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Microglial displacement of GABAergic synapses has endogenous protective function in generation of complex febrile seizures

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中国药理学与毒理学杂志 2018年第9期32卷 723-724页

作者： WAN yu-shan YOU Yi FENG Bo yu jie XU Ceng-lin DAI Hai-bin CHEN Zhong HU Wei-wei Department of Pharmacology School of Basic Medical Sciences and Department of Pharmacy of Second Affiliated Hospital NHC and CAMS Key Laboratory of Medical Neurobiology School of Medicine Zhejiang University Hangzhou 310058 China Laboratory of

OBJECTIVE Microglia-mediated dis-placement of synapses has been reported in the setting of experimental neuroinflammation,but its role in neurological disorders is poorly *** febrile seizures(FS) are the most common infantile seizures,yet its pathological progress is largely *** Mice pups(postnatal 8-10 d) were posted to 43℃ hyperthermia condition to develop FS,and then the latency and threshold of seizures were *** displacement of synapses was observed through immunofluorescence *** researched whether microglial displacement of GABAergic synapses will influence complex FS-induced increase in GABAergic neurotransmission and neuronal excitability with patch-clamp ***,we used the CD11 bD TR mice to selective ablation of microglia or pharmacological inhibition of microglia to observe their effects on susceptibility to FS and synaptic *** GABAergic presynaptic terminals surrounding neuronal soma and GABAergic transmissions were increased in complex ***,the activated microglia ensheathe glutamatergic neuronal soma to displace,but do not phagocytize,GABAergic presynaptic ***-clamp electrophysiology established that the microglial displacement of GABAergic synapses reduced complex FS-induced increase in GABAergic neurotransmission and neuronal excitability,while GABA exerts excitatory action in this immature ***,pharmacological inhibition of microglial displacement of GABAergic synapses or selective ablation of microglia in CD11 bDTR mice promoted the generation of complex *** Displacement of GABAergic synapses by microglia is a protective event in the pathological progress of complex FS.

关键词： microglia synaptic displacement febrile seizure GABAergic neurotransmission

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脉冲填料萃取塔性能强化的研究

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化工进展 2002年第Z1期21卷 66-70页

作者：于杰任钟旗费维扬清华大学化学工程系北京100084 清华大学化学工程系北京100084 清华大学化学工程系北京100084

针对己内酰胺等工业装置脉冲填料萃取塔扩能改造的迫切要求,在(φ)100mm的实验塔中用四种体系研究了填料类型、脉冲强度、体系物性和操作条件等对脉冲填料萃取塔流体力学和传质性能的影响.实验结果表明,QH-1型扁环填料的处理能力和传质... 详细信息

针对己内酰胺等工业装置脉冲填料萃取塔扩能改造的迫切要求,在(φ)100mm的实验塔中用四种体系研究了填料类型、脉冲强度、体系物性和操作条件等对脉冲填料萃取塔流体力学和传质性能的影响.实验结果表明,QH-1型扁环填料的处理能力和传质效率明显高于拉西环填料.脉冲强度对塔内分散相的液滴平均直径、存留分数和塔性能具有重要影响.因此,填料的选型和脉冲强度的调优是脉冲填料萃取塔强化的关键因素.

关键词：脉冲填料萃取塔流体力学传质性能 QH-1型扁环填料脉冲强度

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Activation of NLRC4 downregulates TLR5-mediated antibody immune responses against flagellin

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Cellular & Molecular Immunology 2016年第4期13卷 514-523页

作者： Wei Li Jingyi Yang Ejuan Zhang Maohua Zhong Yang Xiao jie yu Dihan Zhou yuan Cao Yi Yang Yaoming Li Huimin Yan Mucosal Immunity Research Group State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 People's Republic of China

Bacterial flagellin is a unique pathogen-associated molecular pattern （PAMP）, which can be recognized by surface localized Toll-like receptor 5 （TLR5） and the cytosolic NOD-like receptor （NLR） protein 4 （NLRC4） receptors. Activation of the TLR5 and/or NLRC4 signaling pathways by flagellin and the resulting immune responses play important roles in anti-bacterial immunity. However, it remains unclear how the dual activities of flagellin that activate the TLR5 and/or NLRC4 signaling pathways orchestrate the immune responses. In this study, we assessed the effects of flagellin and its mutants lacking the ability to activate TLR5 and NLRC4 alone or in combination on the adaptive immune responses against flagellin. Flagellin that was unable to activate NLRC4 induced a significantly higher antibody response than did wild-type flagellin. The increased antibody response could be eliminated when macrophages were depleted in vivo. The activation of NLRC4 by flagellin downregulated the flagellin-induced and TLR5-mediated immune responses against flagellin.

关键词： flagellin NLRC4 TLR5 macrophage adaptive immunity

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Tree-ring-based drought variability in northern China over the past three centuries

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Journal of Geographical Sciences 2022年第2期32卷 214-224页

作者： ZENG Xueli LIU yu SONG Huiming LI Qiang CAI Qiufang FANG Congxi SUN Changfeng ren Meng The State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentCASXi’an 710061China University of the Chinese Academy of Sciences Beijing 100049China CAS Center for Excellence in Quaternary Science and Global Change CASXi’an 710061China Laboratory for Ocean Dynamics and Climate Pilot Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237ShandongChina School of Human Settlements and Civil Engineering Xi’an Jiaotong UniversityXi’an 710049China Xi’an Institute for Innovative Earth Environment Research Xi’an 710061China

Droughts are the most frequent natural disaster in regions at the margins of the East Asian summer monsoon(EASM),which pose threats to agriculture,the economy,and human ***,the limitations of only approximately 60 years of meteorological observations hamper our understanding of the characteristics and mechanisms of local *** growing in the marginal region of the EASM are usually sensitive to moisture variations and have played important roles in past hydroclimatic ***,a 303-year tree-ring-width chronology of Pinus tabulaeformis from ***,which is located in the junction of the Liaoning Province and Inner Mongolia,China,was used to reconstruct the May-August Palmer drought severity index(PDSI)in the marginal region of the *** transfer function explains 48.0%(or 47.2%after adjusting for the loss of the degrees of freedom)of the variance over the calibration period from 1946 to 2012.A spatial correlation analysis demonstrates that our PDSI reconstruction can represent the drought variability on the northernmost margin of the *** winter Asian polar vortex area index showed a delayed impact on the summer EASM precipitation in the following year.

关键词： tree-ring width Mt.Lama PDSI East Asian summer monsoon Asian polar vortex area index

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The effects and potential of microglial polarization and crosstalk with other cells of the central nervous system in the treatment of Alzheimer’s disease

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Neural Regeneration Research 2023年第5期18卷 947-954页

作者： Yi-Ge Wu Li-Juan Song Li-Jun Yin Jun-Jun Yin Qing Wang jie-Zhong yu Bao-Guo Xiao Cun-Gen Ma The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Research Center of Neurobiology Shanxi University of Chinese MedicineJinzhongShanxi ProvinceChina Department of Physiology Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Zhejiang Chinese Medical University HangzhouZhejiang ProvinceChina Institute of Brain Science/Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases/Medical School Shanxi Datong UniversityDatongShanxi ProvinceChina Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

Microglia are resident immune cells in the central nervous system. During the pathogenesis of Alzheimer’s disease, stimulatory factors continuously act on the microglia causing abnormal activation and unbalanced phenotypic changes;these events have become a significant and promising area of research. In this review, we summarize the effects of microglial polarization and crosstalk with other cells in the central nervous system in the treatment of Alzheimer’s disease. Our literature search found that phenotypic changes occur continuously in Alzheimer’s disease and that microglia exhibit extensive crosstalk with astrocytes, oligodendrocytes, neurons, and penetrated peripheral innate immune cells via specific signaling pathways and cytokines. Collectively, unlike previous efforts to modulate microglial phenotypes at a single level, targeting the phenotypes of microglia and the crosstalk with other cells in the central nervous system may be more effective in reducing inflammation in the central nervous system in Alzheimer’s disease. This would establish a theoretical basis for reducing neuronal death from central nervous system inflammation and provide an appropriate environment to promote neuronal regeneration in the treatment of Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid biomarker central nervous system cytokines diabetes inflammation microglia neuroinflammation phagocytosis tau

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Built-in electric field and core-shell structure of the reconstructed sulfide heterojunction accelerated water splitting

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Chinese Chemical Letters 2024年第12期35卷 166-172页

作者： Shudi yu jie Li Jiongting Yin Wanyu Liang Yangping Zhang Tianpeng Liu Mengyun Hu Yong Wang Zhengying Wu yuefan Zhang yukou Du College of Chemistry Chemical Engineering and Materials Science Soochow University Jiangsu Key Laboratory for Environment Functional Materials School of Materials Science and Engineering Suzhou University of Science and Technology

The rational design of high-performance bifunctional electrocatalysts for overall water splitting(OWS) is the key to popularize hydrogen production technology. The active metal oxyhydroxide(MOOH) formed after surface self-reconfiguration of transition metal sulfide(TMS) electrocatalyst is often regarded as the "actual catalyst" in oxygen evolution reaction(OER). Herein, an Fe doped Co S2/Mo S2hollow TMS polyhedron(Fe-Co S2/Mo S2) with rich Mott-Schottky heterojunction is reported and directly utilized as an OWS electrocatalyst. The spontaneous built-in electric field(BEF) at the heterogeneous interface regulates the electronic structure and D-band center of the catalyst. More importantly, the “TMS-MOOH” core-shell structure obtained in the KOH electrolyte shows enhanced OER properties. And the introduction of Fe ions activates the inert basal plane of Mo S2, which greatly steps up the performance of HER. Hence, the preferable Fe-Co S2/Mo S2–400 presents superior OER activity(η10= 178 m V, η100= 375 m V), HER activity(η10= 92 m V) and ultra-high stability for 50 h. This work has deeply explored the catalytic mechanism of TMS and provided a new idea for the construction of efficient bifunctional catalysts.

关键词： Pre-catalyst Heterostructure Built-in electric field (BEF) Self-reconstruction Oxygen evolution reaction (OER)

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New status of the infrared beamlines at SSRF

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Nuclear Science and Techniques 2019年第12期30卷 83-93页

作者： Xiao-jie Zhou Hua-Chun Zhu Jia-Jia Zhong Wei-Wei Peng Te Ji yue-Cheng Lin yu-Zhao Tang Min Chen National Facility for Protein Science in Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

There are two infrared beamlines at the Shanghai synchrotron radiation facility(SSRF)-BL01B and ***01B was the first infrared beamline of the National Facility for Protein Science in Shanghai at SSRF,which is dedicated to synchrotron infrared *** utilizes bending magnet radiation and edge radiation as light ***-limited spatial resolution is reached in the infrared microspectroscopy ***01B has been in operation for approximately five years since it opened in January *** the past few years,many meaningful results have been published by user groups from various disciplines,such as biomacromolecule materials and pharmaceutical,environmental,and biomedical *** addition,a new infrared beamline station BL06B is under construction,which is optimized for the mid-infrared and far-infrared ***06B is equipped with a vacuum-type Fourier transform infrared spectrometer,infrared microscope,custom longworking-distance infrared microscope,infrared scanning near-field optical microscope,and mid-infrared Mueller *** purpose is to serve experiments with high vacuum requirements and spatial resolution experiments,as well as those that are in situ and time-sensitive,such as high-pressure and atomic force microscopy infrared *** station can be used for research in biomaterials,pharmacy,geophysics,nanotechnology,and semiconductor materials.

关键词： Synchrotron radiation Fourier transform infrared spectroscopy Infrared microspectroscopy Infrared beamlines

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A rabies virus-based toolkit for efficient retrograde labeling and monosynaptic tracing

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Neural Regeneration Research 2023年第8期18卷 1827-1833页

作者： Kun-Zhang Lin Lei Li Wen-yu Ma Xin Yang Zeng-Peng Han Neng-Song Luo jie Wang Fu-Qiang Xu The Brain Cognition and Brain Disease Institute(BCBDI) Shenzhen Key Laboratory of Viral Vectors for BiomedicineShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsNMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsShenzhenKey Laboratory of Quality Control Technology for Virus-Based TherapeuticsGuangdong Provincial Medical Products AdministrationShenzhenGuangdong ProvinceChina State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in WuhanWuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences-Wuhan National Laboratory for OptoelectronicsWuhanHubei ProvinceChina University of Chinese Academy of Sciences BeijingChina Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei ProvinceChina Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions ShenzhenGuangdong ProvinceChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina

Analyzing the structure and function of the brain's neural network is critical for identifying the working principles of the brain and the mechanisms of brain *** rabies viral vectors allow for the retrograde labeling of projection neurons and cell type-specific trans-monosynaptic tracing,making these vectors powerful candidates for the dissection of synaptic *** several attenuated rabies viral vectors have been developed,their application in studies of functional networks is hindered by the long preparation cycle and low yield of these *** overcome these limitations,we developed an improved production system for the rapid rescue and preparation of a high-titer CVS-N2c-ΔG *** results showed that the new CVS-N2c-ΔG-based toolkit performed remarkably:(1)N2cG-coated CVS-N2c-ΔG allowed for efficient retrograde access to projection neurons that were unaddressed by rAAV9-Retro,and the efficiency was six times higher than that of rAAV9-Retro;(2)the trans-monosynaptic efficiency of oG-mediated CVS-N2c-ΔG was 2–3 times higher than that of oG-mediated SAD-B19-ΔG;(3)CVS-N2c-ΔG could delivery modified genes for neural activity monitoring,and the time window during which this was maintained was 3 weeks;and(4)CVS-N2c-ΔG could express sufficient recombinases for efficient transgene *** findings demonstrate that new CVS-N2c-ΔG-based toolkit may serve as a versatile tool for structural and functional studies of neural circuits.

关键词： functional studies neural activity neural circuits projection neurons rAAV9-Retro rabies virus recombination retrograde labeling synaptic inputs trans-monosynaptic tracing

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Ferroptosis-induced anticancer effect of resveratrol with a biomimetic nano-delivery system in colorectal cancer treatment

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Asian Journal of Pharmaceutical Sciences 2022年第5期17卷 751-766页

作者： Ziting Zhang You Ji Nan Hu Qinqi yu Xinrui Zhang jie Li Fenglei Wu Huae Xu Qiyun Tang Xiaolin Li Department of Geriatric Gastroenterology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210009China Department of Pharmaceutics School of PharmacyNanjing Medical UniversityNanjing 211166China Department of Oncology the Affiliated Hospital of Kangda College of Nanjing Medical University&the First People’s Hospital of LianyungangLianyungang 222000China

Ferroptosis is a novel form of programmed cell death impelled by iron-dependent lipid peroxidation,which may be a potential strategy for cancer *** we demonstrated for the first time that Resveratrol(RSV),a traditional Chinese medicine(TCM)chemical monomer,could effectually inhibit the growth of colon cancer cells through the ROS-dependent ferroptosis ***,RSV evoked the increase of reactive oxygen species and lipid peroxidation in colorectal cancer cells,and eventually lead to ***,RSV could promote ferroptosis by downregulating the expression of the channel protein solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4).To improve the delivery efficiency of RSV,a biomimetic nanocarrier was developed by coating RSV-loaded poly(ε-caprolactone)-poly(ethylene glycol)(PCL-PEG)nanoparticles with erythrocyte membrane(RSV-NPs@RBCm).The RSV-NPs@RBCm provide the possibility to escape macrophage phagocytosis and have a long circulation *** addition,when coupled with a tumor-penetrating peptide iRGD,which could trigger enhanced tissue penetration tumor-specifically,the delivery of RSV-NPs@RBCm into tumors would be significantly improved results from the in vivo study demonstrated an excellent treatment efficacy for ***,our study highlighted the therapeutic potential of RSV as a ferroptosis-inducing anticancer agent and when loaded into a biomimetic nanoplatform,it might pave the way for the application of RSV loaded nanosystems for colorectal cancer treatment.

关键词： Resveratrol Red-blood-cell membrane Colorectal cancer Ferroptosis IRGD

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Investigation of weight updating modes on oxide-based resistive switching memory synapse towards neuromorphic computing applications

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Science China(Information Sciences) 2021年第11期64卷 253-254页

作者： Qingting DING Tiancheng GONG jie yu Xiaoxin XU Xiaoyan LI Hangbing LV Jianguo YANG Qing LUO Peng yuAN Feng ZHANG Ming LIU Institute of Microelectronics Chinese Academy of Sciences University of Chinese Academy of Sciences

Dear editor,Memristors, resistive random access memory(RRAM) devices when used in memory applications, have attracted significant interest recently as a promising candidate for neuromorphic computing systems due to their excellent size scalability, fast switching speed and low energy consumption [1].In order to obtain high learning accuracy in neural networks based on back propagation learning rule, the updating behavior of synaptic linear symmetric weights is important [2].

关键词： Gate Voltage Ramping (GVR) Constant Drain Voltage (CDV) Time Lag Plot RTN neuromorphic computing

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