪谈"具有某种跨文化与翻译的特质,正因《怪谈》不仅仅是一本翻译作品,同时也是西方语境中怪谈文学源起的标记性著作,怪谈文类的起源因此可以是翻译研究上的有趣议题。本文企图呈现这种双重书写(double inscription)的逻辑,并依此逻辑展开对于怪谈故事中"起源"概念的分析。本文首先探讨小泉八云在该书序里描述各种关于怪谈源起的方式,其次分析书中名作《雪女》自我否定/再生产的故事结构,来解释"起源"的概念不仅仅是重复叙述/翻译所产生的效应,同时也是叙事结构本身对于故事起源的认定与扬弃的双重需求所致。

关键词：翻译重复叙述双重书写怪谈

Microstructure recognition of steels by machine learning based on visual attention mechanism

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Journal of Iron and Steel Research International 2024年第4期31卷 909-923页

作者： Xing-yu Chen lin Cheng Cheng-yang Hu yu-peng Zhang kai-ming Wu The State Key Laboratory of Refractories and Metallurgy Hubei Province Key Laboratory of Systems Science on Metallurgical ProcessingInternational Research Institute for Steel TechnologyCollaborative Center on Advanced SteelsWuhan University of Science and TechnologyWuhan 430081HubeiChina Metals Valley and Band(Foshan)Metallic Composite Materials Co. Ltd.Foshan 528000GuangdongChina

U-Net has achieved good performance with the small-scale datasets through skip connections to merge the features of the low-level layers and high-level layers and has been widely utilized in biomedical image segmentation as well as recent microstructure image segregation of the *** representative visual attention mechanism modules,named as squeeze-and-excitation networks,convolutional block attention module,and extended calibration algorithm,were intro-duced into the traditional U-Net architecture to further improve the prediction *** is found that compared with the original U-Net architecture,the evaluation index of the improved U-Net architecture has been significantly improved for the microstructure segmentation of the steels with the ferrite/martensite composite microstructure and pearlite/ferrite composite microstructure and the complex martensite/austenite island/bainite microstructure,which demonstrates the advantages of the utilization of the visual attention mechanism in the microstructure *** reasons for the accuracy improvement were discussed based on the feature maps analysis.

关键词： Microstructure recognition-Steel Machine learning Visual attention mechanism Visualization

Metabolic biomarkers and long-term blood pressure variability in military young male adults

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World Journal of Clinical Cases 2020年第11期8卷 2246-2254页

作者： yu-kai lin Pang-Yen Liu Chia-Hao Fan Kun-Zhe Tsai Yen-Po lin Ju-Mi Lee Jiunn-Tay Lee Gen-Min lin Department of Medicine Hualien Armed Forces General HospitalHualien 970Taiwan Departments of Neurology Tri-Service General Hospitaland Graduate Institute of Medical SciencesNational Defense Medical CenterTaipei 114Taiwan Department of Medicine Tri-Service General Hospital and National Defense Medical CenterTaipei 114Taiwan Department of Critical Care Medicine Taipei Tzu-Chi General HospitalNew Taipei City 231Taiwan Department of Preventive Medicine Eulji College of MedicineDaejeon 34824South Korea Department of Preventive Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States

BACKGROUND Metabolic syndrome is a cluster of cardiovascular risk factors, including central obesity, high blood pressure, elevated plasma glucose, reduced high-density lipoprotein and elevated triglyceride *** To investigate the relationship between metabolic biomarkers and long-term blood pressure variability(BPV) in young *** A cohort of 1112 healthy military males aged 18-40 years from the cardiorespiratory fitness and hospitalization events in armed forces study in eastern Taiwan was prospectively included. The following metabolic biomarkers were used: Waist circumference, serum uric acid(SUA), triglycerides, high density lipoprotein, triglycerides, and fasting glycose. BPV was assessed by average real variability(ARV) and standard deviation(SD) across 4 clinic visits during the study period(2012-14, 2014-15, 2015-16, and 2016-18). Multivariable linear regression analysis was used to determine the association after adjusting for age, body mass index, systolic and diastolic blood pressure(SBP and DBP),lipid profiles, physical activity, alcohol intake and tobacco smoking *** In the unadjusted model, waist circumference was significantly and positively correlated with ARVDBP and SDDBP [β(standard errors) = 0.16(0.049) and 0.22(0.065), respectively], as was SUA [β = 0.022(0.009) and 0.038(0.012),respectively]. High-density lipoprotein was negatively correlated with ARVSBP [β=-0.13(0.063)]. There were no associations with the other metabolic *** contrast, only SUA was significantly correlated with SDSBP and SDDBP [β = 0.019(0.011) and 0.027(0.010), respectively] in the adjusted *** Our findings showed that of traditional metabolic biomarkers, SUA had the strongest positive correlation with long-term systolic and diastolic BPV in young male adults, and the clinical relevance needs further investigation.

关键词： Blood pressure variability Metabolic syndrome Serum uric acid Young males

Thermal Decomposition and Oxidative Decomposition Mechanism of HFC-134a by Experimental and DFT Method

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Journal of Thermal Science 2024年第5期33卷 1990-2003页

作者： XU yunting ZHANG kai DAI Xiaoye SHI lin Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Energy and Power EngineeringTsinghua UniversityBeijing 100084China

In response to the Kigali Amendment to the Montreal Protocol and global low-carbon emission environmental requirements,the phase-out and decomposition of numerous HFC refrigerants have become urgent,necessitating efficient and mild decomposition *** study investigates the thermal decomposition and oxidative thermal decomposition pathways of the typical hydrofluorocarbon refrigerant HFC-134a,employing a combination of experimental and quantum chemical DFT simulation *** chemical simulations reveal that the initial reaction bond cleavage serves as the rate-determining step during the thermal decomposition process,with the most easily detectable closed-shell products including CF_(2)=CHF,HF,CH_(3)F,CHF_(3),CH_(2)F_(2),and CF_(4).Reactive oxygen species can significantly reduce the Gibbs free energy barrier for HFC-134a *** achieve efficient degradation of HFC-134a,appropriate catalysts should be developed and selected to increase the level of reactive oxygen species in the reaction *** studies further corroborate that HFC-134a may undergo degradation through distinct reaction pathways under varying temperature(240℃to360℃)and pressure(0.1 MPa to 4.5 MPa)conditions,in agreement with simulation predictions.

关键词： HFC-134a pyrolysis oxidative thermal decomposition DFT refrigerant

Universal and efficient hybrid modeling and direct slicing method for additive manufacturing processes

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Advances in Manufacturing 2024年第2期12卷 300-316页

作者： Sen-lin Wang Li-Chao Zhang Chao Cai Ming-kai Tang Si Chen Jiang Huang yu-Sheng Shi State Key Laboratory of Materials Processing and Die and Mould Technology Huazhong University of Science and TechnologyWuhan430074People’s Republic of China School of Machinery and Automation Wuhan University of Science and TechnologyWuhan430081People’s Republic of China

Model design and slicing contour generation in additive manufacturing(AM)data processing face challenges in terms of efficiency and scalability when stereolithography files generated by complex functionally graded structures have millions of *** paper proposes a hybrid modeling and direct slicing method for AM to efficiently construct and handle complex three-dimensional(3D)*** 3D solids,including conformal multigradient structures,were uniformly described using a small amount of data via signed distance *** hybrid representations were quickly discretized into numerous disordered directed lines using an improved marching squares *** establishing a directional HashMap to construct the topological relationship between lines,a connecting algorithm with linear time complexity is proposed to generate slicing contours for *** method replaces the mesh reconstruction and Boolean operation stages and can efficiently construct complex conformal gradient models of arbitrary topologies through hybrid ***,the time and memory consumption of direct slicing are much lower than those of previous methods when handling hybrid models with hundreds of millions of faces after mesh reconstruction.

关键词： Additive manufacturing(AM) Hybrid modeling Direct slicing Signed distance field

Towards overcoming obstacles of type Ⅱ photodynamic therapy:Endogenous production of light,photosensitizer,and oxygen

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1111-1131页

作者： lin yu Zhen Liu Wei Xu kai Jin Jinliang Liu Xiaohui Zhu Yong Zhang Yihan Wu Department of Chemical and Environmental Engineering Shanghai UniversityShanghai 200433China School of Medicine Shanghai UniversityShanghai 200433China Department of Biomedical Engineering City University of Hong KongHong KongChina

Conventional photodynamic therapy(PDT)approaches face challenges including limited light penetration,low uptake of photosensitizers by tumors,and lack of oxygen in tumor *** promising solution is to internally generate light,photosensitizers,and *** can be accomplished through endogenous production,such as using bioluminescence as an endogenous light source,synthesizing genetically encodable photosensitizers in situ,and modifying cells genetically to express catalase ***,these strategies have been reinforced by the recent rapid advancements in synthetic *** this review,we summarize and discuss the approaches to overcome PDT obstacles by means of endogenous production of excitation light,photosensitizers,and *** envision that as synthetic biology advances,genetically engineered cells could act as precise and targeted“living factories”to produce PDT components,leading to enhanced performance of PDT.

关键词： Photodynamic therapy Cancer Biogenesis Biosynthesis Engineered bacteria Phototherapy Photosensitizers Catalase

The Enhanced Period Map and Equivariant Deformation Quantizations of Nilpotent Orbits

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Acta Mathematica Sinica,English Series 2024年第3期40卷 885-934页

作者： Shi lin yu Department of Mathematics School of Mathematical SciencesXiamen UniversityXiamen 361005P.R.China

In a previous paper,the author and his collaborator studied the problem of lifting Hamil-tonian group actions on symplectic varieties and Lagrangian subvarieties to their graded deformation quantizations and apply the general results to coadjoint orbit method for semisimple Lie *** even quantizations were considered *** this paper,these results are generalized to the case of general quantizations with arbitrary *** key step is to introduce an enhanced version of the(truncated)period map defined by Bezrukavnikov and Kaledin for quantizations of any smooth sym-plectic variety X,with values in the space of Picard Lie algebroid over *** an application,we study quantizations of nilpotent orbits of real semisimple groups satisfying certain codimension condition.

关键词： Coadjoint orbit method deformation quantization Harish-Chandra modules semisimple Liegroups

High-rate lithium-ion battery performance of a ternary sea urchin-shaped CoNiO_(2)@NiP_(6)Mo_(18)/CNTs composites

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Journal of Energy Chemistry 2024年第9期96卷 516-525页

作者： Li-ping Cui Shuang Sun kai yu Shu Zhang Mei-lin Wang Jia-jia Chen Bai-bin Zhou Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Chemistry and Chemical EngineeringHarbin Normal UniversityHarbin 150025HeilongjiangChina State Key Laboratory of Physical Chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringCollaborative Innovation Centre of Chemistry for Energy MaterialsXiamen UniversityXiamen 361005FujianChina

Bimetallic oxides are attractive anode materials for lithium-ion batteries(LIBs)due to their large theoretical ***,the low conductivity,short cycle life,and poor rate capability are the bottlenecks for their further *** overcome above issues,the basket-like polymolybdate(NiP_(6)Mo_(18))and carbon nanotubes(CNTs)were uniformly embedded on the urchin-shaped CoNiO_(2)nanospheres to yield a ternary composites CoNiO_(2)@NiP_(6)Mo_(18)/CNTs via electrostatic *** multi-level morphology of urchin spinules accelerates the diffusion rate of Li^(+);CNT improves the conductivity and enhances cycle stability of the material;and heteropoly acid contributes more redox activity ***,CoNiO_(2)@NiP_(6)Mo_(18)/CNTs as an anode of LIBs exhibits a high initial capacity(1396.7 mA h g^(−1)at 0.1 A g^(−1)),long-term cycling stability(750.2 mA h g^(−1)after 300 cycles),and rate performance(450.3 mA h g^(−1)at 2 A g^(−1)),which are superior to reported metallic oxides anode of *** density functional theory(DFT)and kinetic mechanism suggest that CoNiO_(2)@NiP_(6)Mo_(18)/CNTs delivers an outstanding pseudocapacitance and rapid Li^(+)diffusion behaviors,which is due to the rich surface area of the urchin-like CoNiO_(2)with the uniform embeddedness of NiP_(6)Mo_(18)and *** study provides a new idea for optimizing the performance of bimetallic oxides and developing high-rate lithium-ion battery composites.

关键词： Bi-metal oxides Transition metal oxides Polyoxometalates Nanocomposite LIBs