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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao bai yuan Zhuang Shenghua Lu Qianqian Ge Hao Li yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Two Efficient Parameterized Boundaries for Vee's Asian Option Pricing PDE

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Acta Mathematicae Applicatae Sinica 2012年第4期28卷 643-652页

作者： bai-min yu School of International Trade and Economics University of International Business and Economics

In this paper, we derive two general parameterized boundaries of finite difference scheme for VeSe~＇s PDE which is used to price both fixed and floating strike Asian options. Using these two boundaries, we can deal with all kinds of situations, especially, some extreme cases, like overhigh volatility, very small volatility, etc, under which the Asian option is usually mispriced in many existing numerical methods. Numerical results show that our boundaries are pretty efficient.

关键词： Asian option Vecer's PDE finite difference parameterized boundaries sensitivity

Numerical study of regional environmental carrying capacity for livestock and poultry farming based on planting-breeding balance

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Journal of Environmental Sciences 2013年第9期25卷 1882-1889页

作者： Lihong Peng yu bai College of the Environment & Ecology Xiamen University

In consideration of the need to maintain planting-breeding balance, this article examines the capacity of the soil in Putian City, Fujian Province to absorb livestock and poultry excreta, and computes the environmental carrying capacity for livestock and poultry farming （ECCLPF） in each district of the city in terms of the fertility characteristics of the soil in the city, as well as its mix of crops cultivated and farming methods. On the basis of the computations, this work proceeds to classify the alarm grades of the city＇s environmental carrying capacity for livestock and poultry framing, and assess the environmental impact of the livestock and poultry farming industry. The results of our study indicate that, the city＇s ECCLPF ranges from 8.27 to 23.23 heads per ha when computed on the basis of nitrogen, and from 5.79 to 24.53 heads per ha when computed on the basis of phosphorus. A comparison between our research findings and the existing farming scale in Putian reveals that, in certain parts of the city, ECCLPF is overburdened to varying degrees. Specifically, Chengxiang District is severely overburdened, Hanjiang District and Meizhou Island have a level of overburdening between virtual overburdening and significant overburdening, Licheng District is virtually overburdened, and Xiuyu, Xianyou, and Bei＇an Districts have not exceeded their environmental carrying capacity and therefore have varying levels of potential for growth.

关键词： livestock and poultry farming planting-breeding combination nitrogen and phosphorus balance alarm classification system

Combining the critical nitrogen concentration and machine learning algorithms to estimate nitrogen deficiency in rice from UAV hyperspectral data

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Journal of Integrative Agriculture 2023年第4期22卷 1216-1229页

作者： yu Feng-hua bai ju-chi JIN Zhong-yu GUO Zhong-hui YANG Jia-xin CHEN Chun-ling School of Information and Electrical Engineering Shenyang Agricultural UniversityShenyang 110866P.R.China Key Laboratory of Intelligent Agriculture in Liaoning Province Shenyang 110866P.R.China

Rapid and large area acquisition of nitrogen(N)deficiency status is important for achieving the optimal fertilization of *** existing studies,however,focus on the use of unmanned aerial vehicle(UAV)remote sensing to diagnose N nutrition in rice,while there are fewer studies on the quantitative description of the degree of N deficiency in rice,and the effects of the critical N concentration on the spectral changes in rice have rarely been ***,based on the canopy spectral data obtained by remotely-sensed UAV hyperspectral images,the N content in rice was obtained through field *** construction method of the rice curve for the northeastern critical N concentration was studied,and on this basis,N deficiency was *** the spectrum of the critical N concentration state as the standard spectrum,the spectral reflectivity data were transformed by the ratios and differences,and the feature extraction of the spectral data was carried out by the successive projections algorithm(SPA).Finally,by taking the characteristic band as the input variable and N deficiency as the output variable,a set of multivariate linear regression(MLR),long short-term memory(LSTM)inversion models based on extreme learning machine(ELM),and the nondominated sorting genetic algorithmⅢextreme learning machine(NSGA-Ⅲ-ELM)were *** results showed two key aspects of this system:1)The correlation between the N deficiency data and original spectrum was poor,but the correlation between the N deficiency data and N deficiency could be improved by a difference change and ratio transformation;2)The inversion results based on the ratio spectrum and NSGA-Ⅲ-ELM algorithm were the best,as the R2values of the training set and validation set were 0.852 and 0.810,and the root mean square error(RMSE)values were 0.291 and 0.308,*** the perspective of the spectral data,the inversion accuracy of the ratio spectrum was better than the accuracy of the original s

关键词： UAV hyperspectral nitrogen deficiency critical nitrogen concentration NSGA-Ⅲ

Mean flow and turbulence structure of open channel flow with suspended vegetation

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Journal of Hydrodynamics 2020年第2期32卷 314-325页

作者： Qian Li yu-hong Zeng yu bai State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan430072China

In combination with a channel bed,suspended vegetationin an open channel can alter flow structure and generate vertically asymmetric *** study investigated the mean flow and turbulence structure of an open channel with suspended vegetation through theoretical analysis and laboratory *** patterns of bionic leaves with different roughness were adopted to imitate suspended vegetation,and three-dimensional velocity field was measured by using an acoustic Doppler *** measured data showed that the vertical profile of streamwise velocity obeys a two-power law and that the maximum velocity at the middle depth is close to the smooth boundary(i.e.,the channel bed in the experiment)under the combined action of vegetation cover and channel *** stress is linearly distributed along the vertical axis,and the vertical profile of turbulence intensity obeys an exponential ***,a two-power law expression was adopted to predict the vertical profile of streamwise *** models for the vertical distribution of shear stress and turbulence intensity were also *** predicted results validated by measurements showed that the different magnitudes of vegetation cover and channel bed boundary roughness exert an obvious impact on flow structure.

关键词： Suspended vegetation streamwise velocity shear stress turbulence intensity boundary roughness

Co/Pt multilayer-based pseudo spin valves with perpendicular magnetic anisotropy

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Rare Metals 2014年第6期33卷 646-651页

作者： Shuai Liu Guang-Hua yu Mei-Yin Yang Hai-Lang ju Bao-He Li Xiao-bai Chen School of Materials Science and Engineering University of Science and Technology Beijing State Key Laboratory of Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences School of Science Beijing Technology and Business University

Pseudo spin valves（SVs） exhibiting perpendicular magnetic anisotropy were prepared by magnetron sputtering. Magnetization measurements of the Co/Pt multilayers were performed to select the reference and free layers. The selection criteria are square magnetic hysteresis loops, weaker current shunting effect, and proper coercivity. The optimal reference layer and free layer are Pt（5.0 nm）/[Co（0.4 nm）/Pt（0.6 nm）]3/Co（0.4 nm）/Cu（3.0 nm）and Cu（3.0 nm）/[Co（0.4 nm）/Pt（1.5 nm）]4, *** resulting pseudo SV exhibits two well-separated hysteresis loops when the field is applied perpendicular to the film plane. The minor hysteresis loop corresponding to the free layer shifts toward negative direction of the magnetic field axis, indicating ferromagnetic interlayer exchange coupling between the two magnetic layers. The coupling also enhances the coercivity（HC） of both layers. The perpendicular giant magnetoresistance（GMR） of 2.7 % is achieved with current in plane measurement. The GMR first increases when Pt seed layer is thickened, reaches a maximum of 3.0 % at 4 nm and then decreases with the further increase of thickness. But thicker Cu spacer layer always lowers the GMR of the SV.

关键词： Perpendicular magnetic anisotropy Spin valve Giant magnetoresistance Ferromagnetic coupling Co/Pt multilayers

Performance Analysis of an Ejector Enhanced Two-Stage Auto-Cascade Refrigeration Cycle for Low Temperature Freezer

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Journal of Thermal Science 2021年第6期30卷 2015-2026页

作者： bai Tao LU yu YAN Gang yu Jianlin Department of Refrigeration and Cryogenic Engineering School of Energy and Power EngineeringXi5an Jiaotong UniversityXi'an 710049China

In this paper,an ejector enhanced two-stage auto-cascade refrigeration cycle(EARC)using ternary mixture R600a/R32/R1150 is proposed for application of-80℃*** EARC cycle,an ejector was employed to recover the expansion work in the throttling processes and lifted the suction pressure of the *** performances of the ejector enhanced two-stage auto-cascade refrigeration cycle and conventional auto-cascade refrigeration cycle(CARC)were compared using thermodynamic analysis *** influences of the important operation parameters including mass fraction ratio of the mixture,fluid quality at the second separator inlet,condensation temperature,evaporation temperature,and expansion ratio of expansion valve on the performances of EARC cycle were discussed in *** results indicate that ternary mixture R600a/R32/R1150 has the optimal mass fraction ratio of 0.45/0.2/0.35 with respect to the maximum *** EARC cycle yields higher performance than the CARC cycle in terms of COP,exergy efficiency and volumetric refrigeration *** 4.9%-36.5%improvement in COP and 6.9%-34.3%higher exergy efficiency could be obtained in EARC cycle comparing with CARC *** finding of this study suggests that the EARC cycle has a promising application potential for low temperature freezing.

关键词： two-stage auto-cascade refrigeration zeotropic mixture ejector performance improvement exergy analysis

Recent advances in active control of turbulent boundary layers

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Science China(Physics,Mechanics & Astronomy) 2011年第7期54卷 1289-1295页

作者： ZHOU yu bai HongLei Department of Mechanical Engineering The Hong Kong Polytechnic University Hong Kong China School of Mechanical and Electronic Engineering Harbin Institute of Technology Harbin 150001 China

In this article,we review the recent progress in active control of a turbulent boundary layer for skin-friction drag ***-wall coherent structures,which are closely associated with large skin-friction drag and are thus often the target to be manipulated,are discussed briefly,providing a rationale of various control ***-and closed-loop controls are extensively reviewed,largely focusing on techniques and drag-reduction ***,some concluding remarks are given.

关键词： turbulence boundary layer active control

Rapid instrument exchanging system for the Cassegrain focus of the Lijiang 2.4-m Telescope

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Research in Astronomy and Astrophysics 2015年第6期15卷 918-928页

作者： yu-Feng Fan Jin-Ming bai ju-Jia Zhang Chuan-jun Wang Liang Chang yu-Xin Xin Rui-Long Zhang yunnan Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences

As a facility used for astronomical research, the Lijiang 2.4-m telescope of yunnan Astronomical Observatories, requires the ability to change one auxiliary instrument with another in as short a time as possible. This arises from the need to quickly respond to scientific programs （e.g. transient observation, time domain studies） and changes in observation conditions （e.g. seeing and weather conditions）. In this paper, we describe the design, construction and test of hardware and software in the rapid instrument exchange system （RIES） for the Cassegrain focal station of this telescope, which enables instruments to be quickly changed at night without much loss of observing time. Tests in the laboratory and at the telescope show that the image quality and pointing accuracy of RIES are satisfactory. With RIES, we observed the same Landolt standard stars almost at the same time with the Princeton Instruments VersArray 1300B Camera （PICCD） and the yunnan Faint Object Spectrograph and Camera （YFOSC）, while both were mounted at the Cassegrain focus. A quasi-simultaneous comparison shows that the image quality of the optical system inside the YFOSC is comparable with that provided by the PICCD.

关键词： telescopes Lijiang 2.4-m Telescope -- instrumentation photometers -- instrumentation spectrographs -- telescopes automation