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Novel mutations in CRYBB1/CRYBB2 identified by targeted exome sequencing in Chinese families with congenital cataract

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1577-1582页

作者： Peng Chen Hao Chen xiao-Jing Pan Su-Zhen Tang yu-jun xia Hui Zhang Qingdao University Qingdao 266071 Shandong ProvinceChina Shandong Eye Institute Qingdao 266071 Shandong ProvinceChina Jinan Second People's Hospital Jinan 250022 ShandongProvince China

AIM：To summarize the phenotypes and identify the underlying genetic cause of the CRYBB1 and CRYBB2 gene responsible for congenital cataract in two Chinese ***：Detailed family histories and clinical data were collected from patients during an ophthalmologic examination. Of 523 inheritable genetic vision systemrelated genes were captured and sequenced by targeted next-generation sequencing,and the results were confirmed by Sanger sequencing. The possible functional impacts of an amino acid substitution were performed with Poly Phen-2 and SIFT ***：The patients in the two families were affected with congenital cataract. Sixty-five （FAMILY-1） and sixty two （FAMILY-2） single-nucleotide polymorphisms and indels were selected by recommended filtering *** was then analyzed by applying Sanger sequencing with the family members. A heterozygous CRYBB1 mutation in exon 4 （c.347T〉C, p.L116P） was identified in sixteen patients in FAMILY-1. A heterozygous CRYBB2 mutation in exon 5 （c.355G〉A, p.G119R） was identified in three patients in FAMILY-2. Each mutation cosegregated with the affected individuals and did not exist in unaffected family members and 200 unrelated normal *** mutation was predicted to be highly conservative and to be deleterious by both PolyPhen-2 and ***：TheCRYBB1 mutation（c.347T〉C）and CRYBB2 mutation （c.355G〉A） are novel in patients with congenital cataract. We summarize the variable phenotypes among the patients, which expanded the phenotypic spectrum of congenital cataract in a different ethnic background.

关键词： CRYBB1 CRYBB2 next-generation sequencing congenital cataract

Novel role of microRNAs in prostate cancer

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Chinese Medical Journal 2013年第15期126卷 2960-2964页

作者： yu jun-jie xia Shu-jie Shanghai Jiao Tong Univ Dept Urol Peoples Hosp 1 Shanghai 200080 Peoples R China

Objective To discuss the novel biomarkers of microRNAs in prostate cancer. Date sources The literatures about microRNAs and prostate cancer cited in this review were obtained mainly from Pubmed published in English from 2004 to 2012. Study selection Original articles regarding the novel role of microRNAs in prostate cancer were selected. Results MicroRNAs play an important role in prostate cancer such as cell differentiation, proliferation, apoptosis, and invasion. Especially microRNAs correlate with prostate cancer cell epithelial-mesenchymal transition （EMT）, cancer stem cells （CSCs）, drug sensitivity, cancer microenvironment, energy metabolism, androgen independence transformation, and diagnosis prediction. Conclusions MicroRNAs are involved in various aspects of prostate cancer biology. The role of microRNA in the initiation and development of prostate cancer deserves further study.

关键词： prostate cancer microRNA biomarkers

球磨介质及尺寸对铜锌矿矿浆化学性质及矿物表面化学性质的影响

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中国有色金属学报 2017年第8期27卷 1701-1707页

作者：陈哲夏柳荫 Brian HART 池汝安余军霞武汉工程大学化学与环境工程学院武汉430073 西安大略大学表面化学研究所

采用飞行时间二次离子质谱仪和改良球磨机研究了磨矿环境对铜锌矿矿浆的化学性质和闪锌矿的表面化学性质的影响。通过采用改良后的球磨机实现磨矿过程中溶液p H、矿浆电位、电导率、溶解氧含量及离子浓度等矿浆化学性质的实时监测。随... 详细信息

采用飞行时间二次离子质谱仪和改良球磨机研究了磨矿环境对铜锌矿矿浆的化学性质和闪锌矿的表面化学性质的影响。通过采用改良后的球磨机实现磨矿过程中溶液p H、矿浆电位、电导率、溶解氧含量及离子浓度等矿浆化学性质的实时监测。随着磨矿时间的延长,矿浆p H值缓慢升高,矿浆电位和溶解氧含量迅速下降。结果表明:球形磨矿介质的直径越小,矿浆中溶解氧消耗越快,磨矿后矿浆静电位越低,矿浆的离子浓度也越低。飞行时间二次离子质谱仪对磨矿后闪锌矿的表面化学分析表明,磨矿后铁氧化物和氢氧化物会附着于闪锌矿表面,球磨介质的材料与尺寸大小对矿物表面存在的二次离子有较大影响。分别与不锈钢球或者2.54 cm的大球相比,铸铁球或1.27 cm的小球可为矿浆提供更多的铁离子,促进磨矿环境下的电化学反应,从而在闪锌矿表面累积更多的铁氧化物或氢氧化物,降低铜离子的吸附。因此,矿浆化学性质和闪锌矿的表面化学性质受磨矿介质的材料与介质的尺寸控制。

关键词：闪锌矿磨矿溶液化学表面化学飞行时间二次离子质谱

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基于改进粒子群优化算法的最优潮流计算

电力系统及其自动化学报 2005年第4期17卷 83-88页

作者：俞俊霞赵波浙江大学电气工程学院杭州310027

提出应用粒子群优化算法(PSO)求解最优潮流问题(OPF),并结合动态调整罚函数法将最优潮流问题转化成一个无约束求极值问题,有效提高了PSO算法的全局收敛能力和计算精度。应用此算法对标准IEEE30节点系统进行潮流计算,并与线性规划算法和... 详细信息

提出应用粒子群优化算法(PSO)求解最优潮流问题(OPF),并结合动态调整罚函数法将最优潮流问题转化成一个无约束求极值问题,有效提高了PSO算法的全局收敛能力和计算精度。应用此算法对标准IEEE30节点系统进行潮流计算,并与线性规划算法和遗传算法进行了比较,结果表明,该算法能够更好地获得全局最优解,具有实用意义。

关键词：粒子群优化算法动态调整罚函数法最优潮流计算线性规划算法遗传算法

Evapotranspiration and its components partitioning based on an improved hydrological model: historical attributions and future projections

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Journal of Earth Science 2025年

作者： Hong Du Sidong Zeng Yongyue Ji jun xia College of Resources and Environmental Science， South-Central Minzu University Chongqing Institute of Green and Intelligent Technology， Chinese Academy of Sciences Chongqing School， University of Chinese Academy of Sciences State Key Laboratory of Water Resources and Hydropower Engineering Science， Wuhan University

Estimation and attribution of evapotranspiration （ET） and its components under changing environment is still a challenge but is essential for understanding the mechanisms of water and energy transfer subsequently regional water resources management. In this study， an improved hydrological model is developed to estimate evapotranspiration and its components i.e.， evaporation （E） and transpiration （T） by integrated the advantages of hydrological modeling constrained by water balance and the water-carbon close relationships. Results show that the improved hydrological model could captures ET and its components well in the study region. During the past years， annual ET and E increase obviously about 2.40mm/a and 1.42mm/a， particularly in spring and summer accounting for 90%. T shows less increasement and mainly increases in spring while it decreases in summer. Precipitation is the dominant factor and contributes 74.1% and 90.0% increases of annual ET and E， while the attribution of T changes is more complex by coupling of the positive effects of precipitation， rising temperature and interactive influences， the negative effects of solar diming and elevated CO2. In the future， ET and its components tend to increase under most of the Shared Socioeconomic Pathways （SSP） scenarios except for T decreases under the very high emissions scenario （SSP5-8.5） based on the projections. From seasonal perspective， the changes of ET and the components are mainly in spring and summer accounting for 75%， while more slightly changes are found in autumn and winter. This study highlights the effectiveness of estimating ET and its components by improving hydrological model within water-carbon coupling relationships， and more complex mechanisms of transpiration changes than evapotranspiration and evaporation changes under the interactive effects of climate variability and vegetation dynamics. Besides， decision makers should pay attention to the more increases in the undesirable E than desirab

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： Hui-Feng Wang Wen-Jie Shi yu-Xin Yang Bao-xia Dong Tong-Bu Lu Di-Chang Zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

Actively tunable electromagnetically induced transparency in hybrid Dirac-VO2 metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： DI Ke XIE Meng xia Huarong CHENG Anyu LIU yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and Telecommunications Chongqing Key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

In this paper, we present a metamaterial structure of Dirac and vanadium dioxide（VO2） and investigate its optical properties using the finite-difference time-domain（FDTD） technique. Using the phase transition feature of VO2, the design can realize active tuning of the plasmon induced transparency（PIT） effect at terahertz frequency, thereby converting from a single PIT to a double-PIT. When VO2is in the insulating state, the structure is symmetric to obtain a single-band PIT effect. When VO2is in the metallic state, the structure turns asymmetric to realize a dual-band PIT effect. This design provides a reference direction for the design of actively tunable metamaterials. Additionally, it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear relationship. In addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RIU. Consequently, the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： Transparency

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一个新的BFGS信赖域算法

数学杂志 2015年第1期35卷 131-134页

作者：景书杰于俊霞河南理工大学数学与信息科学学院河南焦作454000

本文对于无约束最优化问题提出了一个新的BFGS信赖域算法.利用BFGS方法和信赖域方法,提出了改进的BFGS信赖域方法.推广了文献[3,5]中的两种算法,得到一个新的BFGS信赖域算法,在适当条件下证明了算法的全局收敛性.

关键词： BFGS修正公式信赖域算法全局收敛性

Structural engineering of high-entropy alloys for advanced electrocatalytic reactions

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Tungsten 2025年第1期7卷 1-31页

作者： Qiao Xie Ying-Jie yu Hai-jun Zhang Ya-Ping Deng Wen Lei The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology Department of Chemical Engineering Waterloo Institute for Sustainable Energy Waterloo Institute for Nanotechnology University of Waterloo

High-entropy alloys(HEAs) have emerged as promising candidates to replace traditional precious metal catalysts,owing to their unique chemical and physical *** review commences by revisiting the fundamental concepts of HEAs,including their synthesis methods and structural control strategies in *** underscores the critical role of meticulously manipulating both macroscopic and microscopic structures of the HEAs to optimize their catalytic performance.A deep understanding of the structure-activity relationship in HEAs across various configurations is pivotal in developing more effective *** review methodically encapsulates the research progress of structural control strategies for HEAs in achieving efficient energy conversion,with the aim of gaining a better understanding of the relationship between structure and *** review concludes by summarizing the current achievements and challenges,and suggestions for potential future directions of HEAs in the fields of energy conversion and environmental purification.

关键词： Electrocatalytic Energy conversion High-entropy alloys Structural modulation