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Roles of microRNAs in immunopathogenesis of non-alcoholic fatty liver disease revealed by integrated analysis of microRNA and mRNA expression profiles

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Hepatobiliary & Pancreatic Diseases International 2017年第1期16卷 65-79页

作者： yu-Jun Zhang Ying Hu jing Li yu-jing chi Wei-Wei Jiang Feng Zhang yu-Lan Liu institute of clinical molecular biology peking university people’s hospital Beiiing 100044 China department of gastroenterology peking university people’s hospital Beiiing 100044 China

BACKGROUND： The integrative analysis of microRNA and mRNA expression profiles can elucidate microRNA-targeted gene function. We used this technique to elucidate insights into the immunological pathology of non-alcoholic fatty liver disease （NAFLD）. METHODS： We analyzed differentially expressed microRNA and mRNA expression profiles of CD4＋ T lymphocytes from the liver and mesenteric lymph nodes （MLNs） of mice with NAFLD using microarrays and RNA sequencing. Normal mice were used as controls. The target genes of microRNAs were predicted by TargetScan. Integrative analysis showed that the mRNAs were overlapped with microRNAs. Furthermore, the Gene Ontology （GO） and Kyoto Encyclopedia of Genes and Genomes （KEGG） analyses were performed to predict the key genes and pathways. Then, 16 microRNAs and 10 mRNAs were validated by qRT-PCR. RESULTS： Microarray analysis suggested that 170 microRNAs were significantly de-regulated in CD4＋ T lymphocytes from the liver between the two groups. Eighty mRNAs corresponded with microRNA targeted genes. KEGG analysis indicated that the MAPK pathway was consistently augmented in the liver of NAFLD mice. miR-23b, let-7e, miR-128 and miR-130b possibly played significant parts in the MAPK pathways. Furthermore, between the two groups, 237 microRNAs were significantly deregulated in CD4＋ T lymphocytes from MLNs. 38 mRNAs coincided with microRNA target genes. The metabolic pathway was consistently enriched in the MLNs of NAFLD mice. miR- 206-3p, miR-181a-Sp, miR-29c-3p and miR-30d-5p likely play important roles in the regulation of metabolic pathways. CONCLUSION： The results of this study presented a new perspective on the application of integrative analysis to identify complex regulation means involved in the immunological pathogenesis of NAFLD.

关键词： microRNA-mRNA gut non-alcoholic fatty liver disease CD4+ T lymphocytes immunopathogenesis

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Value of ultrasound guided biopsy combined with Xpert Mycobacterium tuberculosis/resistance to rifampin assay in the diagnosis of chest wall tuberculosis

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World Journal of Clinical Cases 2023年第28期11卷 6698-6706页

作者： Qing-Hu Yan jing-yu chi Lei Zhang Feng Xue Jia Cui Hai-Li Kong Department of Ultrasound Shandong Public Health Clinical CenterShandong UniversityJinan 250013Shandong ProvinceChina Department of Medicine Shandong Public Health Clinical CenterShandong UniversityJinan 250013Shandong ProvinceChina Department of Acupuncture and Massage Shandong Provincial Third HospitalJinan 250000Shandong ProvinceChina Department of Radiology Qilu HospitalShandong UniversityJinan 250000Shandong ProvinceChina

BACKGROUND The thoracic wall lesions,particularly chest wall tuberculosis,and chest wall tumors and other pyogenic wall and actinomycetes infections,almost always present as a diagnostic *** To explore the value of ultrasound-guided biopsy combined with the Xpert Mycobacterium tuberculosis/resistance to rifampin(MTB/RIF)assay to diagnose chest wall *** We performed a retrospective study of patients with chest wall lesions from March 2018 to March *** patients received the ultrasound-guided biopsy for pathology examination,acid-fast Bacillus staining,mycobacterial culture,and Xpert MTB/RIF *** sensitivity,specificity,and area under the curve(AUC)were calculated for these diagnostic tests,either individually or *** resistance results were compared between the mycobacterial culture and the Xpert MTB/RIF *** In 31 patients with the chest wall lesion biopsy,22 patients were diagnosed with chest wall *** them,3,6,and 21 patients tested positive for mycobacterial culture,acid-fast stain,and Xpert MTB/RIF assay,*** rifampicin resistance results of the 3 culture-positive patients were consistent with their Xpert MTB/RIF assay *** considering the sensitivity,specificity,and AUC value,the Xpert MTB/RIF assay(95.5%,88.9%,and 0.92,respectively)was a better choice than the acid-fast Bacillus stain(27.3%,100.0%,and 0.64,respectively)and mycobacterial culture(13.6%,100.0%,0.57,respectively).No complications were reported during the *** Ultrasound guided biopsy combined with Xpert MTB/RIF has high value in the diagnosis of chest wall tuberculosis,and can also detect rifampicin resistance.

关键词： Tuberculosis Ultrasound Puncture biopsy Chest wall tuberculosis Xpert mycobacterium tuberculosis/resistance

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Orthodontic retreatment of an adult woman with mandibular backward positioning and temporomandibular joint disorder:A case report

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World Journal of Clinical Cases 2022年第2期10卷 691-702页

作者： Li-yuan yu Kai Xia Wen-Tian Sun Xin-Qi Huang jing-yu chi Ling-Jie Wang Zhi-He Zhao Jun Liu State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases Department of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Stomatology Strategic Support Force Medical Center of PLABeijing 10010China Department of Stomatology Qingyang People's HospitalQingyang 745000Gansu ProvinceChina

BACKGROUND The role of occlusal factors on the occurrence of temporomandibular joint disorders(TMDs)is still unclear and it is tricky for orthodontists to treat malocclusions in patients with *** report the case of the second orthodontic treatment of an adult female with Class II division 2 malocclusion associated with *** the removal of anterior occlusal interference,TMD symptoms were alleviated and cone beam computed tomography(CBCT)images showed the bilateral condyles shifted *** SUMMARY This case report presented an orthodontic retreatment of an adult female with TMD and mandibular backward positioning based on CBCT examination and Joint Space Index(JSI)*** left and right JSI values of-38.5 and-52.6 indicated that the position of bilateral condyles had posterior *** years prior to this evaluation,she underwent orthodontic treatment resulting in the extraction of two upper premolars and one lower central *** joint symptoms,including pain and sounds,were alleviated along with verified mandibular forward repositioning by extraction of another lower central *** Mandibular backward positioning could be associated with *** analysis based on CBCT is a convenient way to examine condylar positions quantitatively.

关键词： Cone beam computerized tomography Joint Space Index Temporomandibular joint disorder Case report

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Study of Clinical and Genetic Risk Factors for Aspirin-inducec Gastric Mucosal Injury

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chinese Medical Journal 2016年第2期129卷 174-180页

作者： yun Wu Ying Hu yu-jing chi Jian-Hua Zhou yuan-yuan Zhang yu-Lan Liu Department of Gastroenterology Peking University People's Hospital Beijing 100044 China Central Laboratory Peking University Peopie's Hospital Beijing 100044 China

Background： Current knowledge about clinical and genetic risk factors for aspirin-induced gastric mucosal injury is not sufficient to prevent these gastric mucosal lesions. Methods： We recruited aspirin takers as the exposed group and healthy volunteers as the control group. The exposed group was categorized into two subgroups such as subgroup A as gastric mucosal injury diagnosed by gastroscopy, including erosion, ulcer or bleeding of the esophagus, stomach, or duodenum; subgroup B as no injury of the gastric mucosa was detected by gastroscopy. Clinical information was collected, and 53 single nucleotide polymorphisms were evaluated. Results： Among 385 participants, 234 were in the aspirin-exposed group. According to gastroscopy, 82 belonged to subgroup A, 91 belonged to subgroup B, and gastroscopic results of 61 participants were not available. Using the chi-square test and logistic regression, we found that peptic ulcer history （odds ratio [OR] = 5.924, 95% confidence intervals [C/]： 2.115-16.592）, dual anti-platelet medication （OR = 3.443, 95% CI： 1.154-10.271 ）, current Helicobacterpylori infection （OR = 2.242, 95% CI： 1.032-4.870）, male gender （OR = 2.211, 95% CI： 1.027-4.760）, GG genotype ofrs2243086 （OR = 4.516, 95% CI： I. 180-17.278）, and AA genotype ofrs 1330344 （OR = 2.178, 95% CI： 1.016-4.669） were more frequent in subgroup A than subgroup B. In aspirin users who suffered from upper gastrointestinal bleeding, the frequency of the TT genotype ofrs2238631 and TT genotype ofrs2243100 was higher than in those without upper gastrointestinal bleeding. Conclusions： Peptic ulcer history, dual anti-platelet medication, tt. pylori current infection, and male gender were possible clinical risk factors for aspirin-induced gastric mucosal injury. GG genotype of rs2243086 and AA genotype of rs 1330344 were possible genetic risk factors. TT genotype ofrs2238631 and TT genotype ofrs2243100 may be risk factors for upper gastrointestinal bleeding in aspirin users.

关键词： Aspirin Gastric Mucosal Injury Risk Factors Single Nucleotide Polymorphisms

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小型非球面数控抛光技术的研究

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光学精密工程 2007年第10期15卷 1527-1533页

作者：王毅倪颖余景池苏州大学现代光学技术研究所江苏苏州215006

用计算机控制抛光的方法对小型非球面数控抛光技术进行了研究。对计算机控制小磨头抛光的材料去除作用进行了计算机模拟;依据计算机模拟结果,调整驻留时间函数,进行抛光补偿;最后,在自行研制的三轴联动非球面数控抛光原理样机上高效地... 详细信息

用计算机控制抛光的方法对小型非球面数控抛光技术进行了研究。对计算机控制小磨头抛光的材料去除作用进行了计算机模拟;依据计算机模拟结果,调整驻留时间函数,进行抛光补偿;最后,在自行研制的三轴联动非球面数控抛光原理样机上高效地完成了70 mm左右非球面的抛光,各项指标达到了中等精度要求,表面粗糙度为2.687 nm,面形精度为0.45μm,且重复精度良好。结果表明,该技术有效提高了小型非球面光学零件的批量生产效率。

关键词：数控抛光非球面驻留时间补偿

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内渐进多焦点镜片的加工

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光学技术 2008年第1期34卷 136-140页

作者：秦琳玲余景池苏州大学江苏省现代光学技术重点实验室苏州215006

介绍了加工内渐进多焦点镜片的自由曲面数控机床的基本结构及工作原理,开展了机床的加工工艺实验,用以改善内渐进多焦点镜片的光学性能。实验结果表明,车削阶段影响表面粗糙度的两个主要因素是镜片材料和切削速度;得到了抛光效果良好的... 详细信息

介绍了加工内渐进多焦点镜片的自由曲面数控机床的基本结构及工作原理,开展了机床的加工工艺实验,用以改善内渐进多焦点镜片的光学性能。实验结果表明,车削阶段影响表面粗糙度的两个主要因素是镜片材料和切削速度;得到了抛光效果良好的两个抛光参数:抛光时间是50s—100s,抛光气压是0.03 MPa—0.06 MPa;不同材料的镜片车削后表面粗糙度不同,抛光后表面粗糙度基本相同。

关键词：内渐进多焦点镜片自由曲面表面粗糙度光焦度

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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi yu Faith Teo En Ning Chang Liu yu-chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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非球面成形致动器排布方法的研究

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光学精密工程 2009年第2期17卷 292-300页

作者：曾春梅余景池苏州大学江苏省现代光学技术重点实验室江苏苏州215006 苏州大学现代光学技术研究所江苏苏州215006

为了实现超薄球面镜的非球面成形,提出了一种采用非球面梯度法求致动器排布初始解的方法。给出了该方法的理论依据、排布方法以及计算非球面度梯度的两种公式;以一大口径离轴超薄非球面镜为例,用非球面度梯度的两种计算公式分别求出了... 详细信息

为了实现超薄球面镜的非球面成形,提出了一种采用非球面梯度法求致动器排布初始解的方法。给出了该方法的理论依据、排布方法以及计算非球面度梯度的两种公式;以一大口径离轴超薄非球面镜为例,用非球面度梯度的两种计算公式分别求出了致动器排布初始解,完成了非球面成形的有限元分析,得到了满足面形精度RMS值为21.09 nm的最终解;最后,介绍了致动器排布的优化步骤,比较了非球面梯度法、正方形法和环形法的差异。结果显示,用非球面度梯度平均值公式求出的初始解与最终解最接近,符合非球面度梯度变化率与致动器面密度的关系,而通过优化还能进一步减少致动器数量和面形残差。在相同面形精度下,非球面梯度法排布的致动器个数约为正方形和环形排布的1/2或更少;在相同致动器个数下,非球面梯度法排布的面形残差RMS值约为正方形和环形排布的1/3或更小。结果表明,非球面梯度法更适合在非球面成形领域用于求解致动器排布初始解。

关键词：非球面成形致动器排布非球面度梯度有限元法

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用校正法提高补偿器检测法的精度

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光学精密工程 2006年第2期14卷 202-206页

作者：郭培基余景池苏州大学现代光学技术省重点实验室江苏苏州215006

研究了一种测量、分离补偿法检测补偿器非圆对称误差的技术,这种技术基于波面误差可用泽尼克圆多项式来表述。通过使补偿器或被测非球面绕系统光轴旋转到多个不同的角度,得到多个测量结果,根据这些测量结果,计算得到由补偿器误差带来的... 详细信息

研究了一种测量、分离补偿法检测补偿器非圆对称误差的技术,这种技术基于波面误差可用泽尼克圆多项式来表述。通过使补偿器或被测非球面绕系统光轴旋转到多个不同的角度,得到多个测量结果,根据这些测量结果,计算得到由补偿器误差带来的波面误差的非圆对称项泽尼克圆多项式系数,接着根据这些非圆对称项泽尼克圆多项式系数制作一个校正文件对非球面的测量结果进行校正,利用该技术可有效减轻对补偿器材料、加工及装校的苛刻要求,提高测量精度。实验结果表明:对某一被测非球面不用该技术时测量结果为0.105λ(RMS),应用此技术后的测量结果为0.026λ(RMS),且被测面在几个任意不同角度时的测量结果相差只有0.001λ(RMS),效果很好。该技术已被应用到实际的双曲面凸面反射镜的测量中。

关键词：测量精度补偿器非圆对称误差泽尼克圆多项式校正法

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超精密车削金刚石刀具刃口误差的高精度补偿

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光电工程 2011年第1期38卷 98-102页

作者：王毅余景池苏州大学现代光学技术研究所江苏苏州215006

超精密车削中的金刚石刀具刃口误差的补偿问题一直是制约高精度非球面车削直接成形的瓶颈技术,尤其对于大相对口径,深度非球面的车削,金刚石刀具刃口误差对最终的面形的影响非常大。传统补偿方法是根据轮廓仪的测量结果对刀具刃口误差... 详细信息

超精密车削中的金刚石刀具刃口误差的补偿问题一直是制约高精度非球面车削直接成形的瓶颈技术,尤其对于大相对口径,深度非球面的车削,金刚石刀具刃口误差对最终的面形的影响非常大。传统补偿方法是根据轮廓仪的测量结果对刀具刃口误差进行修正,但是该方法存在测量时间长,高频误差大,加工效率低的缺点,本文最先提出利用车削表面面形误差拟合后的泽尼克多项式系数对刀具刃口误差进行加工补偿,首先对该补偿方法进行了详细的理论推导,然后对补偿效果进行计算机模拟,最后在Nanotech250单点金刚石车床上完成了口径50mm,半径50mm大相对口径实验件的超精密车削及修正车削,面形精度PV=86nm,RMS=7nm。充分证明该补偿符合预期,精度高,误差收敛速度快。

关键词：超精密车削刀具刃口误差补偿光学加工

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