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高胆红素血症对新生儿T淋巴细胞亚群、血清可溶性白细胞介素-2受体变化趋势的影响和意义

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中华围产医学杂志 2011年第1期14卷 45-48页

作者：庞琳曾慧慧何明虞人杰北京地坛医院儿科 100015 清华大学第一附属医院儿科

目的探讨新生儿高胆红素血症（简称高胆）时T淋巴细胞亚群和血清可溶性白细胞介素-2受体（soluble interleukin-2 receptor,sIL-2R）水平的变化趋势及其临床意义.方法选择2006年12月1日至2007年1月31日住院的31例高胆新生儿作为高胆组... 详细信息

目的探讨新生儿高胆红素血症（简称高胆）时T淋巴细胞亚群和血清可溶性白细胞介素-2受体（soluble interleukin-2 receptor,sIL-2R）水平的变化趋势及其临床意义.方法选择2006年12月1日至2007年1月31日住院的31例高胆新生儿作为高胆组,再根据黄疸程度分为重度黄疸组和轻度黄疸组;将其中16例随访病例按照病程分为黄疸高峰期与黄疸恢复期.选取同期与高胆组日龄相匹配的32例健康足月新生儿（无黄疸或血清胆红素水平≤204.0 μmol/L）作为与高胆组相对应的对照组（对照组Ⅰ）;选取同期与黄疸恢复期病例日龄相匹配的26例健康足月新生儿（日龄＞7 d）作为与随访病例相对应的对照组（对照组Ⅱ）.采用方差分析及两两检验比较各组血清胆红素、T淋巴细胞亚群、sIL-2R水平,并分析其间的相关性.结果高胆组新生儿的CD3、CD4、CD4/CD8比值分别为（54.0±5.1）%、（26.8±5.0）%和0.8±0.1,较对照组Ⅰ[（62.0±4.7）%、（43.0±4.7）%和1.4±0.2]降低（P＜0.01）;而黄疸恢复期较黄疸高峰期增高[（62.4±3.3）%和（55.1±4.2）%、（43.6±2.5）%和（26.1±4.4）%、1.4±0.1和0.8±0.1]（P＜0.01）;黄疸高峰期血清sIL-2R水平[（319.4±185.2）kU/L]高于黄疸恢复期[（129.7±99.3）kU/L]和对照组Ⅱ[（171.9±102.2）kU/L]（P＜0.01）.总体的血清胆红素水平与CD4/CD8比值呈负相关（r=-0.99,P＜0.01）,与sIL-2R水平呈正相关（r=0.95,P＜0.05）,sIL-2R水平与CD4/CD8比值呈负相关（r=-0.92,P＜0.05）.结论新生儿高胆时存在细胞免疫功能抑制状态,该抑制状态有随着黄疸消退而逐渐减轻的趋势.

关键词：高胆红素血症,新生儿 T淋巴细胞亚群受体,白细胞介素-2

The Coupling Effect of Flood Discharge and Storm Surge on Extreme Flood Stages: A Case Study in the Pearl River Delta, South China

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International Journal of Disaster Risk Science 2021年第4期12卷 495-509页

作者： Xianwei Wang yu Guo jie ren School of Geography and Planning Sun Yat-sen UniversityGuangzhou510275China Guangdong Provincial Engineering Research Center for Public Security and Disasters Guangzhou510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai519082China School of Marine Science Sun Yat-sen UniversityZhuhai519080China

The low-lying Pearl River Delta in South China is subject to severe flood threats due to watershed floods,sea level rise,and storm *** is still unknown to what extent and how far inland storm surges and sea level rise impact the extreme flood *** study investigated the coupling effect of flood discharge and storm surge on the extreme flood stages in the Pearl River Delta by using on site observations and simulations generated by the Hydrologic Engineering Center-River Analysis System *** results show that flood discharges dominated the flood stages in the middle and upper Pearl River Delta,while the storm surges had maximum impact near the river *** storm surges and flood stages showed a significant increase after 2002 in the Hengmen *** design flood stages for the post-2002 period were 0.23–0.89 m higher than the pre-2002 ones at Hengmen at the six return periods from 5 to 200 years examined in this *** difference declined toward the upper waterway and reduced to zero about 23 km away from the Hengmen *** coincidence of extreme flood discharges and storm surges further escalates the extreme flood stages in the lower 30 km of estuarine *** results quantify the severe threats due to sea level rise and intensified storm surges in the lower Pearl River Delta,and are significant for urban planning and designing and managing flood control facilities in the Pearl River Delta and in other coastal fluvial deltas.

关键词： Extreme flood stages Flood Pearl river delta Sea level rise Storm surge

蒺藜苜蓿膜联蛋白MtANN2基因的表达模式及盐胁迫下的功能分析

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草业学报 2022年第5期31卷 124-134页

作者：刘亚男于人杰高燕丽康俊梅杨青川武志海王珍中国农业科学院北京畜牧兽医研究所北京100193 吉林农业大学农学院吉林长春130118 浙江农林大学林业与生物技术学院浙江杭州311300

膜联蛋白(annexins)是一类进化保守的多基因家族蛋白,它们广泛存在于真核生物中,能通过Ca^(2+)与膜磷脂的结合参与胁迫相关的多种生物学过程。早期对膜联蛋白的研究多集中于脊椎动物,对植物膜联蛋白的认识开始于番茄。关于豆科植物尤其... 详细信息

膜联蛋白(annexins)是一类进化保守的多基因家族蛋白,它们广泛存在于真核生物中,能通过Ca^(2+)与膜磷脂的结合参与胁迫相关的多种生物学过程。早期对膜联蛋白的研究多集中于脊椎动物,对植物膜联蛋白的认识开始于番茄。关于豆科植物尤其是牧草中膜联蛋白的研究还鲜有报道。本研究分析了蒺藜苜蓿膜联蛋白与饲草紫花苜蓿同源蛋白的进化关系,研究了蒺藜苜蓿膜联蛋白基因MtANN2的表达模式,进一步利用拟南芥同源基因的突变体阐明了MtANN2在根系发育和盐胁迫中的功能。RT-qPCR结果显示,MtANN2在根中高丰度表达,且表达水平受NaCl诱导。RNA原位杂交表明MtANN2特异表达于幼苗侧根原基。拟南芥同源基因AtANN2的T-DNA插入突变体植株弱小、侧根数少、根鲜重低,且对盐(100 mmol·L^(-1))处理的敏感性显著高于野生型。超表达MtANN2于atann2后转基因植株的侧根数介于野生型与突变体之间,根鲜重接近野生型,表明MtANN2能在一定程度上互补该突变体的表型缺陷。在盐处理下,该转基因株系的发芽率和长势均恢复到类似野生型的水平。以上结果从分子水平上表明,蒺藜苜蓿膜联蛋白MtANN2参与植物根系生长及盐胁迫响应,高水平表达该基因能够改善植物的耐盐性。本研究为紫花苜蓿耐盐分子育种提供了备选基因。

关键词：蒺藜苜蓿膜联蛋白表达模式超表达盐胁迫

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眼眶软组织肿瘤455例临床病理观察

国际眼科杂志 2019年第10期19卷 1795-1799页

作者：刘辉任雨洁蔡凤梅杨菁茹李元朋王卉芳中国陕西省西安市第四医院病理科

目的:探讨眼眶软组织肿瘤临床病理特征。方法:回顾性分析我院2003-11/2018-11眼眶软组织肿瘤患者455例的病例资料,观察其临床特点、病理分类和少见肿瘤的病理学特征。结果:眼眶软组织肿瘤患者455例中,良性肿瘤421例(92.5%),居于前5位的... 详细信息

目的:探讨眼眶软组织肿瘤临床病理特征。方法:回顾性分析我院2003-11/2018-11眼眶软组织肿瘤患者455例的病例资料,观察其临床特点、病理分类和少见肿瘤的病理学特征。结果:眼眶软组织肿瘤患者455例中,良性肿瘤421例(92.5%),居于前5位的依次为海绵状血管瘤258例、毛细血管瘤58例、神经纤维瘤16例、纤维瘤15例和神经鞘瘤14例;中间型27例(5.9%),其中孤立性纤维性肿瘤(SFT)23例、低度恶性纤维组织细胞瘤2例、低度恶性黏液性神经纤维瘤2例;恶性7例(1.5%),其中眼眶恶性SFT者2例,眼眶髓系肉瘤(MS)2例,黏液样脂肪肉瘤(MLS)、梭形细胞未分化肉瘤和外周原始神经外胚叶肿瘤(PNET)各1例。对部分病例进行免疫组化和分子检测,结果发现新抗体如STAT6和分子检测技术的应用能提高诊断准确性。结论:眼眶软组织肿瘤中,良性肿瘤占大部分,脉管肿瘤中的海绵状血管瘤居于首位,不乏眼眶部位少见软组织肿瘤病理学类型如Erdheim-Chester病(ECD)、砂粒体性骨化性纤维瘤(POF)、平滑肌瘤和黏液瘤等;中间型和恶性肿瘤少见,眼眶部位SFT、MLS、梭形细胞未分化肉瘤和MS等少见的病理学类型常诊断困难,容易漏诊误诊,新型免疫组化抗体和分子检测技术能提高诊断的准确率。

关键词：软组织肿瘤眼眶肿瘤孤立性纤维性肿瘤眼眶髓系肉瘤 Erdheim-Chester病

Sulfolane‑Based Flame‑Retardant Electrolyte for High‑Voltage Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 498-516页

作者： Xuanlong He jie Peng Qingyun Lin Meng Li Weibin Chen Pei Liu Tao Huang Zhencheng Huang yuying Liu Jiaojiao Deng Shenghua Ye Xuming Yang Xiangzhong ren Xiaoping Ouyang Jianhong Liu Biwei Xiao Jiangtao Hu Qianling Zhang Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060People’s Republic of China Center of Electron Microscopy State Key Laboratory of Silicon and Advanced Semiconductor MaterialsSchool of Materials Science and EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China GRINM(Guangdong)Research Institute for Advanced Materials and Technology FoshanGuangdong 528051People’s Republic of China College of Energy Engineering Zhejiang UniversityHangzhouZhejiang 310027People’s Republic of China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105People’s Republic of China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen 518000People’s Republic of China

Sodium-ion batteries hold great promise as next-generation energy storage ***,the high instability of the electrode/electrolyte interphase during cycling has seriously hindered the development of *** particular,an unstable cathode–electrolyte interphase(CEI)leads to successive electrolyte side reactions,transition metal leaching and rapid capacity decay,which tends to be exacerbated under high-voltage ***,constructing dense and stable CEIs are crucial for high-performance *** work reports localized high-concentration electrolyte by incorporating a highly oxidation-resistant sulfolane solvent with non-solvent diluent 1H,1H,5H-octafluoropentyl-1,1,2,2-tetrafluoroethyl ether,which exhibited excellent oxidative stability and was able to form thin,dense and homogeneous *** excellent CEI enabled the O3-type layered oxide cathode NaNi_(1/3)Mn_(1/3)Fe_(1/3)O_(2)(NaNMF)to achieve stable cycling,with a capacity retention of 79.48%after 300 cycles at 1 C and 81.15%after 400 cycles at 2 C with a high charging voltage of 4.2 *** addition,its nonflammable nature enhances the safety of *** work provides a viable pathway for the application of sulfolane-based electrolytes on SIBs and the design of next-generation high-voltage electrolytes.

关键词： Sodium-ion batteries Sulfolane-based electrolyte High voltage Layered oxide cathode Flame retardant

成人血液肿瘤患者并发耶氏肺孢子菌肺炎6例临床分析

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国际呼吸杂志 2018年第6期38卷 401-407页

作者：陈林桂黄李飞余鑫任杰刘健黄怡上海第二军医大学长海医院呼吸内科 200433 上海武警总队医院呼吸科 201103 上海长海医院呼吸及危重症科 200433

目的探讨血液肿瘤患者并发耶氏肺孢子菌肺炎（PJP）临床特点及诊疗策略,以期提高对该病的认识水平。方法对长海医院2012年1月至2016年12月间确诊的6例血液肿瘤并发PJP患者临床表现、影像学特点、血清学检查、BALF细胞学分类及诊治策... 详细信息

目的探讨血液肿瘤患者并发耶氏肺孢子菌肺炎（PJP）临床特点及诊疗策略,以期提高对该病的认识水平。方法对长海医院2012年1月至2016年12月间确诊的6例血液肿瘤并发PJP患者临床表现、影像学特点、血清学检查、BALF细胞学分类及诊治策略等结合文献复习综合分析。结果 ①基础疾病为急性淋巴细胞性白血病3例,急性髓细胞性白血病2例,非何杰金淋巴瘤1例。均接受过化、放疗,长期使用大剂量激素及免疫抑制剂,其中4例接受异基因造血干细胞移植（alo-HSCT）、1例发生慢性移植物抗宿主病（cGVHD）;②5例患者急性起病,主要表现为发热5例（83.33%）,中高热为主;咳嗽咳痰4例（66.67%）;气急4例（66.67%）;胸闷1例;其中仅1例PaO2＆lt;70mmHg;③6例患者中,通过支气管肺泡灌洗液（BALF）涂片确诊5例,痰涂片确诊1例,血清1,3-β-D葡聚糖4例增高,经治疗后3例先增高后复又降低;④6例患者均行胸部CT检查,主要表现为两肺弥漫性磨玻璃影4例,斑片样高密度影3例,支气管充气征2例;⑤6例患者均接受了诊断性支气管肺泡灌洗术（BAL）检查,其中5例BALF常规细胞计数总数增高,细胞分类检查发现6例肺泡巨噬细胞比例均下降,淋巴细胞比例均增高,其中5例患者以淋巴细胞比例增高为主,1例以中性粒细胞比例增高为主;⑥明确诊断后分别给予口服磺胺甲恶唑（SMZ）或静滴卡泊芬净单药或联合治疗,疗程2~4周,其中显效4例,进步2例,确诊30d内6例患者均存活。结论血液肿瘤患者是PJP高危人群,大多起病呈亚急性,常以发热、咳嗽、气急为首发症状,进展快,胸部CT典型表现及血清1,3-β-D葡聚糖对PJP有一定诊断价值;BALF中查到肺孢子菌是诊断的金标准。早诊断早治疗能显著改善预后,降低病死率。此外对于高危患者,应该予以必要的预防用药。

关键词：血液肿瘤耶氏肺孢子菌肺炎临床分析

Principles, developments and applications of laser-induced breakdown spectroscopy in agriculture: A review

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Artificial Intelligence in Agriculture 2020年第1期4卷 127-139页

作者： Keqiang yu jie ren Yanru Zhao College of Mechanical and Electronic Engineering Northwest A&F University22 Xinong RoadYanglingShaanxi 712100PR China Key Laboratory of Agricultural Internet of Things Ministry of Agriculture and Rural AffairsYanglingShaanxi 712100PR China Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent Service YanglingShaanxi 712100PR China

Considering the diversity of soil contents,quality and usability,a systematic scientific study on the elemental and chemical composition(major and minor nutrients elements,trace elements,heavy metals,etc.)of soil is very *** and accurate detection and prevention of soil contamination(mainly in pollutants of heavy metals)is deemed to be a concerned and serious central issue inmodern agriculture and agricultural sustainable *** order to study the chemical composition of soil,laser induced breakdown spectroscopy(LIBS)has been applied *** technology,a kind of atomic emission spectroscopy,is regarded as a future“Superstar”in the field of chemical analysis and green analytical *** this work,the research achievements and trends of soil elements detection based on LIBS technology were *** structural composition and operating principle of LIBS systemwas briefly *** paper offered a reviewof LIBS applications,including detection and analysis of major element,minor nutrient element and heavy metal ***,LIBS applications to analysis of the soil related materials,plants-related issues(nutrients,pesticide residues,and plants disease)were briefly *** research tendency and developing prospects of LIBS in agriculture were presented at last.

关键词： Laser-induced breakdown spectroscopy Soil elements Plants Detection methods Agriculture

From Elastic Spin to Phonon Spin:Symmetry and Fundamental Relations

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Chinese Physics Letters 2022年第12期39卷 41-49页

作者： jie ren Center for Phononics and Thermal Energy Science China-EU Joint Lab on NanophononicsShanghai Key Laboratory of Special Artificial Microstructure Materials and TechnologySchool of Physics Science and EngineeringTongji UniversityShanghai 200092China

This work is mainly based on postgraduate lectures at Tongji University since 2020 *** firstly revisit the elastic spin and orbital angular momentum[*** 115,9951(2018)]but more general for anisotropic systems by applying Noether’s theorem to the elastic Lagrangian and by applying the symmetry argument in the field ***,fundamental relations between elastic energy flux and elastic spin are *** particular cases,the wave spin is closely related to the vorticity of energy flux and ***,we move forward from the elastic spin to revisit the phonon spin[Fizika Tverdogo Tela 3,2160(1961)]by applying the second quantization to elastic *** show that the uncovered phonon spin,a polarized elastic-vibration quanta,is generally not restricted to transverse phonon modes,but applying to general phonon modes,such as the longitudinal phonon modes,surface phonon modes,and hybridized phonon modes,regarded as a consequence of mode *** elastic spin and phonon spin originate from the local rotating of the field polarization in time domain,not the local circulation(vorticity)of displacement or velocity in space *** is hopeful that the present results could advance the fundamental understanding of phonon spin and elastic spin,and promote the spin phononics for hybrid quantum sensing and technology with multiple degrees of freedom.

关键词： theory phonon applying

A model reduction approach for discrete-time linear time-variant systems with delayed inputs

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Science China(Information Sciences) 2024年第4期67卷 197-217页

作者： Ai-Guo WU Guang-ren DUAN yu WANG jie ZHANG School of Mechanical Engineering and Automation Harbin Institute of Technology(Shenzhen) HIT Wuhu Robot Technology Research Institute Center for Control Science and Technology Southern University of Science and Technology

A model reduction approach is presented for discrete-time linear time-variant input-delayed systems. According to this proposed approach, a dynamical variable is constructed by taking advantage of the current state and historical information of input. It is revealed that the behavior of this dynamical variable is governed by a discrete-time linear delay-free system. It is worth noting that the presented variable transformation does not require the system matrix to be invertible. Based on the reduced delay-free models,stabilizing control laws can be easily obtained for the original delayed system. For the case with a single input delay, the constructed variable is an exact prediction for the future state, and thus the stabilizing control law could be designed by replacing the future state with its prediction. Finally, three discrete-time periodic systems with delayed input are employed to illustrate how to utilize the presented model reduction approaches.

关键词： reduction approach predictor-based feedback time-varying systems delayed input periodic system